A Two-Part Mixture Model for Longitudinal Adverse Event Severity Data

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 30, Issue 5, 2003, Pages 315-336

  Kowalski, Kenneth G ^a   McFadyen, Lynn ^b   Hutmacher, Matthew M ^a   Frame, Bill ^a   Miller, Raymond ^a  

^a PFIZER INC   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Adverse events; Empirical Bayes predictions; Mixture model; Model misspecification; Nonlinear mixed effects modeling; NONMEM

Indexed keywords

ARTICLE; BAYES THEOREM; BIOSAFETY; LOGISTIC REGRESSION ANALYSIS; LONGITUDINAL STUDY; MATHEMATICAL COMPUTING; PREDICTION; PRIORITY JOURNAL; PROBABILITY; SIMULATION; STATISTICAL MODEL;

BAYES THEOREM; CLINICAL TRIALS, PHASE III; DRUGS, INVESTIGATIONAL; HUMANS; LOGISTIC MODELS; LONGITUDINAL STUDIES; PREDICTIVE VALUE OF TESTS;

EID: 0347932020     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:JOPA.0000008157.26321.3c     Document Type: Article

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