Design and power of a population pharmacokinetic study

Pharmaceutical Research

Volumn 18, Issue 1, 2001, Pages 75-82

  Lee, P I D ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Population pharmacokinetics; Study power; Study simulation

Indexed keywords

ACCURACY; ARTICLE; DRUG CLEARANCE; DRUG RESEARCH; METHODOLOGY; PATIENT COMPLIANCE; PHARMACOKINETICS; POPULATION RESEARCH; PRIORITY JOURNAL; SAMPLE; SAMPLING; SIMULATION;

ABSORPTION; CLINICAL TRIALS; DRUG MONITORING; FALSE POSITIVE REACTIONS; HUMANS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; PHARMACOKINETICS; SAMPLING STUDIES;

EID: 0035045467     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011030827847     Document Type: Article

References (6)

1. Experimental design and efficient parameter estimation in preclinical pharmacokinetics studies
2. Influence of inter-animal variability on the estimation of population pharmacokinetic parameters in preclinical studies
3. Analysis of animal pharmacokinetic data: Performance of the one point per animal design
4. On the recording of sample times and parameter estimation from repeated measures pharmacokinetic data
5. Do we need full compliance data for population pharmacokinetic analysis?
6. Evaluation of hypothesis testing for comparing two populations using NONMEM analysis