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Volumn 211, Issue 4, 2019, Pages 1131-1141

Complex trait prediction from genome data: Contrasting EBV in livestock to PRS in humans

Author keywords

EBV; Estimated breeding values; Genomic prediction; GenPred; Polygenic risk score; PRS; Segregation variance; Within family variance

Indexed keywords

ARTICLE; BIG DATA; BREED; BREEDING; BREEDING METHOD; EFFECTIVE POPULATION SIZE; ESTIMATED BREEDING VALUE; FAMILY HISTORY; FAMILY SIZE; GENE LINKAGE DISEQUILIBRIUM; GENE SEGREGATION; GENETIC ANALYSIS; GENETIC RISK; GENETIC TRAIT; GENETIC VARIABILITY; GENETIC VARIATION; HERITABILITY; HUMAN; LIVESTOCK; MOLECULAR PHYLOGENY; NONHUMAN; POLYGENIC RISK SCORE; PREDICTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; GENETICS; GENOME-WIDE ASSOCIATION STUDY; MULTIFACTORIAL INHERITANCE; PROCEDURES; QUANTITATIVE TRAIT;

EID: 85064722496     PISSN: 00166731     EISSN: 19432631     Source Type: Journal    
DOI: 10.1534/genetics.119.301859     Document Type: Article
Times cited : (91)

References (83)
  • 1
    • 84901726217 scopus 로고    scopus 로고
    • Accurate and robust genomic prediction of celiac disease using statistical learning
    • (erratum: PLoS Genet. 10: e1004374)
    • Abraham, G., J. A. Tye-Din, O. G. Bhalala, A. Kowalczyk, J. Zobel et al., 2014 Accurate and robust genomic prediction of celiac disease using statistical learning. PLoS Genet. 10: e1004137 (erratum: PLoS Genet. 10: e1004374). https://doi.org/10.1371/journal.pgen.1004137
    • (2014) PLoS Genet , vol.10 , pp. e1004137
    • Abraham, G.1    Tye-Din, J.A.2    Bhalala, O.G.3    Kowalczyk, A.4    Zobel, J.5
  • 3
    • 85041549951 scopus 로고    scopus 로고
    • Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics
    • Beaumont, R. N., N. M. Warrington, A. Cavadino, J. Tyrrell, M. Nodzenski et al., 2018 Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Hum. Mol. Genet. 27: 742-756. https://doi.org/10.1093/hmg/ddx429
    • (2018) Hum. Mol. Genet , vol.27 , pp. 742-756
    • Beaumont, R.N.1    Warrington, N.M.2    Cavadino, A.3    Tyrrell, J.4    Nodzenski, M.5
  • 4
    • 2642581701 scopus 로고    scopus 로고
    • Predicting disease using genomics
    • Bell, J., 2004 Predicting disease using genomics. Nature 429: 453-456. https://doi.org/10.1038/nature02624
    • (2004) Nature , vol.429 , pp. 453-456
    • Bell, J.1
  • 5
    • 65449132092 scopus 로고    scopus 로고
    • Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds
    • Bovine HapMap Consortium, R. A. Gibbs, J. F. Taylor, C. P. Van Tassell, W. Barendse et al., 2009 Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds. Science 324: 528-532. https://doi.org/10.1126/science.1167936
    • (2009) Science , vol.324 , pp. 528-532
    • Gibbs, R.A.1    Taylor, J.F.2    Van Tassell, C.P.3    Barendse, W.4
  • 6
    • 31344465177 scopus 로고    scopus 로고
    • Artificial selection and maintenance of genetic variance in the global dairy cow population
    • Brotherstone, S., and M. Goddard, 2005 Artificial selection and maintenance of genetic variance in the global dairy cow population. Philos. Trans. R. Soc. Lond. B Biol. Sci. 360: 1479-1488. https://doi.org/10.1098/rstb.2005.1668
    • (2005) Philos. Trans. R. Soc. Lond. B Biol. Sci , vol.360 , pp. 1479-1488
    • Brotherstone, S.1    Goddard, M.2
  • 7
    • 84923946495 scopus 로고    scopus 로고
    • LD score regression distinguishes confounding from polygenicity in genome-wide association studies
    • Bulik-Sullivan, B. K., P. R. Loh, H. K. Finucane, S. Ripke, J. Yang et al., 2015 LD score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet. 47: 291-295. https://doi.org/10.1038/ng.3211
    • (2015) Nat. Genet , vol.47 , pp. 291-295
    • Bulik-Sullivan, B.K.1    Loh, P.R.2    Finucane, H.K.3    Ripke, S.4    Yang, J.5
  • 8
    • 84904869948 scopus 로고    scopus 로고
    • Animal models of Alzheimer disease: Historical pitfalls and a path forward
    • Cavanaugh, S. E., J. J. Pippin, and N. D. Barnard, 2014 Animal models of Alzheimer disease: historical pitfalls and a path forward. ALTEX 31: 279-302. https://doi.org/10.14573/altex. 1310071
    • (2014) ALTEX , vol.31 , pp. 279-302
    • Cavanaugh, S.E.1    Pippin, J.J.2    Barnard, N.D.3
  • 9
    • 84930213392 scopus 로고    scopus 로고
    • Second-generation PLINK: Rising to the challenge of larger and richer datasets
    • Chang, C. C., C. C. Chow, L. C. Tellier, S. Vattikuti, S. M. Purcell et al., 2015 Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience 4: 7. https://doi.org/10.1186/s13742-015-0047-8
    • (2015) Gigascience , vol.4 , pp. 7
    • Chang, C.C.1    Chow, C.C.2    Tellier, L.C.3    Vattikuti, S.4    Purcell, S.M.5
  • 10
    • 84965076156 scopus 로고    scopus 로고
    • Developing and evaluating polygenic risk prediction models for stratified disease prevention
    • Chatterjee, N., J. X. Shi, and M. Garcia-Closas, 2016 Developing and evaluating polygenic risk prediction models for stratified disease prevention. Nat. Rev. Genet. 17: 392-406. https://doi. org/10.1038/nrg.2016.27
    • (2016) Nat. Rev. Genet , vol.17 , pp. 392-406
    • Chatterjee, N.1    Shi, J.X.2    Garcia-Closas, M.3
  • 11
    • 0037464588 scopus 로고    scopus 로고
    • A vision for the future of genomics research
    • Collins, F. S., E. D. Green, A. E. Guttmacher M. S. Guyer, and US National Human Genome Research Institute, 2003 A vision for the future of genomics research. Nature 422: 835-847. https://doi.org/10.1038/nature01626
    • (2003) Nature , vol.422 , pp. 835-847
    • Collins, F.S.1    Green, E.D.2    Guttmacher, A.E.3    Guyer, M.S.4
  • 12
    • 84883465830 scopus 로고    scopus 로고
    • Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
    • Cross-Disorder Group of the Psychiatric Genomics Consortium S. H. Lee, S. Ripke, B. M. Neale, S. V. Faraone et al., 2013 Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat. Genet. 45: 984-994. https://doi.org/10.1038/ng.2711
    • (2013) Nat. Genet , vol.45 , pp. 984-994
    • Lee, S.H.1    Ripke, S.2    Neale, B.M.3    Faraone, S.V.4
  • 13
    • 54449097329 scopus 로고    scopus 로고
    • Accuracy of predicting the genetic risk of disease using a genome-wide approach
    • Daetwyler, H. D., B. Villanueva, and J. A. Woolliams, 2008 Accuracy of predicting the genetic risk of disease using a genome-wide approach. PLoS One 3: e3395. https://doi.org/10.1371/journal. pone.0003395
    • (2008) PLoS One , vol.3 , pp. e3395
    • Daetwyler, H.D.1    Villanueva, B.2    Woolliams, J.A.3
  • 14
    • 78649317608 scopus 로고    scopus 로고
    • Predicting genetic predisposition in humans: The promise of whole-genome markers
    • de los Campos, G., D. Gianola, and D. B. Allison, 2010 Predicting genetic predisposition in humans: the promise of whole-genome markers. Nat. Rev. Genet. 11: 880-886. https://doi.org/10.1038/nrg2898
    • (2010) Nat. Rev. Genet , vol.11 , pp. 880-886
    • De Los Campos, G.1    Gianola, D.2    Allison, D.B.3
  • 15
    • 84880802650 scopus 로고    scopus 로고
    • Prediction of complex human traits using the genomic best linear unbiased predictor
    • de los Campos, G., A. I. Vazquez, R. Fernando, Y. C. Klimentidis, and D. Sorensen, 2013 Prediction of complex human traits using the genomic best linear unbiased predictor. PLoS Genet. 9: e1003608. https://doi.org/10.1371/journal.pgen. 1003608
    • (2013) PLoS Genet. , vol.9 , pp. e1003608
    • De Los Campos, G.1    Vazquez, A.I.2    Fernando, R.3    Klimentidis, Y.C.4    Sorensen, D.5
  • 16
    • 84868256748 scopus 로고    scopus 로고
    • Comparison of family history and SNPs for predicting risk of complex disease
    • Do, C. B., D. A. Hinds, U. Francke, and N. Eriksson, 2012 Comparison of family history and SNPs for predicting risk of complex disease. PLoS Genet. 8: e1002973. https://doi.org/10.1371/journal. pgen.1002973
    • (2012) PLoS Genet. , vol.8 , pp. e1002973
    • Do, C.B.1    Hinds, D.A.2    Francke, U.3    Eriksson, N.4
  • 17
    • 0030256396 scopus 로고    scopus 로고
    • Long-term divergent selection for eight-week body weight in White Plymouth Rock chickens
    • Dunnington, E. A., and P. B. Siegel, 1996 Long-term divergent selection for eight-week body weight in White Plymouth Rock chickens. Poult. Sci. 75: 1168-1179. https://doi.org/10.3382/ps.0751168
    • (1996) Poult. Sci , vol.75 , pp. 1168-1179
    • Dunnington, E.A.1    Siegel, P.B.2
  • 18
    • 84876007072 scopus 로고    scopus 로고
    • Powerr and predicative accuracy of polygenic risk scores
    • Dudbridge, F., 2013 Powerr and predicative accuracy of polygenic risk scores. PLoS Genetics e1003348. https://doi.org/10.1371/journal.pgen.1003348.t001
    • (2013) PLoS Genetics , pp. e1003348
    • Dudbridge, F.1
  • 19
    • 69449102525 scopus 로고    scopus 로고
    • Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk
    • Evans, D. M., P. M. Visscher, and N. R. Wray, 2009 Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk. Hum. Mol. Genet. 18: 3525-3531. https://doi.org/10.1093/hmg/ddp295
    • (2009) Hum. Mol. Genet , vol.18 , pp. 3525-3531
    • Evans, D.M.1    Visscher, P.M.2    Wray, N.R.3
  • 20
    • 84971185409 scopus 로고
    • The correlation between relatives on the supposition of Mendelian inheritance
    • Fisher, R. A., 1918 The correlation between relatives on the supposition of Mendelian inheritance. Trans. R. Soc. Edinb. 52: 399-433. https://doi.org/10.1017/S0080456800012163
    • (1918) Trans. R. Soc. Edinb , vol.52 , pp. 399-433
    • Fisher, R.A.1
  • 21
    • 84978079753 scopus 로고    scopus 로고
    • Changes in genetic selection differentials and generation intervals in US Holstein dairy cattle as a result of genomic selection
    • (erratum: Proc. Natl. Acad. Sci. USA 113: E4928)
    • García-Ruiz, A., J. B. Cole, P. M. VanRaden, G. R. Wiggans, F. J. Ruiz-Lopez et al., 2016 Changes in genetic selection differentials and generation intervals in US Holstein dairy cattle as a result of genomic selection. Proc. Natl. Acad. Sci. USA 113: E3995-E4004 (erratum: Proc. Natl. Acad. Sci. USA 113: E4928). https://doi.org/10.1073/pnas.1519061113
    • (2016) Proc. Natl. Acad. Sci. USA , vol.113 , pp. E3995-E4004
    • García-Ruiz, A.1    Cole, J.B.2    VanRaden, P.M.3    Wiggans, G.R.4    Ruiz-Lopez, F.J.5
  • 22
    • 84921811651 scopus 로고    scopus 로고
    • Effective genetic-risk prediction using mixed models
    • Golan, D., and S. Rosset, 2014 Effective genetic-risk prediction using mixed models. Am. J. Hum. Genet. 95: 383-393. https://doi.org/10.1016/j.ajhg.2014.09.007
    • (2014) Am. J. Hum. Genet , vol.95 , pp. 383-393
    • Golan, D.1    Rosset, S.2
  • 23
    • 79956199958 scopus 로고    scopus 로고
    • Extension of the Bayesian alphabet for genomic selection
    • Habier, D., R. L. Fernando, K. Kizilkaya, and D. J. Garrick, 2011 Extension of the Bayesian alphabet for genomic selection. BMC Bioinformatics 12: 186. https://doi.org/10.1186/1471-2105-12-186
    • (2011) BMC Bioinformatics , vol.12 , pp. 186
    • Habier, D.1    Fernando, R.L.2    Kizilkaya, K.3    Garrick, D.J.4
  • 24
    • 85028105754 scopus 로고    scopus 로고
    • Comparison of heritabilities of dairy traits in Australian Holstein-Friesian cattle from genomic and pedigree data and implications for genomic evaluations
    • Haile-Mariam, M., G. J. Nieuwhof, K. T. Beard, K. V. Konstatinov, and B. J. Hayes, 2013 Comparison of heritabilities of dairy traits in Australian Holstein-Friesian cattle from genomic and pedigree data and implications for genomic evaluations. J. Anim. Breed. Genet. 130: 20-31. https://doi.org/10.1111/j.1439-0388.2012.01001.x
    • (2013) J. Anim. Breed. Genet , vol.130 , pp. 20-31
    • Haile-Mariam, M.1    Nieuwhof, G.J.2    Beard, K.T.3    Konstatinov, K.V.4    Hayes, B.J.5
  • 25
    • 0001724911 scopus 로고
    • The genetic basis for constructing selection indexes
    • Hazel, L. N., 1943 The genetic basis for constructing selection indexes. Genetics 28: 476-490.
    • (1943) Genetics , vol.28 , pp. 476-490
    • Hazel, L.N.1
  • 26
    • 85025374820 scopus 로고
    • Use of relationships among sires to increase accuracy of sire evaluation
    • Henderson, C. R., 1975 Use of relationships among sires to increase accuracy of sire evaluation. J. Dairy Sci. 58: 1731-1738. https://doi.org/10.3168/jds.S0022-0302(75)84777-1
    • (1975) J. Dairy Sci , vol.58 , pp. 1731-1738
    • Henderson, C.R.1
  • 27
    • 0002589074 scopus 로고
    • in Selection Experiments in Laboratory and Domestic Animals, edited by A. Robertson. C.A.B., Slough, UK
    • Hill, W. G., 1980 Design of quantitative selection experiments, pp. 1-13 in Selection Experiments in Laboratory and Domestic Animals, edited by A. Robertson. C.A.B., Slough, UK.
    • (1980) Design of quantitative selection experiments , pp. 1-13
    • Hill, W.G.1
  • 28
    • 85048176574 scopus 로고    scopus 로고
    • Can more be learned from selection experiments of value in animal breeding programmes? Or is it time for an obituary?
    • Hill, W. G., 2011 Can more be learned from selection experiments of value in animal breeding programmes? Or is it time for an obituary? J. Anim. Breed. Genet. 128: 87-94. https://doi.org/10.1111/j.1439-0388.2010.00913.x
    • (2011) J. Anim. Breed. Genet , vol.128 , pp. 87-94
    • Hill, W.G.1
  • 29
    • 0027010836 scopus 로고
    • Artificial selection experiments
    • Hill, W. G., and A. Caballero, 1992 Artificial selection experiments. Annu. Rev. Ecol. Syst. 23: 287-310. https://doi.org/10.1146/annurev.es.23.110192.001443
    • (1992) Annu. Rev. Ecol. Syst , vol.23 , pp. 287-310
    • Hill, W.G.1    Caballero, A.2
  • 30
    • 85054026733 scopus 로고    scopus 로고
    • Genomic risk prediction of coronary artery disease in 480,000 adults: Implications for primary prevention
    • Inouye, M., G. Abraham, C. P. Nelson, A. M. Wood, M. J. Sweeting et al., 2018 Genomic risk prediction of coronary artery disease in 480,000 adults: implications for primary prevention. J. Am. Coll. Cardiol. 72: 1883-1893. https://doi.org/10.1016/j.jacc. 2018.07.079
    • (2018) J. Am. Coll. Cardiol , vol.72 , pp. 1883-1893
    • Inouye, M.1    Abraham, G.2    Nelson, C.P.3    Wood, A.M.4    Sweeting, M.J.5
  • 31
    • 33747881836 scopus 로고    scopus 로고
    • Predictive testing for complex diseases using multiple genes: Fact or fiction?
    • Janssens, A. C., Y. S. Aulchenko, S. Elefante, G. J. Borsboom, E. W. Steyerberg et al., 2006 Predictive testing for complex diseases using multiple genes: fact or fiction? Genet. Med. 8: 395-400. https://doi.org/10.1097/01.gim.0000229689.18263.f4
    • (2006) Genet. Med , vol.8 , pp. 395-400
    • Janssens, A.C.1    Aulchenko, Y.S.2    Elefante, S.3    Borsboom, G.J.4    Steyerberg, E.W.5
  • 32
    • 84862183331 scopus 로고    scopus 로고
    • Partitioning additive genetic variance into genomic and remaining polygenic components for complex traits in dairy cattle
    • Jensen, J., G. S. Su, and P. Madsen, 2012 Partitioning additive genetic variance into genomic and remaining polygenic components for complex traits in dairy cattle. BMC Genet. 13: 44. https://doi.org/10.1186/1471-2156-13-44
    • (2012) BMC Genet. , vol.13 , pp. 44
    • Jensen, J.1    Su, G.S.2    Madsen, P.3
  • 33
    • 38649132270 scopus 로고    scopus 로고
    • Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    • (erratum: Nat. Genet. 40: 1384)
    • Kathiresan, S., O. Melander, C. Guiducci, A. Surti, N. P. Burtt et al., 2008 Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat. Genet. 40: 189-197 (erratum: Nat. Genet. 40: 1384). https://doi.org/10.1038/ng.75
    • (2008) Nat. Genet , vol.40 , pp. 189-197
    • Kathiresan, S.1    Melander, O.2    Guiducci, C.3    Surti, A.4    Burtt, N.P.5
  • 34
    • 33845516667 scopus 로고    scopus 로고
    • Resolving the paradox of common, harmful, heritable mental disorders: Which evolutionary genetic models work best?
    • discussion 405-352
    • Keller, M. C., and G. Miller, 2006 Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best? Behav. Brain Sci. 29: 385-404; discussion 405-352. https://doi.org/10.1017/S0140525X06009095
    • (2006) Behav. Brain Sci , vol.29 , pp. 385-404
    • Keller, M.C.1    Miller, G.2
  • 35
    • 84867115663 scopus 로고    scopus 로고
    • Understanding and predicting complex traits: Knowledge from cattle
    • Kemper, K. E., and M. E. Goddard, 2012 Understanding and predicting complex traits: knowledge from cattle. Hum. Mol. Genet. 21: R45-R51. https://doi.org/10.1093/hmg/dds332
    • (2012) Hum. Mol. Genet. , vol.21 , pp. R45-R51
    • Kemper, K.E.1    Goddard, M.E.2
  • 36
    • 84927924534 scopus 로고    scopus 로고
    • Improved precision of QTL mapping using a nonlinear Bayesian method in a multi-breed population leads to greater accuracy of across-breed genomic predictions
    • Kemper, K. E., C. M. Reich, P. J. Bowman, C. J. Vander Jagt, A. J. Chamberlain et al., 2015 Improved precision of QTL mapping using a nonlinear Bayesian method in a multi-breed population leads to greater accuracy of across-breed genomic predictions. Genet. Sel. Evol. 47: 29. https://doi.org/10.1186/s12711-014-0074-4
    • (2015) Genet. Sel. Evol. , vol.47 , pp. 29
    • Kemper, K.E.1    Reich, C.M.2    Bowman, P.J.3    Vander Jagt, C.J.4    Chamberlain, A.J.5
  • 37
    • 85052496079 scopus 로고    scopus 로고
    • Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations
    • Khera, A. V., M. Chaffin, K. G. Aragam, M. E. Haas, C. Roselli et al., 2018 Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. Nat. Genet. 50: 1219-1224. https://doi.org/10.1038/s41588-018-0183-z
    • (2018) Nat. Genet , vol.50 , pp. 1219-1224
    • Khera, A.V.1    Chaffin, M.2    Aragam, K.G.3    Haas, M.E.4    Roselli, C.5
  • 38
    • 33645798616 scopus 로고    scopus 로고
    • Quantifying the health benefits of genetic tests: The importance of a population perspective
    • Khoury, M. J., K. Jones, and S. D. Grosse, 2006 Quantifying the health benefits of genetic tests: the importance of a population perspective. Genet. Med. 8: 191-195. https://doi.org/10.1097/01.gim.0000206278.37405.25
    • (2006) Genet. Med , vol.8 , pp. 191-195
    • Khoury, M.J.1    Jones, K.2    Grosse, S.D.3
  • 39
    • 65649105497 scopus 로고    scopus 로고
    • Linkage disequilibrium in the North American Holstein population
    • Kim, E. S., and B. W. Kirkpatrick, 2009 Linkage disequilibrium in the North American Holstein population. Anim. Genet. 40: 279-288. https://doi.org/10.1111/j.1365-2052.2008.01831.x
    • (2009) Anim. Genet , vol.40 , pp. 279-288
    • Kim, E.S.1    Kirkpatrick, B.W.2
  • 40
    • 0025231585 scopus 로고
    • Analysis of the inheritance, selection and evolution of growth trajectories
    • Kirkpatrick, M., D. Lofsvold, and M. Bulmer, 1990 Analysis of the inheritance, selection and evolution of growth trajectories. Genetics 124: 979-993.
    • (1990) Genetics , vol.124 , pp. 979-993
    • Kirkpatrick, M.1    Lofsvold, D.2    Bulmer, M.3
  • 41
    • 85040991713 scopus 로고    scopus 로고
    • The nature of nurture: Effects of parental genotypes
    • Kong, A., G. Thorleifsson, M. L. Frigge, B. J. Vilhjalmsson, A. I. Young et al., 2018 The nature of nurture: effects of parental genotypes. Science 359: 424-428. https://doi.org/10.1126/science.aan6877
    • (2018) Science , vol.359 , pp. 424-428
    • Kong, A.1    Thorleifsson, G.2    Frigge, M.L.3    Vilhjalmsson, B.J.4    Young, A.I.5
  • 42
    • 0025217786 scopus 로고
    • Efficiency of marker-assisted selection in the improvement of quantitative traits
    • Lande, R., and R. Thompson, 1990 Efficiency of marker-assisted selection in the improvement of quantitative traits. Genetics 124: 743-756.
    • (1990) Genetics , vol.124 , pp. 743-756
    • Lande, R.1    Thompson, R.2
  • 43
    • 84893420135 scopus 로고    scopus 로고
    • Novel genetic analysis for casecontrol genome-wide association studies: Quantification of power and genomic prediction accuracy
    • Lee, S. H., and N. R. Wray, 2013 Novel genetic analysis for casecontrol genome-wide association studies: quantification of power and genomic prediction accuracy. PLoS One 8: e71494. https://doi.org/10.1371/journal.pone.0071494
    • (2013) PLoS One , vol.8 , pp. e71494
    • Lee, S.H.1    Wray, N.R.2
  • 44
    • 85012098079 scopus 로고    scopus 로고
    • Using information of relatives in genomic prediction to apply effective stratified medicine
    • Lee, S. H., W. M. Weerasinghe, N. R. Wray, M. E. Goddard, and J. H. van der Werf, 2017 Using information of relatives in genomic prediction to apply effective stratified medicine. Sci. Rep. 7: 42091. https://doi.org/10.1038/srep42091
    • (2017) Sci. Rep. , vol.7 , pp. 42091
    • Lee, S.H.1    Weerasinghe, W.M.2    Wray, N.R.3    Goddard, M.E.4    Van Der Werf, J.H.5
  • 45
    • 84899655912 scopus 로고    scopus 로고
    • Improving genetic risk prediction by leveraging pleiotropy
    • Li, C., C. Yang, J. Gelernter, and H. Zhao, 2014 Improving genetic risk prediction by leveraging pleiotropy. Hum. Genet. 133: 639-650. https://doi.org/10.1007/s00439-013-1401-5
    • (2014) Hum. Genet , vol.133 , pp. 639-650
    • Li, C.1    Yang, C.2    Gelernter, J.3    Zhao, H.4
  • 46
    • 84923171580 scopus 로고    scopus 로고
    • Genetic studies of body mass index yield new insights for obesity biology
    • Locke, A. E., B. Kahali, S. I. Berndt, A. E. Justice, T. H. Pers et al., 2015 Genetic studies of body mass index yield new insights for obesity biology. Nature 518: 197-206. https://doi.org/10.1038/nature14177
    • (2015) Nature , vol.518 , pp. 197-206
    • Locke, A.E.1    Kahali, B.2    Berndt, S.I.3    Justice, A.E.4    Pers, T.H.5
  • 47
    • 84924060689 scopus 로고    scopus 로고
    • Efficient Bayesian mixed-model analysis increases association power in large cohorts
    • Loh, P. R., G. Tucker, B. K. Bulik-Sullivan, B. J. Vilhjalmsson, H. K. Finucane et al., 2015 Efficient Bayesian mixed-model analysis increases association power in large cohorts. Nat. Genet. 47: 284-290. https://doi.org/10.1038/ng.3190
    • (2015) Nat. Genet , vol.47 , pp. 284-290
    • Loh, P.R.1    Tucker, G.2    Bulik-Sullivan, B.K.3    Vilhjalmsson, B.J.4    Finucane, H.K.5
  • 48
    • 84925130699 scopus 로고    scopus 로고
    • Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder
    • Maier, R., G. Moser, G. B. Chen, S. Ripke, Cross-Disorder Working Group of the Psychiatric Genomics Consortium et al., 2015 Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. Am. J. Hum. Genet. 96: 283-294. https://doi.org/10.1016/j.ajhg.2014.12.006
    • (2015) Am. J. Hum. Genet , vol.96 , pp. 283-294
    • Maier, R.1    Moser, G.2    Chen, G.B.3    Ripke, S.4
  • 49
    • 85048198000 scopus 로고    scopus 로고
    • Improving genetic prediction by leveraging genetic correlations among human diseases and traits
    • Maier, R. M., Z. Zhu, S. H. Lee, M. Trzaskowski, D. M. Ruderfer et al., 2018 Improving genetic prediction by leveraging genetic correlations among human diseases and traits. Nat. Commun. 9: 989. https://doi.org/10.1038/s41467-017-02769-6
    • (2018) Nat. Commun. , vol.9 , pp. 989
    • Maier, R.M.1    Zhu, Z.2    Lee, S.H.3    Trzaskowski, M.4    Ruderfer, D.M.5
  • 50
    • 85063614076 scopus 로고    scopus 로고
    • Modeling functional enrichment improves polygenic prediction accuracy in UK Biobank and 23andMe data sets
    • Marquez-Luna, C., S. Gazal, P.-R. Loh, N. Furlotte, A. Auton et al., 2018 Modeling functional enrichment improves polygenic prediction accuracy in UK Biobank and 23andMe data sets. bioRxiv 375337. https://doi.org/10.1101/375337
    • (2018) bioRxiv 375337
    • Marquez-Luna, C.1    Gazal, S.2    Loh, P.-R.3    Furlotte, N.4    Auton, A.5
  • 51
    • 0035045051 scopus 로고    scopus 로고
    • Prediction of total genetic value using genome-wide dense marker maps
    • Meuwissen, T. H. E., B. J. Hayes, and M. E. Goddard, 2001 Prediction of total genetic value using genome-wide dense marker maps. Genetics 157: 1819-1829.
    • (2001) Genetics , vol.157 , pp. 1819-1829
    • Meuwissen, T.H.E.1    Hayes, B.J.2    Goddard, M.E.3
  • 52
    • 0001426561 scopus 로고    scopus 로고
    • Estimating covariance functions for longitudinal data using a random regression model
    • Meyer, K., 1998 Estimating covariance functions for longitudinal data using a random regression model. Genet. Sel. Evol. 30: 221-240. https://doi.org/10.1186/1297-9686-30-3-221
    • (1998) Genet. Sel. Evol , vol.30 , pp. 221-240
    • Meyer, K.1
  • 53
    • 84930339072 scopus 로고    scopus 로고
    • Simultaneous discovery, estimation and prediction analysis of complex traits using a bayesian mixture model
    • Moser, G., S. H. Lee, B. J. Hayes, M. E. Goddard, N. R. Wray et al., 2015 Simultaneous discovery, estimation and prediction analysis of complex traits using a bayesian mixture model. PLoS Genet. 11: e1004969. https://doi.org/10.1371/journal.pgen.1004969
    • (2015) PLoS Genet. , vol.11 , pp. e1004969
    • Moser, G.1    Lee, S.H.2    Hayes, B.J.3    Goddard, M.E.4    Wray, N.R.5
  • 54
    • 85055519807 scopus 로고    scopus 로고
    • Genotype-covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model
    • Ni, G., J. van der Werf, X. Zhou, E. Hypponen, N. R. Wray et al., 2018 Genotype-covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model. bioRxiv 377796. https://doi.org/10.1101/377796
    • (2018) bioRxiv 377796
    • Ni, G.1    Van Der Werf, J.2    Zhou, X.3    Hypponen, E.4    Wray, N.R.5
  • 55
    • 84994748491 scopus 로고    scopus 로고
    • Dissecting the genetics of complex traits using summary association statistics
    • Pasaniuc, B., and A. L. Price, 2017 Dissecting the genetics of complex traits using summary association statistics. Nat. Rev. Genet. 18: 117-127. https://doi.org/10.1038/nrg.2016.142
    • (2017) Nat. Rev. Genet , vol.18 , pp. 117-127
    • Pasaniuc, B.1    Price, A.L.2
  • 56
    • 45949085378 scopus 로고    scopus 로고
    • Polygenes, risk prediction, and targeted prevention of breast cancer
    • Pharoah, P. D., A. C. Antoniou, D. F. Easton, and B. A. Ponder, 2008 Polygenes, risk prediction, and targeted prevention of breast cancer. N. Engl. J. Med. 358: 2796-2803. https://doi. org/10.1056/NEJMsa0708739
    • (2008) N. Engl. J. Med , vol.358 , pp. 2796-2803
    • Pharoah, P.D.1    Antoniou, A.C.2    Easton, D.F.3    Ponder, B.A.4
  • 57
    • 84871964302 scopus 로고    scopus 로고
    • Fecundity of patients with schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, or substance abuse vs. their unaffected siblings
    • Power, R. A., S. Kyaga, R. Uher, J. H. MacCabe, N. Langstrom et al., 2013 Fecundity of patients with schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, or substance abuse vs. their unaffected siblings. JAMA Psychiatry 70: 22-30. https://doi.org/10.1001/jamapsychiatry.2013.268
    • (2013) JAMA Psychiatry , vol.70 , pp. 22-30
    • Power, R.A.1    Kyaga, S.2    Uher, R.3    MacCabe, J.H.4    Langstrom, N.5
  • 58
    • 33746512512 scopus 로고    scopus 로고
    • Principal components analysis corrects for stratification in genome-wide association studies
    • Price, A. L., N. J. Patterson, R. M. Plenge, M. E. Weinblatt, N. A. Shadick et al., 2006 Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38: 904-909. https://doi.org/10.1038/ng1847
    • (2006) Nat. Genet , vol.38 , pp. 904-909
    • Price, A.L.1    Patterson, N.J.2    Plenge, R.M.3    Weinblatt, M.E.4    Shadick, N.A.5
  • 59
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: A tool set for whole-genome association and population-based linkage analyses
    • Purcell, S., B. Neale, K. Todd-Brown, L. Thomas, M. A. R. Ferreira et al., 2007 PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81: 559-575. https://doi.org/10.1086/519795
    • (2007) Am. J. Hum. Genet , vol.81 , pp. 559-575
    • Purcell, S.1    Neale, B.2    Todd-Brown, K.3    Thomas, L.4    Ferreira, M.A.R.5
  • 60
    • 68449086236 scopus 로고    scopus 로고
    • Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
    • Purcell, S. M., N. R. Wray, J. L. Stone, P. M. Visscher, M. C. O’Donovan et al., 2009 Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460: 748-752.
    • (2009) Nature , vol.460 , pp. 748-752
    • Purcell, S.M.1    Wray, N.R.2    Stone, J.L.3    Visscher, P.M.4    O’Donovan, M.C.5
  • 61
    • 85026347306 scopus 로고    scopus 로고
    • Genotype-covariate interaction effects and the heritability of adult body mass index
    • Robinson, M. R., G. English, G. Moser, L. R. Lloyd-Jones, M. A. Triplett et al., 2017 Genotype-covariate interaction effects and the heritability of adult body mass index. Nat. Genet. 49: 1174-1181. https://doi.org/10.1038/ng.3912
    • (2017) Nat. Genet , vol.49 , pp. 1174-1181
    • Robinson, M.R.1    English, G.2    Moser, G.3    Lloyd-Jones, L.R.4    Triplett, M.A.5
  • 62
    • 84904804929 scopus 로고    scopus 로고
    • Biological insights from 108 schizophreniaassociated genetic loci
    • Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2014 Biological insights from 108 schizophreniaassociated genetic loci. Nature 511: 421-427. https://doi. org/10.1038/nature13595
    • (2014) Nature , vol.511 , pp. 421-427
  • 63
    • 0024757965 scopus 로고
    • Estimation of additive maternal and cytoplasmic genetic variances in animal-models
    • Southwood, O. I., B. W. Kennedy, K. Meyer, and J. P. Gibson, 1989 Estimation of additive maternal and cytoplasmic genetic variances in animal-models. J. Dairy Sci. 72: 3006-3012. https://doi.org/10.3168/jds.S0022-0302(89)79453-4
    • (1989) J. Dairy Sci , vol.72 , pp. 3006-3012
    • Southwood, O.I.1    Kennedy, B.W.2    Meyer, K.3    Gibson, J.P.4
  • 64
    • 84926430250 scopus 로고    scopus 로고
    • UK biobank: An open access resource for identifying the causes of a wide range of complex diseases of middle and old age
    • Sudlow, C., J. Gallacher, N. Allen, V. Beral, P. Burton et al., 2015 UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 12: e1001779. https://doi.org/10.1371/journal.pmed.1001779
    • (2015) PLoS Med. , vol.12 , pp. e1001779
    • Sudlow, C.1    Gallacher, J.2    Allen, N.3    Beral, V.4    Burton, P.5
  • 65
    • 85047270381 scopus 로고    scopus 로고
    • The personal and clinical utility of polygenic risk scores
    • Torkamani, A., N. E.Wineinger, and E. J. Topol, 2018 The personal and clinical utility of polygenic risk scores. Nat. Rev. Genet. 19: 581-590. https://doi.org/10.1038/s41576-018-0018-x
    • (2018) Nat. Rev. Genet , vol.19 , pp. 581-590
    • Torkamani, A.1    Wineinger, N.E.2    Topol, E.J.3
  • 66
    • 85039801269 scopus 로고    scopus 로고
    • Multi-trait analysis of genome-wide association summary statistics using MTAG
    • Turley, P., R. K. Walters, O. Maghzian, A. Okbay, J. J. Lee et al., 2018 Multi-trait analysis of genome-wide association summary statistics using MTAG. Nat. Genet. 50: 229-237. https://doi.org/10.1038/s41588-017-0009-4
    • (2018) Nat. Genet , vol.50 , pp. 229-237
    • Turley, P.1    Walters, R.K.2    Maghzian, O.3    Okbay, A.4    Lee, J.J.5
  • 67
    • 84952665106 scopus 로고    scopus 로고
    • Modeling linkage disequilibrium increases accuracy of polygenic risk scores
    • Vilhjálmsson, B. J., J. Yang, H. K. Finucane, A. Gusev, S. Lindström et al., 2015 Modeling linkage disequilibrium increases accuracy of polygenic risk scores. Am. J. Hum. Genet. 97: 576-592. https://doi.org/10.1016/j.ajhg.2015.09.001
    • (2015) Am. J. Hum. Genet , vol.97 , pp. 576-592
    • Vilhjálmsson, B.J.1    Yang, J.2    Finucane, H.K.3    Gusev, A.4    Lindström, S.5
  • 68
    • 33645760679 scopus 로고    scopus 로고
    • Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings
    • Visscher, P. M., S. E. Medland, M. A. Ferreira, K. I. Morley, G. Zhu et al., 2006 Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings. PLoS Genet. 2: e41. https://doi.org/10.1371/journal.pgen.0020041
    • (2006) PLoS Genet. , vol.2 , pp. e41
    • Visscher, P.M.1    Medland, S.E.2    Ferreira, M.A.3    Morley, K.I.4    Zhu, G.5
  • 69
    • 78650197952 scopus 로고    scopus 로고
    • A commentary on ‘common SNPs explain a large proportion of the heritability for human height’ by Yang et al. (2010)
    • Visscher, P. M., J. Yang, and M. E. Goddard, 2010 A commentary on ‘common SNPs explain a large proportion of the heritability for human height’ by Yang et al. (2010). Twin Res. Hum. Genet. 13: 517-524. https://doi.org/10.1375/twin.13.6.517
    • (2010) Twin Res. Hum. Genet , vol.13 , pp. 517-524
    • Visscher, P.M.1    Yang, J.2    Goddard, M.E.3
  • 71
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Wellcome Trust Case Control Consortium, 2007 Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661-678. https://doi. org/10.1038/nature05911
    • (2007) Nature , vol.447 , pp. 661-678
  • 72
    • 84908890496 scopus 로고    scopus 로고
    • Defining the role of common variation in the genomic and biological architecture of adult human height
    • Wood, A. R., T. Esko, J. Yang, S. Vedantam, T. H. Pers et al., 2014 Defining the role of common variation in the genomic and biological architecture of adult human height. Nat. Genet. 46: 1173-1186. https://doi.org/10.1038/ng.3097
    • (2014) Nat. Genet , vol.46 , pp. 1173-1186
    • Wood, A.R.1    Esko, T.2    Yang, J.3    Vedantam, S.4    Pers, T.H.5
  • 73
    • 34948877698 scopus 로고    scopus 로고
    • Prediction of individual genetic risk to disease from genome-wide association studies
    • Wray, N. R., M. E. Goddard, and P. M. Visscher, 2007 Prediction of individual genetic risk to disease from genome-wide association studies. Genome Res. 17: 1520-1528. https://doi.org/10.1101/gr.6665407
    • (2007) Genome Res , vol.17 , pp. 1520-1528
    • Wray, N.R.1    Goddard, M.E.2    Visscher, P.M.3
  • 74
    • 52949091164 scopus 로고    scopus 로고
    • Prediction of individual genetic risk of complex disease
    • Wray, N. R., M. E. Goddard, and P. M. Visscher, 2008 Prediction of individual genetic risk of complex disease. Curr. Opin. Genet. Dev. 18: 257-263. https://doi.org/10.1016/j.gde.2008.07.006
    • (2008) Curr. Opin. Genet. Dev , vol.18 , pp. 257-263
    • Wray, N.R.1    Goddard, M.E.2    Visscher, P.M.3
  • 75
    • 84879324656 scopus 로고    scopus 로고
    • Pitfalls of predicting complex traits from SNPs
    • Wray, N. R., J. Yang, B. J. Hayes, A. L. Price, M. E. Goddard et al., 2013 Pitfalls of predicting complex traits from SNPs. Nat. Rev. Genet. 14: 507-515. https://doi.org/10.1038/nrg3457
    • (2013) Nat. Rev. Genet , vol.14 , pp. 507-515
    • Wray, N.R.1    Yang, J.2    Hayes, B.J.3    Price, A.L.4    Goddard, M.E.5
  • 76
    • 85046022254 scopus 로고    scopus 로고
    • Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
    • Wray, N. R., S. Ripke, M. Mattheisen, M. Trzaskowski, E. M. Byrne et al., 2018 Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat. Genet. 50: 668-681. https://doi.org/10.1038/s41588-018-0090-3
    • (2018) Nat. Genet , vol.50 , pp. 668-681
    • Wray, N.R.1    Ripke, S.2    Mattheisen, M.3    Trzaskowski, M.4    Byrne, E.M.5
  • 77
    • 77955983296 scopus 로고    scopus 로고
    • Sporadic cases are the norm for complex disease
    • (erratum: Eur. J. Hum. Genet. 18: 1044)
    • Yang, J., P. M. Visscher, and N. R. Wray, 2010a Sporadic cases are the norm for complex disease. Eur. J. Hum. Genet. 18: 1039-1043 (erratum: Eur. J. Hum. Genet. 18: 1044). https://doi.org/10.1038/ejhg.2009.177
    • (2010) Eur. J. Hum. Genet , vol.18 , pp. 1039-1043
    • Yang, J.1    Visscher, P.M.2    Wray, N.R.3
  • 78
    • 77949789670 scopus 로고    scopus 로고
    • Comparing apples and oranges: Equating the power of case-control and quantitative trait association studies
    • Yang, J., N. R. Wray, and P. M. Visscher, 2010b Comparing apples and oranges: equating the power of case-control and quantitative trait association studies. Genet. Epidemiol. 34: 254-257.
    • (2010) Genet. Epidemiol. , vol.34 , pp. 254-257
    • Yang, J.1    Wray, N.R.2    Visscher, P.M.3
  • 79
    • 78650856517 scopus 로고    scopus 로고
    • GCTA: A tool for genome-wide complex trait analysis
    • Yang, J., S. H. Lee, M. E. Goddard, and P. M. Visscher, 2011a GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet. 88: 76-82. https://doi.org/10.1016/j. ajhg.2010.11.011
    • (2011) Am. J. Hum. Genet , vol.88 , pp. 76-82
    • Yang, J.1    Lee, S.H.2    Goddard, M.E.3    Visscher, P.M.4
  • 80
    • 79959241413 scopus 로고    scopus 로고
    • Genomic inflation factors under polygenic inheritance
    • Yang, J., M. N. Weedon, S. Purcell, G. Lettre, K. Estrada et al., 2011b Genomic inflation factors under polygenic inheritance. Eur. J. Hum. Genet. 19: 807-812. https://doi.org/10.1038/ejhg.2011.39
    • (2011) Eur. J. Hum. Genet , vol.19 , pp. 807-812
    • Yang, J.1    Weedon, M.N.2    Purcell, S.3    Lettre, G.4    Estrada, K.5
  • 81
    • 85054297174 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association studies for height and body mass index in _700000 individuals of European ancestry
    • Yengo, L., J. Sidorenko, K. E. Kemper, Z. Zheng, A. R. Wood et al., 2018 Meta-analysis of genome-wide association studies for height and body mass index in _700000 individuals of European ancestry. Hum. Mol. Genet. 27: 3641-3649. https://doi. org/10.1093/hmg/ddy271
    • (2018) Hum. Mol. Genet , vol.27 , pp. 3641-3649
    • Yengo, L.1    Sidorenko, J.2    Kemper, K.E.3    Zheng, Z.4    Wood, A.R.5
  • 82
    • 84878502589 scopus 로고    scopus 로고
    • Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits
    • Zaitlen, N., P. Kraft, N. Patterson, B. Pasaniuc, G. Bhatia et al., 2013 Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits. PLoS Genet. 9: e1003520. https://doi.org/10.1371/journal. pgen.1003520
    • (2013) PLoS Genet. , vol.9 , pp. e1003520
    • Zaitlen, N.1    Kraft, P.2    Patterson, N.3    Pasaniuc, B.4    Bhatia, G.5
  • 83
    • 84923262846 scopus 로고    scopus 로고
    • Growth, efficiency, and yield of commercial broilers from 1957, 1978, and 2005
    • Zuidhof, M. J., B. L. Schneider, V. L. Carney, D. R. Korver, and F. E. Robinson, 2014 Growth, efficiency, and yield of commercial broilers from 1957, 1978, and 2005. Poult. Sci. 93: 2970-2982. https://doi.org/10.3382/ps.2014-04291
    • (2014) Poult. Sci , vol.93 , pp. 2970-2982
    • Zuidhof, M.J.1    Schneider, B.L.2    Carney, V.L.3    Korver, D.R.4    Robinson, F.E.5


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