-
1
-
-
84862909349
-
Five years of GWAS discovery
-
Visscher, P.M., Brown, M.A., McCarthy, M.I. and Yang, J. (2012) Five years of GWAS discovery. Am. J. Hum. Genet., 90, 7–24.
-
(2012)
Am. J. Hum. Genet.
, vol.90
, pp. 7-24
-
-
Visscher, P.M.1
Brown, M.A.2
McCarthy, M.I.3
Yang, J.4
-
2
-
-
85026709756
-
10 years of GWAS discovery: Biology, function, and translation
-
Visscher, P.M., Wray, N.R., Zhang, Q., Sklar, P., McCarthy, M.I., Brown, M.A. and Yang, J. (2017) 10 years of GWAS discovery: biology, function, and translation. Am. J. Hum. Genet., 101, 5–22.
-
(2017)
Am. J. Hum. Genet.
, vol.101
, pp. 5-22
-
-
Visscher, P.M.1
Wray, N.R.2
Zhang, Q.3
Sklar, P.4
McCarthy, M.I.5
Brown, M.A.6
Yang, J.7
-
3
-
-
77957947562
-
Hundreds of variants clustered in genomic loci and biological pathways affect human height
-
Lango Allen, H., Estrada, K., Lettre, G., Berndt, S.I., Weedon, M.N., Rivadeneira, F., Willer, C.J., Jackson, A.U., Vedantam, S., Raychaudhuri, S. et al. (2010) Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature, 467, 832–838.
-
(2010)
Nature
, vol.467
, pp. 832-838
-
-
Lango Allen, H.1
Estrada, K.2
Lettre, G.3
Berndt, S.I.4
Weedon, M.N.5
Rivadeneira, F.6
Willer, C.J.7
Jackson, A.U.8
Vedantam, S.9
Raychaudhuri, S.10
-
4
-
-
78049337953
-
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
-
Speliotes, E.K., Willer, C.J., Berndt, S.I., Monda, K.L., Thorleifsson, G., Jackson, A.U., Lango Allen, H., Lindgren, C.M., Luan, J., Mägi, R. et al. (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat. Genet., 42, 937–948.
-
(2010)
Nat. Genet.
, vol.42
, pp. 937-948
-
-
Speliotes, E.K.1
Willer, C.J.2
Berndt, S.I.3
Monda, K.L.4
Thorleifsson, G.5
Jackson, A.U.6
Lango Allen, H.7
Lindgren, C.M.8
Luan, J.9
Mägi, R.10
-
5
-
-
84908890496
-
Defining the role of common variation in the genomic and biological architecture of adult human height
-
Wood, A.R., Esko, T., Yang, J., Vedantam, S., Pers, T.H., Gustafsson, S., Chu, A.Y., Estrada, K., Luan, J., Kutalik, Z. et al. (2014) Defining the role of common variation in the genomic and biological architecture of adult human height. Nat. Genet., 46, 1173–1186.
-
(2014)
Nat. Genet.
, vol.46
, pp. 1173-1186
-
-
Wood, A.R.1
Esko, T.2
Yang, J.3
Vedantam, S.4
Pers, T.H.5
Gustafsson, S.6
Chu, A.Y.7
Estrada, K.8
Luan, J.9
Kutalik, Z.10
-
6
-
-
84923171580
-
Genetic studies of body mass index yield new insights for obesity biology
-
Locke, A.E., Kahali, B., Berndt, S.I., Justice, A.E., Pers, T.H., Day, F.R., Powell, C., Vedantam, S., Buchkovich, M.L., Yang, J. et al. (2015) Genetic studies of body mass index yield new insights for obesity biology. Nature, 518, 197–206.
-
(2015)
Nature
, vol.518
, pp. 197-206
-
-
Locke, A.E.1
Kahali, B.2
Berndt, S.I.3
Justice, A.E.4
Pers, T.H.5
Day, F.R.6
Powell, C.7
Vedantam, S.8
Buchkovich, M.L.9
Yang, J.10
-
7
-
-
84940830979
-
FTO obesity variant circuitry and adipocyte browning in humans
-
Claussnitzer, M., Dankel, S.N., Kim, K.-H., Quon, G., Meuleman, W., Haugen, C., Glunk, V., Sousa, I.S., Beaudry, J.L., Puviindran, V. et al. (2015) FTO obesity variant circuitry and adipocyte browning in humans. N. Engl. J. Med., 373, 895–907.
-
(2015)
N. Engl. J. Med.
, vol.373
, pp. 895-907
-
-
Claussnitzer, M.1
Dankel, S.N.2
Kim, K.-H.3
Quon, G.4
Meuleman, W.5
Haugen, C.6
Glunk, V.7
Sousa, I.S.8
Beaudry, J.L.9
Puviindran, V.10
-
8
-
-
84958074030
-
Schizophrenia risk from complex variation of complement component 4
-
Sekar, A., Bialas, A.R., de Rivera, H., Davis, A., Hammond, T.R., Kamitaki, N., Tooley, K., Presumey, J., Baum, M., Van Doren, V. et al. (2016) Schizophrenia risk from complex variation of complement component 4. Nature, 530, 177–183.
-
(2016)
Nature
, vol.530
, pp. 177-183
-
-
Sekar, A.1
Bialas, A.R.2
de Rivera, H.3
Davis, A.4
Hammond, T.R.5
Kamitaki, N.6
Tooley, K.7
Presumey, J.8
Baum, M.9
Van Doren, V.10
-
9
-
-
77954140531
-
Common SNPs explain a large proportion of heritability for human height
-
Yang, J., Benyamin, B., McEvoy, B.P., Gordon, S., Henders, A.K., Nyholt, D.R., Madden, P.A., Heath, A.C., Martin, N.G., Montgomery, G.W. et al. (2010) Common SNPs explain a large proportion of heritability for human height. Nat. Genet., 42, 565–569.
-
(2010)
Nat. Genet.
, vol.42
, pp. 565-569
-
-
Yang, J.1
Benyamin, B.2
McEvoy, B.P.3
Gordon, S.4
Henders, A.K.5
Nyholt, D.R.6
Madden, P.A.7
Heath, A.C.8
Martin, N.G.9
Montgomery, G.W.10
-
10
-
-
84944358132
-
Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index
-
Yang, J., Bakshi, A., Zhu, Z., Hemani, G., Vinkhuyzen, A.A.E., Lee, S.H., Robinson, M.R., Perry, J.R.B., Nolte, I.M., van Vliet-Ostaptchouk, J.V. et al. (2015) Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index. Nat. Genet., 47, 1114–1120.
-
(2015)
Nat. Genet.
, vol.47
, pp. 1114-1120
-
-
Yang, J.1
Bakshi, A.2
Zhu, Z.3
Hemani, G.4
Vinkhuyzen, A.A.E.5
Lee, S.H.6
Robinson, M.R.7
Perry, J.R.B.8
Nolte, I.M.9
van Vliet-Ostaptchouk, J.V.10
-
11
-
-
85028714421
-
Concepts, estimation and interpretation of SNP-based heritability
-
Yang, J., Zeng, J., Goddard, M.E., Wray, N.R. and Visscher, P.M. (2017) Concepts, estimation and interpretation of SNP-based heritability. Nat. Genet., 49, 1304–1310.
-
(2017)
Nat. Genet.
, vol.49
, pp. 1304-1310
-
-
Yang, J.1
Zeng, J.2
Goddard, M.E.3
Wray, N.R.4
Visscher, P.M.5
-
12
-
-
84879324656
-
Pitfalls of predicting complex traits from SNPs
-
Wray, N.R., Yang, J., Hayes, B.J., Price, A.L., Goddard, M.E. and Visscher, P.M. (2013) Pitfalls of predicting complex traits from SNPs. Nat. Rev. Genet., 14, 507–515.
-
(2013)
Nat. Rev. Genet.
, vol.14
, pp. 507-515
-
-
Wray, N.R.1
Yang, J.2
Hayes, B.J.3
Price, A.L.4
Goddard, M.E.5
Visscher, P.M.6
-
13
-
-
84924060689
-
Efficient bayesian mixed model analysis increases association power in large cohorts
-
Loh, P.-R., Tucker, G., Bulik-Sullivan, B.K., Vilhjálmsson, B.J., Finucane, H.K., Salem, R.M., Chasman, D.I., Ridker, P.M., Neale, B.M., Berger, B. et al. (2015) Efficient Bayesian mixed model analysis increases association power in large cohorts. Nat. Genet., 47, 284–290.
-
(2015)
Nat. Genet.
, vol.47
, pp. 284-290
-
-
Loh, P.-R.1
Tucker, G.2
Bulik-Sullivan, B.K.3
Vilhjálmsson, B.J.4
Finucane, H.K.5
Salem, R.M.6
Chasman, D.I.7
Ridker, P.M.8
Neale, B.M.9
Berger, B.10
-
14
-
-
85048347065
-
Mixed-model association for biobank-scale datasets
-
Loh, P.-R., Kichaev, G., Gazal, S., Schoech, A.P. and Price, A.L. (2018) Mixed-model association for biobank-scale datasets. Nat. Genet., 50, 906–908.
-
(2018)
Nat. Genet.
, vol.50
, pp. 906-908
-
-
Loh, P.-R.1
Kichaev, G.2
Gazal, S.3
Schoech, A.P.4
Price, A.L.5
-
15
-
-
85039768359
-
Genome-wide genetic data on ∼500 000 UK biobank participants
-
Bycroft, C., Freeman, C., Petkova, D., Band, G., Elliott, L.T., Sharp, K., Motyer, A., Vukcevic, D., Delaneau, O., O’Connell, J. et al. (2017) Genome-wide genetic data on ∼500 000 UK Biobank participants., bioRxiV, 10.1101/166298.
-
(2017)
bioRxiV
-
-
Bycroft, C.1
Freeman, C.2
Petkova, D.3
Band, G.4
Elliott, L.T.5
Sharp, K.6
Motyer, A.7
Vukcevic, D.8
Delaneau, O.9
O’Connell, J.10
-
16
-
-
77955894071
-
Metal: Fast and efficient meta-analysis of genomewide association scans
-
Willer, C.J., Li, Y. and Abecasis, G.R. (2010) METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics, 26, 2190–2191.
-
(2010)
Bioinformatics
, vol.26
, pp. 2190-2191
-
-
Willer, C.J.1
Li, Y.2
Abecasis, G.R.3
-
17
-
-
84923946495
-
LD score regression distinguishes confounding from polygenicity in genome-wide association studies
-
Bulik-Sullivan, B.K., Loh, P.-R., Finucane, H.K., Ripke, S., Yang, J., Schizophrenia Working Group of the Psychiatric Genomics Consortium, Patterson, N., Daly, M.J., Price, A.L. and Neale, B.M. (2015) LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet., 47, 291–295.
-
(2015)
Nat. Genet.
, vol.47
, pp. 291-295
-
-
Bulik-Sullivan, B.K.1
Loh, P.-R.2
Finucane, H.K.3
Ripke, S.4
Yang, J.5
Patterson, N.6
Daly, M.J.7
Price, A.L.8
Neale, B.M.9
-
18
-
-
85000692305
-
An atlas of genetic correlations across human diseases and traits
-
Bulik-Sullivan, B., Finucane, H.K., Anttila, V., Gusev, A., Day, F.R., Loh, P.-R., Duncan, L., Perry, J.R.B., Patterson, N., Robinson, E.B. et al. (2015) An atlas of genetic correlations across human diseases and traits. Nat. Genet., 47, 1236–1241.
-
(2015)
Nat. Genet.
, vol.47
, pp. 1236-1241
-
-
Bulik-Sullivan, B.1
Finucane, H.K.2
Anttila, V.3
Gusev, A.4
Day, F.R.5
Loh, P.-R.6
Duncan, L.7
Perry, J.R.B.8
Patterson, N.9
Robinson, E.B.10
-
19
-
-
78650856517
-
GCTA: A tool for genome-wide complex trait analysis
-
Yang, J., Lee, S.H., Goddard, M.E. and Visscher, P.M. (2011) GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet., 88, 76–82.
-
(2011)
Am. J. Hum. Genet.
, vol.88
, pp. 76-82
-
-
Yang, J.1
Lee, S.H.2
Goddard, M.E.3
Visscher, P.M.4
-
20
-
-
85019180945
-
Quantifying the mapping precision of genome-wide association studies using whole-genome sequencing data
-
Wu, Y., Zheng, Z., Visscher, P.M. and Yang, J. (2017) Quantifying the mapping precision of genome-wide association studies using whole-genome sequencing data. Genome Biol., 18.
-
(2017)
Genome Biol.
, vol.18
-
-
Wu, Y.1
Zheng, Z.2
Visscher, P.M.3
Yang, J.4
-
21
-
-
52449107055
-
Bias-reduced estimators and confidence intervals for odds ratios in genome-wide association studies
-
Zhong, H. and Prentice, R.L. (2008) Bias-reduced estimators and confidence intervals for odds ratios in genome-wide association studies. Biostatistics, 9, 621–634.
-
(2008)
Biostatistics
, vol.9
, pp. 621-634
-
-
Zhong, H.1
Prentice, R.L.2
-
22
-
-
85026680175
-
Statistical correction of the winner’s curse explains replication variability in quantitative trait genome-wide association studies
-
Palmer, C. and Pe’er, I. (2017) Statistical correction of the Winner’s Curse explains replication variability in quantitative trait genome-wide association studies. PLoS Genet., 13, e1006916.
-
(2017)
PLoS Genet.
, vol.13
-
-
Palmer, C.1
Pe’er, I.2
-
23
-
-
85039801269
-
Multi-trait analysis of genome-wide association summary statistics using MTAG
-
Turley, P., Walters, R.K., Maghzian, O., Okbay, A., Lee, J.J., Fontana, M.A., Nguyen-Viet, T.A., Wedow, R., Zacher, M., Furlotte, N.A. et al. (2018) Multi-trait analysis of genome-wide association summary statistics using MTAG. Nat. Genet., 50, 229–237.
-
(2018)
Nat. Genet.
, vol.50
, pp. 229-237
-
-
Turley, P.1
Walters, R.K.2
Maghzian, O.3
Okbay, A.4
Lee, J.J.5
Fontana, M.A.6
Nguyen-Viet, T.A.7
Wedow, R.8
Zacher, M.9
Furlotte, N.A.10
-
24
-
-
85048415370
-
Identifying gene targets for brain-related traits using transcrip-tomic and methylomic data from blood
-
Qi, T., Wu, Y., Zeng, J., Zhang, F., Xue, A., Jiang, L., Zhu, Z., Kemper, K., Yengo, L., Zheng, Z. et al. (2018) Identifying gene targets for brain-related traits using transcrip-tomic and methylomic data from blood. Nat. Commun., 9, 2282.
-
(2018)
Nat. Commun.
, vol.9
, pp. 2282
-
-
Qi, T.1
Wu, Y.2
Zeng, J.3
Zhang, F.4
Xue, A.5
Jiang, L.6
Zhu, Z.7
Kemper, K.8
Yengo, L.9
Zheng, Z.10
-
25
-
-
84961927084
-
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
-
Zhu, Z., Zhang, F., Hu, H., Bakshi, A., Robinson, M.R., Powell, J.E., Montgomery, G.W., Goddard, M.E., Wray, N.R., Visscher, P.M. et al. (2016) Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat. Genet., 48, 481–487.
-
(2016)
Nat. Genet.
, vol.48
, pp. 481-487
-
-
Zhu, Z.1
Zhang, F.2
Hu, H.3
Bakshi, A.4
Robinson, M.R.5
Powell, J.E.6
Montgomery, G.W.7
Goddard, M.E.8
Wray, N.R.9
Visscher, P.M.10
-
26
-
-
85031313737
-
Genetic effects on gene expression across human tissues
-
GTEx Consortium (2017) Genetic effects on gene expression across human tissues. Nature, 550, 204–213.
-
(2017)
Nature
, vol.550
, pp. 204-213
-
-
-
27
-
-
85044824194
-
Identification of 55,000 replicated DNA methylation QTL
-
McRae, A., Marioni, R.E., Shah, S., Yang, J., Powell, J.E., Harris, S.E., Gibson, J., Henders, A.K., Bowdler, L., Painter, J.N. et al. (2017) Identification of 55,000 replicated DNA methylation QTL. bioRxiv, 10.1101/166710.
-
(2017)
bioRxiv
-
-
McRae, A.1
Marioni, R.E.2
Shah, S.3
Yang, J.4
Powell, J.E.5
Harris, S.E.6
Gibson, J.7
Henders, A.K.8
Bowdler, L.9
Painter, J.N.10
-
28
-
-
85011362906
-
Meta-GWAS accuracy and power (MetaGAP) calculator shows that hiding heritability is partially due to imperfect genetic correlations across studies
-
de Vlaming, R., Okbay, A., Rietveld, C.A., Johannesson, M., Magnusson, P.K.E., Uitterlinden, A.G., van Rooij, F.J.A., Hofman, A., Groenen, P.J.F., Thurik, A.R. et al. (2017) Meta-GWAS accuracy and power (MetaGAP) calculator shows that hiding heritability is partially due to imperfect genetic correlations across studies. PLoS Genet., 13, e1006495.
-
(2017)
PLoS Genet.
, vol.13
-
-
de Vlaming, R.1
Okbay, A.2
Rietveld, C.A.3
Johannesson, M.4
Magnusson, P.K.E.5
Uitterlinden, A.G.6
van Rooij, F.J.A.7
Hofman, A.8
Groenen, P.J.F.9
Thurik, A.R.10
-
29
-
-
84943171338
-
A global reference for human genetic variation
-
Genomes Project Consortium, Auton, A., Brooks, L.D., Durbin, R.M., Garrison, E.P., Kang, H.M., Korbel, J.O., Marchini, J.L., McCarthy, S., McVean, G.A. et al. (2015) A global reference for human genetic variation. Nature, 526, 68–74.
-
(2015)
Nature
, vol.526
, pp. 68-74
-
-
Auton, A.1
Brooks, L.D.2
Durbin, R.M.3
Garrison, E.P.4
Kang, H.M.5
Korbel, J.O.6
Marchini, J.L.7
McCarthy, S.8
McVean, G.A.9
-
30
-
-
84983479616
-
A reference panel of 64,976 haplotypes for genotype imputation
-
Haplotype Reference Consortium, McCarthy, S., Das, S., Kretzschmar, W., Delaneau, O., Wood, A.R., Teumer, A., Kang, H.M., Fuchsberger, C., Danecek, P. et al. (2016) A reference panel of 64,976 haplotypes for genotype imputation. Nat. Genet., 48, 1279–1283.
-
(2016)
Nat. Genet.
, vol.48
, pp. 1279-1283
-
-
McCarthy, S.1
Das, S.2
Kretzschmar, W.3
Delaneau, O.4
Wood, A.R.5
Teumer, A.6
Kang, H.M.7
Fuchsberger, C.8
Danecek, P.9
-
31
-
-
84899513456
-
Fast principal component analysis of large-scale genome-wide data
-
Abraham, G. and Inouye, M. (2014) Fast principal component analysis of large-scale genome-wide data. PloS One, 9, e93766.
-
(2014)
PloS One
, vol.9
-
-
Abraham, G.1
Inouye, M.2
-
32
-
-
85061548816
-
Phenotypes associated with female X chromosome aneuploidy in UK biobank: An unselected, adult, population-based cohort
-
Tuke, M.A., Ruth, K.S., Wood, A.R., Beaumont, R.N., Tyrrell, J., Jones, S.E., Yaghootkar, H., Turner, C.L.S., Donohoe, M.E., Brooke, A.M. et al. (2017) Phenotypes associated with female X chromosome aneuploidy in UK Biobank: an unselected, adult, population-based cohort. bioRxiV, 10.1101/177659.
-
(2017)
bioRxiV
-
-
Tuke, M.A.1
Ruth, K.S.2
Wood, A.R.3
Beaumont, R.N.4
Tyrrell, J.5
Jones, S.E.6
Yaghootkar, H.7
Turner, C.L.S.8
Donohoe, M.E.9
Brooke, A.M.10
|