Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention

Journal of the American College of Cardiology

Volumn 72, Issue 16, 2018, Pages 1883-1893

  Inouye, Michael ^a,b,c,d,e   Abraham, Gad ^a,b,c,d   Nelson, Christopher P ^f   Wood, Angela M ^c   Sweeting, Michael J ^c   Dudbridge, Frank ^c,f   Lai, Florence Y ^f   Kaptoge, Stephen ^c,g   Brozynska, Marta ^a,b,c   Wang, Tingting ^a,b,c   Ye, Shu ^f   Webb, Thomas R ^f   Rutter, Martin K ^h,i   Tzoulaki, Ioanna ^j,k   Patel, Riyaz S ^l,m   Loos, Ruth J F ⁿ   Keavney, Bernard ^i,o   Hemingway, Harry ^l   Thompson, John ^f   Watkins, Hugh ^p,q   Deloukas, Panos ^r   Di Angelantonio, Emanuele ^c,g   Butterworth, Adam S ^c,g   Danesh, John ^c,g,s   Samani, Nilesh J ^f,t   more..

^a and Cambridge Australia   (United Kingdom)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e ALAN TURING INSTITUTE   (United Kingdom)

^f UNIVERSITY OF LEICESTER   (United Kingdom)

^g The National Institute for Health Research Health Protection Research Unit in Blood Borne and Sexually Transmitted Infections at University College London in partnership with UK Health Security Agency   (United Kingdom)

^h UNIVERSITY OF MANCHESTER   (United Kingdom)

ⁱ MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^j IMPERIAL COLLEGE LONDON   (United Kingdom)

^k UNIVERSITY OF IOANNINA   (Greece)

^l UNIVERSITY COLLEGE LONDON   (United Kingdom)

^m ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

ⁿ MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^o UNIVERSITY OF MANCHESTER   (United Kingdom)

^p UNIVERSITY OF OXFORD   (United Kingdom)

^q UNIVERSITY OF OXFORD   (United Kingdom)

^r QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^s WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^t UNIVERSITY OF LEICESTER   (United Kingdom)

more..

Author keywords

coronary artery disease; genomic risk prediction; primary prevention

Indexed keywords

ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; CHOLESTEROL;

ADULT; AGED; ARTICLE; BODY MASS; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DISEASE COURSE; FAMILY HISTORY; FEMALE; GENETIC RISK; GENETIC VARIABILITY; GENOMIC RISK SCORE; HUMAN; HYPERTENSION; MALE; PREDICTION; PRIMARY PREVENTION; PRIORITY JOURNAL; SCORING SYSTEM; SELF REPORT; SMOKING; UNITED KINGDOM; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOMICS; MASS SCREENING; METHODOLOGY; MIDDLE AGED; MULTIFACTORIAL INHERITANCE; PREDICTIVE VALUE; PROCEDURES; RISK ASSESSMENT; RISK FACTOR;

CORONARY ARTERY DISEASE; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GENOMICS; HUMANS; MALE; MASS SCREENING; MIDDLE AGED; MULTIFACTORIAL INHERITANCE; PREDICTIVE VALUE OF TESTS; PRIMARY PREVENTION; RESEARCH DESIGN; RISK ASSESSMENT; RISK FACTORS; UNITED KINGDOM;

EID: 85054026733     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2018.07.079     Document Type: Article

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