Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

Nature Genetics

Volumn 50, Issue 9, 2018, Pages 1219-1224

  Khera, Amit V ^a,b,c   Chaffin, Mark ^c   Aragam, Krishna G ^a,b,c   Haas, Mary E ^c   Roselli, Carolina ^c   Choi, Seung Hoan ^c   Natarajan, Pradeep ^a,b,c   Lander, Eric S ^c   Lubitz, Steven A ^a,b,c   Ellinor, Patrick T ^a,b,c   Kathiresan, Sekar ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AREA UNDER THE CURVE; ATRIAL FIBRILLATION; BREAST CANCER; CANCER RISK; CORONARY ARTERY DISEASE; CORONARY RISK; GENETIC RISK; GENOME WIDE POLYGENIC SCORE; GENOME-WIDE ASSOCIATION STUDY; HETEROZYGOTE; HUMAN; INFLAMMATORY BOWEL DISEASE; LETTER; MONOGENIC MUTATION; MUTATION; NON INSULIN DEPENDENT DIABETES MELLITUS; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; SCORING SYSTEM; ADULT; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE MUTATION; GENOME ANALYSIS; HIGH RISK POPULATION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTIFACTORIAL INHERITANCE; AGED; DISEASES; GENETIC PREDISPOSITION; GENETICS; PROCEDURES; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; DISEASE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MIDDLE AGED; MULTIFACTORIAL INHERITANCE; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 85052496079     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/s41588-018-0183-z     Document Type: Letter

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