The metabolic sensor GPR43 receptor plays a role in the control of Klebsiella pneumoniae infection in the lung

Frontiers in Immunology

Volumn 9, Issue FEB, 2018, Pages

  Galvão, Izabela ^a   Tavares, Luciana P ^a   Corrêa, Renan O ^b   Fachi, José Luís ^b   Rocha, Vitor Melo ^a   Rungue, Marcela ^a   Garcia, Cristiana C ^c   Cassali, Geovanni ^a   Ferreira, Caroline M ^d   Martins, Flaviano S ^a   Oliveira, Sergio C ^a   Mackay, Charles R ^e   Teixeira, Mauro M ^a   Vinolo, Marco Aurélio R ^b   Vieira, Angélica T ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

^d FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^e MONASH UNIVERSITY   (Australia)

Author keywords

GPR43; Inflammation; Lung infection; Microbiota; Pneumonia; Short chain fatty acids

Indexed keywords

ACETIC ACID; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 43; INTERLEUKIN 10; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHOALVEOLAR LAVAGE FLUID; CONTROLLED STUDY; CYTOKINE PRODUCTION; HISTOPATHOLOGY; IMMUNE RESPONSE; INFECTION CONTROL; INFECTION SENSITIVITY; INFECTIOUS PNEUMONIA; INTESTINE FLORA; KLEBSIELLA PNEUMONIAE INFECTION; LUNG ALVEOLUS MACROPHAGE; LUNG PARENCHYMA; MALE; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PHAGOCYTOSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 85042323528     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2018.00142     Document Type: Article

References (41)

1. Wardlaw T, Salama P, Johansson EW, Mason E. Pneumonia: the leading killer of children. Lancet (2006) 368(9541):1048-50. doi:10.1016/S0140-6736(06)69334-3
2. Driver C. Pneumonia part 1: pathology, presentation and prevention. Br J Nurs (2012) 21(2):103-6. doi:10.12968/bjon.2012.21.2.103
3. Feldman C, Anderson R. Recent advances in our understanding of Streptococcus pneumoniae infection. F1000Prime Rep (2014) 6:82. doi:10.12703/P6-82
4. Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, et al. Spectrum of pathogen-and model-specific histopathologies in mouse models of acute pneumonia. PLoS One (2017) 12(11):e0188251. doi:10.1371/journal.pone.0188251
5. Song JY, Eun BW, Nahm MH. Diagnosis of pneumococcal pneumonia: current pitfalls and the way forward. Infect Chemother (2013) 45(4):351-66. doi:10.3947/ic.2013.45.4.351
6. Paczosa MK, Mecsas J. Klebsiella pneumoniae: going on the offense with a strong defense. Microbiol Mol Biol Rev (2016) 80(3):629-61. doi:10.1128/MMBR.00078-15
7. Tavares LP, Garcia CC, Vago JP, Queiroz-Junior CM, Galvao I, David BA, et al. Inhibition of phosphodiesterase-4 during pneumococcal pneumonia reduces inflammation and lung injury in mice. Am J Respir Cell Mol Biol (2016) 55(1):24-34. doi:10.1165/rcmb.2015-0083OC
8. Makris S, Paulsen M, Johansson C. Type I interferons as regulators of lung inflammation. Front Immunol (2017) 8:259. doi:10.3389/fimmu.2017.00259
9. Fagundes CT, Amaral FA, Vieira AT, Soares AC, Pinho V, Nicoli JR, et al. Transient TLR activation restores inflammatory response and ability to control pulmonary bacterial infection in germfree mice. J Immunol (2012) 188(3):1411-20. doi:10.4049/jimmunol.1101682
10. Samuelson DR, Welsh DA, Shellito JE. Regulation of lung immunity and host defense by the intestinal microbiota. Front Microbiol (2015) 6:1085. doi:10.3389/fmicb.2015.01085
11. Maslowski KM, Vieira AT, Ng A, Kranich J, Sierro F, Yu D, et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature (2009) 461(7268):1282-6. doi:10.1038/nature08530
12. McKenzie CI, Mackay CR, Macia L. GPR43-a prototypic metabolite sensor linking metabolic and inflammatory diseases. Trends Endocrinol Metab (2015) 26(10):511-2. doi:10.1016/j.tem.2015.07.009
13. Vieira AT, Macia L, Galvao I, Martins FS, Canesso MC, Amaral FA, et al. A role for gut microbiota and the metabolite-sensing receptor GPR43 in a murine model of gout. Arthritis Rheumatol (2015) 67(6):1646-56. doi:10.1002/art.39107
14. Vinolo MA, Rodrigues HG, Nachbar RT, Curi R. Regulation of inflammation by short chain fatty acids. Nutrients (2011) 3(10):858-76. doi:10.3390/nu3100858
15. Le Poul E, Loison C, Struyf S, Springael JY, Lannoy V, Decobecq ME, et al. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem (2003) 278(28):25481-9. doi:10.1074/jbc.M301403200
16. Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, et al. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem (2003) 278(13):11312-9. doi:10.1074/jbc.M211609200
17. Kimura I. [Host energy regulation via SCFAs receptors, as dietary nutrition sensors, by gut microbiota]. Yakugaku Zasshi (2014) 134(10):1037-42. doi:10.1248/yakushi.14-00169
18. de Clercq NC, Groen AK, Romijn JA, Nieuwdorp M. Gut microbiota in obesity and undernutrition. Adv Nutr (2016) 7(6):1080-9. doi:10.3945/an.116.012914
19. Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, Ngom-Bru C, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med (2014) 20(2):159-66. doi:10.1038/nm.3444
20. Wu W, Sun M, Chen F, Cao AT, Liu H, Zhao Y, et al. Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43. Mucosal Immunol (2016) 10(4):946-56. doi:10.1038/mi.2016.114
21. Macia L, Tan J, Vieira AT, Leach K, Stanley D, Luong S, et al. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat Commun (2015) 6:6734. doi:10.1038/ncomms7734
22. Vieira AT, Rocha VM, Tavares L, Garcia CC, Teixeira MM, Oliveira SC, et al. Control of Klebsiella pneumoniae pulmonary infection and immunomodulation by oral treatment with the commensal probiotic Bifidobacterium longum 5(1A). Microbes Infect (2016) 18(3):180-9. doi:10.1016/j.micinf.2015.10.008
23. Correa RO, Vieira A, Sernaglia EM, Lancellotti M, Vieira AT, Avila-Campos MJ, et al. Bacterial short-chain fatty acid metabolites modulate the inflammatory response against infectious bacteria. Cell Microbiol (2017) 19(7):1-4. doi:10.1111/cmi.12720
24. Clarke TB. Early innate immunity to bacterial infection in the lung is regulated systemically by the commensal microbiota via nod-like receptor ligands. Infect Immun (2014) 82(11):4596-606. doi:10.1128/IAI.02212-14
25. Budden KF, Gellatly SL, Wood DL, Cooper MA, Morrison M, Hugenholtz P, et al. Emerging pathogenic links between microbiota and the gut-lung axis. Nat Rev Microbiol (2017) 15(1):55-63. doi:10.1038/nrmicro.2016.142
26. Cisalpino D, Fagundes CT, Brito CB, Ascencao FR, Queiroz-Junior CM, Vieira AT, et al. Microbiota-induced antibodies are essential for host inflammatory responsiveness to sterile and infectious stimuli. J Immunol (2017) 198(10):4096-106. doi:10.4049/jimmunol.1600852
27. Dickson RP, Cox MJ. Gut microbiota and protection from pneumococcal pneumonia. Gut (2017) 66(2):384. doi:10.1136/gutjnl-2016-311823
28. Vieira AT, Galvao I, Macia LM, Sernaglia EM, Vinolo MA, Garcia CC, et al. Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice. J Leukoc Biol (2017) 101(1):275-84. doi:10.1189/jlb.3A1015-453RRR
29. Hong YH, Nishimura Y, Hishikawa D, Tsuzuki H, Miyahara H, Gotoh C, et al. Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43. Endocrinology (2005) 146(12):5092-9. doi:10.1210/en.2005-0545
30. Sharma S, Chhibber S, Mohan H, Sharma S. Dietary supplementation with omega-3 polyunsaturated fatty acids ameliorates acute pneumonia induced by Klebsiella pneumoniae in BALB/c mice. Can J Microbiol (2013) 59(7):503-10. doi:10.1139/cjm-2012-0521
31. Sugimoto MA, Sousa LP, Pinho V, Perretti M, Teixeira MM. Resolution of inflammation: what controls its onset? Front Immunol (2016) 7:160. doi:10.3389/fimmu.2016.00160
32. Russell SL, Gold MJ, Reynolds LA, Willing BP, Dimitriu P, Thorson L, et al. Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases. J Allergy Clin Immunol (2015) 135(1):100-9. doi:10.1016/j.jaci.2014.06.027
33. Thorburn AN, McKenzie CI, Shen S, Stanley D, Macia L, Mason LJ, et al. Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun (2015) 6:7320. doi:10.1038/ncomms8320
34. Brown K, DeCoffe D, Molcan E, Gibson DL. Diet-induced dysbiosis of the intestinal microbiota and the effects on immunity and disease. Nutrients (2012) 4(8):1095-119. doi:10.3390/nu4081095
35. Conlon MA, Bird AR. The impact of diet and lifestyle on gut microbiota and human health. Nutrients (2014) 7(1):17-44. doi:10.3390/nu7010017
36. Villena J, Racedo S, Aguero G, Bru E, Medina M, Alvarez S. Lactobacillus casei improves resistance to pneumococcal respiratory infection in malnourished mice. J Nutr (2005) 135(6):1462-9. doi:10.1093/jn/135.6.1462
37. Villena J, Racedo S, Aguero G, Alvarez S. Yoghurt accelerates the recovery of defence mechanisms against Streptococcus pneumoniae in protein-malnourished mice. Br J Nutr (2006) 95(3):591-602. doi:10.1079/BJN20051663
38. Cunningham-Rundles S, Lin DH. Nutrition and the immune system of the gut. Nutrition (1998) 14(7-8):573-9. doi:10.1016/S0899-9007(98)00029-X
39. Rice AL, Sacco L, Hyder A, Black RE. Malnutrition as an underlying cause of childhood deaths associated with infectious diseases in developing countries. Bull World Health Organ (2000) 78(10):1207-21
40. Desai MS, Seekatz AM, Koropatkin NM, Kamada N, Hickey CA, Wolter M, et al. A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility. Cell (2016) 167(5):1339-53.e1321. doi:10.1016/j.cell.2016.10.043
41. Panigrahi P, Parida S, Nanda NC, Satpathy R, Pradhan L, Chandel DS, et al. A randomized synbiotic trial to prevent sepsis among infants in rural India. Nature (2017) 548(7668):407-12. doi:10.1038/nature23480