Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

Nature Communications

Volumn 9, Issue 1, 2018, Pages

  Fellows, Rachel ^a   Denizot, Jérémy ^a,f   Stellato, Claudia ^a   Cuomo, Alessandro ^b   Jain, Payal ^a   Stoyanova, Elena ^a   Balázsi, Szabina ^a   Hajnády, Zoltán ^a   Liebert, Anke ^a   Kazakevych, Juri ^a   Blackburn, Hector ^a   Corrêa, Renan Oliveira ^c   Fachi, José Luís ^c   Sato, Fabio Takeo ^c   Ribeiro, Willian R ^d   Ferreira, Caroline Marcantonio ^d   Perée, Hélène ^a   Spagnuolo, Mariangela ^a   Mattiuz, Raphaël ^a   Matolcsi, Csaba ^a   Guedes, Joana ^a   Clark, Jonathan ^a   Veldhoen, Marc ^a,g   Bonaldi, Tiziana ^b,c   Vinolo, Marco Aurélio Ramirez ^c,d   Varga Weisz, Patrick ^a,e   more..

^a BABRAHAM INSTITUTE   (United Kingdom)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c UNIVERSITY OF CAMPINAS   (Brazil)

^d FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^e UNIVERSITY OF ESSEX   (United Kingdom)

^f UNIVERSITÉ CLERMONT AUVERGNE   (France)

^g INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE H3; LYSINE; SHORT CHAIN FATTY ACID; CROTONIC ACID DERIVATIVE; HISTONE; HISTONE DEACETYLASE INHIBITOR; VOLATILE FATTY ACID;

CELL; CHEMICAL REACTION; CRASSULACEAN ACID METABOLISM; DIGESTIVE SYSTEM; ENZYME; ENZYME ACTIVITY; FATTY ACID; GENE; GENE EXPRESSION; INHIBITOR; METABOLISM; MICROORGANISM; PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL LOAD; CELL CYCLE ARREST; COLON EPITHELIUM; COMPARATIVE STUDY; CONTROLLED STUDY; DEACETYLATION; GENE CONTROL; HCT 116 CELL LINE; HISTONE MODIFICATION; IC50; INTESTINE EPITHELIUM; INTESTINE FLORA; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MOUSE; NONHUMAN; RNA SEQUENCE; WESTERN BLOTTING; ACYLATION; ANIMAL; C57BL MOUSE; CELL CYCLE; COLON; HUMAN; INTESTINE MUCOSA; MALE; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; PROTEIN PROCESSING;

ACYLATION; ANIMALS; CELL CYCLE; COLON; CROTONATES; FATTY ACIDS, VOLATILE; GASTROINTESTINAL MICROBIOME; HCT116 CELLS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HISTONES; HUMANS; INTESTINAL MUCOSA; MALE; MICE, INBRED C57BL; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 85040571262     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-02651-5     Document Type: Article

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