Effect of broad- and narrow-spectrum antimicrobials on Clostridium difficile and microbial diversity in a model of the distal colon

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue SUPPL. 1, 2011, Pages 4639-4644

  Rea, Mary C ^a,b   Dobson, Alleson ^a,b   O'Sullivan, Orla ^a   Crispie, Fiona ^a,b   Fouhy, Fiona ^a   Cotter, Paul D ^a,b   Shanahan, Fergus ^b,c   Kiely, Barry ^d   Hill, Colin ^b,c   Paul Ross, R ^a,b  

^a TEAGASC FOOD RESEARCH CENTRE   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c UNIVERSITY COLLEGE CORK   (Ireland)

^d ALIMENTARY HEALTH LTD   (Ireland)

Author keywords

Antibiotic; Bacteriocin; Gut microbiota; Pyrosequencing; Thuricin

Indexed keywords

ANTIBIOTIC AGENT; BACTERIOCIN; GENOMIC DNA; LACTICIN 3147; METRONIDAZOLE; RNA 16S; THURICIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ANTIMICROBIAL ACTIVITY; BACILLUS THURINGIENSIS; BACTEROIDES; CLOSTRIDIUM DIFFICILE; COLON; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; FIRMICUTES; HUMAN; INTESTINE FLORA; MICROBIAL COMMUNITY; MICROBIAL DIVERSITY; MICROFLORA; MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEOBACTERIA;

BACILLUS THURINGIENSIS; BACTEROIDETES; CLOSTRIDIUM DIFFICILE; FIRMICUTES; PROTEOBACTERIA;

EID: 79952773376     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1001224107     Document Type: Article

References (39)

1. Vollaard EJ, Clasener HA (1994) Colonization resistance. Antimicrob Agents Chemother 38:409-414. (Pubitemid 24072223)
2. Donskey CJ (2004) The role of the intestinal tract as a reservoir and source for transmission of nosocomial pathogens. Clin Infect Dis 39:219-226.
3. Frank DN, et al. (2007) Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci USA 104:13780-13785. (Pubitemid 350003397)
4. O'Hara AM, Shanahan F (2006) The gut flora as a forgotten organ. EMBO Rep 7:688-693. (Pubitemid 43986264)
5. Shanahan F (2002) The host-microbe interface within the gut. Best Pract Res Clin Gastroenterol 16:915-931.
6. Hall IC, O'Toole E (1935) Intestinal flora in new-born infants with a description of a new pathogenic anaerobe, Bacillus difficilis. Am J Dis Child 49:390-402.
7. George RH, et al. (1978) Identification of Clostridium difficile as a cause of pseudomembranous colitis. Br Med J 1:695. (Pubitemid 8318970)
8. Cramer JP, Burchard GD, Lohse AW (2008) [Old dogmas and new perspectives in antibiotic-associated diarrhea]. Med Klin (Munich) 103:325-338, quiz 339-340.
9. Aslam S, Hamill RJ, Musher DM (2005) Treatment of Clostridium difficile-associated disease: Old therapies and new strategies. Lancet Infect Dis 5:549-557. (Pubitemid 41196754)
10. Peláez T, et al. (2002) Reassessment of Clostridium difficile susceptibility to metronidazole and vancomycin. Antimicrob Agents Chemother 46:1647-1650. (Pubitemid 34535177)
11. Anonymous. Clostridium difficile infection. Available at: http://ecdc.europa.eu/EN/HEALTHTOPICS/Pages/Clostridium-Difficile-Infection. aspx. Accessed May 1, 2010.
12. Kuijper EJ, et al. (2008) Update of Clostridium difficile infection due to PCR ribotype 027 in Europe, 2008. Euro Surveill 13:1-3.
13. Sood S, Malhotra M, Das BK, Kapil A (2008) Enterococcal infections & antimicrobial resistance. Indian J Med Res 128:111-121.
14. Corr SC, et al. (2007) Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118. Proc Natl Acad Sci USA 104:7617-7621. (Pubitemid 47185955)
15. Rea MC, et al. (2007) Antimicrobial activity of lacticin 3,147 against clinical Clostridium difficile strains. J Med Microbiol 56:940-946. (Pubitemid 47047488)
16. Rea MC, et al. (2010) Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile. Proc Natl Acad Sci USA 107:9352-9357.
17. Baines SD, O'Connor R, Saxton K, Freeman J, Wilcox MH (2008) Comparison of oritavancin versus vancomycin as treatments for clindamycin-induced Clostridium difficile PCR ribotype 027 infection in a human gut model. J Antimicrob Chemother 62:1078-1085.
18. Freeman J, Baines SD, Saxton K, Wilcox MH (2007) Effect of metronidazole on growth and toxin production by epidemic Clostridium difficile PCR ribotypes 001 and 027 in a human gut model. J Antimicrob Chemother 60:83-91.
19. Nagy E, Földes J (1991) Inactivation of metronidazole by Enterococcus faecalis. J Antimicrob Chemother 27:63-70.
20. Rafii F, Wynne R, Heinze TM, Paine DD (2003) Mechanism of metronidazole-resistance by isolates of nitroreductase-producing Enterococcus gallinarum and Enterococcus casseliflavus from the human intestinal tract. FEMS Microbiol Lett 225:195-200. (Pubitemid 38373389)
21. Croswell A, Amir E, Teggatz P, Barman M, Salzman NH (2009) Prolonged impact of antibiotics on intestinal microbial ecology and susceptibility to enteric Salmonella infection. Infect Immun 77:2741-2753.
22. Claesson MJ, et al. (2009) Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine. PLoS ONE 4:e6669.
23. Urich T, et al. (2008) Simultaneous assessment of soil microbial community structure and function through analysis of the meta-transcriptome. PLoS ONE 3:e2527.
24. Mariat D, et al. (2009) The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiol 9:123.
25. Dethlefsen L, Huse S, Sogin ML, Relman DA (2008) Thepervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoS Biol 6:e280.
26. Antonopoulos DA, et al. (2009) Reproducible community dynamics of the gastrointestinal microbiota following antibiotic perturbation. Infect Immun 77:2367-2375.
27. Sekirov I, et al. (2008) Antibiotic-induced perturbations of the intestinal microbiota alter host susceptibility to enteric infection. Infect Immun 76:4726-4736.
28. Yap IKS, et al. (2008) Metabonomic and microbiological analysis of the dynamic effect of vancomycin-induced gut microbiota modification in the mouse. J Proteome Res 7:3718-3728.
29. Citron DM, et al. (2003) In vitro activities of ramoplanin, teicoplanin, vancomycin, linezolid, bacitracin, and four other antimicrobials against intestinal anaerobic bacteria. Antimicrob Agents Chemother 47:2334-2338.
30. Hill DA, et al. (2009) Metagenomic analyses reveal antibiotic-induced temporal and spatial changes in intestinal microbiota with associated alterations in immune cell homeostasis. Mucosal Immunol 3:148-158.
31. Garner CD, et al. (2009) Perturbation of the small intestine microbial ecology by streptomycin alters pathology in a Salmonella enterica serovar typhimurium murine model of infection. Infect Immun 77:2691-2702.
32. McFarland LV (2009) Evidence-based review of probiotics for antibiotic-associated diarrhea and Clostridium difficile infections. Anaerobe 15:274-280.
33. Khoruts A, Dicksved J, Jansson JK, Sadowsky MJ (2010) Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea. J Clin Gastroenterol 44:354-360.
34. Louie TJ, Emery J, Krulicki W, Byrne B, Mah M (2009) OPT-80 eliminates Clostridium difficile and is sparing of bacteroides species during treatment of C. difficile infection. Antimicrob Agents Chemother 53:261-263.
35. Ryan MP, Rea MC, Hill C, Ross RP (1996) An application in cheddar cheese manufacture for a strain of Lactococcus lactis producing a novel broad-spectrumbacteriocin, lacticin 3147. Appl Environ Microbiol 62:612-619.
36. Fooks LJ, Gibson GR (2003) Mixed culture fermentation studies on the effects of synbiotics on the human intestinal pathogens Campylobacter jejuni and Escherichia coli. Anaerobe 9:231-242. (Pubitemid 37188670)
37. Schloss PD, Handelsman J (2008) A statistical toolbox for metagenomics: assessing functional diversity in microbial communities. BMC Bioinformatics 9:34.
38. Altschul SF, et al. (1997) Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Res 25:3389-3402. (Pubitemid 27359211)
39. Huson DH, Auch AF, Qi J, Schuster SC (2007) MEGAN analysis of metagenomic data. Genome Res 17:377-386. (Pubitemid 46376747)