Antagonism of dsRNA-induced innate immune pathways by NS4a and NS4b accessory proteins during MERS coronavirus infection

mBio

Volumn 10, Issue 2, 2019, Pages

  Comar, Courtney E ^a   Goldstein, Stephen A ^a   Li, Yize ^a   Yount, Boyd ^b,c   Baric, Ralph S ^b,c   Weiss, Susan R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b IL   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Coronavirus; Interferon antagonist; MERS CoV; Viral accessory proteins

Indexed keywords

DOUBLE STRANDED RNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 29; NONSTRUCTURAL PROTEIN 4A; NONSTRUCTURAL PROTEIN 4B; OLIGOADENYLATE SYNTHETASE; PROTEIN KINASE R; RIBONUCLEASE L; SYNTHETASE; UNCLASSIFIED DRUG; VIRAL PROTEIN; VIRUS RNA;

A-549 CELL LINE; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IFNL1 GENE; IMMUNE DEFICIENCY; IMMUNE EVASION; IMMUNE RESPONSE; INNATE IMMUNITY; MIDDLE EAST RESPIRATORY SYNDROME; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; VIRUS REPLICATION; EPITHELIUM CELL; GENE DELETION; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; METABOLISM; MUTATION; PATHOGENICITY; VIROLOGY;

A549 CELLS; EPITHELIAL CELLS; GENE DELETION; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNE EVASION; IMMUNITY, INNATE; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MUTATION; RNA, DOUBLE-STRANDED; RNA, VIRAL; VIRAL NONSTRUCTURAL PROTEINS; VIRAL REGULATORY AND ACCESSORY PROTEINS; VIRUS REPLICATION;

EID: 85063929856     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.00319-19     Document Type: Article

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