Lineage A betacoronavirus NS2 proteins and the homologous torovirus Berne pp1a carboxy-terminal domain are phosphodiesterases that antagonize activation of RNase L

Journal of Virology

Volumn 91, Issue 5, 2017, Pages

  Goldstein, Stephen A ^a   Thornbrough, Joshua M ^a,c   Zhang, Rong ^a,d   Jha, Babal K ^b   Li, Yize ^a   Elliott, Ruth ^a   Quiroz Figueroa, Katherine ^a   Chen, Annie I ^a   Silverman, Robert H ^b   Weiss, Susan R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c ADELPHI REAL WORLD   (United Kingdom)

^d WASHINGTON UNIVERSITY   (United States)

Author keywords

Interferon antagonist; Lineage A coronavirus; Oligoadenylate synthetase; Phosphodiesterase; RNase L; Torovirus

Indexed keywords

2',5' PHOSPHODIESTERASE; NONSTRUCTURAL PROTEIN 2; PHOSPHODIESTERASE; RIBONUCLEASE L; UNCLASSIFIED DRUG; 2',5'-OLIGOADENYLATE; 2-5A-DEPENDENT RIBONUCLEASE; ADENINE NUCLEOTIDE; OLIGORIBONUCLEOTIDE; RIBONUCLEASE; VIRAL PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONAVIRIDAE; ENZYME ACTIVATION; ENZYME ACTIVITY; EQUINE CORONAVIRUS; EQUINE TOROVIRUS BERNE; HUMAN CORONAVIRUS OC43; HUMAN ENTERIC CORONAVIRUS; LINEAGE A BETACORONAVIRUS; MOUSE; MURINE HEPATITIS VIRUS; NONHUMAN; RNA DEGRADATION; TOROVIRUS; VIRUS PATHOGENESIS; VIRUS REPLICATION; WILD TYPE; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CELL LINE; CHEMISTRY; CONSERVED SEQUENCE; ENZYME ACTIVE SITE; ENZYMOLOGY; HAMSTER; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; PHYSIOLOGY; VIROLOGY;

ADENINE NUCLEOTIDES; AMINO ACID SEQUENCE; ANIMALS; CATALYTIC DOMAIN; CELL LINE; CONSERVED SEQUENCE; CRICETINAE; ENDORIBONUCLEASES; ENZYME ACTIVATION; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MURINE HEPATITIS VIRUS; OLIGORIBONUCLEOTIDES; PHOSPHORIC DIESTER HYDROLASES; TOROVIRUS; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 85013953974     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02201-16     Document Type: Article

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