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Volumn 14, Issue 1, 2018, Pages

MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; IMMUNE RESPONSE; ANIMAL; CELL CULTURE; CORONAVIRUS INFECTION; HAMSTER; HOST PATHOGEN INTERACTION; HUMAN; IMMUNE EVASION; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; PHYSIOLOGY; VIROLOGY;

EID: 85041527551     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1006838     Document Type: Article
Times cited : (103)

References (57)
  • 1
    • 84876310574 scopus 로고    scopus 로고
    • Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome coronavirus
    • 23449793,..;: –. Epub 2013/03/02.; PubMed Central PMCID: PMC3624328
    • Zielecki F, Weber M, Eickmann M, Spiegelberg L, Zaki AM, Matrosovich M, et al. Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome coronavirus. J Virol. 2013;87:5300–4. Epub 2013/03/02. doi: 10.1128/JVI.03496-12 23449793; PubMed Central PMCID: PMC3624328.
    • (2013) J Virol , vol.87 , pp. 5300-5304
    • Zielecki, F.1    Weber, M.2    Eickmann, M.3    Spiegelberg, L.4    Zaki, A.M.5    Matrosovich, M.6
  • 2
    • 84878523342 scopus 로고    scopus 로고
    • Tropism of and innate immune responses to the novel human betacoronavirus lineage C virus in human ex vivo respiratory organ cultures
    • 23552422,..;: –. Epub 2013/04/05.; PubMed Central PMCID: PMC3676115
    • Chan RW, Chan MC, Agnihothram S, Chan LL, Kuok DI, Fong JH, et al. Tropism of and innate immune responses to the novel human betacoronavirus lineage C virus in human ex vivo respiratory organ cultures. J Virol. 2013;87:6604–14. Epub 2013/04/05. doi: 10.1128/JVI.00009-13 23552422; PubMed Central PMCID: PMC3676115.
    • (2013) J Virol , vol.87 , pp. 6604-6614
    • Chan, R.W.1    Chan, M.C.2    Agnihothram, S.3    Chan, L.L.4    Kuok, D.I.5    Fong, J.H.6
  • 3
    • 84874606884 scopus 로고    scopus 로고
    • Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential
    • 23422412,..;: –.; PubMed Central PMCID: PMCPMC3573664
    • Kindler E, Jonsdottir HR, Muth D, Hamming OJ, Hartmann R, Rodriguez R, et al. Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential. MBio. 2013;4:e00611–12. doi: 10.1128/mBio.00611-12 23422412; PubMed Central PMCID: PMCPMC3573664.
    • (2013) MBio , vol.4 , pp. e00611-e00612
    • Kindler, E.1    Jonsdottir, H.R.2    Muth, D.3    Hamming, O.J.4    Hartmann, R.5    Rodriguez, R.6
  • 4
    • 0036781052 scopus 로고    scopus 로고
    • NF-kappaB regulation in the immune system
    • 1236021
    • Li Q, Verma IM, NF-kappaB regulation in the immune system. Nat Rev Immunol. 2002;2:725–34. doi: 10.1038/nri910 12360211.
    • (2002) Nat Rev Immunol , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 5
    • 84891669023 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB mediated inflammation in severe acute respiratory syndome coronavirus-infected mice increases survival
    • 24198408,..;: –. Epub 2013/11/08
    • DeDiego ML, Nieto-Torres JL, Regla-Nava JA, Jimenez-Guardeño JM, Fernandez-Delgado R, Fett C, et al. Inhibition of NF-kappaB mediated inflammation in severe acute respiratory syndome coronavirus-infected mice increases survival. J Virol. 2014;88:913–24. Epub 2013/11/08. doi: 10.1128/JVI.02576-13 24198408.
    • (2014) J Virol , vol.88 , pp. 913-924
    • DeDiego, M.L.1    Nieto-Torres, J.L.2    Regla-Nava, J.A.3    Jimenez-Guardeño, J.M.4    Fernandez-Delgado, R.5    Fett, C.6
  • 6
    • 77649256469 scopus 로고    scopus 로고
    • Exacerbated innate host response to SARS-CoV in aged non-human primates
    • 20140198,..;:. Epub 2010/02/09.; PubMed Central PMCID: PMC2816697
    • Smits SL, de Lang A, van den Brand JM, Leijten LM, van IWF, Eijkemans MJ, et al. Exacerbated innate host response to SARS-CoV in aged non-human primates. PLoS Pathog. 2010;6:e1000756. Epub 2010/02/09. doi: 10.1371/journal.ppat.1000756 20140198; PubMed Central PMCID: PMC2816697.
    • (2010) PLoS Pathog , vol.6 , pp. e1000756
    • Smits, S.L.1    de Lang, A.2    van den Brand, J.M.3    Leijten, L.M.4    van, I.W.F.5    Eijkemans, M.J.6
  • 7
    • 54049111798 scopus 로고    scopus 로고
    • Influenza viruses and the NF-kappaB signaling pathway—towards a novel concept of antiviral therapy
    • 1871301
    • Ludwig S, Planz O, Influenza viruses and the NF-kappaB signaling pathway—towards a novel concept of antiviral therapy. Biol Chem. 2008;389:1307–12. doi: 10.1515/BC.2008.148 18713017.
    • (2008) Biol Chem , vol.389 , pp. 1307-1312
    • Ludwig, S.1    Planz, O.2
  • 8
    • 84887148359 scopus 로고    scopus 로고
    • Engineering a replication-competent, propagation-defective Middle East respiratory syndrome coronavirus as a vaccine candidate
    • 24023385,..;: –. Epub 2013/09/12.; PubMed Central PMCID: PMC3774192
    • Almazan F, DeDiego ML, Sola I, Zuñiga S, Nieto-Torres JL, Marquez-Jurado S, et al. Engineering a replication-competent, propagation-defective Middle East respiratory syndrome coronavirus as a vaccine candidate. MBio. 2013;4:e00650–13. Epub 2013/09/12. doi: 10.1128/mBio.00650-13 24023385; PubMed Central PMCID: PMC3774192.
    • (2013) MBio , vol.4 , pp. e00613-e00650
    • Almazan, F.1    DeDiego, M.L.2    Sola, I.3    Zuñiga, S.4    Nieto-Torres, J.L.5    Marquez-Jurado, S.6
  • 9
    • 84992694820 scopus 로고    scopus 로고
    • Middle East respiratory coronavirus accessory protein 4a inhibits PKR-mediated antiviral stress responses
    • 27783669,..;:.; PubMed Central PMCID: PMCPMC5081173
    • Rabouw HH, Langereis MA, Knaap RC, Dalebout TJ, Canton J, Sola I, et al. Middle East respiratory coronavirus accessory protein 4a inhibits PKR-mediated antiviral stress responses. PLoS Pathog. 2016;12:e1005982. doi: 10.1371/journal.ppat.1005982 27783669; PubMed Central PMCID: PMCPMC5081173.
    • (2016) PLoS Pathog , vol.12 , pp. e1005982
    • Rabouw, H.H.1    Langereis, M.A.2    Knaap, R.C.3    Dalebout, T.J.4    Canton, J.5    Sola, I.6
  • 10
    • 84897055458 scopus 로고    scopus 로고
    • The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling
    • 24443473,.;: –. Epub 2014/01/21
    • Matthews KL, Coleman CM, van der Meer Y, Snijder EJ, Frieman MB, The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling. J Gen Virol. 2014;95:874–82. Epub 2014/01/21. doi: 10.1099/vir.0.062059-0 24443473.
    • (2014) J Gen Virol , vol.95 , pp. 874-882
    • Matthews, K.L.1    Coleman, C.M.2    van der Meer, Y.3    Snijder, E.J.4    Frieman, M.B.5
  • 11
    • 0042164218 scopus 로고    scopus 로고
    • Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage
    • 1292753
    • Snijder EJ, Bredenbeek PJ, Dobbe JC, Thiel V, Ziebuhr J, Poon LLM, et al. Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage. J Mol Biol. 2003;331:991–1004. 12927536
    • (2003) J Mol Biol , vol.331 , pp. 991-1004
    • Snijder, E.J.1    Bredenbeek, P.J.2    Dobbe, J.C.3    Thiel, V.4    Ziebuhr, J.5    Poon, L.L.M.6
  • 12
    • 84886298565 scopus 로고    scopus 로고
    • Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist
    • 24027320,..;: –. Epub 2013/09/13.; PubMed Central PMCID: PMC3807936
    • Niemeyer D, Zillinger T, Muth D, Zielecki F, Horvath G, Suliman T, et al. Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist. J Virol. 2013;87:12489–95. Epub 2013/09/13. doi: 10.1128/JVI.01845-13 24027320; PubMed Central PMCID: PMC3807936.
    • (2013) J Virol , vol.87 , pp. 12489-12495
    • Niemeyer, D.1    Zillinger, T.2    Muth, D.3    Zielecki, F.4    Horvath, G.5    Suliman, T.6
  • 13
    • 84895534920 scopus 로고    scopus 로고
    • Middle East respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in innate antiviral response
    • 24522921,..;: –. Epub 2014/02/14
    • Siu KL, Yeung ML, Kok KH, Yuen KS, Kew C, Lui PY, et al. Middle East respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in innate antiviral response. J Virol. 2014;88:4866–76. Epub 2014/02/14. doi: 10.1128/JVI.03649-13 24522921.
    • (2014) J Virol , vol.88 , pp. 4866-4876
    • Siu, K.L.1    Yeung, M.L.2    Kok, K.H.3    Yuen, K.S.4    Kew, C.5    Lui, P.Y.6
  • 14
    • 0033571108 scopus 로고    scopus 로고
    • The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex
    • 10553091,.;: –. Epub 1999/11/24
    • Hehner SP, Hofmann TG, Droge W, Schmitz ML, The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex. J Immunol. 1999;163:5617–23. Epub 1999/11/24. 10553091.
    • (1999) J Immunol , vol.163 , pp. 5617-5623
    • Hehner, S.P.1    Hofmann, T.G.2    Droge, W.3    Schmitz, M.L.4
  • 15
    • 0027462682 scopus 로고
    • Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha
    • 8460169,.;: –.; PubMed Central PMCID: PMCPMC46122
    • Brown K, Park S, Kanno T, Franzoso G, Siebenlist U, Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha. Proc Natl Acad Sci USA. 1993;90:2532–6. 8460169; PubMed Central PMCID: PMCPMC46122.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2532-2536
    • Brown, K.1    Park, S.2    Kanno, T.3    Franzoso, G.4    Siebenlist, U.5
  • 16
    • 73349140487 scopus 로고    scopus 로고
    • Mechanisms and signals for the nuclear import of proteins
    • 20514217,.;: –.; PubMed Central PMCID: PMCPMC2817886
    • Freitas N, Cunha C, Mechanisms and signals for the nuclear import of proteins. Curr Genomics. 2009;10:550–7. doi: 10.2174/138920209789503941 20514217; PubMed Central PMCID: PMCPMC2817886.
    • (2009) Curr Genomics , vol.10 , pp. 550-557
    • Freitas, N.1    Cunha, C.2
  • 17
    • 84922326889 scopus 로고    scopus 로고
    • Diversification of importin-alpha isoforms in cellular trafficking and disease states
    • 25656054,.;: –.; PubMed Central PMCID: PMCPMC4405237
    • Pumroy RA, Cingolani G, Diversification of importin-alpha isoforms in cellular trafficking and disease states. Biochem J. 2015;466:13–28. doi: 10.1042/BJ20141186 25656054; PubMed Central PMCID: PMCPMC4405237.
    • (2015) Biochem J , vol.466 , pp. 13-28
    • Pumroy, R.A.1    Cingolani, G.2
  • 18
    • 18144426719 scopus 로고    scopus 로고
    • NF-kappa B is transported into the nucleus by importin alpha3 and importin alpha4
    • 1567744
    • Fagerlund R, Kinnunen L, Kohler M, Julkunen I, Melen K, NF-kappaB is transported into the nucleus by importin alpha3 and importin alpha4. J Biol Chem. 2005;280:15942–51. doi: 10.1074/jbc.M500814200 15677444.
    • (2005) J Biol Chem , vol.280 , pp. 15942-15951
    • Fagerlund, R.1    Kinnunen, L.2    Kohler, M.3    Julkunen, I.4    Melen, K.5
  • 19
    • 84890049888 scopus 로고    scopus 로고
    • The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists
    • 24318862,..;: –. Epub 2013/12/10
    • Yang Y, Zhang L, Geng H, Deng Y, Huang B, Guo Y, et al. The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists. Protein Cell. 2013;4:951–61. Epub 2013/12/10. doi: 10.1007/s13238-013-3096-8 24318862.
    • (2013) Protein Cell , vol.4 , pp. 951-961
    • Yang, Y.1    Zhang, L.2    Geng, H.3    Deng, Y.4    Huang, B.5    Guo, Y.6
  • 20
    • 84949257684 scopus 로고    scopus 로고
    • Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets
    • 26631542,..;:.; PubMed Central PMCID: PMCPMC4668369
    • Yang Y, Ye F, Zhu N, Wang W, Deng Y, Zhao Z, et al. Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets. Sci Rep. 2015;5:17554. doi: 10.1038/srep17554 26631542; PubMed Central PMCID: PMCPMC4668369.
    • (2015) Sci Rep , vol.5 , pp. 17554
    • Yang, Y.1    Ye, F.2    Zhu, N.3    Wang, W.4    Deng, Y.5    Zhao, Z.6
  • 21
    • 77955413296 scopus 로고    scopus 로고
    • Viral tricks to grid-lock the type I interferon system
    • 20538505,.;: –. Epub 2010/06/12.; PubMed Central PMCID: PMC2920345
    • Versteeg GA, Garcia-Sastre A, Viral tricks to grid-lock the type I interferon system. Curr Opin Microbiol. 2010;13:508–16. Epub 2010/06/12. doi: 10.1016/j.mib.2010.05.009 20538505; PubMed Central PMCID: PMC2920345.
    • (2010) Curr Opin Microbiol , vol.13 , pp. 508-516
    • Versteeg, G.A.1    Garcia-Sastre, A.2
  • 22
    • 84995489457 scopus 로고    scopus 로고
    • Interaction of SARS and MERS coronaviruses with the antiviral interferon response
    • 2771262
    • Kindler E, Thiel V, Weber F, Interaction of SARS and MERS coronaviruses with the antiviral interferon response. Adv Virus Res. 2016;96:219–43. doi: 10.1016/bs.aivir.2016.08.006 27712625.
    • (2016) Adv Virus Res , vol.96 , pp. 219-243
    • Kindler, E.1    Thiel, V.2    Weber, F.3
  • 23
    • 84890863276 scopus 로고    scopus 로고
    • MERS-CoV papain-like protease has deISGylating and deubiquitinating activities
    • 24503068,.;: –.; PubMed Central PMCID: PMCPMC3957432
    • Mielech AM, Kilianski A, Baez-Santos YM, Mesecar AD, Baker SC, MERS-CoV papain-like protease has deISGylating and deubiquitinating activities. Virology. 2014;450–451:64–70. doi: 10.1016/j.virol.2013.11.040 24503068; PubMed Central PMCID: PMCPMC3957432.
    • (2014) Virology , vol.450-451 , pp. 64-70
    • Mielech, A.M.1    Kilianski, A.2    Baez-Santos, Y.M.3    Mesecar, A.D.4    Baker, S.C.5
  • 24
    • 84871415482 scopus 로고    scopus 로고
    • Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans
    • 23170002,..;: –. Epub 2012/11/22.; PubMed Central PMCID: PMC3509437
    • van Boheemen S, de Graaf M, Lauber C, Bestebroer TM, Raj VS, Zaki AM, et al. Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans. MBio. 2012;3:e00473–12. Epub 2012/11/22. doi: 10.1128/mBio.00473-12 23170002; PubMed Central PMCID: PMC3509437.
    • (2012) MBio , vol.3 , pp. e00412-e00473
    • van Boheemen, S.1    de Graaf, M.2    Lauber, C.3    Bestebroer, T.M.4    Raj, V.S.5    Zaki, A.M.6
  • 25
    • 84890878855 scopus 로고    scopus 로고
    • Characterization of a novel betacoronavirus related to middle East respiratory syndrome coronavirus in European hedgehogs
    • 24131722,..;: –.; PubMed Central PMCID: PMCPMC3911734
    • Corman VM, Kallies R, Philipps H, Gopner G, Muller MA, Eckerle I, et al. Characterization of a novel betacoronavirus related to middle East respiratory syndrome coronavirus in European hedgehogs. J Virol. 2014;88:717–24. doi: 10.1128/JVI.01600-13 24131722; PubMed Central PMCID: PMCPMC3911734.
    • (2014) J Virol , vol.88 , pp. 717-724
    • Corman, V.M.1    Kallies, R.2    Philipps, H.3    Gopner, G.4    Muller, M.A.5    Eckerle, I.6
  • 26
    • 85029156823 scopus 로고    scopus 로고
    • MERS-CoV Accessory ORFs play key role for infection and pathogenesis
    • 28830941,..;: –.; PubMed Central PMCID: PMCPMC5565963
    • Menachery VD, Mitchell HD, Cockrell AS, Gralinski LE, Yount BL, Jr.Graham RL, et al. MERS-CoV Accessory ORFs play key role for infection and pathogenesis. MBio. 2017;8:e00665–17. doi: 10.1128/mBio.00665-17 28830941; PubMed Central PMCID: PMCPMC5565963.
    • (2017) MBio , vol.8 , pp. e00617-e00665
    • Menachery, V.D.1    Mitchell, H.D.2    Cockrell, A.S.3    Gralinski, L.E.4    Yount, B.L.5    Graham, R.L.6
  • 27
    • 84862895252 scopus 로고    scopus 로고
    • SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon
    • 22572391,.;: –. Epub 2012/05/11
    • Totura AL, Baric RS, SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon. Curr Opin Virol. 2012;2:264–75. Epub 2012/05/11. doi: 10.1016/j.coviro.2012.04.004 22572391.
    • (2012) Curr Opin Virol , vol.2 , pp. 264-275
    • Totura, A.L.1    Baric, R.S.2
  • 28
    • 84965112401 scopus 로고    scopus 로고
    • Middle East respiratory syndrome coronavirus NS4b protein inhibits host RNase L activation
    • 27025250,..;:.; PubMed Central PMCID: PMCPMC4817253
    • Thornbrough JM, Jha BK, Yount B, Goldstein SA, Li Y, Elliott R, et al. Middle East respiratory syndrome coronavirus NS4b protein inhibits host RNase L activation. MBio. 2016;7:e00258. doi: 10.1128/mBio.00258-16 27025250; PubMed Central PMCID: PMCPMC4817253.
    • (2016) MBio , vol.7 , pp. e00258
    • Thornbrough, J.M.1    Jha, B.K.2    Yount, B.3    Goldstein, S.A.4    Li, Y.5    Elliott, R.6
  • 29
    • 84969287561 scopus 로고    scopus 로고
    • Continuous and discontinuous RNA synthesis in coronaviruses
    • 2695891
    • Sola I, Almazán F, Zúñiga S, Enjuanes L, Continuous and discontinuous RNA synthesis in coronaviruses. Annu Rev Virol. 2015;2:265–88. doi: 10.1146/annurev-virology-100114-055218 26958916
    • (2015) Annu Rev Virol , vol.2 , pp. 265-288
    • Sola, I.1    Almazán, F.2    Zúñiga, S.3    Enjuanes, L.4
  • 30
    • 67449102609 scopus 로고    scopus 로고
    • Molecular determinants for subcellular localization of the severe acute respiratory syndrome coronavirus open reading frame 3b protein
    • 19403678,.;: –. Epub 2009/05/01.; PubMed Central PMCID: PMC2698541
    • Freundt EC, Yu L, Park E, Lenardo MJ, Xu XN, Molecular determinants for subcellular localization of the severe acute respiratory syndrome coronavirus open reading frame 3b protein. J Virol. 2009;83:6631–40. Epub 2009/05/01. doi: 10.1128/JVI.00367-09 19403678; PubMed Central PMCID: PMC2698541.
    • (2009) J Virol , vol.83 , pp. 6631-6640
    • Freundt, E.C.1    Yu, L.2    Park, E.3    Lenardo, M.J.4    Xu, X.N.5
  • 31
    • 84905901545 scopus 로고    scopus 로고
    • The coronavirus nucleocapsid is a multifunctional protein
    • 25105276,.;: –.; PubMed Central PMCID: PMCPMC4147684
    • McBride R, van Zyl M, Fielding BC, The coronavirus nucleocapsid is a multifunctional protein. Viruses. 2014;6:2991–3018. doi: 10.3390/v6082991 25105276; PubMed Central PMCID: PMCPMC4147684.
    • (2014) Viruses , vol.6 , pp. 2991-3018
    • McBride, R.1    van Zyl, M.2    Fielding, B.C.3
  • 32
    • 84945241899 scopus 로고    scopus 로고
    • Middle East Respiratory Syndrome coronavirus nsp1 inhibits host gene expression by selectively targeting mRNAs transcribed in the nucleus while sparing mRNAs of cytoplasmic origin
    • 26311885,..;: –. Epub 2015/08/28.; PubMed Central PMCID: PMCPMC4621111
    • Lokugamage KG, Narayanan K, Nakagawa K, Terasaki K, Ramirez SI, Tseng CT, et al. Middle East Respiratory Syndrome coronavirus nsp1 inhibits host gene expression by selectively targeting mRNAs transcribed in the nucleus while sparing mRNAs of cytoplasmic origin. J Virol. 2015;89:10970–81. Epub 2015/08/28. doi: 10.1128/JVI.01352-15 26311885; PubMed Central PMCID: PMCPMC4621111.
    • (2015) J Virol , vol.89 , pp. 10970-10981
    • Lokugamage, K.G.1    Narayanan, K.2    Nakagawa, K.3    Terasaki, K.4    Ramirez, S.I.5    Tseng, C.T.6
  • 33
    • 84954202728 scopus 로고    scopus 로고
    • Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1
    • 2677338
    • Zhang Q, Shi K, Yoo D, Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1. Virology. 2016;489:252–68. doi: 10.1016/j.virol.2015.12.010 26773386.
    • (2016) Virology , vol.489 , pp. 252-268
    • Zhang, Q.1    Shi, K.2    Yoo, D.3
  • 34
    • 0142091707 scopus 로고    scopus 로고
    • The interaction of animal cytoplasmic RNA viruses with the nucleus to facilitate replication
    • 1292199
    • Hiscox JA, The interaction of animal cytoplasmic RNA viruses with the nucleus to facilitate replication. Virus Res. 2003;95:13–22. 12921992.
    • (2003) Virus Res , vol.95 , pp. 13-22
    • Hiscox, J.A.1
  • 35
    • 84882725999 scopus 로고    scopus 로고
    • Viral subversion of the nuclear pore complex
    • 23959328,.;: –.; PubMed Central PMCID: PMCPMC3761240
    • Le Sage V, Mouland AJ, Viral subversion of the nuclear pore complex. Viruses. 2013;5:2019–42. doi: 10.3390/v5082019 23959328; PubMed Central PMCID: PMCPMC3761240.
    • (2013) Viruses , vol.5 , pp. 2019-2042
    • Le Sage, V.1    Mouland, A.J.2
  • 36
    • 84859501317 scopus 로고    scopus 로고
    • Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through Nup62, inhibiting host nucleocytoplasmic transport pathways
    • 22334672,..;: –.; PubMed Central PMCID: PMCPMC3320978
    • Malik P, Tabarraei A, Kehlenbach RH, Korfali N, Iwasawa R, Graham SV, et al. Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through Nup62, inhibiting host nucleocytoplasmic transport pathways. J Biol Chem. 2012;287:12277–92. doi: 10.1074/jbc.M111.331777 22334672; PubMed Central PMCID: PMCPMC3320978.
    • (2012) J Biol Chem , vol.287 , pp. 12277-12292
    • Malik, P.1    Tabarraei, A.2    Kehlenbach, R.H.3    Korfali, N.4    Iwasawa, R.5    Graham, S.V.6
  • 37
    • 84921478466 scopus 로고    scopus 로고
    • BGLF4 kinase modulates the structure and transport preference of the nuclear pore complex to facilitate nuclear import of Epstein-Barr virus lytic proteins
    • 25410863,.;: –.; PubMed Central PMCID: PMCPMC4300756
    • Chang CW, Lee CP, Su MT, Tsai CH, Chen MR, BGLF4 kinase modulates the structure and transport preference of the nuclear pore complex to facilitate nuclear import of Epstein-Barr virus lytic proteins. J Virol. 2015;89:1703–18. doi: 10.1128/JVI.02880-14 25410863; PubMed Central PMCID: PMCPMC4300756.
    • (2015) J Virol , vol.89 , pp. 1703-1718
    • Chang, C.W.1    Lee, C.P.2    Su, M.T.3    Tsai, C.H.4    Chen, M.R.5
  • 38
    • 35348845802 scopus 로고    scopus 로고
    • Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane
    • 1759630
    • Frieman M, Yount B, Heise M, Kopecky-Bromberg SA, Palese P, Baric RS, Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane. J Virol. 2007;81:9812–24. doi: 10.1128/JVI.01012-07 17596301.
    • (2007) J Virol , vol.81 , pp. 9812-9824
    • Frieman, M.1    Yount, B.2    Heise, M.3    Kopecky-Bromberg, S.A.4    Palese, P.5    Baric, R.S.6
  • 39
    • 60049100933 scopus 로고    scopus 로고
    • Severe acute respiratory syndrome coronavirus protein 6 is required for optimal replication
    • 1909186
    • Zhao J, Falcon A, Zhou H, Netland J, Enjuanes L, Perez Brena P, et al. Severe acute respiratory syndrome coronavirus protein 6 is required for optimal replication. J Virol. 2009;83:2368–73. doi: 10.1128/JVI.02371-08 19091867.
    • (2009) J Virol , vol.83 , pp. 2368-2373
    • Zhao, J.1    Falcon, A.2    Zhou, H.3    Netland, J.4    Enjuanes, L.5    Perez Brena, P.6
  • 40
    • 77949344988 scopus 로고    scopus 로고
    • The N Terminal Region of Severe Acute Respiratory Syndrome Coronavirus Protein 6 Induces Membrane Rearrangement and Enhances Virus Replication
    • 20106914,.. Epub 2010/01/29
    • Zhou H, Ferraro D, Zhao J, Hussain S, Shao J, Trujillo J, et al. The N Terminal Region of Severe Acute Respiratory Syndrome Coronavirus Protein 6 Induces Membrane Rearrangement and Enhances Virus Replication. J Virol. 2010. Epub 2010/01/29. doi: JVI.02570-09 [pii] doi: 10.1128/JVI.02570-09 20106914.
    • (2010) J Virol
    • Zhou, H.1    Ferraro, D.2    Zhao, J.3    Hussain, S.4    Shao, J.5    Trujillo, J.6
  • 41
    • 33646754920 scopus 로고    scopus 로고
    • Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation
    • 16698996,..;: –.; PubMed Central PMCID: PMCPMC1472181
    • Reid SP, Leung LW, Hartman AL, Martinez O, Shaw ML, Carbonnelle C, et al. Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation. J Virol. 2006;80:5156–67. doi: 10.1128/JVI.02349-05 16698996; PubMed Central PMCID: PMCPMC1472181.
    • (2006) J Virol , vol.80 , pp. 5156-5167
    • Reid, S.P.1    Leung, L.W.2    Hartman, A.L.3    Martinez, O.4    Shaw, M.L.5    Carbonnelle, C.6
  • 42
    • 85020945684 scopus 로고    scopus 로고
    • Enterovirus 71 suppresses interferon responses by blocking Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling through inducing karyopherin-alpha1 degradation
    • 28455446,..;: –.; PubMed Central PMCID: PMCPMC5473229
    • Wang C, Sun M, Yuan X, Ji L, Jin Y, Cardona CJ, et al. Enterovirus 71 suppresses interferon responses by blocking Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling through inducing karyopherin-alpha1 degradation. J Biol Chem. 2017;292:10262–74. doi: 10.1074/jbc.M116.745729 28455446; PubMed Central PMCID: PMCPMC5473229.
    • (2017) J Biol Chem , vol.292 , pp. 10262-10274
    • Wang, C.1    Sun, M.2    Yuan, X.3    Ji, L.4    Jin, Y.5    Cardona, C.J.6
  • 43
    • 0035863125 scopus 로고    scopus 로고
    • Effects of poliovirus infection on nucleo-cytoplasmic trafficking and nuclear pore complex composition
    • 11226174,.;: –.; PubMed Central PMCID: PMCPMC140206
    • Gustin KE, Sarnow P, Effects of poliovirus infection on nucleo-cytoplasmic trafficking and nuclear pore complex composition. EMBO J. 2001;20:240–9. doi: 10.1093/emboj/20.1.240 11226174; PubMed Central PMCID: PMCPMC140206.
    • (2001) EMBO J , vol.20 , pp. 240-249
    • Gustin, K.E.1    Sarnow, P.2
  • 44
    • 0036337963 scopus 로고    scopus 로고
    • Inhibition of nuclear import and alteration of nuclear pore complex composition by rhinovirus
    • 12163599,.;: –.; PubMed Central PMCID: PMCPMC136411
    • Gustin KE, Sarnow P, Inhibition of nuclear import and alteration of nuclear pore complex composition by rhinovirus. J Virol. 2002;76:8787–96. doi: 10.1128/JVI.76.17.8787-8796.2002 12163599; PubMed Central PMCID: PMCPMC136411.
    • (2002) J Virol , vol.76 , pp. 8787-8796
    • Gustin, K.E.1    Sarnow, P.2
  • 45
    • 59749104967 scopus 로고    scopus 로고
    • Hantaan virus nucleocapsid protein binds to importin alpha proteins and inhibits tumor necrosis factor alpha-induced activation of nuclear factor kappa B
    • 19019947,.;: –.; PubMed Central PMCID: PMCPMC2620888
    • Taylor SL, Frias-Staheli N, Garcia-Sastre A, Schmaljohn CS, Hantaan virus nucleocapsid protein binds to importin alpha proteins and inhibits tumor necrosis factor alpha-induced activation of nuclear factor kappa B. J Virol. 2009;83:1271–9. doi: 10.1128/JVI.00986-08 19019947; PubMed Central PMCID: PMCPMC2620888.
    • (2009) J Virol , vol.83 , pp. 1271-1279
    • Taylor, S.L.1    Frias-Staheli, N.2    Garcia-Sastre, A.3    Schmaljohn, C.S.4
  • 46
    • 85016549700 scopus 로고    scopus 로고
    • production by blocking the nuclear translocation of IFN regulatory factor 3 and NF-κB
    • 28179530,. Japanese encephalitis virus NS5 inhibits type I interferon (IFN).;: –.; PubMed Central PMCID: PMCPMC5375679
    • Ye J, Chen Z, Li Y, Zhao Z, He W, Zohaib A, et al. Japanese encephalitis virus NS5 inhibits type I interferon (IFN) production by blocking the nuclear translocation of IFN regulatory factor 3 and NF-κB. J Virol. 2017;91:e00039–17. doi: 10.1128/JVI.00039-17 28179530; PubMed Central PMCID: PMCPMC5375679.
    • (2017) J Virol , vol.91 , pp. e00017-e00039
    • Ye, J.1    Chen, Z.2    Li, Y.3    Zhao, Z.4    He, W.5    Zohaib, A.6
  • 47
    • 85015156314 scopus 로고    scopus 로고
    • Herpes simplex virus 1 UL24 abrogates the DNA sensing signal pathway by inhibiting NF-kappaB activation
    • 28100608,.;: –.; PubMed Central PMCID: PMCPMC5355614
    • Xu H, Su C, Pearson A, Mody CH, Zheng C, Herpes simplex virus 1 UL24 abrogates the DNA sensing signal pathway by inhibiting NF-kappaB activation. J Virol. 2017;91:e00025–17. doi: 10.1128/JVI.00025-17 28100608; PubMed Central PMCID: PMCPMC5355614.
    • (2017) J Virol , vol.91 , pp. e00017-e00025
    • Xu, H.1    Su, C.2    Pearson, A.3    Mody, C.H.4    Zheng, C.5
  • 48
    • 85016514579 scopus 로고    scopus 로고
    • The NF-kappaB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells
    • 28355270,..;:.; PubMed Central PMCID: PMCPMC5386326
    • Poppe M, Wittig S, Jurida L, Bartkuhn M, Wilhelm J, Muller H, et al. The NF-kappaB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells. PLoS Pathog. 2017;13:e1006286. doi: 10.1371/journal.ppat.1006286 28355270; PubMed Central PMCID: PMCPMC5386326.
    • (2017) PLoS Pathog , vol.13 , pp. e1006286
    • Poppe, M.1    Wittig, S.2    Jurida, L.3    Bartkuhn, M.4    Wilhelm, J.5    Muller, H.6
  • 49
    • 67349158649 scopus 로고    scopus 로고
    • Coronaviruses post-SARS: update on replication and pathogenesis
    • 19430490, Epub 2009/05/12 Central PMCID: PMC2830095
    • Perlman S, Netland J, Coronaviruses post-SARS: update on replication and pathogenesis. Nat Rev Microbiol. 2009;7:439–50. Epub 2009/05/12. doi: nrmicro2147 [pii] doi: 10.1038/nrmicro2147 19430490; PubMed Central PMCID: PMC2830095.
    • (2009) Nat Rev Microbiol , vol.7 , pp. 439-450
    • Perlman, S.1    Netland, J.2
  • 50
    • 84875546545 scopus 로고    scopus 로고
    • Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells
    • 23365422,..;: –. Epub 2013/02/01.; PubMed Central PMCID: PMCPmc3624188
    • Sims AC, Tilton SC, Menachery VD, Gralinski LE, Schafer A, Matzke MM, et al. Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells. J Virol. 2013;87:3885–902. Epub 2013/02/01. doi: 10.1128/JVI.02520-12 23365422; PubMed Central PMCID: PMCPmc3624188.
    • (2013) J Virol , vol.87 , pp. 3885-3902
    • Sims, A.C.1    Tilton, S.C.2    Menachery, V.D.3    Gralinski, L.E.4    Schafer, A.5    Matzke, M.M.6
  • 51
    • 23844554435 scopus 로고    scopus 로고
    • A severe acute respiratory syndrome-associated coronavirus-specific protein enhances virulence of an attenuated murine coronavirus
    • 1610318
    • Pewe L, Zhou H, Netland J, Tangudu C, Olivares H, Shi L, et al. A severe acute respiratory syndrome-associated coronavirus-specific protein enhances virulence of an attenuated murine coronavirus. J Virol. 2005;79:11335–42. doi: 10.1128/JVI.79.17.11335-11342.2005 16103185.
    • (2005) J Virol , vol.79 , pp. 11335-11342
    • Pewe, L.1    Zhou, H.2    Netland, J.3    Tangudu, C.4    Olivares, H.5    Shi, L.6
  • 52
    • 85022165906 scopus 로고    scopus 로고
    • Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice
    • 28348219,..;: –.; PubMed Central PMCID: PMCPMC5393213
    • Li K, Wohlford-Lenane CL, Channappanavar R, Park JE, Earnest JT, Bair TB, et al. Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice. Proc Natl Acad Sci USA. 2017;114:E3119–E28. doi: 10.1073/pnas.1619109114 28348219; PubMed Central PMCID: PMCPMC5393213.
    • (2017) Proc Natl Acad Sci USA , vol.114 , pp. E3119-E3128
    • Li, K.1    Wohlford-Lenane, C.L.2    Channappanavar, R.3    Park, J.E.4    Earnest, J.T.5    Bair, T.B.6
  • 53
    • 84999652028 scopus 로고    scopus 로고
    • A mouse model for MERS coronavirus-induced acute respiratory distress syndrome
    • 2789292
    • Cockrell AS, Yount BL, Scobey T, Jensen K, Douglas M, Beall A, et al. A mouse model for MERS coronavirus-induced acute respiratory distress syndrome. Nat Microbiol. 2016;2:16226. doi: 10.1038/nmicrobiol.2016.226 27892925.
    • (2016) Nat Microbiol , vol.2 , pp. 16226
    • Cockrell, A.S.1    Yount, B.L.2    Scobey, T.3    Jensen, K.4    Douglas, M.5    Beall, A.6
  • 54
    • 77649277983 scopus 로고    scopus 로고
    • Dynamic innate immune responses of human bronchial epithelial cells to severe acute respiratory syndrome-associated coronavirus infection
    • 20090954,..;:. Epub 2010/01/22.; PubMed Central PMCID: PMC2806919
    • Yoshikawa T, Hill TE, Yoshikawa N, Popov VL, Galindo CL, Garner HR, et al. Dynamic innate immune responses of human bronchial epithelial cells to severe acute respiratory syndrome-associated coronavirus infection. PLoS One. 2010;5:e8729. Epub 2010/01/22. doi: 10.1371/journal.pone.0008729 20090954; PubMed Central PMCID: PMC2806919.
    • (2010) PLoS One , vol.5 , pp. e8729
    • Yoshikawa, T.1    Hill, T.E.2    Yoshikawa, N.3    Popov, V.L.4    Galindo, C.L.5    Garner, H.R.6
  • 55
    • 85007524131 scopus 로고    scopus 로고
    • The conserved coronavirus macrodomain promotes virulence and suppresses the innate immune response during severe acute respiratory syndrome coronavirus infection
    • 27965448,..;: –.; PubMed Central PMCID: PMCPMC5156301
    • Fehr AR, Channappanavar R, Jankevicius G, Fett C, Zhao J, Athmer J, et al. The conserved coronavirus macrodomain promotes virulence and suppresses the innate immune response during severe acute respiratory syndrome coronavirus infection. MBio. 2016;7:e01721–16. doi: 10.1128/mBio.01721-16 27965448; PubMed Central PMCID: PMCPMC5156301.
    • (2016) MBio , vol.7 , pp. e01716-e01721
    • Fehr, A.R.1    Channappanavar, R.2    Jankevicius, G.3    Fett, C.4    Zhao, J.5    Athmer, J.6
  • 56
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • 11846609,.;: –. Epub 2002/02/16. S1046-2023(01)91262-9 [pi
    • Livak KJ, Schmittgen TD, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25:402–8. Epub 2002/02/16. doi: 10.1006/meth.2001.1262 S1046-2023(01)91262-9 [pii]. 11846609.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 57
    • 78149261092 scopus 로고    scopus 로고
    • REAP: A two minute cell fractionation method
    • 21067583,.;:.; PubMed Central PMCID: PMCPMC2993727
    • Suzuki K, Bose P, Leong-Quong RYY, Fujita DJ, Riabowol K, REAP: A two minute cell fractionation method. BMC Res Notes. 2010;3:294. doi: 10.1186/1756-0500-3-294 21067583; PubMed Central PMCID: PMCPMC2993727.
    • (2010) BMC Res Notes , vol.3 , pp. 294
    • Suzuki, K.1    Bose, P.2    Leong-Quong, R.Y.Y.3    Fujita, D.J.4    Riabowol, K.5


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