Tmprss2 Is Essential for Influenza H1N1 Virus Pathogenesis in Mice

PLoS Pathogens

Volumn 9, Issue 12, 2013, Pages 1-10

  Hatesuer, Bastian ^a,b   Bertram, Stephanie ^c   Mehnert, Nora ^a,b   Bahgat, Mahmoud M ^a,b   Nelson, Peter S ^d   Pöhlman, Stefan ^c   Schughart, Klaus ^a,b  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c GERMAN PRIMATE CENTER   (Germany)

^d Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VIRUS HEMAGGLUTININ; SERINE PROTEINASE; TMPRSS2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DEATH; FEMALE; GENE; GENOTYPE; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INFLUENZA VIRUS A H1N1; LUNG FUNCTION; MALE; MORTALITY; MOUSE; NONHUMAN; OXYGEN SATURATION; PATHOLOGY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TMPRSS2 GENE; VIRUS LOAD; VIRUS PATHOGENESIS; VIRUS VIRULENCE; WEIGHT REDUCTION; ANIMAL; C57BL MOUSE; CELL CULTURE; CHICK EMBRYO; DOG; GENETICS; HEK293 CELL LINE; HOST PATHOGEN INTERACTION; INFLUENZA; INFLUENZA VIRUS A H3N2; KNOCKOUT MOUSE; ORTHOMYXOVIRUS INFECTION; PATHOGENICITY; PHYSIOLOGY; VIROLOGY;

ANIMALS; CELLS, CULTURED; CHICK EMBRYO; DOGS; FEMALE; HEK293 CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA, HUMAN; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORTHOMYXOVIRIDAE INFECTIONS; SERINE ENDOPEPTIDASES;

EID: 84892860172     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003774     Document Type: Article

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