TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein

Journal of Virology

Volumn 88, Issue 2, 2014, Pages 1293-1307

  Heurich, Adeline ^a   Hofmann Winkler, Heike ^a   Gierer, Stefanie ^a   Liepold, Thomas ^b   Jahn, Olaf ^b   Pöhlmann, Stefan ^a  

^a GERMAN PRIMATE CENTER   (Germany)

^b MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; ARGININE; CORONAVIRUS SPIKE GLYCOPROTEIN; LYSINE; PROTEIN ADAM17; PROTEIN TMPRSS2; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; MEMBRANE FUSION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; SARS CORONAVIRUS; VIRION; VIRUS ENTRY;

ADAM PROTEINS; AMINO ACID MOTIFS; CELL LINE; HUMANS; PEPTIDYL-DIPEPTIDASE A; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; RECEPTORS, VIRUS; SARS VIRUS; SERINE ENDOPEPTIDASES; SEVERE ACUTE RESPIRATORY SYNDROME; SPIKE GLYCOPROTEIN, CORONAVIRUS; VIRUS INTERNALIZATION;

EID: 84891703464     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02202-13     Document Type: Article

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