Human Fetal TNF-α-Cytokine-Producing CD4 + Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life

Immunity

Volumn 50, Issue 2, 2019, Pages 462-476.e8

  Schreurs, Renée R C E ^a,b   Baumdick, Martin E ^c   Sagebiel, Adrian F ^c   Kaufmann, Max ^d   Mokry, Michal ^e,f   Klarenbeek, Paul L ^a,g   Schaltenberg, Nicola ^d   Steinert, Fenja L ^c   van Rijn, Jorik M ^e,f   Drewniak, Agata ^a,h   The, Sarah May M L ^a,g   Bakx, Roel ^g   Derikx, Joep P M ^g   de Vries, Niek ^a,g   Corpeleijn, Willemijn E ^b   Pals, Steven T ^g   Gagliani, Nicola ^d,i   Friese, Manuel A ^d   Middendorp, Sabine ^e,f   Nieuwenhuis, Edward E S ^e,f   Reinshagen, Konrad ^d   Geijtenbeek, Teunis B H ^a   van Goudoever, Johannes B ^b   Bunders, Madeleine J ^a,b,c   more..

^a University of Amsterdam   (Netherlands)

^b EMMA CHILDREN S HOSPITAL   (Netherlands)

^c LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^f UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^g ACADEMIC MEDICAL CENTER   (Netherlands)

^h Novartis Vaccines BV Amsterdam   (Netherlands)

ⁱ KAROLINSKA INSTITUTE   (Sweden)

Author keywords

CD4 + T cells; immune ontogeny; intestinal mucosa; intestinal stem cells; organoid technology; stem cell biology; tissue generation; TNF

Indexed keywords

CD4 ANTIGEN; CD69 ANTIGEN; TUMOR NECROSIS FACTOR;

ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CELL GROWTH; CELL PROLIFERATION; CYTOKINE PRODUCTION; ENTERITIS; FETUS; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN DEVELOPMENT; INTESTINAL STEM CELL; INTRACELLULAR SIGNALING; MEMORY T LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; RNA SEQUENCE; SINGLE CELL ANALYSIS; TH1 CELL; ANIMAL; C57BL MOUSE; CYTOLOGY; EMBRYOLOGY; EPITHELIUM CELL; FEMALE; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; INTESTINE; INTESTINE MUCOSA; METABOLISM; NEWBORN; PREGNANCY; STEM CELL;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; EPITHELIAL CELLS; FEMALE; FETUS; HUMANS; IMMUNOLOGIC MEMORY; INFANT, NEWBORN; INTESTINAL MUCOSA; INTESTINES; MICE, INBRED C57BL; PREGNANCY; STEM CELLS; TH1 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85061150132     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2018.12.010     Document Type: Article

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