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Volumn 51, Issue 3, 2019, Pages 445-451

Multivariate genome-wide analyses of the well-being spectrum

Author keywords

[No Author keywords available]

Indexed keywords

ANATOMICAL CONCEPTS; ANGULAR GYRUS; ARTICLE; ASTROCYTE; BRAIN CELL; BRAIN REGION; BRAIN STEM; BRAIN TISSUE; CEREBELLUM; CINGULATE GYRUS; CPG ISLAND; DEPRESSION; EFFECT SIZE; ENDOTHELIUM CELL; EXPRESSION QUANTITATIVE TRAIT LOCUS; FETUS BRAIN; GABAERGIC SYSTEM; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC CORRELATION; GENETIC TRAIT; GENOME WIDE ASSOCIATION META ANALYSIS; GENOME-WIDE ASSOCIATION STUDY; HERITABILITY; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INTERNEURON; LIFE SATISFACTION; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; METHYLATION QUANTITATIVE TRAIT LOCI; MICROGLIA; NEUROSIS; NULL HYPOTHESIS; OLIGODENDROGLIA; OVERLAPPING GENE; PHENOTYPE; PREDICTION; PREFRONTAL CORTEX; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; SPECTRUM; SUBICULUM; SUBSTANTIA NIGRA; TEMPORAL LOBE; TRANSCRIPTOMICS; UNITED KINGDOM; WELLBEING; BIOLOGY; BRAIN; GENETICS; HUMAN GENOME; META ANALYSIS; MULTIFACTORIAL INHERITANCE; MULTIVARIATE ANALYSIS; PHYSIOLOGY; PROCEDURES;

EID: 85060113237     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/s41588-018-0320-8     Document Type: Article
Times cited : (187)

References (55)
  • 1
    • 85026709756 scopus 로고    scopus 로고
    • 10 Years of GWAS discovery: biology, function, and translation
    • COI: 1:CAS:528:DC%2BC2sXhtFChu7rI
    • Visscher, P. M. et al. 10 Years of GWAS discovery: biology, function, and translation. Am. J. Hum. Genet. 101, 5–22 (2017).
    • (2017) Am. J. Hum. Genet. , vol.101 , pp. 5-22
    • Visscher, P.M.1
  • 2
    • 84923946495 scopus 로고    scopus 로고
    • LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
    • COI: 1:CAS:528:DC%2BC2MXhvFCntb8%3D
    • Bulik-Sullivan, B. K. et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet. 47, 291–295 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 291-295
    • Bulik-Sullivan, B.K.1
  • 3
    • 85000692305 scopus 로고    scopus 로고
    • An atlas of genetic correlations across human diseases and traits
    • COI: 1:CAS:528:DC%2BC2MXhsFKqu7vM
    • Bulik-Sullivan, B. K. et al. An atlas of genetic correlations across human diseases and traits. Nat. Genet. 47, 1236–1241 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 1236-1241
    • Bulik-Sullivan, B.K.1
  • 4
    • 85049284114 scopus 로고    scopus 로고
    • Analysis of shared heritability in common disorders of the brain
    • Anttila, V. et al. Analysis of shared heritability in common disorders of the brain. Science 360, 6395 (2018).
    • (2018) Science , vol.360 , pp. 6395
    • Anttila, V.1
  • 5
    • 84860473457 scopus 로고    scopus 로고
    • MultiPhen: joint model of multiple phenotypes can increase discovery in GWAS
    • O’Reilly, P. F. et al. MultiPhen: joint model of multiple phenotypes can increase discovery in GWAS. PLoS One 7, e34861 (2012).
    • (2012) PLoS One , vol.7
    • O’Reilly, P.F.1
  • 6
    • 58049204427 scopus 로고    scopus 로고
    • A. multivariate test of association
    • COI: 1:CAS:528:DC%2BD1MXmvFSn
    • Ferreira, M. A. R. & Purcell, S. M. A. multivariate test of association. Bioinformatics 25, 132–133 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 132-133
    • Ferreira, M.A.R.1    Purcell, S.M.2
  • 7
    • 84899972622 scopus 로고    scopus 로고
    • Maximizing the power of principal-component analysis of correlated phenotypes in genome-wide association studies
    • COI: 1:CAS:528:DC%2BC2cXmsVChtrg%3D
    • Aschard, H. et al. Maximizing the power of principal-component analysis of correlated phenotypes in genome-wide association studies. Am. J. Hum. Genet. 94, 662–676 (2014).
    • (2014) Am. J. Hum. Genet. , vol.94 , pp. 662-676
    • Aschard, H.1
  • 8
    • 84879818733 scopus 로고    scopus 로고
    • Unified framework for association analysis with multiple related phenotypes
    • COI: 1:CAS:528:DC%2BC3sXhtFKktLrO
    • Stephens, M. Unified framework for association analysis with multiple related phenotypes. PLoS One 8, e65245 (2013).
    • (2013) PLoS One , vol.8
    • Stephens, M.1
  • 9
    • 84920858732 scopus 로고    scopus 로고
    • Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension
    • COI: 1:CAS:528:DC%2BC2cXitFCqs7bL
    • Zhu, X. et al. Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension. Am. J. Hum. Genet. 96, 21–36 (2015).
    • (2015) Am. J. Hum. Genet. , vol.96 , pp. 21-36
    • Zhu, X.1
  • 10
    • 85039801269 scopus 로고    scopus 로고
    • Multi-trait analysis of genome-wide association summary statistics using MTAG
    • COI: 1:CAS:528:DC%2BC1cXkslGitLY%3D
    • Turley, P. et al. Multi-trait analysis of genome-wide association summary statistics using MTAG. Nat. Genet. 50, 229–237 (2018).
    • (2018) Nat. Genet. , vol.50 , pp. 229-237
    • Turley, P.1
  • 11
    • 84873489284 scopus 로고    scopus 로고
    • TATES: efficient multivariate genotype-phenotype analysis for genome-wide association studies
    • van der Sluis, S., Posthuma, D. & Dolan, C. V. TATES: efficient multivariate genotype-phenotype analysis for genome-wide association studies. PLoS Genet. 9, e1003235 (2013).
    • (2013) PLoS Genet. , vol.9
    • van der Sluis, S.1    Posthuma, D.2    Dolan, C.V.3
  • 13
    • 71549167581 scopus 로고    scopus 로고
    • Born to be happy? The etiology of subjective well-being
    • Bartels, M. & Boomsma, D. I. Born to be happy? The etiology of subjective well-being. Behav. Genet. 39, 605–615 (2009).
    • (2009) Behav. Genet. , vol.39 , pp. 605-615
    • Bartels, M.1    Boomsma, D.I.2
  • 14
    • 84878993284 scopus 로고    scopus 로고
    • Molecular genetics and subjective well-being
    • COI: 1:CAS:528:DC%2BC3sXhtFOrt7bJ
    • Rietveld, C. A. et al. Molecular genetics and subjective well-being. Proc. Natl Acad. Sci. USA 110, 9692–9697 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 9692-9697
    • Rietveld, C.A.1
  • 15
    • 84964388798 scopus 로고    scopus 로고
    • Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
    • COI: 1:CAS:528:DC%2BC28Xmt1eksbc%3D
    • Okbay, A. et al. Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat. Genet. 48, 624–633 (2016).
    • (2016) Nat. Genet. , vol.48 , pp. 624-633
    • Okbay, A.1
  • 16
    • 85054180561 scopus 로고    scopus 로고
    • A genetic perspective on the relationship between eudaimonic -and hedonic well-being
    • COI: 1:CAS:528:DC%2BC1MXpsFOrtw%3D%3D
    • Baselmans, B. M. L. & Bartels, M. A genetic perspective on the relationship between eudaimonic -and hedonic well-being. Sci. Rep. 8, 1–10 (2018).
    • (2018) Sci. Rep. , vol.8 , pp. 1-10
    • Baselmans, B.M.L.1    Bartels, M.2
  • 18
    • 85002374791 scopus 로고    scopus 로고
    • Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders
    • COI: 1:CAS:528:DC%2BC28XitVSrurnJ
    • Lo, M.-T. et al. Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nat. Genet. 49, 152–156 (2017).
    • (2017) Nat. Genet. , vol.49 , pp. 152-156
    • Lo, M.T.1
  • 19
    • 84980347551 scopus 로고    scopus 로고
    • Identification of 15 genetic loci associated with risk of major depression in individuals of European descent
    • COI: 1:CAS:528:DC%2BC28Xht1KlsrrJ
    • Hyde, C. L. et al. Identification of 15 genetic loci associated with risk of major depression in individuals of European descent. Nat. Genet. 48, 1031–1036 (2016).
    • (2016) Nat. Genet. , vol.48 , pp. 1031-1036
    • Hyde, C.L.1
  • 20
    • 84875211424 scopus 로고    scopus 로고
    • A genome-wide association study of depressive symptoms
    • COI: 1:CAS:528:DC%2BC3sXhvVWlug%3D%3D
    • Hek, K. et al. A genome-wide association study of depressive symptoms. Biol. Psychiatry 73, 667–678 (2013).
    • (2013) Biol. Psychiatry , vol.73 , pp. 667-678
    • Hek, K.1
  • 21
    • 85046022254 scopus 로고    scopus 로고
    • Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
    • COI: 1:CAS:528:DC%2BC1cXosVCks74%3D
    • Wray, N. R. et al. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat. Genet. 50, 668 (2018).
    • (2018) Nat. Genet. , vol.50 , pp. 668
    • Wray, N.R.1
  • 22
    • 84908890496 scopus 로고    scopus 로고
    • Defining the role of common variation in the genomic and biological architecture of adult human height
    • COI: 1:CAS:528:DC%2BC2cXhs1yht77I
    • Wood, A. R. et al. Defining the role of common variation in the genomic and biological architecture of adult human height. Nat. Genet. 46, 1173–1186 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 1173-1186
    • Wood, A.R.1
  • 23
    • 84873901396 scopus 로고    scopus 로고
    • The Adult Netherlands Twin Register: twenty-five years of survey and biological data collection
    • Willemsen, G. et al. The Adult Netherlands Twin Register: twenty-five years of survey and biological data collection. Twin. Res. Hum. Genet. 16, 271–281 (2013).
    • (2013) Twin. Res. Hum. Genet. , vol.16 , pp. 271-281
    • Willemsen, G.1
  • 24
    • 84961927084 scopus 로고    scopus 로고
    • Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
    • COI: 1:CAS:528:DC%2BC28XkvFGrs7g%3D
    • Zhu, Z. et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat. Genet. 48, 481–487 (2016).
    • (2016) Nat. Genet. , vol.48 , pp. 481-487
    • Zhu, Z.1
  • 25
    • 85048415370 scopus 로고    scopus 로고
    • Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood
    • Qi, T. et al. Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood. Nat. Commun. 9, 2282 (2018).
    • (2018) Nat. Commun. , vol.9 , pp. 2282
    • Qi, T.1
  • 26
    • 84959547986 scopus 로고    scopus 로고
    • Integrative approaches for large-scale transcriptome-wide association studies
    • COI: 1:CAS:528:DC%2BC28Xit1ajtbc%3D
    • Gusev, A. et al. Integrative approaches for large-scale transcriptome-wide association studies. Nat. Genet. 48, 245–252 (2016).
    • (2016) Nat. Genet. , vol.48 , pp. 245-252
    • Gusev, A.1
  • 27
    • 84958074030 scopus 로고    scopus 로고
    • Schizophrenia risk from complex variation of complement component 4
    • COI: 1:CAS:528:DC%2BC28XhsFyitb4%3D
    • Sekar, A. et al. Schizophrenia risk from complex variation of complement component 4. Nature 530, 177–183 (2016).
    • (2016) Nature , vol.530 , pp. 177-183
    • Sekar, A.1
  • 28
    • 85000443086 scopus 로고    scopus 로고
    • Partitioning heritability by functional annotation using GWAS summary statistics
    • COI: 1:CAS:528:DC%2BC2MXhsFKqu7rF
    • Finucane, H. K. et al. Partitioning heritability by functional annotation using GWAS summary statistics. Nat. Genet. 47, 1228–1235 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 1228-1235
    • Finucane, H.K.1
  • 29
    • 84866518216 scopus 로고    scopus 로고
    • An anatomically comprehensive atlas of the adult human brain transcriptome
    • COI: 1:CAS:528:DC%2BC38Xhtlymu77N
    • Hawrylycz, M. J. et al. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature 489, 391–399 (2012).
    • (2012) Nature , vol.489 , pp. 391-399
    • Hawrylycz, M.J.1
  • 30
    • 0035126982 scopus 로고    scopus 로고
    • The subiculum: a review of form, physiology and function
    • O’Mara, S. M., Commins, S., Anderson, M. & Gigg, J. The subiculum: a review of form, physiology and function. Prog. Neurobiol. 64, 129–155 (2001).
    • (2001) Prog. Neurobiol. , vol.64 , pp. 129-155
    • O’Mara, S.M.1    Commins, S.2    Anderson, M.3    Gigg, J.4
  • 31
    • 33750035484 scopus 로고    scopus 로고
    • Role of the ventral subiculum in stress integration
    • COI: 1:CAS:528:DC%2BD28XhtFSlu7bM
    • Herman, J. P. & Mueller, N. K. Role of the ventral subiculum in stress integration. Behav. Brain Res. 174, 215–224 (2006).
    • (2006) Behav. Brain Res. , vol.174 , pp. 215-224
    • Herman, J.P.1    Mueller, N.K.2
  • 32
    • 84969760786 scopus 로고    scopus 로고
    • Genome-wide association study identifies 74 loci associated with educational attainment
    • COI: 1:CAS:528:DC%2BC28XotVWgt70%3D
    • Okbay, A. et al. Genome-wide association study identifies 74 loci associated with educational attainment. Nature 533, 539–542 (2016).
    • (2016) Nature , vol.533 , pp. 539-542
    • Okbay, A.1
  • 33
    • 84904804929 scopus 로고    scopus 로고
    • Biological insights from 108 schizophrenia-associated genetic loci
    • COI: 1:CAS:528:DC%2BC2cXht1WlurrN
    • Ripke, S. et al. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421–427 (2014).
    • (2014) Nature , vol.511 , pp. 421-427
    • Ripke, S.1
  • 34
    • 85031046570 scopus 로고    scopus 로고
    • Massively parallel single-nucleus RNA-seq with DroNc-seq
    • COI: 1:CAS:528:DC%2BC2sXhtl2gtL7L
    • Habib, N. et al. Massively parallel single-nucleus RNA-seq with DroNc-seq. Nat. Methods 14, 955–958 (2017).
    • (2017) Nat. Methods , vol.14 , pp. 955-958
    • Habib, N.1
  • 37
    • 84931274624 scopus 로고    scopus 로고
    • A survey of human brain transcriptome diversity at the single cell level
    • COI: 1:CAS:528:DC%2BC2MXosVKrurg%3D
    • Darmanis, S. et al. A survey of human brain transcriptome diversity at the single cell level. Proc. Natl Acad. Sci. USA 112, 7285–7290 (2015).
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. 7285-7290
    • Darmanis, S.1
  • 38
    • 80054993342 scopus 로고    scopus 로고
    • Spatio-temporal transcriptome of the human brain
    • COI: 1:CAS:528:DC%2BC3MXhtlOnur%2FL
    • Kang, H. J. et al. Spatio-temporal transcriptome of the human brain. Nature 478, 483–489 (2011).
    • (2011) Nature , vol.478 , pp. 483-489
    • Kang, H.J.1
  • 39
    • 84929684999 scopus 로고    scopus 로고
    • Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets
    • COI: 1:CAS:528:DC%2BC2MXpt1Sgt7o%3D
    • Macosko, E. Z. et al. Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161, 1202–1214 (2015).
    • (2015) Cell , vol.161 , pp. 1202-1214
    • Macosko, E.Z.1
  • 40
    • 84890014591 scopus 로고    scopus 로고
    • DIST: direct imputation of summary statistics for unmeasured SNPs
    • COI: 1:CAS:528:DC%2BC3sXhslWnsLfL
    • Lee, D., Bigdeli, T. B., Riley, B. P., Fanous, A. H. & Bacanu, S. A. DIST: direct imputation of summary statistics for unmeasured SNPs. Bioinformatics 29, 2925–2927 (2013).
    • (2013) Bioinformatics , vol.29 , pp. 2925-2927
    • Lee, D.1    Bigdeli, T.B.2    Riley, B.P.3    Fanous, A.H.4    Bacanu, S.A.5
  • 41
    • 85033517914 scopus 로고
    • Bayesian extension of the minimum AIC procedure of autoregressive model fitting
    • Akaike, H. A. Bayesian extension of the minimum AIC procedure of autoregressive model fitting. Biometrika 66, 237–242 (1979).
    • (1979) Biometrika , vol.66 , pp. 237-242
    • Akaike, H.A.1
  • 42
    • 77958110812 scopus 로고    scopus 로고
    • Conducting meta-analyses in R with the metafor package
    • Viechtbauer, W. Conducting meta-analyses in R with the metafor package. J. Stat. Softw. 36, 1–48 (2009).
    • (2009) J. Stat. Softw. , vol.36 , pp. 1-48
    • Viechtbauer, W.1
  • 44
    • 84873937105 scopus 로고    scopus 로고
    • The Young Netherlands Twin Register (YNTR): longitudinal twin and family studies in over 70,000 children
    • van Beijsterveldt, C. E. M. et al. The Young Netherlands Twin Register (YNTR): longitudinal twin and family studies in over 70,000 children. Twin. Res. Hum. Genet. 16, 252–267 (2013).
    • (2013) Twin. Res. Hum. Genet. , vol.16 , pp. 252-267
    • van Beijsterveldt, C.E.M.1
  • 46
    • 0032970693 scopus 로고    scopus 로고
    • A measure of subjective happiness: preliminary reliability and construct validation
    • Lyubomirsky, S. & Lepper, H. S. A measure of subjective happiness: preliminary reliability and construct validation. Soc. Indic. Res. 46, 137–155 (1999).
    • (1999) Soc. Indic. Res. , vol.46 , pp. 137-155
    • Lyubomirsky, S.1    Lepper, H.S.2
  • 49
    • 38949168815 scopus 로고    scopus 로고
    • The Warwick-Edinburgh mental well-being scale (WEMWBS): Development and UK validation
    • Tennant, R. et al. The Warwick-Edinburgh mental well-being scale (WEMWBS): Development and UK validation. Health Qual. Life Outcomes 5, 1–13 (2007).
    • (2007) Health Qual. Life Outcomes , vol.5 , pp. 1-13
    • Tennant, R.1
  • 50
    • 84975795680 scopus 로고    scopus 로고
    • An integrated map of genetic variation from 1,092 human genomes
    • Altshuler, D. M. et al. An integrated map of genetic variation from 1,092 human genomes. Nature 491, 56–65 (2012).
    • (2012) Nature , vol.491 , pp. 56-65
    • Altshuler, D.M.1
  • 51
    • 85018726619 scopus 로고    scopus 로고
    • Conditional eQTL analysis reveals allelic heterogeneity of gene expression
    • COI: 1:CAS:528:DC%2BC1cXhtlSqsbo%3D
    • Jansen, R. et al. Conditional eQTL analysis reveals allelic heterogeneity of gene expression. Hum. Mol. Genet. 26, 1444–1451 (2017).
    • (2017) Hum. Mol. Genet. , vol.26 , pp. 1444-1451
    • Jansen, R.1
  • 52
    • 85002486916 scopus 로고    scopus 로고
    • Identification of context-dependent expression quantitative trait loci in whole blood
    • COI: 1:CAS:528:DC%2BC28XitVSrurnO
    • Zhernakova, D. V. et al. Identification of context-dependent expression quantitative trait loci in whole blood. Nat. Genet. 49, 139–145 (2017).
    • (2017) Nat. Genet. , vol.49 , pp. 139-145
    • Zhernakova, D.V.1
  • 53
    • 80052322958 scopus 로고    scopus 로고
    • Trans-eqtls reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the hla
    • COI: 1:CAS:528:DC%2BC3MXhtFWiurbE
    • Fehrmann, R. S. N. et al. Trans-eqtls reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the hla. PLoS Genet. 7, e1002197 (2011).
    • (2011) PLoS Genet. , vol.7
    • Fehrmann, R.S.N.1
  • 54
    • 85002263457 scopus 로고    scopus 로고
    • Disease variants alter transcription factor levels and methylation of their binding sites
    • COI: 1:CAS:528:DC%2BC28XitVSrurnP
    • Bonder, M. J. et al. Disease variants alter transcription factor levels and methylation of their binding sites. Nat. Genet. 49, 131–138 (2017).
    • (2017) Nat. Genet. , vol.49 , pp. 131-138
    • Bonder, M.J.1
  • 55
    • 85045328177 scopus 로고    scopus 로고
    • Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types
    • COI: 1:CAS:528:DC%2BC1cXnsVGrtr4%3D
    • Finucane, H. K. et al. Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types. Nat. Genet. 50, 621–629 (2018).
    • (2018) Nat. Genet. , vol.50 , pp. 621-629
    • Finucane, H.K.1


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