The Adult Netherlands Twin Register: Twenty-five years of survey and biological data collection

Twin Research and Human Genetics

Volumn 16, Issue 1, 2013, Pages 271-281

  Willemsen, Gonneke ^a,b   Vink, Jacqueline M ^a,c   Abdellaoui, Abdel ^a,c   Den Braber, Anouk ^a,c   Van Beek, Jenny H D A ^a,b   Draisma, Harmen H M ^a,b   Van Dongen, Jenny ^a,b   Van 'T Ent, Dennis ^a,c   Geels, Lot M ^a,b   Van Lien, Rene ^a,b   Ligthart, Lannie ^a,b   Kattenberg, Mathijs ^a   Mbarek, Hamdi ^a,b   De Moor, Marleen H M ^a,b   Neijts, Melanie ^a,b   Pool, Rene ^a,b   Stroo, Natascha ^a   Kluft, Cornelis ^d   Suchiman, H Eka D ^a,e   Slagboom, P Eline ^e   De Geus, Eco J C ^a,b,c   Boomsma, Dorret I ^a,b,c   more..

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c Neuroscience Campus Amsterdam ^*  (Netherlands)

^d Good Biomarker Sciences   (Netherlands)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

biobank; DNA; gene finding; longitudinal surveys; twin family studies

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; ATTENTION DEFICIT DISORDER; AUTONOMIC NERVOUS SYSTEM; BORDERLINE STATE; COGNITION; CONTROLLED STUDY; DATA ANALYSIS; DEMOGRAPHY; DNA DETERMINATION; DNA SEQUENCE; EPIGENETICS; FEMALE; GENETIC ASSOCIATION; GENOME ANALYSIS; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HEALTH BEHAVIOR; HEALTH SURVEY; HERITABILITY; HUMAN; LIFESPAN; LIFESTYLE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; METABOLOMICS; MORBIDITY; MORTALITY; NEUROIMAGING; PARENT; PHENOTYPE; PRIORITY JOURNAL; PROGENY; REGISTER; RNA SEQUENCE; SIBLING; TELOMERE; TWINS;

ADOLESCENT; ADULT; BIOLOGICAL SPECIMEN BANKS; BIOMEDICAL RESEARCH; DISEASES IN TWINS; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LONGITUDINAL STUDIES; MALE; NETHERLANDS; REGISTRIES; TWINS; YOUNG ADULT;

EID: 84873901396     PISSN: 18324274     EISSN: None     Source Type: Journal    
DOI: 10.1017/thg.2012.140     Document Type: Article

References (64)

1. Abdellaoui, A., Hottenga, J. J., deKnijff, P., Nivard, M.G., Xiao, X, Scheet, P., . Boomsma, D. I. (submitted). Increasing genome-wide ancestry signals to study population structure. Manuscript submitted for publication.
2. Alders, M. (2002). Allochtonenprognose 2002-2050: Bijna twee miljoen niet-westerse allochtonen in 2010. [Immigrant prognosis 2002-2050: Almost two million non-western immigrants in 2010.] Bevolkingstrends, 1e kwartaal 2003, 34-41.
3. Statistics Netherlands. Accessed on 1st November, 2012. Retrieved fromhttp://www.cbs.nl/NR/ rdonlyres/900AFF25-7E54-4F8C-92DE-435270FD3E68/0/ 2003k1b15p034art.pdf.
4. Baar'e, W. F., Hulshoff Pol, H. E., Boomsma, D. I., Posthuma, D., de Geus, E. J.C., Schnack, H. G., . Kahn, R. S. (2001). Quantitative geneticmodeling of variation in human brain morphology. Cerebral Cortex, 11, 816-824.
5. Boomsma, D. I., Beem, A. L., Van den Berg, M., Dolan, C. V., Koopmans, J. R., Vink, J. M., . Slagboom, P. E. (2000). Netherlands twin family study of anxious depression (NETSAD). Twin Research, 3, 323-334.
6. Boomsma, D. I., de Geus, E. J. C., Vink, J. M., Stubbe, J. H., Distel, M. A., Hottenga, J. J., . Willemsen, G. (2006). Netherlands Twin Register: From twins to twin families. Twin Research and Human Genetics, 9, 849-857.
7. Boomsma, D. I., Kempen, H. J., Gevers Leuven, J. A., Havekes, L., deKnijff, P., &Frants, R.R. (1996).Genetic analysis of sex and generation differences in plasma lipid, lipoprotein, and apolipoprotein levels in adolescent twins and their parents. Genetic Epidemiology, 13, 49-60.
8. Boomsma, D. I., Saviouk, V., Hottenga, J. J., Distel, M. A., de Moor, M. H., Vink, J. M., . Willemsen, G. (2010). Genetic epidemiology of attention deficit hyperactivity disorder (ADHD index) in adults. PLoS One, 5, e10621.
9. Boomsma, D. I., Vink, J. M., van Beijsterveldt, C. E. M., de Geus, E. J. C., Beem, A. L., Mulder, E. J. C. M., . van Baal, G. C. M. (2002). Netherlands Twin Register: A focus on longitudinal research. Twin Research, 5, 401-406.
10. Boomsma, D. I., Willemsen, G., Sullivan, P. F., Heutink, P., Meijer, P., Sondervan, D., . Penninx, B. W. J. H. (2008). Genome-wide association of major depression: Description of samples for the GAIN Major Depressive Disorder Study: NTR andNESDA biobank project. European Journal of Human Genetics, 16, 335-342.
11. De Geus, E. J., Kupper, N., Boomsma, D. I., & Snieder, H. (2007a). Bivariate genetic modeling of cardiovascular stress reactivity: Does stress uncover genetic variance? Psychosomatic Medicine, 69, 356-364.
12. De Geus, E. J. C., van't Ent, D., Wolfensberger, S. P., Heutink, P., Hoogendijk, W. J., Boomsma, D. I., & Veltman, D. J. (2007b). Intrapair differences in hippocampal volume in monozygotic twins discordant for the risk for anxiety and depression. Biological Psychiatry, 61, 1062- 1071.
13. De Moor, M. H., Boomsma, D. I., Stubbe, J. H., Willemsen, G., & de Geus, E. J. (2008). Testing causality in the association between regular exercise and symptoms of anxiety and depression. Archives of General Psychiatry, 65, 897- 905.
14. De Moor, M. H., Willemsen, G., Rebollo-Mesa, I., Stubbe, J. H., De Geus, E. J., & Boomsma, D. I. (2011). Exercise participation in adolescents and their parents: Evidence for genetic and generation specific environmental effects. Behavior Genetics, 41, 211-222.
15. den Braber, A., van 't Ent, D., Boomsma, D. I., Cath, D. C., Veltman, D. J., Thompson, P. M., & de Geus, E. J. C. (2011). White matter differences in monozygotic twins discordant or concordant for obsessive-compulsive symptoms: A combined diffusion tensor imaging/voxel-based morphometry study. Biological Psychiatry, 70, 969-977.
16. den Braber, A., van 't Ent, D., Cath, D. C., Veltman, D. J., Boomsma, D. I., & de Geus, E. J. C. (2012). Brain activation during response interference in twins discordant or concordant for obsessive compulsive symptoms. Twin Research and Human Genetics, 15, 372-383.
17. Distel, M. A., Middeldorp, C. M., Trull, T. J., Derom, C. A., Willemsen, G., & Boomsma, D. I. (2011). Life events and borderline personality features: The influence of geneenvironment interaction and gene-environment correlation. Psychological Medicine, 41, 849-860.
18. Draisma, H. H. M., Reijmers, T. H., Meulman, J. J., Boomsma, D. I., van der Greef, J., & Hankemeier, T. (2012). Hierarchical clustering analysis of blood plasma lipidomics profiles from mono- and dizygotic twin families. European Journal of Human Genetics. Advance online publication. doi:10.1038/ejhg.2012.110.
19. Draisma, H. H. M., Reijmers, T. H., van der Kloet, F., Bobeldijk-Pastorova, I., Spies-Faber, E., Vogels, J. T., . Hankemeier, T. (2010). Equating, or correction for between-block effectswith application to bodyfluid LC-MS andNMRmetabolomics data sets. Analytical Chemistry, 82, 1039-1046.
20. Duncan, L. E., & Keller, M. C. (2011). A critical review of the first 10 years of candidate gene-by-environment Interaction research in psychiatry. American Journal of Psychiatry, 168, 1041-1049.
21. Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A. U., . Barroso, I. (2010). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genetics, 42, 105-116.
22. Ehli, E. A., Abdellaoui, A., Hu, Y., Hottenga, J. J., Kattenberg, M., van Beijsterveldt, T., . Davies, G. E. (2012). De novo and inherited CNVs in MZ twin pairs selected for discordance and concordance on attention problems. European Journal of Human Genetics, 20(10), 1037-1043.
23. Elks, C. E., Perry, J.R., Sulem, P., Chasman, D. I., Franceschini, N., He, C., . Murray, A. (2010). Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nature Genetics, 42, 1077-1085.
24. Geels, L. M., Vink, J. M., van Beek, J. H. D. A., Bartels, M., Willemsen, G., & Boomsma, D. I. (submitted). Increases in alcohol consumption in Dutch women and elderly groups: Evidence from an epidemiological study.Manuscript submitted for publication.
25. Hoekstra, C., Willemsen, G., van Beijsterveldt, T. C., Montgomery, G. W., & Boomsma, D. I. (2008). Familial twinning and fertility in Dutchmothers of twins. American Journal of Medical Genetics, 146A, 3147-3156.
26. Hottenga, J. J., Whitfield, J. B., Posthuma, D., Willemsen, G., de Geus, E. J., Martin, N. G., & Boomsma, D. I. (2007). Genome-wide scan for blood pressure in Australian and Dutch subjects suggests linkage at 5P, 14Q, and 17P. Hypertension, 49, 832-838.
27. Jansen, R., Batista, S., Willemsen, G., van Grootheest, G., Madar, V., Peyrot, W., . Penninx, B. W. J. H. (submitted). Sex differences in the human peripheral blood transcriptome. Manuscript submitted for publication.
28. Koopmans, J. R., & Boomsma, D. I. (1996). Familial resemblances in alcohol use: Genetic or cultural transmission? Journal of Studies on Alcohol, 57, 19-28.
29. Koopmans, J.R., Slutske, W.S., vanBaal, G.C.M., &Boomsma, D. I. (1999). The influence of religion on alcohol use initiation: Evidence for genotype X environment interaction. Behavior Genetics, 29, 445-453.
30. Kupper, N., de Geus, E. J., van den Berg, M., Kirschbaum, C., Boomsma, D. I., & Willemsen, G. (2005). Familial influences on basal salivary cortisol in an adult population. Psychoneuroendocrinology, 30, 857-868.
31. Kupper, N., Willemsen, G., Boomsma, D. I., & de Geus, E. J. (2006). Heritability of indices for cardiac contractility in ambulatory recordings. Journal of Cardiovascular Electrophysiology, 17, 877-883.
32. Lango Allen, H., Estrada, K., Lettre, G., Berndt, S. I., Weedon, M. N., Rivadeneira, F., . Hirschhorn, J. N. (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature, 467, 832- 838.
33. Ligthart, L., de Vries, B., Smith, A.V., Ikram, M. A., Amin, N., Hottenga, J. J., . Boomsma, D. I. (2011).Meta-analysis of genome-wide association for migraine in six populationbased European cohorts. European Journal of Human Genetics, 19, 901-907.
34. Ligthart, L., Nyholt, D. R., Penninx, B. W., & Boomsma, D. I. (2010). The shared genetics of migraine and anxious depression. Headache, 50, 1549-1560.
35. Middeldorp, C.M., deGeus, E. J. C., Willemsen, G., Hottenga, J. J., Slagboom, P. E., & Boomsma, D. I. (2010). The serotonin transporter gene length polymorphism (5-HTTLPR) and life events:Noevidence for aninteractioneffect onneuroticism and anxious depressive symptoms. Twin Research and Human Genetics, 13, 544-549.
36. Painter, J. N., Willemsen, G., Nyholt, D., Hoekstra, C., Duffy, D. L., Henders, A. K., . Montgomery, G. W. (2010). A genome wide linkage scan for dizygotic twinning in 525 families of mothers of dizygotic twins. Human Reproduction, 25, 1569-1580.
37. Poelen, E. A., Scholte, R. H., Engels, R. C., Boomsma, D. I., & Willemsen, G. (2005). Prevalence and trends of alcohol use and misuse among adolescents and young adults in theNetherlands from 1993 to 2000. Drug and Alcohol Dependency, 79, 413-421.
38. Posthuma, D., Luciano, M., Geus, E. J., Wright, M. J., Slagboom, P. E., Montgomery, G. W., Martin, N. G. (2005). A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p. American Journal of Human Genetics, 77, 318-326.
39. Posthuma, D., Mulder, E. J., Boomsma, D. I., & de Geus, E. J. (2002). Genetic analysis of IQ, processing speed and stimulus-response incongruency effects. Biological Psychology, 61, 157-182.
40. Reiling, E., Ling, C., Uitterlinden, A. G., Van't Riet, E., Welschen, L. M., Ladenvall, C., . 't Hart, L. M. (2010). The association of mitochondrial content with prevalent and incident type 2 diabetes. Journal of Clinical Endocrinology & Metabolism, 95, 1909-1915.
41. Saviouk, V., Hottenga, J. J., Slagboom, E. P., Distel, M. A., de Geus, E. J., Willemsen, G., &Boomsma, D. I. (2011).ADHD in Dutch adults: Heritability and linkage study. American Journal of Medical Genetics Part B: Neuropsychiaticr Genetics, 156B, 352-362.
42. Scheet, P., Ehli, E. A., Xiao, X., van Beijsterveldt, C. E. M., Abdellaoui, A., Althoff, R. R., . Boomsma, D. I. (2012). Twins, tissue and time: An Assessment of SNPs and CNVs. Twin Research and Human Genetics, 28, 1-9.
43. Silventoinen, K., Sammalisto, S., Perola, M., Boomsma, D. I., Cornes, B. K., Davis, C., . Kaprio, J. (2003). Heritability of adult body height: A comparative study of twin cohorts in eight countries. Twin Research, 6, 399-408.
44. Simonis-Bik, A. M., Eekhoff, E. M., Diamant, M., Boomsma, D. I., Heine, R. J., Dekker, J.M., . de Geus, E. J. (2008). The heritability of HbA1c and fasting blood glucose in different measurement settings. Twin Research and Human Genetics, 11, 597-602.
45. Smit, D. J., Boomsma, D. I., Schnack, H. G., Hulshoff Pol, H. E., & de Geus, E. J. C (2012). Individual differences in EEG spectral power reflect genetic variance in gray and white matter volumes. Twin Research and Human Genetics, 15, 384-392.
46. Smit, D. J., Posthuma, D., Boomsma, D. I., & de Geus, E. J. C. (2007). Genetic contribution to the P3 in young and middle-aged adults. Twin Research and Human Genetics, 10, 335-347.
47. Snieder, H., van Doornen, L. J., & Boomsma, D. I. (1997). The age dependency of gene expression for plasma lipids, lipoproteins, and apolipoproteins. American Journal of Human Genetics, 60, 638-650.
48. Speliotes, E. K., Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., Jackson, A. U., . Loos, R. J. (2010). Association analyses of 249, 796 individuals reveal 18 new loci associated with body mass index. Nature Genetics, 42, 937- 948.
49. Sullivan, P. F., de Geus, E. J. C., Willemsen, G., James, M. R., Smit, J.H., Zandbelt, T., .Penninx, B.W. (2009).Genomewide association for major depressive disorder: A possible role for the presynaptic protein piccolo. Molecular Psychiatry, 14, 359-375.
50. Talens, R. P., Christensen, K., Putter, H., Willemsen, G., Christiansen, L., Kremer, D., .Heijmans, B.T. (2012).Epigenetic variation during the adult lifespan: Cross-sectional and longitudinal data on monozygotic twin pairs. Aging Cell, 11, 694-703.
51. Thorgeirsson, T. E., Gudbjartsson, D. F., Surakka, I., Vink, J. M., Amin, N., Geller, F., Sulem, P., . Stefansson, K. (2010). Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nature Genetics, 42, 448-453.
52. Tobacco and Genetics Consortium. (2010). Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nature Genetics, 42, 441-447.
53. Van Beijsterveldt, C. E. M., Groen-Blokhuis, M., Franic, S., Lamb, D., Huppertz, C., de Zeeuw, E., . Boomsma, D. I. (2013). The Young Netherlands Twin Registry (YNTR): Longitudinal twin and family studies in over 70, 000 children. Twin Research and Human Genetics.
54. Van Beijsterveldt, C. E., van Baal, G.C., Molenaar, P. C., Boomsma, D. I., & de Geus, E. J. (2001). Stability of genetic and environmental influences on P300 amplitude: A longitudinal study in adolescent twins. Behavior Genetics, 31, 533-543.
55. Vink, J. M., Boomsma, D. I., Medland, S. E., de Moor, M. H., Stubbe, J. H., Cornes, B. K., . de Geus, E. J. C. (2011a). Variance components models for physical activity with age as modifier: A comparative twin study in seven countries. Twin Research and Human Genetics, 14, 25-34.
56. Vink, J. M., Smit, A. B., de Geus, E. J., Sullivan, P., Willemsen, G., Hottenga, J.J., . Boomsma, D. I. (2009). Genomewide association study of smoking initiation and current smoking. American Journal of Human Genetics, 84, 367- 379.
57. Vink, J. M., van Kemenade, F. J., Meijer, C. J., Casparie, M. K., Meijer, G. A., & Boomsma, D. I. (2011b). Cervix smear abnormalities: Linking pathology data in female twins, their mothers and sisters. European Journal of Human Genetics, 19, 108-111.
58. Vink, J. M., Willemsen, G., & Boomsma, D. I. (2005). Heritability of smoking initiation and nicotine dependence. Behavior Genetics, 35, 397-406.
59. Vink, J. M., Wolters, L. M., Neale, M. C., & Boomsma, D. I. (2010). Heritability of cannabis initiation in Dutch adult twins. Addictive Behaviors, 35, 172-174.
60. Willemsen, G., &Boomsma, D. I. (2007). Religious upbringing and neuroticism in Dutch twin families. Twin Research and Human Genetics, 10, 327-333.
61. Willemsen, G., de Geus, E. J. C., Bartels, M., van Beijsterveldt, C. E. M., Brooks, A. I., Estourgie-van Burk, D. A., . Boomsma, D. I. (2010). The Netherlands Twin Register biobank: A resource for genetic epidemiological studies. Twin Research and Human Genetics, 13, 231- 245.
62. Willemsen, G., vanBeijsterveldt, T.C., vanBaal, C. G., Postma, D., & Boomsma, D. I. (2008). Heritability of self-reported asthma and allergy: A study in adult Dutch twins, siblings and parents. Twin Research and Human Genetics, 11, 132- 142.
63. Wolfensberger, S. P., Veltman, D. J., Hoogendijk, W. J., Boomsma, D. I., & de Geus, E. J. C. (2008). Amygdala responses to emotional faces in twins discordant or concordant for the risk for anxiety and depression. Neuroimage, 41, 544-552.
64. Wu, T., Boezen, H. M., Postma, D. S., Los, H., Postmus, P. E., Snieder, H., & Boomsma, D. I. (2010). Genetic and environmental influences on objective intermediate asthma phenotypes in Dutch twins. European Respiratory Journal, 36, 261-268.