메뉴 건너뛰기




Volumn 25, Issue 4, 2020, Pages 831-843

Schizophrenia risk variants influence multiple classes of transcripts of sorting nexin 19 (SNX19)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; SORTING NEXIN 19; UNCLASSIFIED DRUG; SNX19 PROTEIN, MOUSE; SORTING NEXIN;

EID: 85059907226     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/s41380-018-0293-0     Document Type: Article
Times cited : (29)

References (43)
  • 3
    • 85083616583 scopus 로고    scopus 로고


  • 5
    • 84904804929 scopus 로고    scopus 로고
    • Biological insights from 108 schizophrenia-associated genetic loci
    • Schizophrenia Working Group of the Psychiatric Genomics C. Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014;511:421–7.
    • (2014) Nature , vol.511 , pp. 421-427
  • 7
    • 85007605391 scopus 로고    scopus 로고
    • Molecular mechanisms underlying noncoding risk variations in psychiatric genetic studies
    • COI: 1:CAS:528:DC%2BC2sXjs1Gg
    • Xiao X, Chang H, Li M. Molecular mechanisms underlying noncoding risk variations in psychiatric genetic studies. Mol Psychiatry. 2017;22:497–511.
    • (2017) Mol Psychiatry , vol.22 , pp. 497-511
    • Xiao, X.1    Chang, H.2    Li, M.3
  • 8
    • 84966657282 scopus 로고    scopus 로고
    • A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus
    • COI: 1:CAS:528:DC%2BC28XnsV2ksLo%3D
    • Li M, Jaffe AE, Straub RE, Tao R, Shin JH, Wang Y, et al. A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus. Nat Med. 2016;22:649–56.
    • (2016) Nat Med , vol.22 , pp. 649-656
    • Li, M.1    Jaffe, A.E.2    Straub, R.E.3    Tao, R.4    Shin, J.H.5    Wang, Y.6
  • 9
    • 85016161935 scopus 로고    scopus 로고
    • The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)
    • COI: 1:CAS:528:DC%2BC1cXhslWhs7c%3D
    • MacArthur J, Bowler E, Cerezo M, Gil L, Hall P, Hastings E, et al. The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog). Nucleic Acids Res. 2017;45:D896–D901.
    • (2017) Nucleic Acids Res , vol.45 , pp. D896-D901
    • MacArthur, J.1    Bowler, E.2    Cerezo, M.3    Gil, L.4    Hall, P.5    Hastings, E.6
  • 10
    • 85046022254 scopus 로고    scopus 로고
    • Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
    • COI: 1:CAS:528:DC%2BC1cXosVCks74%3D
    • Wray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A, et al. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet. 2018;50:668–81.
    • (2018) Nat Genet , vol.50 , pp. 668-681
    • Wray, N.R.1    Ripke, S.2    Mattheisen, M.3    Trzaskowski, M.4    Byrne, E.M.5    Abdellaoui, A.6
  • 12
    • 85083617329 scopus 로고    scopus 로고


  • 13
    • 85032570667 scopus 로고    scopus 로고
    • Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia
    • Consortium ASDWGoTPG. Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. Mol Autism. 2017;8:21.
    • (2017) Mol Autism , vol.8
  • 14
    • 84988697987 scopus 로고    scopus 로고
    • Gene expression elucidates functional impact of polygenic risk for schizophrenia
    • COI: 1:CAS:528:DC%2BC28XhsFOmsLnN
    • Fromer M, Roussos P, Sieberts SK, Johnson JS, Kavanagh DH, Perumal TM, et al. Gene expression elucidates functional impact of polygenic risk for schizophrenia. Nat Neurosci. 2016;19:1442–53.
    • (2016) Nat Neurosci , vol.19 , pp. 1442-1453
    • Fromer, M.1    Roussos, P.2    Sieberts, S.K.3    Johnson, J.S.4    Kavanagh, D.H.5    Perumal, T.M.6
  • 15
    • 84961927084 scopus 로고    scopus 로고
    • Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
    • COI: 1:CAS:528:DC%2BC28XkvFGrs7g%3D
    • Zhu Z, Zhang F, Hu H, Bakshi A, Robinson MR, Powell JE, et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet. 2016;48:481–7.
    • (2016) Nat Genet , vol.48 , pp. 481-487
    • Zhu, Z.1    Zhang, F.2    Hu, H.3    Bakshi, A.4    Robinson, M.R.5    Powell, J.E.6
  • 16
    • 84885018609 scopus 로고    scopus 로고
    • Systematic identification of trans eQTLs as putative drivers of known disease associations
    • COI: 1:CAS:528:DC%2BC3sXhtl2ksLzK
    • Westra HJ, Peters MJ, Esko T, Yaghootkar H, Schurmann C, Kettunen J, et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat Genet. 2013;45:1238–43.
    • (2013) Nat Genet , vol.45 , pp. 1238-1243
    • Westra, H.J.1    Peters, M.J.2    Esko, T.3    Yaghootkar, H.4    Schurmann, C.5    Kettunen, J.6
  • 17
    • 84921750431 scopus 로고    scopus 로고
    • Genetic variability in the regulation of gene expression in ten regions of the human brain
    • Ramasamy A, Trabzuni D, Guelfi S, Varghese V, Smith C, Walker R, et al. Genetic variability in the regulation of gene expression in ten regions of the human brain. Nat Neurosci. 2014;10:1418–28.
    • (2014) Nat Neurosci , Issue.10 , pp. 1418-1428
    • Ramasamy, A.1    Trabzuni, D.2    Guelfi, S.3    Varghese, V.4    Smith, C.5    Walker, R.6
  • 18
    • 85020096431 scopus 로고    scopus 로고
    • Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci
    • COI: 1:CAS:528:DC%2BC1cXhsFais7s%3D
    • Fullard JF, Giambartolomei C, Hauberg ME, Xu K, Voloudakis G, Shao Z, et al. Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci. Hum Mol Genet. 2017;26:1942–51.
    • (2017) Hum Mol Genet , vol.26 , pp. 1942-1951
    • Fullard, J.F.1    Giambartolomei, C.2    Hauberg, M.E.3    Xu, K.4    Voloudakis, G.5    Shao, Z.6
  • 19
    • 85042767167 scopus 로고    scopus 로고
    • Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits
    • Wu Y, Zeng J, Zhang F, Zhu Z, Qi T, Zheng Z, et al. Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits. Nat Commun. 2018;9:918.
    • (2018) Nat Commun , vol.9
    • Wu, Y.1    Zeng, J.2    Zhang, F.3    Zhu, Z.4    Qi, T.5    Zheng, Z.6
  • 20
    • 84893637845 scopus 로고    scopus 로고
    • Revisiting DARPP-32 in postmortem human brain: changes in schizophrenia and bipolar disorder and genetic associations with t-DARPP-32 expression
    • COI: 1:CAS:528:DC%2BC2cXhsVClsLc%3D
    • Kunii Y, Hyde TM, Ye T, Li C, Kolachana B, Dickinson D, et al. Revisiting DARPP-32 in postmortem human brain: changes in schizophrenia and bipolar disorder and genetic associations with t-DARPP-32 expression. Mol Psychiatry. 2014;19:192–9.
    • (2014) Mol Psychiatry , vol.19 , pp. 192-199
    • Kunii, Y.1    Hyde, T.M.2    Ye, T.3    Li, C.4    Kolachana, B.5    Dickinson, D.6
  • 21
    • 33748745764 scopus 로고    scopus 로고
    • Critical factors in gene expression in postmortem human brain: focus on studies in schizophrenia
    • COI: 1:CAS:528:DC%2BD28XpvFeltrc%3D
    • Lipska BK, Deep-Soboslay A, Weickert CS, Hyde TM, Martin CE, Herman MM, et al. Critical factors in gene expression in postmortem human brain: focus on studies in schizophrenia. Biol Psychiatry. 2006;60:650–8.
    • (2006) Biol Psychiatry , vol.60 , pp. 650-658
    • Lipska, B.K.1    Deep-Soboslay, A.2    Weickert, C.S.3    Hyde, T.M.4    Martin, C.E.5    Herman, M.M.6
  • 22
    • 33747816814 scopus 로고    scopus 로고
    • Virtual Ribosome—a comprehensive DNA translation tool with support for integration of sequence feature annotation
    • COI: 1:CAS:528:DC%2BD28Xps1yhsLk%3D
    • Wernersson R. Virtual Ribosome—a comprehensive DNA translation tool with support for integration of sequence feature annotation. Nucleic Acids Res. 2006;34(Web Server issue):W385–388.
    • (2006) Nucleic Acids Res , vol.34 , Issue.Web Server issue , pp. W385-W388
    • Wernersson, R.1
  • 23
    • 34547571027 scopus 로고    scopus 로고
    • The M-Coffee web server: a meta-method for computing multiple sequence alignments by combining alternative alignment methods
    • Moretti S, Armougom F, Wallace IM, Higgins DG, Jongeneel CV, Notredame C. The M-Coffee web server: a meta-method for computing multiple sequence alignments by combining alternative alignment methods. Nucleic Acids Res. 2007;35(Web Server issue):W645–48.
    • (2007) Nucleic Acids Res , vol.35 , Issue.Web Server issue , pp. W645-W648
    • Moretti, S.1    Armougom, F.2    Wallace, I.M.3    Higgins, D.G.4    Jongeneel, C.V.5    Notredame, C.6
  • 24
    • 65449188232 scopus 로고    scopus 로고
    • Jalview Version 2—a multiple sequence alignment editor and analysis workbench
    • COI: 1:CAS:528:DC%2BD1MXltFWis7Y%3D
    • Waterhouse AM, Procter JB, Martin DM, Clamp M, Barton GJ. Jalview Version 2—a multiple sequence alignment editor and analysis workbench. Bioinformatics. 2009;25:1189–91.
    • (2009) Bioinformatics , vol.25 , pp. 1189-1191
    • Waterhouse, A.M.1    Procter, J.B.2    Martin, D.M.3    Clamp, M.4    Barton, G.J.5
  • 25
    • 84953762043 scopus 로고    scopus 로고
    • Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex
    • COI: 1:CAS:528:DC%2BC2MXhvVyrsbvI
    • Jaffe AE, Gao Y, Deep-Soboslay A, Tao R, Hyde TM, Weinberger DR, et al. Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex. Nat Neurosci. 2016;19:40–47.
    • (2016) Nat Neurosci , vol.19 , pp. 40-47
    • Jaffe, A.E.1    Gao, Y.2    Deep-Soboslay, A.3    Tao, R.4    Hyde, T.M.5    Weinberger, D.R.6
  • 26
    • 84861153094 scopus 로고    scopus 로고
    • Matrix eQTL: ultra fast eQTL analysis via large matrix operations
    • COI: 1:CAS:528:DC%2BC38XmvF2ksb8%3D
    • Shabalin AA. Matrix eQTL: ultra fast eQTL analysis via large matrix operations. Bioinformatics. 2012;28:1353–8.
    • (2012) Bioinformatics , vol.28 , pp. 1353-1358
    • Shabalin, A.A.1
  • 28
    • 85083616707 scopus 로고    scopus 로고


  • 29
    • 0023020183 scopus 로고
    • The moderator−mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations
    • COI: 1:STN:280:DyaL2s7ht1SrsQ%3D%3D
    • Baron RM, Kenny DA. The moderator−mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 1986;51:1173–82.
    • (1986) J Pers Soc Psychol , vol.51 , pp. 1173-1182
    • Baron, R.M.1    Kenny, D.A.2
  • 30
    • 0002037905 scopus 로고
    • Asymptotic confidence intervals for indirect effects in structural equation models
    • Sobel ME. Asymptotic confidence intervals for indirect effects in structural equation models. Sociol Methodol. 1982;13:290–312.
    • (1982) Sociol Methodol , vol.13 , pp. 290-312
    • Sobel, M.E.1
  • 31
    • 0004768977 scopus 로고
    • The probability function of the product of two normally distributed variables
    • Aroian LA. The probability function of the product of two normally distributed variables. Ann Math Stat. 1947;18:265–71.
    • (1947) Ann Math Stat , vol.18 , pp. 265-271
    • Aroian, L.A.1
  • 33
    • 84907743604 scopus 로고    scopus 로고
    • Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: a novel transcript fetally regulated by the psychosis risk variant rs1344706
    • Tao R, Cousijn H, Jaffe AE, Burnet PW, Edwards F, Eastwood SL, et al. Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: a novel transcript fetally regulated by the psychosis risk variant rs1344706. JAMA Psychiatry. 2014;71:1112–20.
    • (2014) JAMA Psychiatry , vol.71 , pp. 1112-1120
    • Tao, R.1    Cousijn, H.2    Jaffe, A.E.3    Burnet, P.W.4    Edwards, F.5    Eastwood, S.L.6
  • 34
    • 85021725602 scopus 로고    scopus 로고
    • qSVA framework for RNA quality correction in differential expression analysis
    • COI: 1:CAS:528:DC%2BC2sXhtVanurjK
    • Jaffe AE, Tao R, Norris AL, Kealhofer M, Nellore A, Shin JH, et al. qSVA framework for RNA quality correction in differential expression analysis. Proc Natl Acad Sci USA. 2017;114:7130–5.
    • (2017) Proc Natl Acad Sci USA , vol.114 , pp. 7130-7135
    • Jaffe, A.E.1    Tao, R.2    Norris, A.L.3    Kealhofer, M.4    Nellore, A.5    Shin, J.H.6
  • 35
    • 84879663784 scopus 로고    scopus 로고
    • Global epigenomic reconfiguration during mammalian brain development
    • COI: 1:CAS:528:DC%2BC3sXht1WqtbjM
    • Lister R, Mukamel EA, Nery JR, Urich M, Puddifoot CA, Johnson ND, et al. Global epigenomic reconfiguration during mammalian brain development. Science. 2013;341:629–41.
    • (2013) Science , vol.341 , pp. 629-641
    • Lister, R.1    Mukamel, E.A.2    Nery, J.R.3    Urich, M.4    Puddifoot, C.A.5    Johnson, N.D.6
  • 36
    • 84917732422 scopus 로고    scopus 로고
    • Genome-wide identification and characterization of functional neuronal activity-dependent enhancers
    • COI: 1:CAS:528:DC%2BC2cXhsFKms7jE
    • Malik AN, Vierbuchen T, Hemberg M, Rubin AA, Ling E, Couch CH, et al. Genome-wide identification and characterization of functional neuronal activity-dependent enhancers. Nat Neurosci. 2014;17:1330–9.
    • (2014) Nat Neurosci , vol.17 , pp. 1330-1339
    • Malik, A.N.1    Vierbuchen, T.2    Hemberg, M.3    Rubin, A.A.4    Ling, E.5    Couch, C.H.6
  • 37
    • 84055185227 scopus 로고    scopus 로고
    • Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease
    • COI: 1:CAS:528:DC%2BC3MXhs1Cgs7jE
    • Teasdale RD, Collins BM. Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease. Biochem J. 2012;441:39–59.
    • (2012) Biochem J , vol.441 , pp. 39-59
    • Teasdale, R.D.1    Collins, B.M.2
  • 38
    • 84907859630 scopus 로고    scopus 로고
    • Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling
    • COI: 1:CAS:528:DC%2BC2cXhslektLvK
    • Mas C, Norwood SJ, Bugarcic A, Kinna G, Leneva N, Kovtun O, et al. Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling. J Biol Chem. 2014;289:28554–68.
    • (2014) J Biol Chem , vol.289 , pp. 28554-28568
    • Mas, C.1    Norwood, S.J.2    Bugarcic, A.3    Kinna, G.4    Leneva, N.5    Kovtun, O.6
  • 39
    • 85044535543 scopus 로고    scopus 로고
    • The retromer complex and sorting nexins in neurodegenerative diseases
    • COI: 1:CAS:528:DC%2BC1MXhtFWju7%2FO
    • Zhang H, Huang T, Hong Y, Yang W, Zhang X, Luo H, et al. The retromer complex and sorting nexins in neurodegenerative diseases. Front Aging Neurosci. 2018;10:79.
    • (2018) Front Aging Neurosci , vol.10 , pp. 79
    • Zhang, H.1    Huang, T.2    Hong, Y.3    Yang, W.4    Zhang, X.5    Luo, H.6
  • 41
    • 84863147501 scopus 로고    scopus 로고
    • Sorting nexin 19 regulates the number of dense core vesicles in pancreatic beta-cells
    • COI: 1:CAS:528:DC%2BC38XltV2rtrY%3D
    • Harashima S, Horiuchi T, Wang Y, Notkins AL, Seino Y, Inagaki N. Sorting nexin 19 regulates the number of dense core vesicles in pancreatic beta-cells. J Diabetes Investig. 2012;3:52–61.
    • (2012) J Diabetes Investig , vol.3 , pp. 52-61
    • Harashima, S.1    Horiuchi, T.2    Wang, Y.3    Notkins, A.L.4    Seino, Y.5    Inagaki, N.6
  • 43
    • 85047823512 scopus 로고    scopus 로고
    • Placental gene expression mediates the interaction between obstetrical history and genetic risk for schizophrenia
    • COI: 1:CAS:528:DC%2BC1cXhtVelsbvK
    • Ursini G, Punzi G, Chen Q, Marenco S, Robinson J, Porcelli A, et al. Placental gene expression mediates the interaction between obstetrical history and genetic risk for schizophrenia. Nat Med. 2018;24:792–801.
    • (2018) Nat Med , vol.24 , pp. 792-801
    • Ursini, G.1    Punzi, G.2    Chen, Q.3    Marenco, S.4    Robinson, J.5    Porcelli, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.