-
1
-
-
66349138520
-
Loss of the transcriptional repressor PAG-3/Gfi-1 results in enhanced neurosecretion that is dependent on the dense-core vesicle membrane protein IDA-1/IA-2
-
Cai T., Hirai H., Fukushige T., Yu P., Zhang G., Notkins A.L., and Krause M. Loss of the transcriptional repressor PAG-3/Gfi-1 results in enhanced neurosecretion that is dependent on the dense-core vesicle membrane protein IDA-1/IA-2. PLoS Genet. 5 (2009) e1000447
-
(2009)
PLoS Genet.
, vol.5
-
-
Cai, T.1
Hirai, H.2
Fukushige, T.3
Yu, P.4
Zhang, G.5
Notkins, A.L.6
Krause, M.7
-
2
-
-
2242484656
-
Multimerization of the protein-tyrosine phosphatase (PTP)-like insulin-dependent diabetes mellitus autoantigens IA-2 and IA-2beta with receptor PTPs (RPTPs). Inhibition of RPTPalpha enzymatic activity
-
Gross S., Blanchetot C., Schepens J., Albet S., Lammers R., den Hertog J., and Hendriks W. Multimerization of the protein-tyrosine phosphatase (PTP)-like insulin-dependent diabetes mellitus autoantigens IA-2 and IA-2beta with receptor PTPs (RPTPs). Inhibition of RPTPalpha enzymatic activity. J. Biol. Chem. 277 (2002) 48139-48145
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 48139-48145
-
-
Gross, S.1
Blanchetot, C.2
Schepens, J.3
Albet, S.4
Lammers, R.5
den Hertog, J.6
Hendriks, W.7
-
3
-
-
20844448907
-
The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion
-
Harashima S., Clark A., Christie M.R., and Notkins A.L. The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 8704-8709
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 8704-8709
-
-
Harashima, S.1
Clark, A.2
Christie, M.R.3
Notkins, A.L.4
-
4
-
-
41149154844
-
Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta
-
Henquin J.C., Nenquin M., Szollosi A., Kubosaki A., and Louis Notkins A. Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta. J. Endocrinol. 196 (2008) 573-581
-
(2008)
J. Endocrinol.
, vol.196
, pp. 573-581
-
-
Henquin, J.C.1
Nenquin, M.2
Szollosi, A.3
Kubosaki, A.4
Louis Notkins, A.5
-
5
-
-
28444483946
-
The IA-2 interactome
-
Hu Y.F., Zhang H.L., Cai T., Harashima S., and Notkins A.L. The IA-2 interactome. Diabetologia 48 (2005) 2576-2581
-
(2005)
Diabetologia
, vol.48
, pp. 2576-2581
-
-
Hu, Y.F.1
Zhang, H.L.2
Cai, T.3
Harashima, S.4
Notkins, A.L.5
-
6
-
-
0029549920
-
Differential effects of 2,4-dithiobiuret on the synthesis and release of acetylcholine and dopamine from rat pheochromocytoma (PC12) cells
-
Ireland L.M., Yan C.H., Nelson L.M., and Atchison W.D. Differential effects of 2,4-dithiobiuret on the synthesis and release of acetylcholine and dopamine from rat pheochromocytoma (PC12) cells. J. Pharmacol. Exp. Ther. 275 (1995) 1453-1462
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.275
, pp. 1453-1462
-
-
Ireland, L.M.1
Yan, C.H.2
Nelson, L.M.3
Atchison, W.D.4
-
7
-
-
35448983211
-
Detection of proteolytic cleavages of diabetes-associated protein IA-2 beta in the pancreas and the brain using novel anti-IA-2 beta monoclonal antibodies
-
Kawakami T., Saeki K., Takeyama N., Wu G., Sakudo A., Matsumoto Y., Hayashi T., and Onodera T. Detection of proteolytic cleavages of diabetes-associated protein IA-2 beta in the pancreas and the brain using novel anti-IA-2 beta monoclonal antibodies. Int. J. Mol. Med. 20 (2007) 177-185
-
(2007)
Int. J. Mol. Med.
, vol.20
, pp. 177-185
-
-
Kawakami, T.1
Saeki, K.2
Takeyama, N.3
Wu, G.4
Sakudo, A.5
Matsumoto, Y.6
Hayashi, T.7
Onodera, T.8
-
8
-
-
1542399886
-
Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis
-
Knoch K.P., Bergert H., Borgonovo B., Saeger H.D., Altkruger A., Verkade P., and Solimena M. Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis. Nat. Cell Biol. 6 (2004) 207-214
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 207-214
-
-
Knoch, K.P.1
Bergert, H.2
Borgonovo, B.3
Saeger, H.D.4
Altkruger, A.5
Verkade, P.6
Solimena, M.7
-
9
-
-
3042704212
-
Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice
-
Kubosaki A., Gross S., Miura J., Saeki K., Zhu M., Nakamura S., Hendriks W., and Notkins A.L. Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice. Diabetes 53 (2004) 1684-1691
-
(2004)
Diabetes
, vol.53
, pp. 1684-1691
-
-
Kubosaki, A.1
Gross, S.2
Miura, J.3
Saeki, K.4
Zhu, M.5
Nakamura, S.6
Hendriks, W.7
Notkins, A.L.8
-
10
-
-
33644746303
-
Dense core vesicle proteins IA-2 and IA-2beta: metabolic alterations in double knockout mice
-
Kubosaki A., Nakamura S., and Notkins A.L. Dense core vesicle proteins IA-2 and IA-2beta: metabolic alterations in double knockout mice. Diabetes 54 Suppl. 2 (2005) S46-51
-
(2005)
Diabetes
, vol.54
, Issue.SUPPL. 2
-
-
Kubosaki, A.1
Nakamura, S.2
Notkins, A.L.3
-
11
-
-
0027930455
-
Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma
-
Lan M.S., Lu J., Goto Y., and Notkins A.L. Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol. 13 (1994) 505-514
-
(1994)
DNA Cell Biol.
, vol.13
, pp. 505-514
-
-
Lan, M.S.1
Lu, J.2
Goto, Y.3
Notkins, A.L.4
-
12
-
-
0029975769
-
IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus
-
Lan M.S., Wasserfall C., Maclaren N.K., and Notkins A.L. IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 6367-6370
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 6367-6370
-
-
Lan, M.S.1
Wasserfall, C.2
Maclaren, N.K.3
Notkins, A.L.4
-
13
-
-
0029927890
-
Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment
-
Lu J., Li Q., Xie H., Chen Z.J., Borovitskaya A.E., Maclaren N.K., Notkins A.L., and Lan M.S. Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 2307-2311
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 2307-2311
-
-
Lu, J.1
Li, Q.2
Xie, H.3
Chen, Z.J.4
Borovitskaya, A.E.5
Maclaren, N.K.6
Notkins, A.L.7
Lan, M.S.8
-
14
-
-
0006700068
-
Substitution of two variant residues in the protein tyrosine phosphatase-like PTP35/IA-2 sequence reconstitutes catalytic activity
-
Magistrelli G., Toma S., and Isacchi A. Substitution of two variant residues in the protein tyrosine phosphatase-like PTP35/IA-2 sequence reconstitutes catalytic activity. Biochem. Biophys. Res. Commun. 227 (1996) 581-588
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.227
, pp. 581-588
-
-
Magistrelli, G.1
Toma, S.2
Isacchi, A.3
-
15
-
-
38649136568
-
ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs
-
Mziaut H., Kersting S., Knoch K.P., Fan W.H., Trajkovski M., Erdmann K., Bergert H., Ehehalt F., Saeger H.D., and Solimena M. ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs. Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 674-679
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 674-679
-
-
Mziaut, H.1
Kersting, S.2
Knoch, K.P.3
Fan, W.H.4
Trajkovski, M.5
Erdmann, K.6
Bergert, H.7
Ehehalt, F.8
Saeger, H.D.9
Solimena, M.10
-
16
-
-
60849109187
-
Disturbances in the secretion of neurotransmitters in IA-2/IA-2β null mice: changes in behavior, learning and lifespan
-
Nishimura T., Kubosaki A., Ito Y., and Notkins A.L. Disturbances in the secretion of neurotransmitters in IA-2/IA-2β null mice: changes in behavior, learning and lifespan. Neuroscience 159 (2009) 427-437
-
(2009)
Neuroscience
, vol.159
, pp. 427-437
-
-
Nishimura, T.1
Kubosaki, A.2
Ito, Y.3
Notkins, A.L.4
-
17
-
-
33947405211
-
New predictors of disease. Molecules called predictive autoantibodies appear in the blood years before people show symptoms of various disorders. Tests that detected these molecules could warn of the need to take preventive action
-
Notkins A.L. New predictors of disease. Molecules called predictive autoantibodies appear in the blood years before people show symptoms of various disorders. Tests that detected these molecules could warn of the need to take preventive action. Sci. Am. 296 (2007) 72-79
-
(2007)
Sci. Am.
, vol.296
, pp. 72-79
-
-
Notkins, A.L.1
-
18
-
-
0035197969
-
Autoimmune type 1 diabetes: resolved and unresolved issues
-
Notkins A.L., and Lernmark A. Autoimmune type 1 diabetes: resolved and unresolved issues. J. Clin. Invest. 108 (2001) 1247-1252
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1247-1252
-
-
Notkins, A.L.1
Lernmark, A.2
-
19
-
-
0034977535
-
Expression of the protein tyrosine phosphatase-like protein IA-2 during pancreatic islet development
-
Roberts C., Roberts G.A., Lobner K., Bearzatto M., Clark A., Bonifacio E., and Christie M.R. Expression of the protein tyrosine phosphatase-like protein IA-2 during pancreatic islet development. J. Histochem. Cytochem. 49 (2001) 767-776
-
(2001)
J. Histochem. Cytochem.
, vol.49
, pp. 767-776
-
-
Roberts, C.1
Roberts, G.A.2
Lobner, K.3
Bearzatto, M.4
Clark, A.5
Bonifacio, E.6
Christie, M.R.7
-
20
-
-
0033736094
-
Genomic structure of mouse IA-2: comparison with its human homologue
-
Saeki K., Xie J., and Notkins A.L. Genomic structure of mouse IA-2: comparison with its human homologue. Diabetologia 43 (2000) 1429-1434
-
(2000)
Diabetologia
, vol.43
, pp. 1429-1434
-
-
Saeki, K.1
Xie, J.2
Notkins, A.L.3
-
21
-
-
0036263648
-
Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion
-
Saeki K., Zhu M., Kubosaki A., Xie J., Lan M.S., and Notkins A.L. Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion. Diabetes 51 (2002) 1842-1850
-
(2002)
Diabetes
, vol.51
, pp. 1842-1850
-
-
Saeki, K.1
Zhu, M.2
Kubosaki, A.3
Xie, J.4
Lan, M.S.5
Notkins, A.L.6
-
22
-
-
0036459950
-
Protein kinase C-mediated translocation of secretory vesicles to plasma membrane and enhancement of neurotransmitter release from PC12 cells
-
Shoji-Kasai Y., Itakura M., Kataoka M., Yamamori S., and Takahashi M. Protein kinase C-mediated translocation of secretory vesicles to plasma membrane and enhancement of neurotransmitter release from PC12 cells. Eur. J. Neurosci. 15 (2002) 1390-1394
-
(2002)
Eur. J. Neurosci.
, vol.15
, pp. 1390-1394
-
-
Shoji-Kasai, Y.1
Itakura, M.2
Kataoka, M.3
Yamamori, S.4
Takahashi, M.5
-
23
-
-
0029940504
-
ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules
-
Solimena M., Dirkx Jr. R., Hermel J.M., Pleasic-Williams S., Shapiro J.A., Caron L., and Rabin D.U. ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules. EMBO J. 15 (1996) 2102-2114
-
(1996)
EMBO J.
, vol.15
, pp. 2102-2114
-
-
Solimena, M.1
Dirkx Jr., R.2
Hermel, J.M.3
Pleasic-Williams, S.4
Shapiro, J.A.5
Caron, L.6
Rabin, D.U.7
-
24
-
-
65049084821
-
Localization of insulinoma associated protein 2, IA-2 in mouse neuroendocrine tissues using two novel monoclonal antibodies
-
Takeyama N., Ano Y., Wu G., Kubota N., Saeki K., Sakudo A., Momotani E., Sugiura K., Yukawa M., and Onodera T. Localization of insulinoma associated protein 2, IA-2 in mouse neuroendocrine tissues using two novel monoclonal antibodies. Life Sci. (2009)
-
(2009)
Life Sci.
-
-
Takeyama, N.1
Ano, Y.2
Wu, G.3
Kubota, N.4
Saeki, K.5
Sakudo, A.6
Momotani, E.7
Sugiura, K.8
Yukawa, M.9
Onodera, T.10
-
25
-
-
57749107709
-
Regulation of insulin granule turnover in pancreatic {beta}-cells by cleaved ICA512
-
Trajkovski M., Mziaut H., Schubert S., Kalaidzidis Y., Altkruger A., and Solimena M. Regulation of insulin granule turnover in pancreatic {beta}-cells by cleaved ICA512. J. Biol. Chem. 283 (2008) 33719-33729
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 33719-33729
-
-
Trajkovski, M.1
Mziaut, H.2
Schubert, S.3
Kalaidzidis, Y.4
Altkruger, A.5
Solimena, M.6
-
26
-
-
0029999246
-
Molecular cloning of phogrin, a protein-tyrosine phosphatase homologue localized to insulin secretory granule membranes
-
Wasmeier C., and Hutton J.C. Molecular cloning of phogrin, a protein-tyrosine phosphatase homologue localized to insulin secretory granule membranes. J. Biol. Chem. 271 (1996) 18161-18170
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 18161-18170
-
-
Wasmeier, C.1
Hutton, J.C.2
-
27
-
-
0031716158
-
Expression, characterization, processing and immunogenicity of an insulin-dependent diabetes mellitus autoantigen, IA-2, in Sf-9 cells
-
Xie H., Deng Y.J., Notkins A.L., and Lan M.S. Expression, characterization, processing and immunogenicity of an insulin-dependent diabetes mellitus autoantigen, IA-2, in Sf-9 cells. Clin. Exp. Immunol. 113 (1998) 367-372
-
(1998)
Clin. Exp. Immunol.
, vol.113
, pp. 367-372
-
-
Xie, H.1
Deng, Y.J.2
Notkins, A.L.3
Lan, M.S.4
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