메뉴 건너뛰기




Volumn 18, Issue 7, 2017, Pages 492-505

Genetics of schizophrenia: A consensus paper of the WFSBP Task Force on Genetics

(29)  Giegling, Ina a,b   Hosak, Ladislav c   Mössner, Rainald d   Serretti, Alessandro e   Bellivier, Frank f,g   Claes, Stephan h,i   Collier, David A j,k   Corrales, Alejo l   DeLisi, Lynn E m,n   Gallo, Carla o   Gill, Michael p   Kennedy, James L q,r,s   Leboyer, Marion t,u,v,w   Maier, Wolfgang x   Marquez, Miguel y   Massat, Isabelle z,aa   Mors, Ole ab,ac   Muglia, Pierandrea ad   Nöthen, Markus M x,ae   Ospina Duque, Jorge af   more..


Author keywords

genetic; Genetics; genome; polygenic; psychiatry; psychosis; schizophrenia; sequencing

Indexed keywords

CONSENSUS; COPY NUMBER VARIATION; GENE DELETION; GENE DUPLICATION; GENE IDENTIFICATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC RISK; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE ENVIRONMENT INTERACTION; HERITABILITY; HUMAN; MULTIFACTORIAL INHERITANCE; NEXT GENERATION SEQUENCING; NONHUMAN; PATHOGENESIS; REVIEW; SCHIZOPHRENIA; GENETICS;

EID: 85010686603     PISSN: 15622975     EISSN: 18141412     Source Type: Journal    
DOI: 10.1080/15622975.2016.1268715     Document Type: Review
Times cited : (51)

References (112)
  • 1
    • 84865957688 scopus 로고    scopus 로고
    • 15q11.2 proximal imbalances associated with a diverse array of neuropsychiatric disorders and mild dysmorphic features
    • Abdelmoity AT, LePichon J-B, Nyp SS, Soden SE, Daniel CA, Yu S., 2012. 15q11.2 proximal imbalances associated with a diverse array of neuropsychiatric disorders and mild dysmorphic features. J Dev Behav Pediatr. 33:570–576.
    • (2012) J Dev Behav Pediatr , vol.33 , pp. 570-576
    • Abdelmoity, A.T.1    LePichon, J.-B.2    Nyp, S.S.3    Soden, S.E.4    Daniel, C.A.5    Yu, S.6
  • 2
    • 84858440288 scopus 로고    scopus 로고
    • Reduced Chrna7 expression in mice is associated with decreases in hippocampal markers of inhibitory function: implications for neuropsychiatric diseases
    • Adams CE, Yonchek JC, Schulz KM, Graw SL, Stitzel J, Teschke PU, Stevens KE., 2012. Reduced Chrna7 expression in mice is associated with decreases in hippocampal markers of inhibitory function:implications for neuropsychiatric diseases. Neuroscience. 207:274–282.
    • (2012) Neuroscience , vol.207 , pp. 274-282
    • Adams, C.E.1    Yonchek, J.C.2    Schulz, K.M.3    Graw, S.L.4    Stitzel, J.5    Teschke, P.U.6    Stevens, K.E.7
  • 4
    • 84911397798 scopus 로고    scopus 로고
    • Epigenetic mechanisms in schizophrenia
    • Akbarian S., 2014. Epigenetic mechanisms in schizophrenia. Dialogues Clin Neurosci. 16:405–417.
    • (2014) Dialogues Clin Neurosci , vol.16 , pp. 405-417
    • Akbarian, S.1
  • 5
    • 0023913272 scopus 로고
    • Partial trisomy chromosome 5 cosegregating with schizophrenia
    • Bassett AS, McGillivray BC, Jones BD, Pantzar JT., 1988. Partial trisomy chromosome 5 cosegregating with schizophrenia. Lancet. 1:799–801.
    • (1988) Lancet , vol.1 , pp. 799-801
    • Bassett, A.S.1    McGillivray, B.C.2    Jones, B.D.3    Pantzar, J.T.4
  • 7
    • 0034060459 scopus 로고    scopus 로고
    • Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics
    • Cardno AG, Gottesman II., 2000. Twin studies of schizophrenia:from bow-and-arrow concordances to star wars Mx and functional genomics. Am J Med Genet. 97:12–17.
    • (2000) Am J Med Genet , vol.97 , pp. 12-17
    • Cardno, A.G.1    Gottesman, I.I.2
  • 8
    • 84997770295 scopus 로고    scopus 로고
    • Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
    • CNV and Schizophrenia Working Groups of the Psychiatric Genomics Consortium, Psychosis Endophenotypes International Consortium. 2016. Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nat Genet. doi:10.1038/ng.3725 [Epub ahead of print].
    • (2016) Nat Genet
  • 11
    • 84902577447 scopus 로고    scopus 로고
    • Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations
    • EU-GEI. 2014. Identifying gene-environment interactions in schizophrenia:contemporary challenges for integrated, large-scale investigations. Schizophr Bull. 40:729–736.
    • (2014) Schizophr Bull , vol.40 , pp. 729-736
  • 14
    • 84919385896 scopus 로고    scopus 로고
    • Specific and common genes implicated across major mental disorders: a review of meta-analysis studies
    • Gatt JM, Burton KL, Williams LM, Schofield PR., 2015. Specific and common genes implicated across major mental disorders:a review of meta-analysis studies. J Psychiatr Res. 60:1–13.
    • (2015) J Psychiatr Res , vol.60 , pp. 1-13
    • Gatt, J.M.1    Burton, K.L.2    Williams, L.M.3    Schofield, P.R.4
  • 22
    • 85029178981 scopus 로고
    • Pagon R.A., Adam M.P., Ardinger H.H., Wallace S.E., Amemiya A., Bean L.J.H., (eds), Seattle, WA: GeneReviews(R)
    • Haldeman-Englert CR, Jewett T., 1993–2016. 1q21.1 Recurrent Microdeletion. In Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, et al., editors. Seattle, WA:GeneReviews(R).
    • (1993) 1q21.1 Recurrent Microdeletion
    • Haldeman-Englert, C.R.1    Jewett, T.2
  • 23
    • 84878220679 scopus 로고    scopus 로고
    • Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC
    • Hamshere ML, Walters JT, Smith R, Richards AL, Green E, Grozeva D, Jones I, Forty L, Jones L, Gordon-Smith K, et al. 2013. Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC. Mol Psychiatry. 18:708–712.
    • (2013) Mol Psychiatry , vol.18 , pp. 708-712
    • Hamshere, M.L.1    Walters, J.T.2    Smith, R.3    Richards, A.L.4    Green, E.5    Grozeva, D.6    Jones, I.7    Forty, L.8    Jones, L.9    Gordon-Smith, K.10
  • 27
    • 51649107017 scopus 로고    scopus 로고
    • Rare chromosomal deletions and duplications increase risk of schizophrenia
    • International Schizophrenia Consortium. 2008. Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature. 455:237–241.
    • (2008) Nature , vol.455 , pp. 237-241
  • 28
    • 68449086236 scopus 로고    scopus 로고
    • Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
    • International Schizophrenia Consortium, Purcell SM, Wray NR, Stone JL, Visscher PM, O'Donovan MC, Sullivan PF, Sklar P., 2009. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature. 460:748–752.
    • (2009) Nature , vol.460 , pp. 748-752
    • Purcell, S.M.1    Wray, N.R.2    Stone, J.L.3    Visscher, P.M.4    O'Donovan, M.C.5    Sullivan, P.F.6    Sklar, P.7
  • 29
    • 84866616686 scopus 로고    scopus 로고
    • Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia
    • Irish Schizophrenia Genomics Consortium and the Wellcome Trust Case Control Consortium 2. 2012. Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia. Biol Psychiatry. 72:620–628.
    • (2012) Biol Psychiatry , vol.72 , pp. 620-628
  • 31
    • 34247531449 scopus 로고    scopus 로고
    • Gene-environment correlations: a review of the evidence and implications for prevention of mental illness
    • Jaffee SR, Price TS., 2007. Gene-environment correlations:a review of the evidence and implications for prevention of mental illness. Mol Psychiatry. 12:432–442.
    • (2007) Mol Psychiatry , vol.12 , pp. 432-442
    • Jaffee, S.R.1    Price, T.S.2
  • 32
    • 84937916250 scopus 로고    scopus 로고
    • Neurexin 1 (NRXN1) splice isoform expression during human neocortical development and aging
    • Jenkins AK, Paterson C, Wang Y, Hyde TM, Kleinman JE, Law AJ., 2016. Neurexin 1 (NRXN1) splice isoform expression during human neocortical development and aging. Mol Psychiatry. 21:701–706.
    • (2016) Mol Psychiatry , vol.21 , pp. 701-706
    • Jenkins, A.K.1    Paterson, C.2    Wang, Y.3    Hyde, T.M.4    Kleinman, J.E.5    Law, A.J.6
  • 33
    • 84922233014 scopus 로고    scopus 로고
    • Joint history of the nature of genetic variation and the nature of schizophrenia
    • Kendler KSA., 2015. Joint history of the nature of genetic variation and the nature of schizophrenia. Mol Psychiatry. 20:77–83.
    • (2015) Mol Psychiatry , vol.20 , pp. 77-83
    • Kendler, K.S.A.1
  • 40
    • 79952710338 scopus 로고    scopus 로고
    • Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications
    • Levinson DF, Duan J, Oh S, Wang K, Sanders AR, Shi J, Zhang N, Mowry BJ, Olincy A, Amin F, et al. 2011. Copy number variants in schizophrenia:confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications. Am J Psychiatry. 168:302–316.
    • (2011) Am J Psychiatry , vol.168 , pp. 302-316
    • Levinson, D.F.1    Duan, J.2    Oh, S.3    Wang, K.4    Sanders, A.R.5    Shi, J.6    Zhang, N.7    Mowry, B.J.8    Olincy, A.9    Amin, F.10
  • 42
    • 58149464318 scopus 로고    scopus 로고
    • Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study
    • Lichtenstein P, Yip BH, Björk C, Pawitan Y, Cannon TD, Sullivan PF, Hultman CM., 2009. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families:a population-based study. Lancet. 373:234–239.
    • (2009) Lancet , vol.373 , pp. 234-239
    • Lichtenstein, P.1    Yip, B.H.2    Björk, C.3    Pawitan, Y.4    Cannon, T.D.5    Sullivan, P.F.6    Hultman, C.M.7
  • 43
    • 84858434210 scopus 로고    scopus 로고
    • CNVs: harbingers of a rare variant revolution in psychiatric genetics
    • Malhotra D, Sebat J., 2012. CNVs:harbingers of a rare variant revolution in psychiatric genetics. Cell. 148:1223–1241.
    • (2012) Cell , vol.148 , pp. 1223-1241
    • Malhotra, D.1    Sebat, J.2
  • 44
    • 84860791082 scopus 로고    scopus 로고
    • Why schizophrenia genetics needs epigenetics: a review
    • Maric NP, Svrakic DM., 2012. Why schizophrenia genetics needs epigenetics:a review. Psychiatr Danub. 24:2–18.
    • (2012) Psychiatr Danub , vol.24 , pp. 2-18
    • Maric, N.P.1    Svrakic, D.M.2
  • 48
    • 0034235003 scopus 로고    scopus 로고
    • Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia
    • Millar JK, Christie S, Semple CA, Porteous DJ., 2000. Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia. Genomics. 67:69–77.
    • (2000) Genomics , vol.67 , pp. 69-77
    • Millar, J.K.1    Christie, S.2    Semple, C.A.3    Porteous, D.J.4
  • 50
    • 84886295886 scopus 로고    scopus 로고
    • Molecular genetic gene-environment studies using candidate genes in schizophrenia: A systematic review
    • Modinos G, Iyegbe C, Prata D, Rivera M, Kempton MJ, Valmaggia LR, et al. 2013. Molecular genetic gene-environment studies using candidate genes in schizophrenia:A systematic review. Schizophr Res. 150:356–365.
    • (2013) Schizophr Res , vol.150 , pp. 356-365
    • Modinos, G.1    Iyegbe, C.2    Prata, D.3    Rivera, M.4    Kempton, M.J.5    Valmaggia, L.R.6
  • 51
    • 18344396274 scopus 로고    scopus 로고
    • Strategy for investigating interactions between measured genes and measured environments
    • Moffitt TE, Caspi A, Rutter M., 2005. Strategy for investigating interactions between measured genes and measured environments. Arch Gen Psychiatry. 62:473–481.
    • (2005) Arch Gen Psychiatry , vol.62 , pp. 473-481
    • Moffitt, T.E.1    Caspi, A.2    Rutter, M.3
  • 61
  • 64
    • 12344274135 scopus 로고    scopus 로고
    • Expanding the 'central dogma': the regulatory role of nonprotein coding genes and implications for the genetic liability to schizophrenia
    • Perkins DO, Jeffries C, Sullivan P., 2005. Expanding the 'central dogma':the regulatory role of nonprotein coding genes and implications for the genetic liability to schizophrenia. Mol Psychiatry. 10:69–78.
    • (2005) Mol Psychiatry , vol.10 , pp. 69-78
    • Perkins, D.O.1    Jeffries, C.2    Sullivan, P.3
  • 69
    • 84898732566 scopus 로고    scopus 로고
    • Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system
    • Randall AD, Kurihara M, Brandon NJ, Brown JT., 2014. Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system. Eur J Neurosci. 39:1068–1073.
    • (2014) Eur J Neurosci , vol.39 , pp. 1068-1073
    • Randall, A.D.1    Kurihara, M.2    Brandon, N.J.3    Brown, J.T.4
  • 74
    • 33644821448 scopus 로고    scopus 로고
    • Gene-environment interplay and psychopathology: multiple varieties but real effects
    • Rutter M, Moffitt TE, Caspi A., 2006. Gene-environment interplay and psychopathology:multiple varieties but real effects. J Child Psychol Psychiatry. 47:226–261.
    • (2006) J Child Psychol Psychiatry , vol.47 , pp. 226-261
    • Rutter, M.1    Moffitt, T.E.2    Caspi, A.3
  • 77
    • 80053384370 scopus 로고    scopus 로고
    • Genome-wide association study identifies five new schizophrenia loci
    • Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium. 2011. Genome-wide association study identifies five new schizophrenia loci. Nat Genet. 43:969–976.
    • (2011) Nat Genet , vol.43 , pp. 969-976
  • 78
    • 84904804929 scopus 로고    scopus 로고
    • Biological insights from 108 schizophrenia-associated genetic loci
    • Schizophrenia Working Group of the Psychiatric Genomics Consortium. 2014. Biological insights from 108 schizophrenia-associated genetic loci. Nature. 511:421–427.
    • (2014) Nature , vol.511 , pp. 421-427
  • 79
    • 84975109840 scopus 로고    scopus 로고
    • Consensus paper of the WFSBP task force on biological markers: criteria for biomarkers and endophenotypes of schizophrenia part II: cognition, neuroimaging and genetics
    • Schmitt A, Rujescu D, Gawlik M, Hasan A, Hashimoto K, Iceta S, Jarema M, Kambeitz J, Kasper S, Keeser D, WFSBP Task Force on Biological Markers, et al. 2016. Consensus paper of the WFSBP task force on biological markers:criteria for biomarkers and endophenotypes of schizophrenia part II:cognition, neuroimaging and genetics. World J Biol Psychiatry. 17:406–428.
    • (2016) World J Biol Psychiatry , vol.17 , pp. 406-428
    • Schmitt, A.1    Rujescu, D.2    Gawlik, M.3    Hasan, A.4    Hashimoto, K.5    Iceta, S.6    Jarema, M.7    Kambeitz, J.8    Kasper, S.9    Keeser, D.10
  • 80
    • 84901937317 scopus 로고    scopus 로고
    • Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: results from the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome
    • Schneider M, Debbané M, Bassett AS, Chow EW, Fung WL, van den Bree M, Owen M, Murphy KC, Niarchou M, Kates WR, International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome, et al. 2014. Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome:results from the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome. Am J Psychiatry. 171:627–639.
    • (2014) Am J Psychiatry , vol.171 , pp. 627-639
    • Schneider, M.1    Debbané, M.2    Bassett, A.S.3    Chow, E.W.4    Fung, W.L.5    van den Bree, M.6    Owen, M.7    Murphy, K.C.8    Niarchou, M.9    Kates, W.R.10
  • 81
    • 10644253628 scopus 로고    scopus 로고
    • A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders
    • Shih RA, Belmonte PL, Zandi PP., 2004. A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders. IntRev Psychiatry. 16:260–283.
    • (2004) IntRev Psychiatry , vol.16 , pp. 260-283
    • Shih, R.A.1    Belmonte, P.L.2    Zandi, P.P.3
  • 87
    • 84889584327 scopus 로고    scopus 로고
    • 22q11 deletion syndrome: a review of the neuropsychiatric features and their neurobiological basis
    • Squarcione C, Torti MC, Di Fabio F, Biondi M., 2013. 22q11 deletion syndrome:a review of the neuropsychiatric features and their neurobiological basis. Neuropsychiatr Dis Treat. 9:1873–1884.
    • (2013) Neuropsychiatr Dis Treat , vol.9 , pp. 1873-1884
    • Squarcione, C.1    Torti, M.C.2    Di Fabio, F.3    Biondi, M.4
  • 93
    • 0344305525 scopus 로고    scopus 로고
    • Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies
    • Sullivan PF, Kendler KS, Neale MC., 2003. Schizophrenia as a complex trait:evidence from a meta-analysis of twin studies. Arch Gen Psychiatry. 60:1187–1192.
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 1187-1192
    • Sullivan, P.F.1    Kendler, K.S.2    Neale, M.C.3
  • 96
    • 84928295107 scopus 로고    scopus 로고
    • Epigenetics, a key for unlocking complex CNS disorders? Therapeutic implications
    • Szyf M., 2015. Epigenetics, a key for unlocking complex CNS disorders? Therapeutic implications. Eur Neuropsychopharmacol. 25:682–702.
    • (2015) Eur Neuropsychopharmacol , vol.25 , pp. 682-702
    • Szyf, M.1
  • 97
    • 84904460857 scopus 로고    scopus 로고
    • Gene-environment interactions in severe mental illness
    • Uher R., 2014. Gene-environment interactions in severe mental illness. Front Psychiatry. 5:48
    • (2014) Front Psychiatry , vol.5 , pp. 48
    • Uher, R.1
  • 98
    • 84874217052 scopus 로고    scopus 로고
    • The evolutionary paradox and the missing heritability of schizophrenia
    • van Dongen J, Boomsma DI., 2013. The evolutionary paradox and the missing heritability of schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 162B:122–136.
    • (2013) Am J Med Genet B Neuropsychiatr Genet , vol.162B , pp. 122-136
    • van Dongen, J.1    Boomsma, D.I.2
  • 99
    • 69949099211 scopus 로고    scopus 로고
    • Gene-environment-wide interaction studies in psychiatry
    • van Os J, Rutten BPF., 2009. Gene-environment-wide interaction studies in psychiatry. Am J Psychiatry. 166:964–966.
    • (2009) Am J Psychiatry , vol.166 , pp. 964-966
    • van Os, J.1    Rutten, B.P.F.2
  • 100
    • 54249166128 scopus 로고    scopus 로고
    • Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions
    • van Os J, Rutten BPF, Poulton R., 2008. Gene-environment interactions in schizophrenia:review of epidemiological findings and future directions. Schizophr Bull. 34:1066–1082.
    • (2008) Schizophr Bull , vol.34 , pp. 1066-1082
    • van Os, J.1    Rutten, B.P.F.2    Poulton, R.3
  • 101
    • 54249120358 scopus 로고    scopus 로고
    • Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction
    • van Winkel R, Stefanis NC, Myin-Germeys I., 2008. Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction. Schizophr Bull. 34:1095–1105.
    • (2008) Schizophr Bull , vol.34 , pp. 1095-1105
    • van Winkel, R.1    Stefanis, N.C.2    Myin-Germeys, I.3
  • 103
    • 84898736761 scopus 로고    scopus 로고
    • Revisiting schizophrenia linkage data in the NIMH Repository: reanalysis of regularized data across multiple studies
    • Vieland VJ, Walters KA, Lehner T, Azaro M, Tobin K, Huang Y, Brzustowicz LM., 2014. Revisiting schizophrenia linkage data in the NIMH Repository:reanalysis of regularized data across multiple studies. Am J Psychiatry. 171:350–359.
    • (2014) Am J Psychiatry , vol.171 , pp. 350-359
    • Vieland, V.J.1    Walters, K.A.2    Lehner, T.3    Azaro, M.4    Tobin, K.5    Huang, Y.6    Brzustowicz, L.M.7
  • 105
    • 0043093697 scopus 로고    scopus 로고
    • Transposable elements: targets for early nutritional effects on epigenetic gene regulation
    • Waterland RA, Jirtle RL., 2003. Transposable elements:targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. 23:5293–5300.
    • (2003) Mol Cell Biol , vol.23 , pp. 5293-5300
    • Waterland, R.A.1    Jirtle, R.L.2
  • 107
    • 17444403604 scopus 로고    scopus 로고
    • Phenotypic differences in genetically identical organisms: the epigenetic perspective
    • Wong AH, Gottesman II, Petronis A., 2005. Phenotypic differences in genetically identical organisms:the epigenetic perspective. Hum Mol Genet. 14:R11–18.
    • (2005) Hum Mol Genet , vol.14 , pp. R11-R18
    • Wong, A.H.1    Gottesman, I.I.2    Petronis, A.3
  • 108
    • 84869025817 scopus 로고    scopus 로고
    • Using summary data from the danish national registers to estimate heritabilities for schizophrenia, bipolar disorder, and major depressive disorder
    • Wray NR, Gottesman II., 2012. Using summary data from the danish national registers to estimate heritabilities for schizophrenia, bipolar disorder, and major depressive disorder. Front Genet. 3:118.
    • (2012) Front Genet , vol.3 , pp. 118
    • Wray, N.R.1    Gottesman, I.I.2
  • 110


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.