Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: Structures, functions and roles in disease

Biochemical Journal

Volumn 441, Issue 1, 2012, Pages 39-59

  Teasdale, Rohan D ^a   Collins, Brett M ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Alzheimer's disease; Endosome; Phosphoinositide; Phox homology domain (PX domain); Retromer; Sorting nexin (SNX)

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; LIPID BINDING PROTEIN; MEMBRANE PROTEIN; PHOSPHATIDYLINOSITIDE; PHOX HOMOLOGY DOMAIN PROTEIN; PROTEIN; PROTEOME; PTDINS3P PROTEIN; SORTING NEXIN; SORTING NEXIN 1; SORTING NEXIN 14; SORTING NEXIN 16; SORTING NEXIN 17; SORTING NEXIN 18; SORTING NEXIN 19; SORTING NEXIN 2; SORTING NEXIN 22; SORTING NEXIN 25; SORTING NEXIN 27; SORTING NEXIN 29; SORTING NEXIN 3; SORTING NEXIN 30; SORTING NEXIN 31; SORTING NEXIN 32; SORTING NEXIN 33; SORTING NEXIN 4; SORTING NEXIN 5; SORTING NEXIN 6; SORTING NEXIN 9; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; BREAST CANCER; CANCER RISK; COLON CANCER; ENDOCYTOSIS; EPILEPSY; HEART INFARCTION; INFLAMMATION; JACOBSEN SYNDROME; LUNG NON SMALL CELL CANCER; METASTASIS; MYELOID LEUKEMIA; OSTEOARTHRITIS; OVARY CANCER; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; GENE EXPRESSION REGULATION; HUMANS; LIPID METABOLISM; MAMMALS; MULTIGENE FAMILY; PHOSPHATIDYLINOSITOLS; SORTING NEXINS;

EID: 84055185227     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20111226     Document Type: Review

References (223)

1. Cole, C., Barber, J. D. and Barton, G. J. (2008) The Jpred 3 secondary structure prediction server. Nucleic Acids Res. 36, W197-W201
2. Gouet, P., Courcelle, E., Stuart, D. I. and Metoz, F. (1999) ESPript: analysis of multiple sequence alignments in PostScript. Bioinformatics 15, 305-308 (Pubitemid 29213756)
3. Haft, C. R., de la Luz Sierra, M., Bafford, R., Lesniak, M. A., Barr, V. A. and Taylor, S. I. (2000) Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Mol. Biol. Cell 11, 4105-4116
4. Kurten, R. C., Eddington, A. D., Chowdhury, P., Smith, R. D., Davidson, A. D. and Shank, B. B. (2001) Self-assembly and binding of a sorting nexin to sorting endosomes. J. Cell Sci. 114, 1743-1756 (Pubitemid 32454672)
5. Wassmer, T., Attar, N., Harterink, M., Weering, J. R., Traer, C. J., Oakley, J., Goud, B., Stephens, D. J., Korswagen, H. C. and Cullen, P. J. (2009) The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev. Cell 17, 110-122
6. Haft, C. R., de la Luz Sierra, M., Barr, V. A., Haft, D. H. and Taylor, S. I. (1998) Identification of a family of sorting nexin molecules and characterization of their association with receptors. Mol. Cell. Biol. 18, 7278-7287
7. Rojas, R., Kametaka, S., Haft, C. R. and Bonifacino, J. S. (2007) Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. Mol. Cell. Biol. 27, 1112-1124 (Pubitemid 46174571)
8. Glued and mediates endosome-to-TGN transport. Cell Res. 19, 1334-1349
9. Kerr, M. C., Lindsay, M. R., Luetterforst, R., Hamilton, N., Simpson, F., Parton, R. G., Gleeson, P. A. and Teasdale, R. D. (2006) Visualisation of macropinosome maturation by the recruitment of sorting nexins. J. Cell Sci. 119, 3967-3980 (Pubitemid 44650870)
10. Liu, H., Liu, Z. Q., Chen, C. X., Magill, S., Jiang, Y. and Liu, Y. J. (2006) Inhibitory regulation of EGF receptor degradation by sorting nexin 5. Biochem. Biophys. Res. Commun. 342, 537-546 (Pubitemid 43289024)
11. Parks, W. T., Frank, D. B., Huff, C., Renfrew Haft, C., Martin, J., Meng, X., de Caestecker, M. P., McNally, J. G., Reddi, A., Taylor, S. I. et al. (2001) Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-β family of receptor serine-threonine kinases. J. Biol. Chem. 276, 19332-19339 (Pubitemid 37411268)
12. Yoon, T., Kim, M. and Lee, K. (2006) Inhibition of Na,K-ATPase- suppressive activity of translationally controlled tumor protein by sorting nexin 6. FEBS Lett. 580, 3558-3564 (Pubitemid 43795894)
13. Kurten, R. C., Cadena, D. L. and Gill, G. N. (1996) Enhanced degradation of EGF receptors by a sorting nexin, SNX1. Science 272, 1008-1010 (Pubitemid 26259317)
14. Heydorn, A., Sondergaard, B. P., Hadrup, N., Holst, B., Haft, C. R. and Schwartz, T. W. (2004) Distinct in vitro interaction pattern of dopamine receptor subtypes with adaptor proteins involved in post-endocytotic receptor targeting. FEBS Lett. 556, 276-280 (Pubitemid 38058592)
15. Heydorn, A., Sondergaard, B. P., Ersboll, B., Holst, B., Nielsen, F. C., Haft, C. R., Whistler, J. and Schwartz, T. W. (2004) A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP). J. Biol. Chem. 279, 54291-54303 (Pubitemid 40053167)
16. Williams, R., Schluter, T., Roberts, M. S., Knauth, P., Bohnensack, R. and Cutler, D. F. (2004) Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin. Mol. Biol. Cell 15, 3095-3105 (Pubitemid 38850107)
17. Chin, L. S., Raynor, M. C., Wei, X., Chen, H. Q. and Li, L. (2001) Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor. J. Biol. Chem. 276, 7069-7078
18. Popoff, V., Mardones, G. A., Bai, S. K., Chambon, V., Tenza, D., Burgos, P. V., Shi, A., Benaroch, P., Urbé, S., Lamaze, C. et al. (2009) Analysis of articulation between clathrin and retromer in retrograde sorting on early endosomes. Traffic 10, 1868-1880
19. Gullapalli, A., Garrett, T. A., Paing, M. M., Griffin, C. T., Yang, Y. and Trejo, J. (2004) A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking. Mol. Biol. Cell 15, 2143-2155 (Pubitemid 38580634)
20. Harterink, M., Port, F., Lorenowicz, M. J., McGough, I. J., Silhankova, M., Betist, M. C., van Weering, J. R., van Heesbeen, R. G., Middelkoop, T. C., Basler, K. et al. (2011) A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nat. Cell Biol. 13, 914-923
21. Skanland, S. S., Walchli, S., Brech, A. and Sandvig, K. (2009) SNX4 in complex with clathrin and dynein: implications for endosome movement. PLoS ONE 4, e5935
22. Pons, V., Hullin-Matsuda, F., Nauze, M., Barbaras, R., Peres, C., Collet, X., Perret, B., Chap, H. and Gassama-Diagne, A. (2003) Enterophilin-1, a new partner of sorting nexin 1, decreases cell surface epidermal growth factor receptor. J. Biol. Chem. 278, 21155-21161 (Pubitemid 36806429)
23. Shi, A., Sun, L., Banerjee, R., Tobin, M., Zhang, Y. and Grant, B. D. (2009) Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein RME-8. EMBO J. 28, 3290-3302
24. Piek, E., Van Dinther, M., Parks, W. T., Sallee, J. M., Bottinger, E. P., Roberts, A. B. and Ten Dijke, P. (2004) RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-β (TGF-β) target gene that negatively regulates transcriptional activity induced by TGF-β. Biochem. J. 383, 187-199 (Pubitemid 39389465)
25. Prosser, D. C., Tran, D., Schooley, A., Wendland, B. and Ngsee, J. K. (2010) A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling. Traffic 11, 1347-1362
26. Gomez, T. S. and Billadeau, D. D. (2009) A FAM21-containing WASH complex regulates retromer-dependent sorting. Dev. Cell 17, 699-711
27. Harbour, M. E., Breusegem, S. Y., Antrobus, R., Freeman, C., Reid, E. and Seaman, M. N. (2010) The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics. J. Cell Sci. 123, 3703-3717
28. Schaaf, C. P., Benzing, J., Schmitt, T., Erz, D. H., Tewes, M., Bartram, C. R. and Janssen, J. W. (2005) Novel interaction partners of the TPR/MET tyrosine kinase. FASEB J. 19, 267-269 (Pubitemid 40189277)
29. Fuchs, U., Rehkamp, G., Haas, O. A., Slany, R., Konig, M., Bojesen, S., Bohle, R. M., Damm-Welk, C., Ludwig, W. D., Harbott, J. and Borkhardt, A. (2001) The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia. Proc. Natl. Acad. Sci. U.S.A. 98, 8756-8761 (Pubitemid 32678100)
30. Abdul-Ghani, M., Hartman, K. L. and Ngsee, J. K. (2005) Abstrakt interacts with and regulates the expression of sorting nexin-2. J. Cell. Physiol. 204, 210-218 (Pubitemid 40776824)
31. Traer, C. J., Rutherford, A. C., Palmer, K. J., Wassmer, T., Oakley, J., Attar, N., Carlton, J. G., Kremerskothen, J., Stephens, D. J. and Cullen, P. J. (2007) SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment. Nat. Cell Biol. 9, 1370-1380 (Pubitemid 350201750)
32. Wang, X., Venable, J., LaPointe, P., Hutt, D. M., Koulov, A. V., Coppinger, J., Gurkan, C., Kellner, W., Matteson, J., Plutner, H. et al. (2006) Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Cell 127, 803-815 (Pubitemid 44716255)
33. Leprince, C., Le Scolan, E., Meunier, B., Fraisier, V., Brandon, N., De Gunzburg, J. and Camonis, J. (2003) Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking. J. Cell Sci. 116, 1937-1948 (Pubitemid 36622292)
34. Towler, M. C., Gleeson, P. A., Hoshino, S., Rahkila, P., Manalo, V., Ohkoshi, N., Ordahl, C., Parton, R. G. and Brodsky, F. M. (2004) Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration. Mol. Biol. Cell 15, 3181-3195 (Pubitemid 38850115)
35. Hara, S., Kiyokawa, E., Iemura, S., Natsume, T., Wassmer, T., Cullen, P. J., Hiai, H. and Matsuda, M. (2008) The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport. Mol. Biol. Cell 19, 3823-3835
36. Otsuki, T., Kajigaya, S., Ozawa, K. and Liu, J. M. (1999) SNX5, a new member of the sorting nexin family, binds to the Fanconi anemia complementation group A protein. Biochem. Biophys. Res. Commun. 265, 630-635
37. Reuter, T. Y., Medhurst, A. L., Waisfisz, Q., Zhi, Y., Herterich, S., Hoehn, H., Gross, H. J., Joenje, H., Hoatlin, M. E., Mathew, C. G. and Huber, P. A. (2003) Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. Exp. Cell Res. 289, 211-221 (Pubitemid 37117407)
38. Yoo, K. W., Kim, E. H., Jung, S. H., Rhee, M., Koo, B. K., Yoon, K. J., Kong, Y. Y. and Kim, C. H. (2006) Snx5, as a Mind bomb-binding protein, is expressed in hematopoietic and endothelial precursor cells in zebrafish. FEBS Lett. 580, 4409-4416 (Pubitemid 44118261)
39. Hao, X., Wang, Y., Ren, F., Zhu, S., Ren, Y., Jia, B., Li, Y. P., Shi, Y. and Chang, Z. (2011) SNX25 regulates TGF-β signaling by enhancing the receptor degradation. Cell. Signal. 23, 935-946
40. Okada, H., Zhang, W., Peterhoff, C., Hwang, J. C., Nixon, R. A., Ryu, S. H. and Kim, T. W. (2010) Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing. FASEB J. 24, 2783-2794
41. Cavet, M. E., Pang, J., Yin, G. and Berk, B. C. (2008) An epidermal growth factor (EGF)-dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor. FASEB J. 22, 3607-3616
42. Ishibashi, Y., Maita, H., Yano, M., Koike, N., Tamai, K., Ariga, H. and Iguchi-Ariga, S. M. (2001) Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus. FEBS Lett. 506, 33-38 (Pubitemid 32925227)
43. Fuster, J. J., Gonzalez, J. M., Edo, M. D., Viana, R., Boya, P., Cervera, J., Verges, M., Rivera, J. and Andres, V. (2010) Tumor suppressor p27Kip1 undergoes endolysosomal degradation through its interaction with sorting nexin 6. FASEB J. 24, 2998-3009
44. Rivera, J., Megías, D. and Bravo, J. (2010) Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression. J. Cell. Biochem. 111, 1464-1472
45. Sowa, M. E., Bennett, E. J., Gygi, S. P. and Harper, J. W. (2009) Defining the human deubiquitinating enzyme interaction landscape. Cell 138, 389-403
46. Wu, C., Ma, M. H., Brown, K. R., Geisler, M., Li, L., Tzeng, E., Jia, C. Y., Jurisica, I. and Li, S. S. (2007) Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. Proteomics 7, 1775-1785 (Pubitemid 46910998)
47. Pylypenko, O., Lundmark, R., Rasmuson, E., Carlsson, S. R. and Rak, A. (2007) The PX-BAR membrane-remodeling unit of sorting nexin 9. EMBO J. 26, 4788-4800 (Pubitemid 350126794)
48. Wang, Q., Kaan, H. Y., Hooda, R. N., Goh, S. L. and Sondermann, H. (2008) Structure and plasticity of endophilin and sorting nexin 9. Structure 16, 1574-1587
49. Childress, C., Lin, Q. and Yang, W. (2006) Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2. Biochem. J. 394, 693-698
50. Shin, N., Lee, S., Ahn, N., Kim, S. A., Ahn, S. G., YongPark, Z. and Chang, S. (2007) Sorting nexin 9 interacts with dynamin 1 and N-WASP and coordinates synaptic vesicle endocytosis. J. Biol. Chem. 282, 28939-28950 (Pubitemid 47606053)
51. Park, S., Kim, Y., Lee, S., Park, P., Park, Z., Sun, W., Kim, H. and Chang, S. (2010) SNX18 shares a redundant role with SNX9 and modulates endoctyic trafficking at the plasma membrane. J. Cell Sci. 123, 1742-1750
52. Zhang, J., Zhang, X., Guo, Y., Xu, L. and Pei, D. (2009) Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein. J. Biol. Chem. 284, 21659-21669
53. Howard, L., Nelson, K. K., Maciewicz, R. A. and Blobel, C. P. (1999) Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. J. Biol. Chem. 274, 31693-31699
54. Macaulay, S. L., Stoichevska, V., Grusovin, J., Gough, K. H., Castelli, L. A. and Ward, C. W. (2003) Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action. Biochem. J. 376, 123-134 (Pubitemid 37487208)
55. Lundmark, R. and Carlsson, S. R. (2002) The β-appendages of the four adaptor-protein (AP) complexes: structure and binding properties, and identification of sorting nexin 9 as an accessory protein to AP-2. Biochem. J. 362, 597-607 (Pubitemid 34242310)
56. Lundmark, R. and Carlsson, S. R. (2003) Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components. J. Biol. Chem. 278, 46772-46781 (Pubitemid 37452256)
57. Lundmark, R. and Carlsson, S. R. (2004) Regulated membrane recruitment of dynamin-2 mediated by sorting nexin 9. J. Biol. Chem. 279, 42694-42702 (Pubitemid 39372155)
58. Soulet, F., Yarar, D., Leonard, M. and Schmid, S. L. (2005) SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. Mol. Biol. Cell 16, 2058-2067 (Pubitemid 40471971)
59. Shin, N., Ahn, N., Chang-Ileto, B., Park, J., Takei, K., Ahn, S. G., Kim, S. A., Di Paolo, G. and Chang, S. (2008) SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2. J. Cell Sci. 121, 1252-1263 (Pubitemid 351753509)
60. Yeow-Fong, L., Lim, L. and Manser, E. (2005) SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1. FEBS Lett. 579, 5040-5048 (Pubitemid 41242850)
61. Miele, A. E., Watson, P. J., Evans, P. R., Traub, L. M. and Owen, D. J. (2004) Two distinct interaction motifs in amphiphysin bind two independent sites on the clathrin terminal domain β-propeller. Nat. Struct. Mol. Biol. 11, 242-248 (Pubitemid 38282769)
62. Baumann, C., Lindholm, C. K., Rimoldi, D. and Levy, F. (2010) The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain. FEBS J. 277, 2803-2814
63. Schulze, W. X. and Mann, M. (2004) A novel proteomic screen for peptide-protein interactions. J. Biol. Chem. 279, 10756-10764 (Pubitemid 38372689)
64. Badour, K., McGavin, M. K., Zhang, J., Freeman, S., Vieira, C., Filipp, D., Julius, M., Mills, G. B. and Siminovitch, K. A. (2007) Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells. Proc. Natl. Acad. Sci. U.S.A. 104, 1593-1598 (Pubitemid 46214635)
65. Lin, Q., Lo, C. G., Cerione, R. A. and Yang, W. (2002) The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation. J. Biol. Chem. 277, 10134-10138 (Pubitemid 34968125)
66. Yarar, D., Waterman-Storer, C. M. and Schmid, S. L. (2007) SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis. Dev. Cell 13, 43-56 (Pubitemid 46972030)
67. Rangarajan, E. S., Park, H., Fortin, E., Sygusch, J. and Izard, T. (2010) Mechanism of aldolase control of sorting nexin 9 function in endocytosis. J. Biol. Chem. 285, 11983-11990
68. Marches, O., Batchelor, M., Shaw, R. K., Patel, A., Cummings, N., Nagai, T., Sasakawa, C., Carlsson, S. R., Lundmark, R., Cougoule, C. et al. (2006) EspF of enteropathogenic Escherichia coli binds sorting nexin 9. J. Bacteriol. 188, 3110-3115
69. Alto, N. M., Weflen, A. W., Rardin, M. J., Yarar, D., Lazar, C. S., Tonikian, R., Koller, A., Taylor, S. S., Boone, C., Sidhu, S. S. et al. (2007) The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J. Cell Biol. 178, 1265-1278 (Pubitemid 47480231)
70. Dislich, B., Than, M. E. and Lichtenthaler, S. F. (2010) Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33. Biochem. J. 433, 75-83
71. Haberg, K., Lundmark, R. and Carlsson, S. R. (2008) SNX18 is an SNX9 paralog that acts as a membrane tubulator in AP-1-positive endosomal trafficking. J. Cell Sci. 121, 1495-1505 (Pubitemid 351936314)
72. Nakazawa, S., Gotoh, N., Matsumoto, H., Murayama, C., Suzuki, T. and Yamamoto, T. (2011) Expression of sorting nexin 18 (SNX18) is dynamically regulated in developing spinal motor neurons. J. Histochem. Cytochem. 59, 202-213
73. Karkkainen, S., Hiipakka, M., Wang, J. H., Kleino, I., Vaha-Jaakkola, M., Renkema, G. H., Liss, M., Wagner, R. and Saksela, K. (2006) Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome. EMBO Rep. 7, 186-191
74. Schobel, S., Neumann, S., Hertweck, M., Dislich, B., Kuhn, P. H., Kremmer, E., Seed, B., Baumeister, R., Haass, C. and Lichtenthaler, S. F. (2008) A novel sorting nexin modulates endocytic trafficking and α-secretase cleavage of the amyloid precursor protein. J. Biol. Chem. 283, 14257-14268
75. Abram, C. L., Seals, D. F., Pass, I., Salinsky, D., Maurer, L., Roth, T. M. and Courtneidge, S. A. (2003) The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. J. Biol. Chem. 278, 16844-16851 (Pubitemid 36799554)
76. Zhong, J. L., Poghosyan, Z., Pennington, C. J., Scott, X., Handsley, M. M., Warn, A., Gavrilovic, J., Honert, K., Kruger, A., Span, P. N. et al. (2008) Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma. Mol. Cancer Res. 6, 383-394 (Pubitemid 351416529)
77. Oikawa, T., Itoh, T. and Takenawa, T. (2008) Sequential signals toward podosome formation in NIH-src cells. J. Cell Biol. 182, 157-169 (Pubitemid 352008629)
78. Rufer, A. C., Rumpf, J., von Holleben, M., Beer, S., Rittinger, K. and Groemping, Y. (2009) Isoform-selective interaction of the adaptor protein Tks5/FISH with Sos1 and dynamins. J. Mol. Biol. 390, 939-950
79. Stylli, S. S., Stacey, T. T., Verhagen, A. M., Xu, S. S., Pass, I., Courtneidge, S. A. and Lock, P. (2009) Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation. J. Cell Sci. 122, 2727-2740
80. Thompson, O., Kleino, I., Crimaldi, L., Gimona, M., Saksela, K. and Winder, S. J. (2008) Dystroglycan, Tks5 and Src mediated assembly of podosomes in myoblasts. PLoS ONE 3, e3638
81. phox participate in activation of superoxide-producing NADPH oxidases. J. Biol. Chem. 278, 25234-25246
82. phox in the structural maturation and subcellular targeting of Nox3. Biochem. J. 403, 97-108
83. phox and NOXA1. PLoS ONE 5, e10478
84. Park, H. S., Park, D. and Bae, Y. S. (2006) Molecular interaction of NADPH oxidase 1 with βPix and Nox organizer 1. Biochem. Biophys. Res. Commun. 339, 985-990 (Pubitemid 41772908)
85. Yamamoto, A., Kami, K., Takeya, R. and Sumimoto, H. (2007) Interaction between the SH3 domains and C-terminal proline-rich region in NADPH oxidase organizer 1 (Noxo1). Biochem. Biophys. Res. Commun. 352, 560-565 (Pubitemid 44838523)
86. Valente, A. J., El Jamali, A., Epperson, T. K., Gamez, M. J., Pearson, D. W. and Clark, R. A. (2007) NOX1 NADPH oxidase regulation by the NOXA1 SH3 domain. Free Radic. Biol. Med. 43, 384-396 (Pubitemid 46977629)
87. phox of the neutrophil oxidase complex using the two-hybrid system. J. Biol. Chem. 270, 5695-5697
88. phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains. Biochem. J. 296, 557-561
89. phox. FEBS Lett. 385, 229-232
90. phox using the two-hybrid system. Biochim. Biophys. Acta 1312, 39-47
91. phox. Biochem. J. 317, 919-924
92. Wilson, L., Butcher, C., Finan, P. and Kellie, S. (1997) SH3 domain-mediated interactions involving the phox components of the NADPH oxidase. Inflamm. Res. 46, 265-271 (Pubitemid 27354738)
93. Grizot, S., Grandvaux, N., Fieschi, F., Faure, J., Massenet, C., Andrieu, J. P., Fuchs, A., Vignais, P. V., Timmins, P. A., Dagher, M. C. and Pebay-Peyroula, E. (2001) Small angle neutron scattering and gel filtration analyses of neutrophil NADPH oxidase cytosolic factors highlight the role of the C-terminal end of p47phox in the association with p40phox. Biochemistry 40, 3127-3133 (Pubitemid 32205356)
94. phox. J. Biol. Chem. 277, 10121-10128
95. phox SH3 domains. J. Biol. Chem. 280, 13752-13761
96. phox in B lymphocytes. J. Cell Sci. 112, 503-513
97. Grogan, A., Reeves, E., Keep, N., Wientjes, F., Totty, N. F., Burlingame, A. L., Hsuan, J. J. and Segal, A. W. (1997) Cytosolic phox proteins interact with and regulate the assembly of coronin in neutrophils. J. Cell Sci. 110, 3071-3081
98. phox bind to moesin through their PX domain. Biochem. Biophys. Res. Commun. 289, 382-388
99. phox PX domain of NADPH oxidase targets cell membrane via moesin-mediated association with the actin cytoskeleton. J. Cell. Biochem. 92, 795-809
100. phox. Biochem. Biophys. Res. Commun. 199, 1378-1387
101. phox. J. Exp. Med. 184, 893-902
102. phox, SH3 domain-containing cytosolic factors of the phagocyte NADPH oxidase. Eur. J. Biochem. 251, 583-589
103. Wilson, M. I., Gill, D. J., Perisic, O., Quinn, M. T. and Williams, R. L. (2003) PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62. Mol. Cell 12, 39-50 (Pubitemid 36957832)
104. phox, a phagocyte oxidase component, using a yeast two-hybrid system. Immunol. Lett. 68, 155-159
105. Hiroaki, H., Ago, T., Ito, T., Sumimoto, H. and Kohda, D. (2001) Solution structure of the PX domain, a target of the SH3 domain. Nat. Struct. Biol. 8, 526-530 (Pubitemid 32525012)
106. phox-PX domain of the assembled NADPH oxidase via a novel binding site in its C2 domain. J. Biol. Chem. 283, 31898-31908
107. phox participates in activation of RelA in endothelial cells. J. Biol. Chem. 278, 17210-17217
108. phox and mediates respiratory burst activity in human neutrophils. J. Immunol. 170, 5302-5308
109. phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells: role in NAD(P)H oxidase regulation by angiotensin II. Arterioscler. Thromb. Vasc. Biol. 25, 512-518
110. phox an organizer protein of NADPH oxidase. FEBS Lett. 580, 261-267
111. Finan, P., Shimizu, Y., Gout, I., Hsuan, J., Truong, O., Butcher, C., Bennett, P., Waterfield, M. D. and Kellie, S. (1994) An SH3 domain and proline-rich sequence mediate an interaction between two components of the phagocyte NADPH oxidase complex. J. Biol. Chem. 269, 13752-13755 (Pubitemid 24191115)
112. phox in cytosol of unstimulated human neutrophils. J. Biol. Chem. 269, 22405-22411
113. phox of the human neutrophil NADPH oxidase that are not required for activation in the cell-free system. J. Biol. Chem. 270, 11216-11221
114. phox. J. Biol. Chem. 271, 17013-17020
115. phox SH3 domain interactions in NADPH oxidase assembly and activation. Mol. Cell. Biol. 17, 2177-2185
116. phox. Arch. Biochem. Biophys. 444, 185-194
117. Sumimoto, H., Kage, Y., Nunoi, H., Sasaki, H., Nose, T., Fukumaki, Y., Ohno, M., Minakami, S. and Takeshige, K. (1994) Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase. Proc. Natl. Acad. Sci. U.S.A. 91, 5345-5349 (Pubitemid 24174323)
118. phox is required for activation of the NADPH oxidase. J. Biol. Chem. 271, 22152-22158
119. Liu, H., Nakazawa, T., Tezuka, T. and Yamamoto, T. (2006) Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP. J. Biol. Chem. 281, 23611-23619 (Pubitemid 44274136)
120. Chiang, S. H., Hwang, J., Legendre, M., Zhang, M., Kimura, A. and Saltiel, A. R. (2003) TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport. EMBO J. 22, 2679-2691 (Pubitemid 36712365)
121. Nakamura, T., Komiya, M., Sone, K., Hirose, E., Gotoh, N., Morii, H., Ohta, Y. and Mori, N. (2002) Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules. Mol. Cell. Biol. 22, 8721-8734 (Pubitemid 35397185)
122. Hayashi, T., Okabe, T., Nasu-Nishimura, Y., Sakaue, F., Ohwada, S., Matsuura, K., Akiyama, T. and Nakamura, T. (2007) PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development. Genes Cells 12, 929-939 (Pubitemid 47261988)
123. Okabe, T., Nakamura, T., Nishimura, Y. N., Kohu, K., Ohwada, S., Morishita, Y. and Akiyama, T. (2003) RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the β-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling. J. Biol. Chem. 278, 9920-9927 (Pubitemid 36800496)
124. Nakazawa, T., Watabe, A. M., Tezuka, T., Yoshida, Y., Yokoyama, K., Umemori, H., Inoue, A., Okabe, S., Manabe, T. and Yamamoto, T. (2003) p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-D-aspartate receptor signaling. Mol. Biol. Cell 14, 2921-2934 (Pubitemid 36871531)
125. Zhao, C., Ma, H., Bossy-Wetzel, E., Lipton, S. A., Zhang, Z. and Feng, G. S. (2003) GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. J. Biol. Chem. 278, 34641-34653 (Pubitemid 37553313)
126. Shang, X., Moon, S. Y. and Zheng, Y. (2007) p200 RhoGAP promotes cell proliferation by mediating cross-talk between Ras and Rho signaling pathways. J. Biol. Chem. 282, 8801-8811 (Pubitemid 47093525)
127. Nakamura, T., Hayashi, T., Mimori-Kiyosue, Y., Sakaue, F., Matsuura, K., Iemura, S., Natsume, T. and Akiyama, T. (2010) The PX-RICS-14-3-3ζ/θ complex couples N-cadherin-β-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum. J. Biol. Chem. 285, 16145-16154
128. Nakamura, T., Hayashi, T., Nasu-Nishimura, Y., Sakaue, F., Morishita, Y., Okabe, T., Ohwada, S., Matsuura, K. and Akiyama, T. (2008) PX-RICS mediates ER-to-Golgi transport of the N-cadherin/β-catenin complex. Genes Dev. 22, 1244-1256 (Pubitemid 351656582)
129. Florian, V., Schluter, T. and Bohnensack, R. (2001) A new member of the
130. Knauth, P., Schluter, T., Czubayko, M., Kirsch, C., Florian, V., Schreckenberger, S., Hahn, H. and Bohnensack, R. (2005) Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking. J. Mol. Biol. 347, 813-825 (Pubitemid 40357922)
131. Betts, G. N., van der Geer, P. and Komives, E. A. (2008) Structural and functional consequences of tyrosine phosphorylation in the LRP1 cytoplasmic domain. J. Biol. Chem. 283, 15656-15664
132. Donoso, M., Cancino, J., Lee, J., van Kerkhof, P., Retamal, C., Bu, G., Gonzalez, A., Caceres, A. and Marzolo, M. P. (2009) Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y-dependent sorting motifs in different pathways. Mol. Biol. Cell 20, 481-497
133. Stockinger, W., Sailler, B., Strasser, V., Recheis, B., Fasching, D., Kahr, L., Schneider, W. J. and Nimpf, J. (2002) The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor. EMBO J. 21, 4259-4267
134. van Kerkhof, P., Lee, J., McCormick, L., Tetrault, E., Lu, W., Schoenfish, M., Oorschot, V., Strous, G. J., Klumperman, J. and Bu, G. (2005) Sorting nexin 17 facilitates LRP recycling in the early endosome. EMBO J. 24, 2851-2861 (Pubitemid 43079889)
135. Burden, J. J., Sun, X. M., Garcia, A. B. and Soutar, A. K. (2004) Sorting motifs in the intracellular domain of the low density lipoprotein receptor interact with a novel domain of sorting nexin-17. J. Biol. Chem. 279, 16237-16245 (Pubitemid 38509317)
136. Lee, J., Retamal, C., Cuitino, L., Caruano-Yzermans, A., Shin, J. E., van Kerkhof, P., Marzolo, M. P. and Bu, G. (2008) Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes. J. Biol. Chem. 283, 11501-11508
137. Ghai, R., Mobli, M., Norwood, S. J., Bugarcic, A., Teasdale, R. D., King, G. F. and Collins, B. M. (2011) Phox homology band 4.1/ezrin/radixin/moesin- like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases. Proc. Natl. Acad. Sci. U.S.A 108, 7763-7768
138. Adachi, H. and Tsujimoto, M. (2010) Adaptor protein sorting nexin 17 interacts with the scavenger receptor FEEL-1/stabilin-1 and modulates its expression on the cell surface. Biochim. Biophys. Acta 1803, 553-563
139. Czubayko, M., Knauth, P., Schluter, T., Florian, V. and Bohnensack, R. (2006) Sorting nexin 17, a non-self-assembling and a PtdIns(3)P high class affinity protein, interacts with the cerebral cavernous malformation related protein KRIT1. Biochem. Biophys. Res. Commun. 345, 1264-1272 (Pubitemid 44218788)
140. Seog, D. H. and Han, J. (2008) Sorting nexin 17 interacts directly with kinesin superfamily KIF1Bβ protein. Korean J. Physiol. Pharmacol. 12, 199-204
141. 4a receptor splice variant: roles in receptor targeting. J. Cell Sci. 117, 5367-5379
142. Lunn, M. L., Nassirpour, R., Arrabit, C., Tan, J., McLeod, I., Arias, C. M., Sawchenko, P. E., Yates, 3rd, J.R. and Slesinger, P. A. (2007) A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction. Nat. Neurosci. 10, 1249-1259 (Pubitemid 47480290)
143. Nassirpour, R. and Slesinger, P. A. (2007) Subunit-specific regulation of Kir3 channels by sorting nexin 27. Channels (Austin) 1, 331-333
144. Balana, B., Maslennikov, I., Kwiatkowski, W., Stern, K. M., Bahima, L., Choe, S. and Slesinger, P. A. (2011) Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27. Proc. Natl. Acad. Sci. U.S.A. 108, 5831-5836
145. Cai, L., Loo, L. S., Atlashkin, V., Hanson, B. J. and Hong, W. (2011) Deficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-aspartate (NMDA) receptor 2C (NR2C). Mol. Cell. Biol. 31, 1734-1747
146. Lauffer, B. E., Melero, C., Temkin, P., Lei, C., Hong, W., Kortemme, T. and von Zastrow, M. (2010) SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane. J. Cell Biol. 190, 565-574
147. MacNeil, A. J., Mansour, M. and Pohajdak, B. (2007) Sorting nexin 27 interacts with the cytohesin associated scaffolding protein (CASP) in lymphocytes. Biochem. Biophys. Res. Commun. 359, 848-853 (Pubitemid 46946896)
148. MacNeil, A. J. and Pohajdak, B. (2009) Getting a GRASP on CASP: properties and role of the cytohesin-associated scaffolding protein in immunity. Immunol. Cell Biol. 87, 72-80
149. Rincon, E., Santos, T., Avila-Flores, A., Albar, J. P., Lalioti, V., Lei, C., Hong, W. and Merida, I. (2007) Proteomics identification of sorting nexin 27 as a diacylglycerol kinase ζ-associated protein: new diacylglycerol kinase roles in endocytic recycling. Mol. Cell. Proteomics 6, 1073-1087 (Pubitemid 47019408)
150. Rincon, E., de Guinoa, J. S., Gharbi, S. I., Sorzano, C. O., Carrasco, Y. R. and Merida, I. (2011) Translocation dynamics of sorting nexin 27 in activated T cells. J. Cell Sci. 124, 776-788
151. Temkin, P., Lauffer, B., Jager, S., Cimermancic, P., Krogan, N. J. and von Zastrow, M. (2011) SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. Nat. Cell Biol. 13, 715-721
152. Zheng, B., Lavoie, C., Tang, T. D., Ma, P., Meerloo, T., Beas, A. and Farquhar, M. G. (2004) Regulation of epidermal growth factor receptor degradation by heterotrimeric Gαsprotein. Mol. Biol. Cell 15, 5538-5550 (Pubitemid 39564745)
153. αs and sorting nexin in vesicular trafficking. Science 294, 1939-1942
154. Hu, Y. F., Zhang, H. L., Cai, T., Harashima, S. and Notkins, A. L. (2005) The IA-2 interactome. Diabetologia 48, 2576-2581 (Pubitemid 41738225)
155. Mao, H., Ferguson, T. S., Cibulsky, S. M., Holmqvist, M., Ding, C., Fei, H. and Levitan, I. B. (2005) MONaKA, a novel modulator of the plasma membrane Na,K-ATPase. J. Neurosci. 25, 7934-7943 (Pubitemid 41254396)
156. Takeuchi, H., Takeuchi, T., Gao, J., Cantley, L. C. and Hirata, M. (2010) Characterization of PXK as a protein involved in epidermal growth factor receptor trafficking. Mol. Cell. Biol. 30, 1689-1702
157. Hayashi, S., Okada, T., Igarashi, N., Fujita, T., Jahangeer, S. and Nakamura, S. (2002) Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein. J. Biol. Chem. 277, 33319-33324 (Pubitemid 34984853)
158. Liu, L., Yang, C., Yuan, J., Chen, X., Xu, J., Wei, Y., Yang, J., Lin, G. and Yu, L. (2005) RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains. Mol. Cells 19, 39-45
159. Slagsvold, T., Marchese, A., Brech, A. and Stenmark, H. (2006) CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4. EMBO J. 25, 3738-3749 (Pubitemid 44300260)
160. Dai, F., Yu, L., He, H., Chen, Y., Yu, J., Yang, Y., Xu, Y., Ling, W. and Zhao, S. (2002) Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 β (GSK-3β) at serine-9 through direct interaction. Biochem. Biophys. Res. Commun. 293, 1191-1196 (Pubitemid 34681067)
161. Gaidarov, I., Smith, M. E., Domin, J. and Keen, J. H. (2001) The class II phosphoinositide 3-kinase C2α is activated by clathrin and regulates clathrin-mediated membrane trafficking. Mol. Cell 7, 443-449 (Pubitemid 32206511)
162. Gaidarov, I., Zhao, Y. and Keen, J. H. (2005) Individual phosphoinositide 3-kinase C2α domain activities independently regulate clathrin function. J. Biol. Chem. 280, 40766-40772 (Pubitemid 41780567)
163. Zhao, Y., Gaidarov, I. and Keen, J. H. (2007) Phosphoinositide 3-kinase C2α links clathrin to microtubule-dependent movement. J. Biol. Chem. 282, 1249-1256 (Pubitemid 47076586)
164. Arcaro, A., Zvelebil, M. J., Wallasch, C., Ullrich, A., Waterfield, M. D. and Domin, J. (2000) Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. Mol. Cell. Biol. 20, 3817-3830 (Pubitemid 30314481)
165. Wheeler, M. and Domin, J. (2006) The N-terminus of phosphoinositide 3-kinase-C2β regulates lipid kinase activity and binding to clathrin. J. Cell. Physiol. 206, 586-593 (Pubitemid 43191032)
166. Katso, R. M., Pardo, O. E., Palamidessi, A., Franz, C. M., Marinov, M., De Laurentiis, A., Downward, J., Scita, G., Ridley, A. J., Waterfield, M. D. and Arcaro, A. (2006) Phosphoinositide 3-kinase C2β regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms. Mol. Biol. Cell 17, 3729-3744 (Pubitemid 44330861)
167. Wheeler, M. and Domin, J. (2001) Recruitment of the class II phosphoinositide 3-kinase C2β to the epidermal growth factor receptor: role of Grb2. Mol. Cell. Biol. 21, 6660-6667 (Pubitemid 32927432)
168. 3 integrin engagement. Biochem. Biophys. Res. Commun. 297, 261-266
169. Kam, Y. and Exton, J. H. (2002) Dimerization of phospholipase D isozymes. Biochem. Biophys. Res. Commun. 290, 375-380 (Pubitemid 34694509)
170. Slaaby, R., Jensen, T., Hansen, H. S., Frohman, M. A. and Seedorf, K. (1998) PLD2 complexes with the EGF receptor and undergoes tyrosine phosphorylation at a single site upon agonist stimulation. J. Biol. Chem. 273, 33722-33727 (Pubitemid 29005762)
171. Jin, J. K., Ahn, B. H., Na, Y. J., Kim, J. I., Kim, Y. S., Choi, E. K., Ko, Y. G., Chung, K. C., Kozlowski, P. B. and Min, D. S. (2007) Phospholipase D1 is associated with amyloid precursor protein in Alzheimer's disease. Neurobiol. Aging 28, 1015-1027 (Pubitemid 46661823)
172. Cai, D., Netzer, W. J., Zhong, M., Lin, Y., Du, G., Frohman, M., Foster, D. A., Sisodia, S. S., Xu, H., Gorelick, F. S. and Greengard, P. (2006) Presenilin-1 uses phospholipase D1 as a negative regulator of β-amyloid formation. Proc. Natl. Acad. Sci. U.S.A. 103, 1941-1946 (Pubitemid 43228797)
173. Kim, J. H., Lee, S. D., Han, J. M., Lee, T. G., Kim, Y., Park, J. B., Lambeth, J. D., Suh, P. G. and Ryu, S. H. (1998) Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA. FEBS Lett. 430, 231-235 (Pubitemid 28337919)
174. Luo, J. Q., Liu, X., Hammond, S. M., Colley, W. C., Feig, L. A., Frohman, M. A., Morris, A. J. and Foster, D. A. (1997) RalA interacts directly with the Arf-responsive, PIP2-dependent phospholipase D1. Biochem. Biophys. Res. Commun. 235, 854-859 (Pubitemid 27326574)
175. Vitale, N., Mawet, J., Camonis, J., Regazzi, R., Bader, M. F. and Chasserot-Golaz, S. (2005) The Small GTPase RalA controls exocytosis of large dense core secretory granules by interacting with ARF6-dependent phospholipase D1. J. Biol. Chem. 280, 29921-29928 (Pubitemid 41177070)
176. Liu, L., Liao, H., Castle, A., Zhang, J., Casanova, J., Szabo, G. and Castle, D. (2005) SCAMP2 interacts with Arf6 and phospholipase D1 and links their function to exocytotic fusion pore formation in PC12 cells. Mol. Biol. Cell 16, 4463-4472 (Pubitemid 41416433)
177. Kim, J. H., Han, J. M., Lee, S., Kim, Y., Lee, T. G., Park, J. B., Lee, S. D., Suh, P. G. and Ryu, S. H. (1999) Phospholipase D1 in caveolae: regulation by protein kinase Cα and caveolin-1. Biochemistry 38, 3763-3769
178. Haga, Y., Miwa, N., Jahangeer, S., Okada, T. and Nakamura, S. (2009) CtBP1/BARS is an activator of phospholipase D1 necessary for agonist-induced macropinocytosis. EMBO J. 28, 1197-1207
179. Lee, H. Y., Park, J. B., Jang, I. H., Chae, Y. C., Kim, J. H., Kim, I. S., Suh, P. G. and Ryu, S. H. (2004) Munc-18-1 inhibits phospholipase D activity by direct interaction in an epidermal growth factor-reversible manner. J. Biol. Chem. 279, 16339-16348 (Pubitemid 38509330)
180. Lee, C. S., Kim, I. S., Park, J. B., Lee, M. N., Lee, H. Y., Suh, P. G. and Ryu, S. H. (2006) The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis. Nat. Cell Biol. 8, 477-484
181. Lee, C., Kim, S. R., Chung, J. K., Frohman, M. A., Kilimann, M. W. and Rhee, S. G. (2000) Inhibition of phospholipase D by amphiphysins. J. Biol. Chem. 275, 18751-18758 (Pubitemid 30422835)
182. Cho, J. H., Oh, D. Y., Kim, H. J., Park, S. Y., Choi, H. J., Kwon, S. J., Lee, K. S. and Han, J. S. (2011) The TSP motif in AP180 inhibits phospholipase D1 activity resulting in increased efficacy of anticancer drug via its direct binding to carboxyl terminal of phospholipase D1. Cancer Lett. 302, 144-154
183. Sung, T. C., Zhang, Y., Morris, A. J. and Frohman, M. A. (1999) Structural analysis of human phospholipase D1. J. Biol. Chem. 274, 3659-3666 (Pubitemid 29077210)
184. Hu, T. and Exton, J. H. (2003) Mechanisms of regulation of phospholipase D1 by protein kinase Cα. J. Biol. Chem. 278, 2348-2355 (Pubitemid 36801306)
185. Hu, T. and Exton, J. H. (2004) Protein kinase Cα translocates to the perinuclear region to activate phospholipase D1. J. Biol. Chem. 279, 35702-35708 (Pubitemid 39100574)
186. Jin, J. K., Kim, N. H., Lee, Y. J., Kim, Y. S., Choi, E. K., Kozlowski, P. B., Park, M. H., Kim, H. S. and Min, D. S. (2006) Phospholipase D1 is up-regulated in the mitochondrial fraction from the brains of Alzheimer's disease patients. Neurosci. Lett. 407, 263-267 (Pubitemid 44425384)
187. Jang, I. H., Lee, S., Park, J. B., Kim, J. H., Lee, C. S., Hur, E. M., Kim, I. S., Kim, K. T., Yagisawa, H., Suh, P. G. and Ryu, S. H. (2003) The direct interaction of phospholipase C-γ1 with phospholipase D2 is important for epidermal growth factor signaling. J. Biol. Chem. 278, 18184-18190 (Pubitemid 36799434)
188. Divecha, N., Roefs, M., Halstead, J. R., D'Andrea, S., Fernandez-Borga, M., Oomen, L., Saqib, K. M., Wakelam, M. J. and D'Santos, C. (2000) Interaction of the type Iα PIP kinase with phospholipase D: a role for the local generation of phosphatidylinositol 4,5-bisphosphate in the regulation of PLD2 activity. EMBO J. 19, 5440-5449
189. Zhang, Y., Redina, O., Altshuller, Y. M., Yamazaki, M., Ramos, J., Chneiweiss, H., Kanaho, Y. and Frohman, M. A. (2000) Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them. J. Biol. Chem. 275, 35224-35232
190. Ahn, B. H., Min, G., Bae, Y. S. and Min, D. S. (2006) Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells. Exp. Mol. Med. 38, 55-62 (Pubitemid 43352434)
191. Ahn, B. H., Kim, S. Y., Kim, E. H., Choi, K. S., Kwon, T. K., Lee, Y. H., Chang, J. S., Kim, M. S., Jo, Y. H. and Min, D. S. (2003) Transmodulation between phospholipase D and c-Src enhances cell proliferation. Mol. Cell. Biol. 23, 3103-3115 (Pubitemid 36459225)
192. Yoon, M. S., Cho, C. H., Lee, K. S. and Han, J. S. (2006) Binding of Cdc42 to phospholipase D1 is important in neurite outgrowth of neural stem cells. Biochem. Biophys. Res. Commun. 347, 594-600 (Pubitemid 44092626)
193. Yamazaki, M., Zhang, Y., Watanabe, H., Yokozeki, T., Ohno, S., Kaibuchi, K., Shibata, H., Mukai, H., Ono, Y., Frohman, M. A. and Kanaho, Y. (1999) Interaction of the small G protein RhoA with the C terminus of human phospholipase D1. J. Biol. Chem. 274, 6035-6038 (Pubitemid 29111004)
194. Jang, M. J., Lee, M. J., Park, H. Y., Bae, Y. S., Min, D. S., Ryu, S. H. and Kwak, J. Y. (2004) Phosphorylation of phospholipase D1 and the modulation of its interaction with RhoA by cAMP-dependent protein kinase. Exp. Mol. Med. 36, 172-178 (Pubitemid 38667926)
195. Kusner, D. J., Barton, J. A., Wen, K. K., Wang, X., Rubenstein, P. A. and Iyer, S. S. (2002) Regulation of phospholipase D activity by actin. Actin exerts bidirectional modulation of mammalian phospholipase D activity in a polymerization-dependent, isoform-specific manner. J. Biol. Chem. 277, 50683-50692 (Pubitemid 36042230)
196. Ahn, B. H., Rhim, H., Kim, S. Y., Sung, Y. M., Lee, M. Y., Choi, J. Y., Wolozin, B., Chang, J. S., Lee, Y. H., Kwon, T. K. et al. (2002) α-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells. J. Biol. Chem. 277, 12334-12342 (Pubitemid 34952804)
197. Park, J. B., Lee, C. S., Lee, H. Y., Kim, I. S., Lee, B. D., Jang, I. H., Jung, Y. W., Oh, Y. S., Han, M. Y., Jensen, O. N. et al. (2004) Regulation of phospholipase D2 by GTP-dependent interaction with dynamin. Adv. Enzyme Regul. 44, 249-264 (Pubitemid 39568175)
198. Czarny, M., Fiucci, G., Lavie, Y., Banno, Y., Nozawa, Y. and Liscovitch, M. (2000) Phospholipase D2: functional interaction with caveolin in low-density membrane microdomains. FEBS Lett. 467, 326-332 (Pubitemid 30081759)
199. Ha, S. H., Kim, D. H., Kim, I. S., Kim, J. H., Lee, M. N., Lee, H. J., Jang, S. K., Suh, P. G. and Ryu, S. H. (2006) PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals. Cell. Signal. 18, 2283-2291 (Pubitemid 44636169)
200. Lee, J. H., Kim, Y. M., Kim, N.W., Kim, J. W., Her, E., Kim, B. K., Kim, J. H., Ryu, S. H., Park, J. W., Seo, D. W. et al. (2006) Phospholipase D2 acts as an essential adaptor protein in the activation of Syk in antigen-stimulated mast cells. Blood 108, 956-964 (Pubitemid 44154631)
201. Horn, J., Lopez, I., Miller, M. W. and Gomez-Cambronero, J. (2005) The uncovering of a novel regulatory mechanism for PLD2: formation of a ternary complex with protein tyrosine phosphatase PTP1B and growth factor receptor-bound protein GRB2. Biochem. Biophys. Res. Commun. 332, 58-67 (Pubitemid 40719457)
202. Kim, J. H., Ohba, M., Suh, P. G. and Ryu, S. H. (2005) Novel functions of the phospholipase D2-Phox homology domain in protein kinase Cζ activation. Mol. Cell. Biol. 25, 3194-3208 (Pubitemid 40464321)
203. Di Fulvio, M., Frondorf, K., Henkels, K. M., Lehman, N. and Gomez-Cambronero, J. (2007) The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGF. J. Mol. Biol. 367, 814-824 (Pubitemid 46330378)
204. Di Fulvio, M., Lehman, N., Lin, X., Lopez, I. and Gomez-Cambronero, J. (2006) The elucidation of novel SH2 binding sites on PLD2. Oncogene 25, 3032-3040 (Pubitemid 43780467)
205. Mahankali, M., Peng, H. J., Cox, D. and Gomez-Cambronero, J. (2011) The mechanism of cell membrane ruffling relies on a phospholipase D2 (PLD2), Grb2 and Rac2 association. Cell. Signal. 23, 1291-1298
206. Peng, H. J., Henkels, K. M., Mahankali, M., Dinauer, M. C. and Gomez-Cambronero, J. (2011) Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2. J. Biol. Chem. 286, 16308-16320
207. Lee, S., Park, J. B., Kim, J. H., Kim, Y., Shin, K. J., Lee, J. S., Ha, S. H., Suh, P. G. and Ryu, S. H. (2001) Actin directly interacts with phospholipase D, inhibiting its activity. J. Biol. Chem. 276, 28252-28260
208. Jeon, H., Kwak, D., Noh, J., Lee, M. N., Lee, C. S., Suh, P. G. and Ryu, S. H. (2011) Phospholipase D2 induces stress fiber formation through mediating nucleotide exchange for RhoA. Cell. Signal. 23, 1320-1326
209. Kim, J. H., Lee, S., Lee, T. G., Hirata, M., Suh, P. G. and Ryu, S. H. (2002) Phospholipase D2 directly interacts with aldolase via Its PH domain. Biochemistry 41, 3414-3421 (Pubitemid 34214040)
210. Schaff, U. Y., Shih, H. H., Lorenz, M., Sako, D., Kriz, R., Milarski, K., Bates, B., Tchernychev, B., Shaw, G. D. and Simon, S. I. (2008) SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1. Eur. J. Immunol. 38, 550-564
211. Boulkroun, S., Ruffieux-Daidie, D., Vitagliano, J. J., Poirot, O., Charles, R. P., Lagnaz, D., Firsov, D., Kellenberger, S. and Staub, O. (2008) Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3. Am. J. Physiol. Renal Physiol. 295, F889-F900
212. Takemoto, Y., Furuta, M., Sato, M., Kubo, M. and Hashimoto, Y. (1999) Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3. Int. Immunol. 11, 1957-1964 (Pubitemid 30009155)
213. Phillips, S. A., Barr, V. A., Haft, D. H., Taylor, S. I. and Haft, C. R. (2001) Identification and characterization of SNX15, a novel sorting nexin involved in protein trafficking. J. Biol. Chem. 276, 5074-5084
214. Lim, K. P. and Hong, W. (2004) Human Nischarin/imidazoline receptor antisera-selected protein is targeted to the endosomes by a combined action of a PX domain and a coiled-coil region. J. Biol. Chem. 279, 54770-54782
215. Alahari, S. K., Lee, J. W. and Juliano, R. L. (2000) Nischarin, a novel protein that interacts with the integrin α5 subunit and inhibits cell migration. J. Cell Biol. 151, 1141-1154
216. Alahari, S. K. and Nasrallah, H. (2004) A membrane proximal region of the integrin α5 subunit is important for its interaction with nischarin. Biochem. J. 377, 449-457 (Pubitemid 38142200)
217. Sano, H., Liu, S. C., Lane, W. S., Piletz, J. E. and Lienhard, G. E. (2002) Insulin receptor substrate 4 associates with the protein IRAS. J. Biol. Chem. 277, 19439-19447 (Pubitemid 34967453)
218. Alahari, S. K., Reddig, P. J. and Juliano, R. L. (2004) The integrin-binding protein nischarin regulates cell migration by inhibiting PAK. EMBO J. 23, 2777-2788 (Pubitemid 39013550)
219. Ding, Y., Milosavljevic, T. and Alahari, S. K. (2008) Nischarin inhibits LIM kinase to regulate cofilin phosphorylation and cell invasion. Mol. Cell. Biol. 28, 3742-3756 (Pubitemid 351732909)
220. Reddig, P. J., Xu, D. and Juliano, R. L. (2005) Regulation of p21-activated kinase-independent Rac1 signal transduction by nischarin. J. Biol. Chem. 280, 30994-31002 (Pubitemid 41291832)
221. Choi, J. H., Hong, W. P., Kim, M. J., Kim, J. H., Ryu, S. H. and Suh, P. G. (2004) Sorting nexin 16 regulates EGF receptor trafficking by phosphatidylinositol-3-phosphate interaction with the Phox domain. J. Cell Sci. 117, 4209-4218 (Pubitemid 39328308)
222. Hanson, B. J. and Hong, W. (2003) Evidence for a role of SNX16 in regulating traffic between the early and later endosomal compartments. J. Biol. Chem. 278, 34617-34630 (Pubitemid 37553311)
223. Kienle, N., Kloepper, T. H. and Fasshauer, D. (2009) Phylogeny of the SNARE vesicle fusion machinery yields insights into the conservation of the secretory pathway in fungi. BMC Evol. Biol. 9, 19