Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

Cell Metabolism

Volumn 29, Issue 1, 2019, Pages 192-201.e7

  Son, Sung Min ^a   Park, So Jung ^a   Lee, Huikyong ^a   Siddiqi, Farah ^a   Lee, Jong Eun ^b   Menzies, Fiona M ^a   Rubinsztein, David C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

acetyl CoA; amino acid sensing; autophagy; leucine; mTOR; Raptor; starvation

Indexed keywords

2 OXOISOCAPROIC ACID; ACETYL COENZYME A; ACETYLCYSTEINE; ACYLTRANSFERASE; ALPHA TUBULIN; AUTOPHAGY RELATED PROTEIN 7; E1A ASSOCIATED P300 PROTEIN; HISTONE H3; INITIATION FACTOR 4E BINDING PROTEIN 1; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PYRUVATE DEHYDROGENASE; RAGA PROTEIN; RAGB PROTEIN; REACTIVE OXYGEN METABOLITE; REGULATORY ASSOCIATED PROTEIN OF MTOR; S6 KINASE; UNCLASSIFIED DRUG; EP300 PROTEIN, HUMAN; EP300 PROTEIN, MOUSE;

AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CYTOPLASM; FEMALE; HEK293T CELL LINE; HELA CELL LINE; HUMAN; HUMAN TISSUE; LYSOSOME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ACETYLATION; ANIMAL; C57BL MOUSE; CELL LINE; METABOLISM; PHYSIOLOGY;

ACETYL COENZYME A; ANIMALS; CELL LINE; E1A-ASSOCIATED P300 PROTEIN; FEMALE; HUMANS; LEUCINE; MALE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MICE; MICE, INBRED C57BL; REGULATORY-ASSOCIATED PROTEIN OF MTOR;

EID: 85058494304     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2018.08.013     Document Type: Article

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