Regulatory T cells are expanded by Teriparatide treatment in humans and mediate intermittent PTH-induced bone anabolism in mice

EMBO Reports

Volumn 19, Issue 1, 2018, Pages 156-171

  Yu, Mingcan ^a   D'Amelio, Patrizia ^b   Tyagi, Abdul Malik ^a   Vaccaro, Chiara ^a   Li, Jau Yi ^a   Hsu, Emory ^a   Buondonno, Ilaria ^b   Sassi, Francesca ^b   Adams, Jonathan ^a   Weitzmann, M Neale ^a,c   DiPaolo, Richard ^d   Pacifici, Roberto ^a,e  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TURIN   (Italy)

^c ATLANTA VA MEDICAL CENTER   (United States)

^d SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e EMORY UNIVERSITY   (United States)

Author keywords

bone; bone formation; parathyroid hormone; regulatory T cells

Indexed keywords

BONE SIALOPROTEIN; CALCIUM; CD4 ANTIGEN; COLLAGEN TYPE 1; INTERLEUKIN 2 RECEPTOR ALPHA; OSTEOCALCIN; PARATHYROID HORMONE[1-34]; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA1; VITAMIN D; 25-HYDROXYVITAMIN D; BIOLOGICAL MARKER; BONE DENSITY CONSERVATION AGENT; RUNX2 PROTEIN, MOUSE; SP7 PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA;

AGED; ANIMAL CELL; APOPTOSIS; ARTICLE; BIOSYNTHESIS; BONE MASS; BONE METABOLISM; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL EXPANSION; CELL PROLIFERATION; CONTROLLED STUDY; CORTICAL THICKNESS (BONE); DISTAL FEMUR; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MICRO-COMPUTED TOMOGRAPHY; MORPHOMETRY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOLYSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; TGF BETA SIGNALING; TRABECULAR BONE; ANALOGS AND DERIVATIVES; ANIMAL; CYTOLOGY; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION; GENETICS; LYMPHOCYTE COUNT; METABOLISM; OVARIECTOMY; PATHOLOGY; TREATMENT OUTCOME;

AGED; ANIMALS; BIOMARKERS; BONE DENSITY CONSERVATION AGENTS; CALCIUM; CALCIUM-REGULATING HORMONES AND AGENTS; COLLAGEN TYPE I; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; HUMANS; INTEGRIN-BINDING SIALOPROTEIN; LYMPHOCYTE COUNT; MICE; OSTEOCALCIN; OSTEOPOROSIS, POSTMENOPAUSAL; OVARIECTOMY; SP7 TRANSCRIPTION FACTOR; T-LYMPHOCYTES, REGULATORY; TERIPARATIDE; TRANSFORMING GROWTH FACTOR BETA; TREATMENT OUTCOME; VITAMIN D;

EID: 85034606258     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201744421     Document Type: Article

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