CTLA-4Ig-induced T cell anergy promotes Wnt-10b production and bone formation in a mouse model

Arthritis and Rheumatology

Volumn 66, Issue 4, 2014, Pages 990-999

  Roser Page, Susanne ^a   Vikulina, Tatyana ^b   Zayzafoon, Majd ^c   Weitzmann, M Neale ^a,b  

^a ATLANTA VA MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; BIOCHEMICAL MARKER; CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; IMMUNOGLOBULIN; WNT10B PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE STRUCTURE; BONE TURNOVER; CLONAL ANERGY; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; MOUSE MODEL; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; PROTEIN INDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ARTHRITIS, RHEUMATOID; BONE DENSITY; DISEASE MODELS, ANIMAL; FEMALE; IMMUNOCONJUGATES; LYMPHOCYTE ACTIVATION; MICE; OSTEOGENESIS; T-LYMPHOCYTES; WNT PROTEINS;

EID: 84898604782     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.38319     Document Type: Article

References (40)

1. Deodhar AA, Woolf AD,. Bone mass measurement and bone metabolism in rheumatoid arthritis: a review. Br J Rheumatol 1996; 35: 309-22.
2. Dequeker J, Maenaut K, Verwilghen J, Westhovens R,. Osteoporosis in rheumatoid arthritis. Clin Exp Rheumatol 1995; 13 Suppl 12: S21-6.
3. Gough AK, Peel NF, Eastell R, Holder RL, Lilley J, Emery P,. Excretion of pyridinium crosslinks correlates with disease activity and appendicular bone loss in early rheumatoid arthritis. Ann Rheum Dis 1994; 53: 14-7.
4. Fournier C,. Where do T cells stand in rheumatoid arthritis? Joint Bone Spine 2005; 72: 527-32.
5. Kong YY, Feige U, Sarosi I, Bolon B, Tafuri A, Morony S, et al. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 1999; 402: 304-9.
6. Edwards JC, Szczepanski L, Szechinski J, Filipowicz-Sosnowska A, Emery P, Close DR, et al. Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med 2004; 350: 2572-81.
7. He X, Kang AH, Stuart JM,. Anti-human type II collagen CD19+ B cells are present in patients with rheumatoid arthritis and healthy individuals. J Rheumatol 2001; 28: 2168-75.
8. Yanaba K, Hamaguchi Y, Venturi GM, Steeber DA, St Clair EW, Tedder TF,. B cell depletion delays collagen-induced arthritis in mice: arthritis induction requires synergy between humoral and cell-mediated immunity. J Immunol 2007; 179: 1369-80.
9. Vikulina T, Fan X, Yamaguchi M, Roser-Page S, Zayzafoon M, Guidot DM, et al. Alterations in the immuno-skeletal interface drive bone destruction in HIV-1 transgenic rats. Proc Natl Acad Sci U S A 2010; 107: 13848-53.
10. Li Y, Toraldo G, Li A, Yang X, Zhang H, Qian WP, et al. B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo. Blood 2007; 109: 3839-48.
11. Weitzmann MN, Pacifici R,. Estrogen deficiency and bone loss: an inflammatory tale. J Clin Invest 2006; 116: 1186-94.
12. Rifas L, Weitzmann MN,. A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner. Arthritis Rheum 2009; 60: 3324-35.
13. Weitzmann MN, Cenci S, Rifas L, Haug J, Dipersio J, Pacifici R,. T cell activation induces human osteoclast formation via receptor activator of nuclear factor κB ligand-dependent and -independent mechanisms. J Bone Miner Res 2001; 16: 328-37.
14. Jarry CR, Duarte PM, Freitas FF, de Macedo CG, Clemente-Napimoga JT, Saba-Chujfi E, et al. Secreted osteoclastogenic factor of activated T cells (SOFAT), a novel osteoclast activator, in chronic periodontitis. Hum Immunol 2013; 74: 861-6.
15. Yun TJ, Chaudhary PM, Shu GL, Frazer JK, Ewings MK, Schwartz SM, et al. OPG/FDCR-1, a TNF receptor family member, is expressed in lymphoid cells and is up-regulated by ligating CD40. J Immunol 1998; 161: 6113-21.
16. Ofotokun I, Weitzmann MN,. HIV-1 infection and antiretroviral therapies: risk factors for osteoporosis and bone fracture. Curr Opin Endocrinol Diabetes Obes 2010; 17: 523-9.
17. Ofotokun I, Weitzmann MN,. HIV and bone metabolism. Discov Med 2011; 11: 385-93.
18. Sayegh MH,. Finally, CTLA4Ig graduates to the clinic. J Clin Invest 1999; 103: 1223-5.
19. Najafian N, Sayegh MH,. CTLA4-Ig: a novel immunosuppressive agent. Expert Opin Investig Drugs 2000; 9: 2147-57.
20. Vital EM, Emery P,. Abatacept in the treatment of rheumatoid arthritis. Ther Clin Risk Manag 2006; 2: 365-75.
21. Ilowite NT,. Update on biologics in juvenile idiopathic arthritis. Curr Opin Rheumatol 2008; 20: 613-8.
22. Grassi F, Tell G, Robbie-Ryan M, Gao Y, Terauchi M, Yang X, et al. Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation. Proc Natl Acad Sci U S A 2007; 104: 15087-92.
23. Bedi B, Li JY, Grassi F, Tawfeek H, Weitzmann MN, Pacifici R,. Inhibition of antigen presentation and T cell costimulation blocks PTH-induced bone loss. Ann N Y Acad Sci 2010; 1192: 215-21.
24. Axmann R, Herman S, Zaiss M, Franz S, Polzer K, Zwerina J, et al. CTLA-4 directly inhibits osteoclast formation. Ann Rheum Dis 2008; 67: 1603-9.
25. Toraldo G, Roggia C, Qian WP, Pacifici R, Weitzmann MN,. IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor κB ligand and tumor necrosis factor α from T cells. Proc Natl Acad Sci U S A 2003; 100: 125-30.
26. Bouxsein ML, Boyd SK, Christiansen BA, Guldberg RE, Jepsen KJ, Muller R,. Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res 2010; 25: 1468-86.
27. Livak KJ, Schmittgen TD,. Analysis of relative gene expression data using real-time quantitative PCR and the 2 T -ΔΔC method. Methods 2001; 25: 402-8.
28. Kamphorst AO, Guermonprez P, Dudziak D, Nussenzweig MC,. Route of antigen uptake differentially impacts presentation by dendritic cells and activated monocytes. J Immunol 2010; 185: 3426-35.
29. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, et al. Bone histomorphometry: standardization of nomenclature, symbols, and units: report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987; 2: 595-610.
30. Terauchi M, Li JY, Bedi B, Baek KH, Tawfeek H, Galley S, et al. T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab 2009; 10: 229-40.
31. Michelangeli F, Cordier M, Melandri P, Gaspaillard M, Migliori G, Maestracci P,. Study of pressor drops during continuous peridural analgesia in gerontologic surgery. Ann Anesthesiol Fr 1975; 16: 429-36. In French.
32. Weitzmann MN, Roggia C, Toraldo G, Weitzmann L, Pacifici R,. Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency. J Clin Invest 2002; 110: 1643-50.
33. Cenci S, Weitzmann MN, Roggia C, Namba N, Novack D, Woodring J, et al. Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α. J Clin Invest 2000; 106: 1229-37.
34. Bjorgo E, Solheim SA, Abrahamsen H, Baillie GS, Brown KM, Berge T, et al. Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase A signaling pathways at the level of a protein kinase B/β-arrestin/cAMP phosphodiesterase 4 complex. Mol Cell Biol 2010; 30: 1660-72.
35. Zha Y, Marks R, Ho AW, Peterson AC, Janardhan S, Brown I, et al. T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-α. Nat Immunol 2006; 7: 1166-73.
36. Bedi B, Li JY, Tawfeek H, Baek KH, Adams J, Vangara SS, et al. Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH. Proc Natl Acad Sci USA 2012; 109: E725-33.
37. Hardiman G, Kastelein RA, Bazan JF,. Isolation, characterization and chromosomal localization of human WNT10B. Cytogenet Cell Genet 1997; 77: 278-82.
38. Ouji Y, Yoshikawa M, Shiroi A, Ishizaka S,. Wnt-10b secreted from lymphocytes promotes differentiation of skin epithelial cells. Biochem Biophys Res Commun 2006; 342: 1063-9.
39. Gyarmati J Jr, Mandi B, Fachet J, Varga S, Sikula J,. Alterations of the connective tissue in nude mice. Thymus 1983; 5: 383-92.
40. Lee SK, Kadono Y, Okada F, Jacquin C, Koczon-Jaremko B, Gronowicz G, et al. T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy. J Bone Miner Res 2006; 21: 1704-12.