Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/β-catenin and TGFβ signaling pathways

European Journal of Nutrition

Volumn 58, Issue 8, 2019, Pages 3207-3219

  Cruz Lozano, Marina ^a,b   González González, Adrián ^a,b   Marchal, Juan A ^b   Muñoz Muela, Esperanza ^a,b   Molina, Maria P ^a,b   Cara, Francisca E ^a,b   Brown, Anthony M ^c   García Rivas, Gerardo ^d   Hernández Brenes, Carmen ^d   Lorente, Jose A ^b   Sanchez Rovira, Pedro ^a,b   Chang, Jenny C ^e   Granados Principal, Sergio ^a,b  

^a Medical Oncology Department   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d HOSPITAL ZAMBRANO HELLION   (Mexico)

^e HOUSTON METHODIST HOSPITAL   (United States)

Author keywords

Cancer stem cells; Epithelial to mesenchymal transition; Hydroxytyrosol; Olive oil; Triple negative breast cancer

Indexed keywords

ALDEHYDE DEHYDROGENASE; BETA CATENIN; CD24 ANTIGEN; CYCLIN D1; DICKKOPF 1 PROTEIN; HERMES ANTIGEN; HYDROXYTYROSOL; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR ZEB1; TRANSFORMING GROWTH FACTOR BETA; VIMENTIN; WNT PROTEIN; WNT1 PROTEIN; 3,4-DIHYDROXYPHENYLETHANOL; ANTIOXIDANT; PHENETHYL ALCOHOL;

ARTICLE; BT-549 CELL LINE; CANCER INHIBITION; CANCER STEM CELL; CELL INVASION; CELL SUBPOPULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG TARGETING; EPITHELIAL MESENCHYMAL TRANSITION; FLOW CYTOMETRY; HS 578T CELL LINE; HUMAN; HUMAN CELL; MDA-MB-231 CELL LINE; METASTASIS INHIBITION; METASTASIS POTENTIAL; MIGRATION INHIBITION; PROTEIN EXPRESSION LEVEL; STEM CELL SELF-RENEWAL; SUM159PT CELL LINE; TGF BETA SIGNALING; TRIPLE NEGATIVE BREAST CANCER; WESTERN BLOTTING; WNT SIGNALING; WOUND HEALING ASSAY; DRUG EFFECT; TUMOR CELL CULTURE;

ANTIOXIDANTS; BETA CATENIN; BLOTTING, WESTERN; EPITHELIAL-MESENCHYMAL TRANSITION; FLOW CYTOMETRY; HUMANS; NEOPLASTIC STEM CELLS; PHENYLETHYL ALCOHOL; TRANSFORMING GROWTH FACTOR BETA; TRIPLE NEGATIVE BREAST NEOPLASMS; TUMOR CELLS, CULTURED; WNT SIGNALING PATHWAY;

EID: 85056892642     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-018-1864-1     Document Type: Article

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