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Volumn 9, Issue 1, 2018, Pages

Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; FRIZZLED 8 PROTEIN; FRIZZLED PROTEIN; MESSENGER RNA; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; WNT11 PROTEIN; ATF2 PROTEIN, HUMAN; CELL SURFACE RECEPTOR; FZD8 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; WNT PROTEIN; WNT11 PROTEIN, HUMAN;

EID: 85046423484     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-018-04042-w     Document Type: Article
Times cited : (79)

References (70)
  • 2
    • 84858041599 scopus 로고    scopus 로고
    • Androgen receptor signaling in prostate cancer development and progression
    • Peter E. Lonergan, Tindall D. J. Androgen receptor signaling in prostate cancer development and progression. J. Carcinog. 10, 20 (2011).
    • (2011) J. Carcinog. , vol.10 , pp. 20
    • Lonergan, P.E.1    Tindall, D.J.2
  • 3
    • 36448936367 scopus 로고    scopus 로고
    • Guidelines on prostate cancer
    • Mottet, N. et al. Guidelines on prostate cancer. Eur. Assoc. Urol. https://doi. org/10.1016/j.eururo.2007.09.002 (2016).
    • (2016) Eur. Assoc. Urol
    • Mottet, N.1
  • 4
    • 84890555121 scopus 로고    scopus 로고
    • Prostate cancer progression after androgen deprivation therapy: Mechanisms of castrate resistance and novel therapeutic approaches
    • Karantanos, T., Corn, P. G. &Thompson, T. C. Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approaches. Oncogene 32, 5501-5511 (2013).
    • (2013) Oncogene , vol.32 , pp. 5501-5511
    • Karantanos, T.1    Corn, P.G.2    Thompson, T.C.3
  • 5
    • 84934297555 scopus 로고    scopus 로고
    • Mechanisms of resistance in castration-resistant prostate cancer (CRPC)
    • Chandrasekar, T., Yang, J. C., Gao, A. C. &Evans, C. P. Mechanisms of resistance in castration-resistant prostate cancer (CRPC). Transl. Androl. Urol. 4, 365-380 (2015).
    • (2015) Transl. Androl. Urol. , vol.4 , pp. 365-380
    • Chandrasekar, T.1    Yang, J.C.2    Gao, A.C.3    Evans, C.P.4
  • 6
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • Logan, C. &Nusse, R. The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 20, 781-810 (2004).
    • (2004) Annu. Rev. Cell Dev. Biol. , vol.20 , pp. 781-810
    • Logan, C.1    Nusse, R.2
  • 7
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling in development and disease
    • Clevers, H. Wnt/β-catenin signaling in development and disease. Cell 127, 469-480 (2006).
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 8
    • 84871846692 scopus 로고    scopus 로고
    • WNT signalling pathways as therapeutic targets in cancer
    • Anastas, J. N. &Moon, R. T. WNT signalling pathways as therapeutic targets in cancer. Nat. Rev. Cancer 13, 11-26 (2013).
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 11-26
    • Anastas, J.N.1    Moon, R.T.2
  • 9
    • 84870252814 scopus 로고    scopus 로고
    • The complex world of WNT receptor signalling
    • Niehrs, C. The complex world of WNT receptor signalling. Mol. Cell Biol. 13, 767-779 (2012).
    • (2012) Mol. Cell Biol. , vol.13 , pp. 767-779
    • Niehrs, C.1
  • 10
    • 45849117967 scopus 로고    scopus 로고
    • Wnt signal transduction pathways
    • Komiya, Y. &Habas, R. Wnt signal transduction pathways. Organogenesis 4, 68-75 (2008).
    • (2008) Organogenesis , vol.4 , pp. 68-75
    • Komiya, Y.1    Habas, R.2
  • 11
    • 0041695485 scopus 로고    scopus 로고
    • A second canon: Functions and mechanisms of β-catenin-independent Wnt signaling
    • Veeman, M. T., Axelrod, J. D. &Moon, R. T. A second canon: functions and mechanisms of β-catenin-independent Wnt signaling. Dev. Cell 5, 367-377 (2003).
    • (2003) Dev. Cell , vol.5 , pp. 367-377
    • Veeman, M.T.1    Axelrod, J.D.2    Moon, R.T.3
  • 12
    • 0242691046 scopus 로고    scopus 로고
    • AP-1: A double-edged sword in tumorigenesis
    • Eferl, R. &Wagner, E. F. AP-1: a double-edged sword in tumorigenesis. Nat. Rev. Cancer 3, 859-868 (2003).
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 859-868
    • Eferl, R.1    Wagner, E.F.2
  • 13
    • 24644499046 scopus 로고    scopus 로고
    • Wnt and calcium signaling: Beta-cateninindependent pathways
    • Kohn, A. D. &Moon, R. T. Wnt and calcium signaling: beta-cateninindependent pathways. Cell Calcium 38, 439-446 (2005).
    • (2005) Cell Calcium , vol.38 , pp. 439-446
    • Kohn, A.D.1    Moon, R.T.2
  • 14
    • 83155180656 scopus 로고    scopus 로고
    • Wnt11 in 2011\-The regulation and function of a non-canonical Wnt
    • Uysal-Onganer, P. &Kypta, R. M. Wnt11 in 2011\-The regulation and function of a non-canonical Wnt. Acta Physiol. 204, 52-64 (2012).
    • (2012) Acta Physiol. , vol.204 , pp. 52-64
    • Uysal-Onganer, P.1    Kypta, R.M.2
  • 15
    • 44049104628 scopus 로고    scopus 로고
    • Noncanonical Wnt11 signaling is sufficient to induce cardiomyogenic differentiation in unfractionated bone marrow mononuclear cells
    • Flaherty, M. P. et al. Noncanonical Wnt11 signaling is sufficient to induce cardiomyogenic differentiation in unfractionated bone marrow mononuclear cells. Circulation 117, 2241-2252 (2008).
    • (2008) Circulation , vol.117 , pp. 2241-2252
    • Flaherty, M.P.1
  • 16
    • 34748911728 scopus 로고    scopus 로고
    • Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFβ2
    • Zhou, W. et al. Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFβ2. Nat. Genet. 39, 1225-1234 (2007).
    • (2007) Nat. Genet. , vol.39 , pp. 1225-1234
    • Zhou, W.1
  • 17
    • 78650323458 scopus 로고    scopus 로고
    • An ATF2-based luciferase reporter to monitor non-canonical Wnt signaling in Xenopus embryos
    • Ohkawara, B. &Niehrs, C. An ATF2-based luciferase reporter to monitor non-canonical Wnt signaling in Xenopus embryos. Dev. Dyn. 240, 188-194 (2011).
    • (2011) Dev. Dyn. , vol.240 , pp. 188-194
    • Ohkawara, B.1    Niehrs, C.2
  • 18
    • 84906860674 scopus 로고    scopus 로고
    • Avian facial morphogenesis is regulated by c-Jun N-terminal Kinase/planar cell polarity (JNK/PCP) wingless-related (WNT) signaling
    • Geetha-Loganathan, P., Nimmagadda, S., Fu, K. &Richman, J. M. Avian facial morphogenesis is regulated by c-Jun N-terminal Kinase/planar cell polarity (JNK/PCP) wingless-related (WNT) signaling. J. Biol. Chem. 289, 24153-24167 (2014).
    • (2014) J. Biol. Chem. , vol.289 , pp. 24153-24167
    • Geetha-Loganathan, P.1    Nimmagadda, S.2    Fu, K.3    Richman, J.M.4
  • 19
    • 47349089698 scopus 로고    scopus 로고
    • Wnt-11 signaling leads to down-regulation of the Wnt/beta-catenin, JNK/AP-1 and NF-kappaB pathways and promotes viability in the CHO-K1 cells
    • Railo, A., Nagy, I., Kilpeläinen, P. &Vainio, S. Wnt-11 signaling leads to down-regulation of the Wnt/beta-catenin, JNK/AP-1 and NF-kappaB pathways and promotes viability in the CHO-K1 cells. Exp. Cell Res. 314, 2389-2399 (2008).
    • (2008) Exp. Cell Res. , vol.314 , pp. 2389-2399
    • Railo, A.1    Nagy, I.2    Kilpeläinen, P.3    Vainio, S.4
  • 20
    • 2642582621 scopus 로고    scopus 로고
    • Multiple mechanisms for Wnt11-mediated repression of the canonical Wnt signaling pathway
    • Maye, P., Zheng, J., Li, L. &Wu, D. Multiple mechanisms for Wnt11-mediated repression of the canonical Wnt signaling pathway. J. Biol. Chem. 279, 24659-24665 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 24659-24665
    • Maye, P.1    Zheng, J.2    Li, L.3    Wu, D.4
  • 21
    • 0033868542 scopus 로고    scopus 로고
    • Role of Frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis
    • Djiane, A., Riou, J.-F. R., Umbhauer, M., Boucaut, J.-C. &Shi, D.-L. Role of Frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis. Development 127, 3091-3100 (2000).
    • (2000) Development , vol.127 , pp. 3091-3100
    • Djiane, A.1    Riou, J.-F.R.2    Umbhauer, M.3    Boucaut, J.-C.4    Shi, D.-L.5
  • 22
    • 34547907162 scopus 로고    scopus 로고
    • Wnt11 stimulation induces polarized accumulation of Dishevelled at apical adherens junctions through Frizzled 7
    • Yamanaka, H. &Nishida, E. Wnt11 stimulation induces polarized accumulation of Dishevelled at apical adherens junctions through Frizzled 7. Genes Cells 12, 961-967 (2007).
    • (2007) Genes Cells , vol.12 , pp. 961-967
    • Yamanaka, H.1    Nishida, E.2
  • 23
    • 21544452772 scopus 로고    scopus 로고
    • Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/β-catenin pathway
    • Cavodeassi, F. et al. Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/β-catenin pathway. Neuron 47, 43-56 (2005).
    • (2005) Neuron , vol.47 , pp. 43-56
    • Cavodeassi, F.1
  • 24
    • 79955140570 scopus 로고    scopus 로고
    • Genetic mosaic analysis reveals a major role for Frizzled 4 and Frizzled 8 in controlling ureteric growth in the developing kidney
    • Ye, X., Wang, Y., Rattner, A. &Nathans, J. Genetic mosaic analysis reveals a major role for Frizzled 4 and Frizzled 8 in controlling ureteric growth in the developing kidney. Development 138, 1161-1172 (2011).
    • (2011) Development , vol.138 , pp. 1161-1172
    • Ye, X.1    Wang, Y.2    Rattner, A.3    Nathans, J.4
  • 25
    • 78349276165 scopus 로고    scopus 로고
    • Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors
    • Grumolato, L. et al. Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors. Genes Dev. 24, 2517-2530 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 2517-2530
    • Grumolato, L.1
  • 26
    • 84905401862 scopus 로고    scopus 로고
    • Ror2 receptor mediates wnt11 ligand signaling and affects convergence and extension movements in zebrafish
    • Bai, Y. et al. Ror2 receptor mediates wnt11 ligand signaling and affects convergence and extension movements in zebrafish. J. Biol. Chem. 289, 20664-20676 (2014).
    • (2014) J. Biol. Chem. , vol.289 , pp. 20664-20676
    • Bai, Y.1
  • 27
    • 52249098269 scopus 로고    scopus 로고
    • Ryk cooperates with Frizzled 7 to promote Wnt11-mediated endocytosis and is essential for Xenopus laevis convergent extension movements
    • Kim, G., Her, J. &Han, J. Ryk cooperates with Frizzled 7 to promote Wnt11-mediated endocytosis and is essential for Xenopus laevis convergent extension movements. J. Cell Biol. 182, 1073-1082 (2008).
    • (2008) J. Cell Biol. , vol.182 , pp. 1073-1082
    • Kim, G.1    Her, J.2    Han, J.3
  • 28
    • 7444256731 scopus 로고    scopus 로고
    • Analysis of Wnt gene expression in prostate cancer: Mutual inhibition by WNT11 and the androgen
    • Zhu, H. et al. Analysis of Wnt gene expression in prostate cancer: mutual inhibition by WNT11 and the androgen. Receptor 64, 7918-7926 (2004).
    • (2004) Receptor , vol.64 , pp. 7918-7926
    • Zhu, H.1
  • 29
    • 77949428236 scopus 로고    scopus 로고
    • Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells
    • Uysal-Onganer, P. et al. Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells. Mol. Cancer 9, 55 (2010).
    • (2010) Mol. Cancer , vol.9 , pp. 55
    • Uysal-Onganer, P.1
  • 30
    • 77956290679 scopus 로고    scopus 로고
    • FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells
    • Gupta, S. et al. FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells. Cancer Res. 70, 6735-6745 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 6735-6745
    • Gupta, S.1
  • 32
    • 84876498823 scopus 로고    scopus 로고
    • Tumor Initiating Cells and FZD8 play a major role in drug resistance in triple-negative breast cancer
    • Yin, S. et al. Tumor Initiating Cells and FZD8 play a major role in drug resistance in triple-negative breast cancer. Mol. Cancer Ther. 12, 491-498 (2013).
    • (2013) Mol. Cancer Ther. , vol.12 , pp. 491-498
    • Yin, S.1
  • 33
    • 84903749666 scopus 로고    scopus 로고
    • Protein tyrosine kinase 7 (PTK7) as a predictor of lymph node metastases and a novel prognostic biomarker in patients with prostate cancer
    • Zhang, H. et al. Protein tyrosine kinase 7 (PTK7) as a predictor of lymph node metastases and a novel prognostic biomarker in patients with prostate cancer. Int. J. Mol. Sci. 15, 11665-11677 (2014).
    • (2014) Int. J. Mol. Sci. , vol.15 , pp. 11665-11677
    • Zhang, H.1
  • 34
    • 74549186394 scopus 로고    scopus 로고
    • Gene expression relationship between prostate cancer cells of Gleason 3, 4 and normal epithelial cells as revealed by cell type-specific transcriptomes
    • Pascal, L. E. et al. Gene expression relationship between prostate cancer cells of Gleason 3, 4 and normal epithelial cells as revealed by cell type-specific transcriptomes. BMC Cancer 9, 452 (2009).
    • (2009) BMC Cancer , vol.9 , pp. 452
    • Pascal, L.E.1
  • 35
    • 84866002291 scopus 로고    scopus 로고
    • The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data
    • Cerami, E. et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2, 401-404 (2012).
    • (2012) Cancer Discov. , vol.2 , pp. 401-404
    • Cerami, E.1
  • 36
    • 84946195510 scopus 로고    scopus 로고
    • The molecular taxonomy of primary prostate
    • Abeshouse, A. et al. The molecular taxonomy of primary prostate. Cancer Cell 163, 1011-1025 (2015).
    • (2015) Cancer Cell , vol.163 , pp. 1011-1025
    • Abeshouse, A.1
  • 37
    • 84930225081 scopus 로고    scopus 로고
    • Integrative clinical genomics of advanced prostate cancer
    • Robinson, D. et al. Integrative clinical genomics of advanced prostate cancer. Cell 161, 1215-1228 (2015).
    • (2015) Cell , vol.161 , pp. 1215-1228
    • Robinson, D.1
  • 38
    • 84917691199 scopus 로고    scopus 로고
    • Targeting the c-Met/FZD8 signaling axis eliminates patientderived cancer stem-like cells in head and neck squamous carcinomas
    • Sun, S. et al. Targeting the c-Met/FZD8 signaling axis eliminates patientderived cancer stem-like cells in head and neck squamous carcinomas. Cancer Res. 74, 7546-7559 (2014).
    • (2014) Cancer Res. , vol.74 , pp. 7546-7559
    • Sun, S.1
  • 39
    • 33845352082 scopus 로고    scopus 로고
    • Wnts as ligands: Processing, secretion and reception
    • Mikels, A. &Nusse, R. Wnts as ligands: processing, secretion and reception. Oncogene 25, 7461-7468 (2006).
    • (2006) Oncogene , vol.25 , pp. 7461-7468
    • Mikels, A.1    Nusse, R.2
  • 40
    • 84950327126 scopus 로고    scopus 로고
    • Structure-based discovery of novel small molecule Wnt signaling inhibitors by targeting the cysteine rich domain of Frizzled
    • Lee, H.-J. et al. Structure-based discovery of novel small molecule Wnt signaling inhibitors by targeting the cysteine rich domain of Frizzled. J. Biol. Chem. 290, 30596-30606 (2015).
    • (2015) J. Biol. Chem. , vol.290 , pp. 30596-30606
    • Lee, H.-J.1
  • 41
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery, J. P. Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer 2, 442-454 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 42
    • 84862279514 scopus 로고    scopus 로고
    • Activation of Wnt11 by transforming growth factor-β drives mesenchymal gene expression through non-canonical Wnt protein signaling in renal epithelial cells
    • Zhang, P., Cai, Y., Soofi, A. &Dressler, G. R. Activation of Wnt11 by transforming growth factor-β drives mesenchymal gene expression through non-canonical Wnt protein signaling in renal epithelial cells. J. Biol. Chem. 287, 21290-21302 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 21290-21302
    • Zhang, P.1    Cai, Y.2    Soofi, A.3    Dressler, G.R.4
  • 43
    • 77956287380 scopus 로고    scopus 로고
    • A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses
    • Härma, V. et al. A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses. PLoS ONE 5, e10431 (2010).
    • (2010) PLoS ONE , vol.5 , pp. e10431
    • Härma, V.1
  • 44
    • 84865041687 scopus 로고    scopus 로고
    • Chick chorioallantoic membrane (CAM) assay as an in vivo model to study the effect of newly identified molecules on ovarian cancer invasion and metastasis
    • Lokman, N. A., Elder, A. S. F., Ricciardelli, C. &Oehler, M. K. Chick chorioallantoic membrane (CAM) assay as an in vivo model to study the effect of newly identified molecules on ovarian cancer invasion and metastasis. Int. J. Mol. Sci. 13, 9959-9970 (2012).
    • (2012) Int. J. Mol. Sci. , vol.13 , pp. 9959-9970
    • Lokman, N.A.1    Elder, A.S.F.2    Ricciardelli, C.3    Oehler, M.K.4
  • 45
    • 40549085666 scopus 로고    scopus 로고
    • Overexpression of vimentin contributes to prostate cancer invasion and metastasis via Src regulation
    • Wei, J. et al. Overexpression of vimentin contributes to prostate cancer invasion and metastasis via Src regulation. Anticancer Res. 28, 327-334 (2008).
    • (2008) Anticancer Res. , vol.28 , pp. 327-334
    • Wei, J.1
  • 46
    • 0037699018 scopus 로고    scopus 로고
    • Overexpression of vimentin: Role in the invasive phenotype in an androgen-independent model of prostate cancer
    • Singh, S., Sadacharan, S. &Su, S. Overexpression of vimentin: role in the invasive phenotype in an androgen-independent model of prostate cancer. Cancer Res. 63, 2306-2311 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 2306-2311
    • Singh, S.1    Sadacharan, S.2    Su, S.3
  • 47
    • 77954255681 scopus 로고    scopus 로고
    • Integrative genomic profiling of human prostate cancer
    • Taylor, B., Schultz, N. &Hieronymus, H. Integrative genomic profiling of human prostate cancer. Cancer Cell 18, 11-22 (2010).
    • (2010) Cancer Cell , vol.18 , pp. 11-22
    • Taylor, B.1    Schultz, N.2    Hieronymus, H.3
  • 48
    • 58149216052 scopus 로고    scopus 로고
    • Signaling cross-talk between TGF-beta/BMP and other pathways
    • Guo, X. &Wang, X.-F. Signaling cross-talk between TGF-beta/BMP and other pathways. Cell Res. 19, 71-88 (2009).
    • (2009) Cell Res. , vol.19 , pp. 71-88
    • Guo, X.1    Wang, X.-F.2
  • 49
    • 84880055491 scopus 로고    scopus 로고
    • Signal integration in TGF-β, WNT, and Hippo pathways
    • Attisano, L. &Wrana, J. L. Signal integration in TGF-β, WNT, and Hippo pathways. F1000Prime Rep. 5, 17 (2013).
    • (2013) F1000Prime Rep. , vol.5 , pp. 17
    • Attisano, L.1    Wrana, J.L.2
  • 50
    • 58149236744 scopus 로고    scopus 로고
    • Roles of TGFbeta in metastasis
    • Padua, D. &Massagué, J. Roles of TGFbeta in metastasis. Cell Res. 19, 89-102 (2009).
    • (2009) Cell Res. , vol.19 , pp. 89-102
    • Padua, D.1    Massagué, J.2
  • 51
    • 75649088874 scopus 로고    scopus 로고
    • Mechanisms of epithelialmesenchymal transition by TGF-β
    • Wendt, M. K., Allington, T. M. &Schiemann, W. P. Mechanisms of epithelialmesenchymal transition by TGF-β. Future Oncol. 5, 1145-1168 (2009).
    • (2009) Future Oncol. , vol.5 , pp. 1145-1168
    • Wendt, M.K.1    Allington, T.M.2    Schiemann, W.P.3
  • 52
    • 0033605562 scopus 로고    scopus 로고
    • ATF-2 is a common nuclear target of smad and TAK1 pathways in transforming growth factor-β signaling
    • Sano, Y. et al. ATF-2 is a common nuclear target of smad and TAK1 pathways in transforming growth factor-β signaling. J. Biol. Chem. 274, 8949-8957 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 8949-8957
    • Sano, Y.1
  • 53
    • 0036724089 scopus 로고    scopus 로고
    • Classification of human B-ZIP proteins based on dimerization properties
    • Vinson, C. et al. Classification of human B-ZIP proteins based on dimerization properties. ASHA 22, 6321-6335 (2002).
    • (2002) ASHA , vol.22 , pp. 6321-6335
    • Vinson, C.1
  • 54
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • Shi, Y. &Massagué, J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113, 685-700 (2003).
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massagué, J.2
  • 56
    • 84863938543 scopus 로고    scopus 로고
    • Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors
    • Gurney, A. et al. Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors. Proc. Natl Acad. Sci. USA 109, 11717-11722 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 11717-11722
    • Gurney, A.1
  • 57
    • 79751531916 scopus 로고    scopus 로고
    • Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin
    • Wei, W., Chua, M.-S., Grepper, S. &So, S. K. Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin. Mol. Cancer 10, 16 (2011).
    • (2011) Mol. Cancer , vol.10 , pp. 16
    • Wei, W.1    Chua, M.-S.2    Grepper, S.3    So, S.K.4
  • 58
    • 84966373487 scopus 로고    scopus 로고
    • TGFβ-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8
    • Spanjer, A. I. R. et al. TGFβ-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8. FASEB J. 30, 1823-1835 (2016).
    • (2016) FASEB J. , vol.30 , pp. 1823-1835
    • Spanjer, A.I.R.1
  • 59
    • 85020775090 scopus 로고    scopus 로고
    • FZD8, a target of p53, promotes bone metastasis in prostate cancer by activating canonical Wnt/β-catenin signaling
    • Li, Q. et al. FZD8, a target of p53, promotes bone metastasis in prostate cancer by activating canonical Wnt/β-catenin signaling. Cancer Lett. 402, 166-176 (2017).
    • (2017) Cancer Lett. , vol.402 , pp. 166-176
    • Li, Q.1
  • 60
    • 84961262615 scopus 로고    scopus 로고
    • Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin
    • Mihara, E. et al. Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin. eLife 5, e11621 (2016).
    • (2016) ELife , vol.5 , pp. e11621
    • Mihara, E.1
  • 61
    • 0029062390 scopus 로고
    • A transition in transcriptional activation by the glucocorticoid and retinoic acid receptors at the tumor stage of dermal fibrosarcoma development
    • Vivanco, M. D., Johnson, R., Galante, P. E., Hanahan, D. &Yamamoto, K. R. A transition in transcriptional activation by the glucocorticoid and retinoic acid receptors at the tumor stage of dermal fibrosarcoma development. EMBO J. 14, 2217-2228 (1995).
    • (1995) EMBO J. , vol.14 , pp. 2217-2228
    • Vivanco, M.D.1    Johnson, R.2    Galante, P.E.3    Hanahan, D.4    Yamamoto, K.R.5
  • 62
    • 0032101178 scopus 로고    scopus 로고
    • Direct binding of Smad3 and Smad4 to critical TGF β-inducible elements in the promoter of human plasminogen activator inhibitor-type 1
    • Dennler, S., Itoh, S., Vivien, D., Dijke, P. &Gauthier, J. Direct binding of Smad3 and Smad4 to critical TGF β-inducible elements in the promoter of human plasminogen activator inhibitor-type 1. Gene 17, 3091-3100 (1998).
    • (1998) Gene , vol.17 , pp. 3091-3100
    • Dennler, S.1    Itoh, S.2    Vivien, D.3    Dijke, P.4    Gauthier, J.5
  • 63
    • 10644260259 scopus 로고    scopus 로고
    • Induction of CCAAT/enhancer-binding protein (C/EBP)-homologous protein/growth arrest and DNA damage-inducible protein 153 expression during inhibition of phosphatidylcholine synthesis is mediated via activation of a C/EBP-activating transcription factor-r
    • van der Sanden, M. H. M., Meems, H., Houweling, M., Helms, J. B. &Vaandrager, A. B. Induction of CCAAT/enhancer-binding protein (C/EBP)-homologous protein/growth arrest and DNA damage-inducible protein 153 expression during inhibition of phosphatidylcholine synthesis is mediated via activation of a C/EBP-activating transcription factor-r. J. Biol. Chem. 279, 52007-52015 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 52007-52015
    • Van Der Sanden, M.H.M.1    Meems, H.2    Houweling, M.3    Helms, J.B.4    Vaandrager, A.B.5
  • 64
    • 84868552930 scopus 로고    scopus 로고
    • Frizzled 2 and Frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: Evidence for a network of interacting genes
    • Yu, H., Ye, X., Guo, N. &Nathans, J. Frizzled 2 and Frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes. Development 139, 4383-4394 (2012).
    • (2012) Development , vol.139 , pp. 4383-4394
    • Yu, H.1    Ye, X.2    Guo, N.3    Nathans, J.4
  • 65
    • 1642523622 scopus 로고    scopus 로고
    • SREBP-1 dimerization specificity maps to both the helix-loophelix and leucine zipper domains: Use of a dominant negative
    • Rishi, V. et al. SREBP-1 dimerization specificity maps to both the helix-loophelix and leucine zipper domains: use of a dominant negative. J. Biol. Chem. 279, 11863-11874 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 11863-11874
    • Rishi, V.1
  • 66
    • 0026496172 scopus 로고
    • TGF beta signals through a heteromeric protein kinase receptor complex
    • Wrana, J. et al. TGF beta signals through a heteromeric protein kinase receptor complex. Cell 71, 1003-1014 (1992).
    • (1992) Cell , vol.71 , pp. 1003-1014
    • Wrana, J.1
  • 67
    • 17544376741 scopus 로고    scopus 로고
    • Ligand-independent activation of transforming growth factor (TGF) beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors
    • Feng, X. &Derynck, R. Ligand-independent activation of transforming growth factor (TGF) beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors. J. Biol. Chem. 271, 13123-13129 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 13123-13129
    • Feng, X.1    Derynck, R.2
  • 68
    • 0035954281 scopus 로고    scopus 로고
    • Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6
    • Semenov, M. V. et al. Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr. Biol. 11, 951-961 (2001).
    • (2001) Curr. Biol. , vol.11 , pp. 951-961
    • Semenov, M.V.1
  • 69
    • 79960844882 scopus 로고    scopus 로고
    • Effects of estrogen on the proportion of stem cells in the breast
    • Simões, B. et al. Effects of estrogen on the proportion of stem cells in the breast. Breast Cancer Res. Treat. 129, 23-25 (2011).
    • (2011) Breast Cancer Res. Treat. , vol.129 , pp. 23-25
    • Simões, B.1
  • 70
    • 84901501094 scopus 로고    scopus 로고
    • Quantification of dynamic morphological drug responses in 3D organotypic cell cultures by automated image analysis
    • Härma, V. et al. Quantification of dynamic morphological drug responses in 3D organotypic cell cultures by automated image analysis. PLoS ONE 9, e96426 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e96426
    • Härma, V.1


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