-
1
-
-
77953720558
-
Cancer stem cells and self-renewal
-
O'Brien CA, Kreso A, Jamieson CH: Cancer stem cells and self-renewal. Clin Cancer Res. 2010, 16: 3113-3120. 10.1158/1078-0432.CCR-09-2824.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3113-3120
-
-
O'Brien, C.A.1
Kreso, A.2
Jamieson, C.H.3
-
2
-
-
69449096005
-
Heterogeneity in cancer: cancer stem cells versus clonal evolution
-
Shackleton M, Quintana E, Fearon ER, Morrison SJ: Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell. 2009, 138: 822-829. 10.1016/j.cell.2009.08.017.
-
(2009)
Cell
, vol.138
, pp. 822-829
-
-
Shackleton, M.1
Quintana, E.2
Fearon, E.R.3
Morrison, S.J.4
-
3
-
-
33745065756
-
Common critical pathways in embryogenesis and cancer
-
Kelleher FC, Fennelly D, Rafferty M: Common critical pathways in embryogenesis and cancer. Acta Oncol. 2006, 45: 375-388. 10.1080/02841860600602946.
-
(2006)
Acta Oncol
, vol.45
, pp. 375-388
-
-
Kelleher, F.C.1
Fennelly, D.2
Rafferty, M.3
-
4
-
-
55249090137
-
Wnt1 overexpression promotes tumour progression in non-small cell lung cancer
-
Huang CL, Liu D, Ishikawa S, Nakashima T, Nakashima N, Yokomise H, Kadota K, Ueno M: Wnt1 overexpression promotes tumour progression in non-small cell lung cancer. Eur J Cancer. 2008, 44: 2680-2688. 10.1016/j.ejca.2008.08.004.
-
(2008)
Eur J Cancer
, vol.44
, pp. 2680-2688
-
-
Huang, C.L.1
Liu, D.2
Ishikawa, S.3
Nakashima, T.4
Nakashima, N.5
Yokomise, H.6
Kadota, K.7
Ueno, M.8
-
5
-
-
77950394022
-
LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy
-
Liu CC, Prior J, Piwnica-Worms D, Bu G: LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy. Proc Natl Acad Sci USA. 2010, 107: 5136-5141. 10.1073/pnas.0911220107.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 5136-5141
-
-
Liu, C.C.1
Prior, J.2
Piwnica-Worms, D.3
Bu, G.4
-
6
-
-
65249147725
-
Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer
-
Mullendore ME, Koorstra JB, Li YM, Offerhaus GJ, Fan X, Henderson CM, Matsui W, Eberhart CG, Maitra A, Feldmann G: Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer. Clin Cancer Res. 2009, 15: 2291-2301. 10.1158/1078-0432.CCR-08-2004.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2291-2301
-
-
Mullendore, M.E.1
Koorstra, J.B.2
Li, Y.M.3
Offerhaus, G.J.4
Fan, X.5
Henderson, C.M.6
Matsui, W.7
Eberhart, C.G.8
Maitra, A.9
Feldmann, G.10
-
8
-
-
77953696850
-
Controversies in cancer stem cells: targeting embryonic signaling pathways
-
Takebe N, Ivy SP: Controversies in cancer stem cells: targeting embryonic signaling pathways. Clin Cancer Res. 2010, 16: 3106-3112. 10.1158/1078-0432.CCR-09-2934.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3106-3112
-
-
Takebe, N.1
Ivy, S.P.2
-
9
-
-
0037169354
-
Cancer susceptibility and the functions of BRCA1 and BRCA2
-
Venkitaraman AR: Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell. 2002, 108: 171-182. 10.1016/S0092-8674(02)00615-3.
-
(2002)
Cell
, vol.108
, pp. 171-182
-
-
Venkitaraman, A.R.1
-
10
-
-
40349100163
-
BRCA1 regulates human mammary stem/progenitor cell fate
-
Liu S, Ginestier C, Charafe-Jauffret E, Foco H, Kleer CG, Merajver SD, Dontu G, Wicha MS: BRCA1 regulates human mammary stem/progenitor cell fate. Proc Natl Acad Sci USA. 2008, 105: 1680-1685. 10.1073/pnas.0711613105.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 1680-1685
-
-
Liu, S.1
Ginestier, C.2
Charafe-Jauffret, E.3
Foco, H.4
Kleer, C.G.5
Merajver, S.D.6
Dontu, G.7
Wicha, M.S.8
-
11
-
-
55749106963
-
Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells
-
Grimshaw MJ, Cooper L, Papazisis K, Coleman JA, Bohnenkamp HR, Chiapero-Stanke L, Taylor-Papadimitriou J, Burchell JM: Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells. Breast Cancer Res. 2008, 10: R52. 10.1186/bcr2106.
-
(2008)
Breast Cancer Res
, vol.10
, pp. R52
-
-
Grimshaw, M.J.1
Cooper, L.2
Papazisis, K.3
Coleman, J.A.4
Bohnenkamp, H.R.5
Chiapero-Stanke, L.6
Taylor-Papadimitriou, J.7
Burchell, J.M.8
-
12
-
-
0037388204
-
Prospective identification of tumorigenic breast cancer cells
-
Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF: Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA. 2003, 100: 3983-3988. 10.1073/pnas.0530291100.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 3983-3988
-
-
Al-Hajj, M.1
Wicha, M.S.2
Benito-Hernandez, A.3
Morrison, S.J.4
Clarke, M.F.5
-
13
-
-
42549142322
-
Brca1 breast tumors contain distinct CD44+/CD24- and CD133+ cells with cancer stem cell characteristics
-
Wright MH, Calcagno AM, Salcido CD, Carlson MD, Ambudkar SV, Varticovski L: Brca1 breast tumors contain distinct CD44+/CD24- and CD133+ cells with cancer stem cell characteristics. Breast Cancer Res. 2008, 10: R10. 10.1186/bcr1855.
-
(2008)
Breast Cancer Res
, vol.10
, pp. R10
-
-
Wright, M.H.1
Calcagno, A.M.2
Salcido, C.D.3
Carlson, M.D.4
Ambudkar, S.V.5
Varticovski, L.6
-
14
-
-
68349130357
-
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
-
Lim E, Vaillant F, Wu D, Forrest NC, Pal B, Hart AH, Asselin-Labat ML, Gyorki DE, Ward T, Partanen A, Feleppa F, Huschtscha LI, Thorne HJ, kConFab, Fox SB, Yan M, French JD, Brown MA, Smyth GK, Visvader JE, Lindeman GJ: Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med. 2009, 15: 907-913. 10.1038/nm.2000.
-
(2009)
Nat Med
, vol.15
, pp. 907-913
-
-
Lim, E.1
Vaillant, F.2
Wu, D.3
Forrest, N.C.4
Pal, B.5
Hart, A.H.6
Asselin-Labat, M.L.7
Gyorki, D.E.8
Ward, T.9
Partanen, A.10
Feleppa, F.11
Huschtscha, L.I.12
Thorne, H.J.13
Fox, S.B.14
Yan, M.15
French, J.D.16
Brown, M.A.17
Smyth, G.K.18
Visvader, J.E.19
Lindeman, G.J.20
more..
-
15
-
-
35848955428
-
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
-
Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, Jacquemier J, Viens P, Kleer CG, Liu S, Schott A, Hayes D, Birnbaum D, Wicha MS, Dontu G: ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell. 2007, 1: 555-567. 10.1016/j.stem.2007.08.014.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 555-567
-
-
Ginestier, C.1
Hur, M.H.2
Charafe-Jauffret, E.3
Monville, F.4
Dutcher, J.5
Brown, M.6
Jacquemier, J.7
Viens, P.8
Kleer, C.G.9
Liu, S.10
Schott, A.11
Hayes, D.12
Birnbaum, D.13
Wicha, M.S.14
Dontu, G.15
-
16
-
-
60549111070
-
Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature
-
Charafe-Jauffret E, Ginestier C, Iovino F, Wicinski J, Cervera N, Finetti P, Hur MH, Diebel ME, Monville F, Dutcher J, Brown M, Viens P, Xerri L, Bertucci F, Stassi G, Dontu G, Birnbaum D, Wicha MS: Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res. 2009, 69: 1302-1313. 10.1158/0008-5472.CAN-08-2741.
-
(2009)
Cancer Res
, vol.69
, pp. 1302-1313
-
-
Charafe-Jauffret, E.1
Ginestier, C.2
Iovino, F.3
Wicinski, J.4
Cervera, N.5
Finetti, P.6
Hur, M.H.7
Diebel, M.E.8
Monville, F.9
Dutcher, J.10
Brown, M.11
Viens, P.12
Xerri, L.13
Bertucci, F.14
Stassi, G.15
Dontu, G.16
Birnbaum, D.17
Wicha, M.S.18
-
17
-
-
58849131828
-
Cancer and the tumor microenvironment: a review of an essential relationship
-
Mbeunkui F, Johann DJ: Cancer and the tumor microenvironment: a review of an essential relationship. Cancer Chemother Pharmacol. 2009, 63: 571-582. 10.1007/s00280-008-0881-9.
-
(2009)
Cancer Chemother Pharmacol
, vol.63
, pp. 571-582
-
-
Mbeunkui, F.1
Johann, D.J.2
-
18
-
-
44049100934
-
Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy
-
Li X, Lewis MT, Huang J, Gutierrez C, Osborne CK, Wu MF, Hilsenbeck SG, Pavlick A, Zhang X, Chamness GC, Wong H, Rosen J, Chang JC: Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J Natl Cancer Inst. 2008, 100: 672-679. 10.1093/jnci/djn123.
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 672-679
-
-
Li, X.1
Lewis, M.T.2
Huang, J.3
Gutierrez, C.4
Osborne, C.K.5
Wu, M.F.6
Hilsenbeck, S.G.7
Pavlick, A.8
Zhang, X.9
Chamness, G.C.10
Wong, H.11
Rosen, J.12
Chang, J.C.13
-
19
-
-
77951224759
-
ABCG2: a potential marker of stem cells and novel target in stem cell and cancer therapy
-
Ding XW, Wu JH, Jiang CP: ABCG2: a potential marker of stem cells and novel target in stem cell and cancer therapy. Life Sci. 2010, 86: 631-637. 10.1016/j.lfs.2010.02.012.
-
(2010)
Life Sci
, vol.86
, pp. 631-637
-
-
Ding, X.W.1
Wu, J.H.2
Jiang, C.P.3
-
20
-
-
13044249156
-
A multidrug resistance transporter from human MCF-7 breast cancer cells
-
Doyle LA, Yang W, Abruzzo LV, Krogmann T, Gao Y, Rishi AK, Ross DD: A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci USA. 1998, 95: 15665-15670. 10.1073/pnas.95.26.15665.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 15665-15670
-
-
Doyle, L.A.1
Yang, W.2
Abruzzo, L.V.3
Krogmann, T.4
Gao, Y.5
Rishi, A.K.6
Ross, D.D.7
-
21
-
-
77958025244
-
Structure and function of the human breast cancer resistance protein (BCRP/ABCG2)
-
Ni Z, Bikadi Z, Rosenberg MF, Mao Q: Structure and function of the human breast cancer resistance protein (BCRP/ABCG2). Curr Drug Metab. 2010, 11: 603-617. 10.2174/138920010792927325.
-
(2010)
Curr Drug Metab
, vol.11
, pp. 603-617
-
-
Ni, Z.1
Bikadi, Z.2
Rosenberg, M.F.3
Mao, Q.4
-
22
-
-
33845904383
-
The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation
-
Phillips TM, McBride WH, Pajonk F: The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation. J Natl Cancer Inst. 2006, 98: 1777-1785. 10.1093/jnci/djj495.
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 1777-1785
-
-
Phillips, T.M.1
McBride, W.H.2
Pajonk, F.3
-
23
-
-
77956034139
-
Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment
-
Lagadec C, Vlashi E, Della Donna L, Meng Y, Dekmezian C, Kim K, Pajonk F: Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment. Breast Cancer Res. 2010, 12: R13. 10.1186/bcr2479.
-
(2010)
Breast Cancer Res
, vol.12
, pp. R13
-
-
Lagadec, C.1
Vlashi, E.2
Della Donna, L.3
Meng, Y.4
Dekmezian, C.5
Kim, K.6
Pajonk, F.7
-
24
-
-
64749093574
-
Association of reactive oxygen species levels and radioresistance in cancer stem cells
-
Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, Kulp AN, Qian D, Lam JS, Ailles LE, Wong M, Joshua B, Kaplan MJ, Wapnir I, Dirbas FM, Somlo G, Garberoglio C, Paz B, Shen J, Lau SK, Quake SR, Brown JM, Weissman IL, Clarke MF: Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature. 2009, 458: 780-783. 10.1038/nature07733.
-
(2009)
Nature
, vol.458
, pp. 780-783
-
-
Diehn, M.1
Cho, R.W.2
Lobo, N.A.3
Kalisky, T.4
Dorie, M.J.5
Kulp, A.N.6
Qian, D.7
Lam, J.S.8
Ailles, L.E.9
Wong, M.10
Joshua, B.11
Kaplan, M.J.12
Wapnir, I.13
Dirbas, F.M.14
Somlo, G.15
Garberoglio, C.16
Paz, B.17
Shen, J.18
Lau, S.K.19
Quake, S.R.20
Brown, J.M.21
Weissman, I.L.22
Clarke, M.F.23
more..
-
25
-
-
44649107292
-
Mechanisms of disease: cancer stem cells - targeting the evil twin
-
Trumpp A, Wiestler OD: Mechanisms of disease: cancer stem cells - targeting the evil twin. Nat Clin Pract Oncol. 2008, 5: 337-347.
-
(2008)
Nat Clin Pract Oncol
, vol.5
, pp. 337-347
-
-
Trumpp, A.1
Wiestler, O.D.2
-
26
-
-
33846287519
-
WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells
-
Woodward WA, Chen MS, Behbod F, Alfaro MP, Buchholz TA, Rosen JM: WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells. Proc Natl Acad Sci USA. 2007, 104: 618-623. 10.1073/pnas.0606599104.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 618-623
-
-
Woodward, W.A.1
Chen, M.S.2
Behbod, F.3
Alfaro, M.P.4
Buchholz, T.A.5
Rosen, J.M.6
-
27
-
-
77953722864
-
The difficulty of targeting cancer stem cell niches
-
LaBarge MA: The difficulty of targeting cancer stem cell niches. Clin Cancer Res. 2010, 16: 3121-3129. 10.1158/1078-0432.CCR-09-2933.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3121-3129
-
-
LaBarge, M.A.1
-
28
-
-
33645469482
-
Stem cells and their niches
-
Moore KA, Lemischka IR: Stem cells and their niches. Science. 2006, 311: 1880-1885. 10.1126/science.1110542.
-
(2006)
Science
, vol.311
, pp. 1880-1885
-
-
Moore, K.A.1
Lemischka, I.R.2
-
29
-
-
79551600015
-
Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways
-
Takebe N, Harris PJ, Warren RQ, Ivy SP: Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol. 2011, 8: 97-106.
-
(2011)
Nat Rev Clin Oncol
, vol.8
, pp. 97-106
-
-
Takebe, N.1
Harris, P.J.2
Warren, R.Q.3
Ivy, S.P.4
-
30
-
-
58149216052
-
Signaling cross-talk between TGF-beta/BMP and other pathways
-
Guo X, Wang XF: Signaling cross-talk between TGF-beta/BMP and other pathways. Cell Res. 2009, 19: 71-88. 10.1038/cr.2008.302.
-
(2009)
Cell Res
, vol.19
, pp. 71-88
-
-
Guo, X.1
Wang, X.F.2
-
31
-
-
47549090432
-
TGFbeta in Cancer
-
Massague J: TGFbeta in Cancer. Cell. 2008, 134: 215-230. 10.1016/j.cell.2008.07.001.
-
(2008)
Cell
, vol.134
, pp. 215-230
-
-
Massague, J.1
-
32
-
-
54049096261
-
HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion
-
Korkaya H, Paulson A, Iovino F, Wicha MS: HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion. Oncogene. 2008, 27: 6120-6130. 10.1038/onc.2008.207.
-
(2008)
Oncogene
, vol.27
, pp. 6120-6130
-
-
Korkaya, H.1
Paulson, A.2
Iovino, F.3
Wicha, M.S.4
-
33
-
-
0030910099
-
Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH
-
Chen Y, Fischer WH, Gill GN: Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH. J Biol Chem. 1997, 272: 14110-14114. 10.1074/jbc.272.22.14110.
-
(1997)
J Biol Chem
, vol.272
, pp. 14110-14114
-
-
Chen, Y.1
Fischer, W.H.2
Gill, G.N.3
-
34
-
-
62549096930
-
Tumor-initiating cells of HER2-positive carcinoma cell lines express the highest oncoprotein levels and are sensitive to trastuzumab
-
Magnifico A, Albano L, Campaner S, Delia D, Castiglioni F, Gasparini P, Sozzi G, Fontanella E, Menard S, Tagliabue E: Tumor-initiating cells of HER2-positive carcinoma cell lines express the highest oncoprotein levels and are sensitive to trastuzumab. Clin Cancer Res. 2009, 15: 2010-2021. 10.1158/1078-0432.CCR-08-1327.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2010-2021
-
-
Magnifico, A.1
Albano, L.2
Campaner, S.3
Delia, D.4
Castiglioni, F.5
Gasparini, P.6
Sozzi, G.7
Fontanella, E.8
Menard, S.9
Tagliabue, E.10
-
35
-
-
48549103124
-
Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches
-
Rizzo P, Miao H, D'Souza G, Osipo C, Song LL, Yun J, Zhao H, Mascarenhas J, Wyatt D, Antico G, Hao L, Yao K, Rajan P, Hicks C, Siziopikou K, Selvaggi S, Bashir A, Bhandari D, Marchese A, Lendahl U, Qin JZ, Tonetti DA, Albain K, Nickoloff BJ, Miele L: Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. Cancer Res. 2008, 68: 5226-5235. 10.1158/0008-5472.CAN-07-5744.
-
(2008)
Cancer Res
, vol.68
, pp. 5226-5235
-
-
Rizzo, P.1
Miao, H.2
D'Souza, G.3
Osipo, C.4
Song, L.L.5
Yun, J.6
Zhao, H.7
Mascarenhas, J.8
Wyatt, D.9
Antico, G.10
Hao, L.11
Yao, K.12
Rajan, P.13
Hicks, C.14
Siziopikou, K.15
Selvaggi, S.16
Bashir, A.17
Bhandari, D.18
Marchese, A.19
Lendahl, U.20
Qin, J.Z.21
Tonetti, D.A.22
Albain, K.23
Nickoloff, B.J.24
Miele, L.25
more..
-
36
-
-
0033617522
-
Notch signaling: cell fate control and signal integration in development
-
Artavanis-Tsakonas S, Rand MD, Lake RJ: Notch signaling: cell fate control and signal integration in development. Science. 1999, 284: 770-776. 10.1126/science.284.5415.770.
-
(1999)
Science
, vol.284
, pp. 770-776
-
-
Artavanis-Tsakonas, S.1
Rand, M.D.2
Lake, R.J.3
-
37
-
-
77953700950
-
Targeting Notch to target cancer stem cells
-
Pannuti A, Foreman K, Rizzo P, Osipo C, Golde T, Osborne B, Miele L: Targeting Notch to target cancer stem cells. Clin Cancer Res. 2010, 16: 3141-3152. 10.1158/1078-0432.CCR-09-2823.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3141-3152
-
-
Pannuti, A.1
Foreman, K.2
Rizzo, P.3
Osipo, C.4
Golde, T.5
Osborne, B.6
Miele, L.7
-
38
-
-
63049123066
-
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
-
Polyak K, Weinberg RA: Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer. 2009, 9: 265-273. 10.1038/nrc2620.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 265-273
-
-
Polyak, K.1
Weinberg, R.A.2
-
39
-
-
33645049305
-
Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells
-
Wang Z, Banerjee S, Li Y, Rahman KM, Zhang Y, Sarkar FH: Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. Cancer Res. 2006, 66: 2778-2784. 10.1158/0008-5472.CAN-05-4281.
-
(2006)
Cancer Res
, vol.66
, pp. 2778-2784
-
-
Wang, Z.1
Banerjee, S.2
Li, Y.3
Rahman, K.M.4
Zhang, Y.5
Sarkar, F.H.6
-
40
-
-
0037663379
-
Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain
-
McGill MA, McGlade CJ: Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J Biol Chem. 2003, 278: 23196-23203. 10.1074/jbc.M302827200.
-
(2003)
J Biol Chem
, vol.278
, pp. 23196-23203
-
-
McGill, M.A.1
McGlade, C.J.2
-
41
-
-
7244250027
-
Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis
-
Pece S, Serresi M, Santolini E, Capra M, Hulleman E, Galimberti V, Zurrida S, Maisonneuve P, Viale G, Di Fiore PP: Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol. 2004, 167: 215-221. 10.1083/jcb.200406140.
-
(2004)
J Cell Biol
, vol.167
, pp. 215-221
-
-
Pece, S.1
Serresi, M.2
Santolini, E.3
Capra, M.4
Hulleman, E.5
Galimberti, V.6
Zurrida, S.7
Maisonneuve, P.8
Viale, G.9
Di Fiore, P.P.10
-
42
-
-
24944506696
-
High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
-
Reedijk M, Odorcic S, Chang L, Zhang H, Miller N, McCready DR, Lockwood G, Egan SE: High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res. 2005, 65: 8530-8537. 10.1158/0008-5472.CAN-05-1069.
-
(2005)
Cancer Res
, vol.65
, pp. 8530-8537
-
-
Reedijk, M.1
Odorcic, S.2
Chang, L.3
Zhang, H.4
Miller, N.5
McCready, D.R.6
Lockwood, G.7
Egan, S.E.8
-
43
-
-
1842524153
-
Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition
-
Zavadil J, Cermak L, Soto-Nieves N, Bottinger EP: Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition. EMBO J. 2004, 23: 1155-1165. 10.1038/sj.emboj.7600069.
-
(2004)
EMBO J
, vol.23
, pp. 1155-1165
-
-
Zavadil, J.1
Cermak, L.2
Soto-Nieves, N.3
Bottinger, E.P.4
-
44
-
-
43049165453
-
The epithelial-mesenchymal transition generates cells with properties of stem cells
-
Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campbell LL, Polyak K, Brisken C, Yang J, Weinberg RA: The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008, 133: 704-715. 10.1016/j.cell.2008.03.027.
-
(2008)
Cell
, vol.133
, pp. 704-715
-
-
Mani, S.A.1
Guo, W.2
Liao, M.J.3
Eaton, E.N.4
Ayyanan, A.5
Zhou, A.Y.6
Brooks, M.7
Reinhard, F.8
Zhang, C.C.9
Shipitsin, M.10
Campbell, L.L.11
Polyak, K.12
Brisken, C.13
Yang, J.14
Weinberg, R.A.15
-
45
-
-
44449144396
-
Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis
-
Yang J, Weinberg RA: Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell. 2008, 14: 818-829. 10.1016/j.devcel.2008.05.009.
-
(2008)
Dev Cell
, vol.14
, pp. 818-829
-
-
Yang, J.1
Weinberg, R.A.2
-
46
-
-
0038106228
-
Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail
-
Ikenouchi J, Matsuda M, Furuse M, Tsukita S: Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail. J Cell Sci. 2003, 116: 1959-1967. 10.1242/jcs.00389.
-
(2003)
J Cell Sci
, vol.116
, pp. 1959-1967
-
-
Ikenouchi, J.1
Matsuda, M.2
Furuse, M.3
Tsukita, S.4
-
47
-
-
68249092353
-
A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition
-
Vincent T, Neve EP, Johnson JR, Kukalev A, Rojo F, Albanell J, Pietras K, Virtanen I, Philipson L, Leopold PL, Crystal RG, de Herreros AG, Moustakas A, Pettersson RF, Fuxe J: A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition. Nat Cell Biol. 2009, 11: 943-950. 10.1038/ncb1905.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 943-950
-
-
Vincent, T.1
Neve, E.P.2
Johnson, J.R.3
Kukalev, A.4
Rojo, F.5
Albanell, J.6
Pietras, K.7
Virtanen, I.8
Philipson, L.9
Leopold, P.L.10
Crystal, R.G.11
de Herreros, A.G.12
Moustakas, A.13
Pettersson, R.F.14
Fuxe, J.15
-
48
-
-
0035577854
-
Hedgehog signaling in animal development: paradigms and principles
-
Ingham PW, McMahon AP: Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 2001, 15: 3059-3087. 10.1101/gad.938601.
-
(2001)
Genes Dev
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
49
-
-
0034646625
-
Mapping sonic hedgehog-receptor interactions by steric interference
-
Pepinsky RB, Rayhorn P, Day ES, Dergay A, Williams KP, Galdes A, Taylor FR, Boriack-Sjodin PA, Garber EA: Mapping sonic hedgehog-receptor interactions by steric interference. J Biol Chem. 2000, 275: 10995-11001. 10.1074/jbc.275.15.10995.
-
(2000)
J Biol Chem
, vol.275
, pp. 10995-11001
-
-
Pepinsky, R.B.1
Rayhorn, P.2
Day, E.S.3
Dergay, A.4
Williams, K.P.5
Galdes, A.6
Taylor, F.R.7
Boriack-Sjodin, P.A.8
Garber, E.A.9
-
50
-
-
0009603803
-
Sonic hedgehog signaling by the patched-smoothened receptor complex
-
Murone M, Rosenthal A, de Sauvage FJ: Sonic hedgehog signaling by the patched-smoothened receptor complex. Curr Biol. 1999, 9: 76-84. 10.1016/S0960-9822(99)80018-9.
-
(1999)
Curr Biol
, vol.9
, pp. 76-84
-
-
Murone, M.1
Rosenthal, A.2
de Sauvage, F.J.3
-
51
-
-
33244457232
-
The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity
-
Cayuso J, Ulloa F, Cox B, Briscoe J, Marti E: The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity. Development. 2006, 133: 517-528. 10.1242/dev.02228.
-
(2006)
Development
, vol.133
, pp. 517-528
-
-
Cayuso, J.1
Ulloa, F.2
Cox, B.3
Briscoe, J.4
Marti, E.5
-
52
-
-
33947254016
-
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers
-
Feldmann G, Dhara S, Fendrich V, Bedja D, Beaty R, Mullendore M, Karikari C, Alvarez H, Iacobuzio-Donahue C, Jimeno A, Gabrielson KL, Matsui W, Maitra A: Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res. 2007, 67: 2187-2196. 10.1158/0008-5472.CAN-06-3281.
-
(2007)
Cancer Res
, vol.67
, pp. 2187-2196
-
-
Feldmann, G.1
Dhara, S.2
Fendrich, V.3
Bedja, D.4
Beaty, R.5
Mullendore, M.6
Karikari, C.7
Alvarez, H.8
Iacobuzio-Donahue, C.9
Jimeno, A.10
Gabrielson, K.L.11
Matsui, W.12
Maitra, A.13
-
53
-
-
0029553183
-
An overview of epithelio-mesenchymal transformation
-
Hay ED: An overview of epithelio-mesenchymal transformation. Acta Anat (Basel). 1995, 154: 8-20. 10.1159/000147748.
-
(1995)
Acta Anat (Basel)
, vol.154
, pp. 8-20
-
-
Hay, E.D.1
-
54
-
-
6044243650
-
Hedgehog signalling in prostate regeneration, neoplasia and metastasis
-
Karhadkar SS, Bova GS, Abdallah N, Dhara S, Gardner D, Maitra A, Isaacs JT, Berman DM, Beachy PA: Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature. 2004, 431: 707-712. 10.1038/nature02962.
-
(2004)
Nature
, vol.431
, pp. 707-712
-
-
Karhadkar, S.S.1
Bova, G.S.2
Abdallah, N.3
Dhara, S.4
Gardner, D.5
Maitra, A.6
Isaacs, J.T.7
Berman, D.M.8
Beachy, P.A.9
-
55
-
-
0037108828
-
Comparative gene expression profile analysis of GLI and c-MYC in an epithelial model of malignant transformation
-
Louro ID, Bailey EC, Li X, South LS, McKie-Bell PR, Yoder BK, Huang CC, Johnson MR, Hill AE, Johnson RL, Ruppert JM: Comparative gene expression profile analysis of GLI and c-MYC in an epithelial model of malignant transformation. Cancer Res. 2002, 62: 5867-5873.
-
(2002)
Cancer Res
, vol.62
, pp. 5867-5873
-
-
Louro, I.D.1
Bailey, E.C.2
Li, X.3
South, L.S.4
McKie-Bell, P.R.5
Yoder, B.K.6
Huang, C.C.7
Johnson, M.R.8
Hill, A.E.9
Johnson, R.L.10
Ruppert, J.M.11
-
56
-
-
53049097596
-
Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (review)
-
Katoh Y, Katoh M: Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (review). Int J Mol Med. 2008, 22: 271-275.
-
(2008)
Int J Mol Med
, vol.22
, pp. 271-275
-
-
Katoh, Y.1
Katoh, M.2
-
57
-
-
77953693899
-
Targeting Hedgehog - a cancer stem cell pathway
-
Merchant AA, Matsui W: Targeting Hedgehog - a cancer stem cell pathway. Clin Cancer Res. 2010, 16: 3130-3140. 10.1158/1078-0432.CCR-09-2846.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3130-3140
-
-
Merchant, A.A.1
Matsui, W.2
-
58
-
-
73649145223
-
Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
-
Varnat F, Duquet A, Malerba M, Zbinden M, Mas C, Gervaz P, Ruiz i Altaba A: Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion. EMBO Mol Med. 2009, 1: 338-351. 10.1002/emmm.200900039.
-
(2009)
EMBO Mol Med
, vol.1
, pp. 338-351
-
-
Varnat, F.1
Duquet, A.2
Malerba, M.3
Zbinden, M.4
Mas, C.5
Gervaz, P.6
Ruiz i Altaba, A.7
-
59
-
-
78651339164
-
A Wnt-ow of opportunity: targeting the Wnt/beta-catenin pathway in breast cancer
-
Prosperi JR, Goss KH: A Wnt-ow of opportunity: targeting the Wnt/beta-catenin pathway in breast cancer. Curr Drug Targets. 2010, 11: 1074-1088. 10.2174/138945010792006780.
-
(2010)
Curr Drug Targets
, vol.11
, pp. 1074-1088
-
-
Prosperi, J.R.1
Goss, K.H.2
-
60
-
-
19644373254
-
Wnt signaling in disease and in development
-
Nusse R: Wnt signaling in disease and in development. Cell Res. 2005, 15: 28-32. 10.1038/sj.cr.7290260.
-
(2005)
Cell Res
, vol.15
, pp. 28-32
-
-
Nusse, R.1
-
61
-
-
33747339465
-
Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors
-
Gordon MD, Nusse R: Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem. 2006, 281: 22429-22433. 10.1074/jbc.R600015200.
-
(2006)
J Biol Chem
, vol.281
, pp. 22429-22433
-
-
Gordon, M.D.1
Nusse, R.2
-
62
-
-
0034636153
-
Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression
-
Lin SY, Xia W, Wang JC, Kwong KY, Spohn B, Wen Y, Pestell RG, Hung MC: Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci USA. 2000, 97: 4262-4266. 10.1073/pnas.060025397.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 4262-4266
-
-
Lin, S.Y.1
Xia, W.2
Wang, J.C.3
Kwong, K.Y.4
Spohn, B.5
Wen, Y.6
Pestell, R.G.7
Hung, M.C.8
-
64
-
-
0038271868
-
From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression
-
Schmidt-Kittler O, Ragg T, Daskalakis A, Granzow M, Ahr A, Blankenstein TJ, Kaufmann M, Diebold J, Arnholdt H, Muller P, Bischoff J, Harich D, Schlimok G, Riethmuller G, Eils R, Klein CA: From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression. Proc Natl Acad Sci USA. 2003, 100: 7737-7742. 10.1073/pnas.1331931100.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 7737-7742
-
-
Schmidt-Kittler, O.1
Ragg, T.2
Daskalakis, A.3
Granzow, M.4
Ahr, A.5
Blankenstein, T.J.6
Kaufmann, M.7
Diebold, J.8
Arnholdt, H.9
Muller, P.10
Bischoff, J.11
Harich, D.12
Schlimok, G.13
Riethmuller, G.14
Eils, R.15
Klein, C.A.16
-
65
-
-
28644432204
-
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
-
Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, MacDonald DD, Jin DK, Shido K, Kerns SA, Zhu Z, Hicklin D, Wu Y, Port JL, Altorki N, Port ER, Ruggero D, Shmelkov SV, Jensen KK, Rafii S, Lyden D: VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005, 438: 820-827. 10.1038/nature04186.
-
(2005)
Nature
, vol.438
, pp. 820-827
-
-
Kaplan, R.N.1
Riba, R.D.2
Zacharoulis, S.3
Bramley, A.H.4
Vincent, L.5
Costa, C.6
MacDonald, D.D.7
Jin, D.K.8
Shido, K.9
Kerns, S.A.10
Zhu, Z.11
Hicklin, D.12
Wu, Y.13
Port, J.L.14
Altorki, N.15
Port, E.R.16
Ruggero, D.17
Shmelkov, S.V.18
Jensen, K.K.19
Rafii, S.20
Lyden, D.21
more..
-
66
-
-
0035524455
-
The functional and clinical roles of osteopontin in cancer and metastasis
-
Furger KA, Menon RK, Tuck AB, Bramwell VH, Chambers AF: The functional and clinical roles of osteopontin in cancer and metastasis. Curr Mol Med. 2001, 1: 621-632. 10.2174/1566524013363339.
-
(2001)
Curr Mol Med
, vol.1
, pp. 621-632
-
-
Furger, K.A.1
Menon, R.K.2
Tuck, A.B.3
Bramwell, V.H.4
Chambers, A.F.5
-
67
-
-
34948896045
-
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
-
Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R, Weinberg RA: Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature. 2007, 449: 557-563. 10.1038/nature06188.
-
(2007)
Nature
, vol.449
, pp. 557-563
-
-
Karnoub, A.E.1
Dash, A.B.2
Vo, A.P.3
Sullivan, A.4
Brooks, M.W.5
Bell, G.W.6
Richardson, A.L.7
Polyak, K.8
Tubo, R.9
Weinberg, R.A.10
-
68
-
-
34548863946
-
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
-
Herschkowitz JI, Simin K, Weigman VJ, Mikaelian I, Usary J, Hu Z, Rasmussen KE, Jones LP, Assefnia S, Chandrasekharan S, Backlund MG, Yin Y, Khramtsov AI, Bastein R, Quackenbush J, Glazer RI, Brown PH, Green JE, Kopelovich L, Furth PA, Palazzo JP, Olopade OI, Bernard PS, Churchill GA, Van Dyke T, Perou CM: Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol. 2007, 8: R76. 10.1186/gb-2007-8-5-r76.
-
(2007)
Genome Biol
, vol.8
, pp. R76
-
-
Herschkowitz, J.I.1
Simin, K.2
Weigman, V.J.3
Mikaelian, I.4
Usary, J.5
Hu, Z.6
Rasmussen, K.E.7
Jones, L.P.8
Assefnia, S.9
Chandrasekharan, S.10
Backlund, M.G.11
Yin, Y.12
Khramtsov, A.I.13
Bastein, R.14
Quackenbush, J.15
Glazer, R.I.16
Brown, P.H.17
Green, J.E.18
Kopelovich, L.19
Furth, P.A.20
Palazzo, J.P.21
Olopade, O.I.22
Bernard, P.S.23
Churchill, G.A.24
Van Dyke, T.25
Perou, C.M.26
more..
-
69
-
-
69549131213
-
Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features
-
Creighton CJ, Li X, Landis M, Dixon JM, Neumeister VM, Sjolund A, Rimm DL, Wong H, Rodriguez A, Herschkowitz JI, Fan C, Zhang X, He X, Pavlick A, Gutierrez MC, Renshaw L, Larionov AA, Faratian D, Hilsenbeck SG, Perou CM, Lewis MT, Rosen JM, Chang JC: Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc Natl Acad Sci USA. 2009, 106: 13820-13825. 10.1073/pnas.0905718106.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 13820-13825
-
-
Creighton, C.J.1
Li, X.2
Landis, M.3
Dixon, J.M.4
Neumeister, V.M.5
Sjolund, A.6
Rimm, D.L.7
Wong, H.8
Rodriguez, A.9
Herschkowitz, J.I.10
Fan, C.11
Zhang, X.12
He, X.13
Pavlick, A.14
Gutierrez, M.C.15
Renshaw, L.16
Larionov, A.A.17
Faratian, D.18
Hilsenbeck, S.G.19
Perou, C.M.20
Lewis, M.T.21
Rosen, J.M.22
Chang, J.C.23
more..
-
70
-
-
77957262381
-
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
-
Taube JH, Herschkowitz JI, Komurov K, Zhou AY, Gupta S, Yang J, Hartwell K, Onder TT, Gupta PB, Evans KW, Hollier BG, Ram PT, Lander ES, Rosen JM, Weinberg RA, Mani SA: Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci USA. 2010, 107: 15449-15454. 10.1073/pnas.1004900107.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 15449-15454
-
-
Taube, J.H.1
Herschkowitz, J.I.2
Komurov, K.3
Zhou, A.Y.4
Gupta, S.5
Yang, J.6
Hartwell, K.7
Onder, T.T.8
Gupta, P.B.9
Evans, K.W.10
Hollier, B.G.11
Ram, P.T.12
Lander, E.S.13
Rosen, J.M.14
Weinberg, R.A.15
Mani, S.A.16
-
71
-
-
0036595629
-
Epithelial-mesenchymal transitions in tumour progression
-
Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2002, 2: 442-454. 10.1038/nrc822.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 442-454
-
-
Thiery, J.P.1
-
72
-
-
0031686121
-
Mutations of the human E-cadherin (CDH1) gene
-
Berx G, Becker KF, Hofler H, van Roy F: Mutations of the human E-cadherin (CDH1) gene. Hum Mutat. 1998, 12: 226-237. 10.1002/(SICI)1098-1004(1998)12:4<226::AID-HUMU2>3.0.CO;2-D.
-
(1998)
Hum Mutat
, vol.12
, pp. 226-237
-
-
Berx, G.1
Becker, K.F.2
Hofler, H.3
van Roy, F.4
-
73
-
-
33644834687
-
E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines
-
Lombaerts M, van Wezel T, Philippo K, Dierssen JW, Zimmerman RM, Oosting J, van Eijk R, Eilers PH, van de Water B, Cornelisse CJ, Cleton-Jansen AM: E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines. Br J Cancer. 2006, 94: 661-671.
-
(2006)
Br J Cancer
, vol.94
, pp. 661-671
-
-
Lombaerts, M.1
van Wezel, T.2
Philippo, K.3
Dierssen, J.W.4
Zimmerman, R.M.5
Oosting, J.6
van Eijk, R.7
Eilers, P.H.8
van de Water, B.9
Cornelisse, C.J.10
Cleton-Jansen, A.M.11
-
74
-
-
0033789680
-
The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
-
Batlle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J, Garcia De Herreros A: The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol. 2000, 2: 84-89. 10.1038/35000034.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 84-89
-
-
Batlle, E.1
Sancho, E.2
Franci, C.3
Dominguez, D.4
Monfar, M.5
Baulida, J.6
Garcia De Herreros, A.7
-
75
-
-
0033784843
-
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
-
Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, Portillo F, Nieto MA: The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol. 2000, 2: 76-83. 10.1038/35000025.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 76-83
-
-
Cano, A.1
Perez-Moreno, M.A.2
Rodrigo, I.3
Locascio, A.4
Blanco, M.J.5
del Barrio, M.G.6
Portillo, F.7
Nieto, M.A.8
-
76
-
-
46949102805
-
Mechanisms of malignant progression
-
Weinberg RA: Mechanisms of malignant progression. Carcinogenesis. 2008, 29: 1092-1095. 10.1093/carcin/bgn104.
-
(2008)
Carcinogenesis
, vol.29
, pp. 1092-1095
-
-
Weinberg, R.A.1
-
77
-
-
0028849277
-
E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas
-
Graff JR, Herman JG, Lapidus RG, Chopra H, Xu R, Jarrard DF, Isaacs WB, Pitha PM, Davidson NE, Baylin SB: E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res. 1995, 55: 5195-5199.
-
(1995)
Cancer Res
, vol.55
, pp. 5195-5199
-
-
Graff, J.R.1
Herman, J.G.2
Lapidus, R.G.3
Chopra, H.4
Xu, R.5
Jarrard, D.F.6
Isaacs, W.B.7
Pitha, P.M.8
Davidson, N.E.9
Baylin, S.B.10
-
78
-
-
0642336851
-
E-cadherin expression in primary carcinomas of the breast and its distant metastases
-
Kowalski PJ, Rubin MA, Kleer CG: E-cadherin expression in primary carcinomas of the breast and its distant metastases. Breast Cancer Res. 2003, 5: R217-222. 10.1186/bcr651.
-
(2003)
Breast Cancer Res
, vol.5
, pp. R217-222
-
-
Kowalski, P.J.1
Rubin, M.A.2
Kleer, C.G.3
-
79
-
-
77954862083
-
The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells
-
Taylor MA, Parvani JG, Schiemann WP: The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells. J Mammary Gland Biol Neoplasia. 2010, 15: 169-190. 10.1007/s10911-010-9181-1.
-
(2010)
J Mammary Gland Biol Neoplasia
, vol.15
, pp. 169-190
-
-
Taylor, M.A.1
Parvani, J.G.2
Schiemann, W.P.3
-
80
-
-
63049085576
-
MicroRNAs - the micro steering wheel of tumour metastases
-
Nicoloso MS, Spizzo R, Shimizu M, Rossi S, Calin GA: MicroRNAs - the micro steering wheel of tumour metastases. Nat Rev Cancer. 2009, 9: 293-302. 10.1038/nrc2619.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 293-302
-
-
Nicoloso, M.S.1
Spizzo, R.2
Shimizu, M.3
Rossi, S.4
Calin, G.A.5
-
81
-
-
58249088751
-
MicroRNAs: target recognition and regulatory functions
-
Bartel DP: MicroRNAs: target recognition and regulatory functions. Cell. 2009, 136: 215-233. 10.1016/j.cell.2009.01.002.
-
(2009)
Cell
, vol.136
, pp. 215-233
-
-
Bartel, D.P.1
-
82
-
-
47249091921
-
The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
-
Korpal M, Lee ES, Hu G, Kang Y: The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem. 2008, 283: 14910-14914. 10.1074/jbc.C800074200.
-
(2008)
J Biol Chem
, vol.283
, pp. 14910-14914
-
-
Korpal, M.1
Lee, E.S.2
Hu, G.3
Kang, Y.4
-
83
-
-
70449718853
-
MicroRNAs: crucial multi-tasking components in the complex circuitry of tumor metastasis
-
Valastyan S, Weinberg RA: MicroRNAs: crucial multi-tasking components in the complex circuitry of tumor metastasis. Cell Cycle. 2009, 8: 3506-3512. 10.4161/cc.8.21.9802.
-
(2009)
Cell Cycle
, vol.8
, pp. 3506-3512
-
-
Valastyan, S.1
Weinberg, R.A.2
-
84
-
-
38049115129
-
Endogenous human microRNAs that suppress breast cancer metastasis
-
Tavazoie SF, Alarcon C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL, Massague J: Endogenous human microRNAs that suppress breast cancer metastasis. Nature. 2008, 451: 147-152. 10.1038/nature06487.
-
(2008)
Nature
, vol.451
, pp. 147-152
-
-
Tavazoie, S.F.1
Alarcon, C.2
Oskarsson, T.3
Padua, D.4
Wang, Q.5
Bos, P.D.6
Gerald, W.L.7
Massague, J.8
-
85
-
-
56749095797
-
Transcriptional regulation of cell polarity in EMT and cancer
-
Moreno-Bueno G, Portillo F, Cano A: Transcriptional regulation of cell polarity in EMT and cancer. Oncogene. 2008, 27: 6958-6969. 10.1038/onc.2008.346.
-
(2008)
Oncogene
, vol.27
, pp. 6958-6969
-
-
Moreno-Bueno, G.1
Portillo, F.2
Cano, A.3
-
86
-
-
51449085561
-
Generation of breast cancer stem cells through epithelial-mesenchymal transition
-
Morel AP, Lievre M, Thomas C, Hinkal G, Ansieau S, Puisieux A: Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One. 2008, 3: e2888. 10.1371/journal.pone.0002888.
-
(2008)
PLoS One
, vol.3
-
-
Morel, A.P.1
Lievre, M.2
Thomas, C.3
Hinkal, G.4
Ansieau, S.5
Puisieux, A.6
-
87
-
-
0032076718
-
Polycombing the genome: PcG, trxG, and chromatin silencing
-
Pirrotta V: Polycombing the genome: PcG, trxG, and chromatin silencing. Cell. 1998, 93: 333-336. 10.1016/S0092-8674(00)81162-9.
-
(1998)
Cell
, vol.93
, pp. 333-336
-
-
Pirrotta, V.1
-
88
-
-
72849130207
-
The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
-
Song LB, Li J, Liao WT, Feng Y, Yu CP, Hu LJ, Kong QL, Xu LH, Zhang X, Liu WL, Li MZ, Zhang L, Kang TB, Fu LW, Huang WL, Xia YF, Tsao SW, Li M, Band V, Band H, Shi QH, Zeng YX, Zeng MS: The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest. 2009, 119: 3626-3636. 10.1172/JCI39374.
-
(2009)
J Clin Invest
, vol.119
, pp. 3626-3636
-
-
Song, L.B.1
Li, J.2
Liao, W.T.3
Feng, Y.4
Yu, C.P.5
Hu, L.J.6
Kong, Q.L.7
Xu, L.H.8
Zhang, X.9
Liu, W.L.10
Li, M.Z.11
Zhang, L.12
Kang, T.B.13
Fu, L.W.14
Huang, W.L.15
Xia, Y.F.16
Tsao, S.W.17
Li, M.18
Band, V.19
Band, H.20
Shi, Q.H.21
Zeng, Y.X.22
Zeng, M.S.23
more..
-
89
-
-
60649089997
-
Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells
-
Kudo-Saito C, Shirako H, Takeuchi T, Kawakami Y: Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. Cancer Cell. 2009, 15: 195-206. 10.1016/j.ccr.2009.01.023.
-
(2009)
Cancer Cell
, vol.15
, pp. 195-206
-
-
Kudo-Saito, C.1
Shirako, H.2
Takeuchi, T.3
Kawakami, Y.4
-
90
-
-
68449102356
-
Staurosporine augments EGF-mediated EMT in PMC42-LA cells through actin depolymerisation, focal contact size reduction and Snail1 induction - a model for cross-modulation
-
Hugo HJ, Wafai R, Blick T, Thompson EW, Newgreen DF: Staurosporine augments EGF-mediated EMT in PMC42-LA cells through actin depolymerisation, focal contact size reduction and Snail1 induction - a model for cross-modulation. BMC Cancer. 2009, 9: 235. 10.1186/1471-2407-9-235.
-
(2009)
BMC Cancer
, vol.9
, pp. 235
-
-
Hugo, H.J.1
Wafai, R.2
Blick, T.3
Thompson, E.W.4
Newgreen, D.F.5
-
91
-
-
33744912774
-
Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: implications for progression of ErbB2-overexpressing tumors
-
Zhan L, Xiang B, Muthuswamy SK: Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: implications for progression of ErbB2-overexpressing tumors. Cancer Res. 2006, 66: 5201-5208. 10.1158/0008-5472.CAN-05-4081.
-
(2006)
Cancer Res
, vol.66
, pp. 5201-5208
-
-
Zhan, L.1
Xiang, B.2
Muthuswamy, S.K.3
-
92
-
-
70350736098
-
Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer
-
Zhang D, LaFortune TA, Krishnamurthy S, Esteva FJ, Cristofanilli M, Liu P, Lucci A, Singh B, Hung MC, Hortobagyi GN, Ueno NT: Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer. Clin Cancer Res. 2009, 15: 6639-6648. 10.1158/1078-0432.CCR-09-0951.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6639-6648
-
-
Zhang, D.1
LaFortune, T.A.2
Krishnamurthy, S.3
Esteva, F.J.4
Cristofanilli, M.5
Liu, P.6
Lucci, A.7
Singh, B.8
Hung, M.C.9
Hortobagyi, G.N.10
Ueno, N.T.11
-
93
-
-
51849144571
-
Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells
-
Nelson CM, Khauv D, Bissell MJ, Radisky DC: Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells. J Cell Biochem. 2008, 105: 25-33. 10.1002/jcb.21821.
-
(2008)
J Cell Biochem
, vol.105
, pp. 25-33
-
-
Nelson, C.M.1
Khauv, D.2
Bissell, M.J.3
Radisky, D.C.4
-
94
-
-
47549089080
-
Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development
-
Orlichenko LS, Radisky DC: Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development. Clin Exp Metastasis. 2008, 25: 593-600. 10.1007/s10585-008-9143-9.
-
(2008)
Clin Exp Metastasis
, vol.25
, pp. 593-600
-
-
Orlichenko, L.S.1
Radisky, D.C.2
-
95
-
-
5644272705
-
Invasive potential induced under long-term oxidative stress in mammary epithelial cells
-
Mori K, Shibanuma M, Nose K: Invasive potential induced under long-term oxidative stress in mammary epithelial cells. Cancer Res. 2004, 64: 7464-7472. 10.1158/0008-5472.CAN-04-1725.
-
(2004)
Cancer Res
, vol.64
, pp. 7464-7472
-
-
Mori, K.1
Shibanuma, M.2
Nose, K.3
|