Inhibition of RSK with the novel small-molecule inhibitor LJI308 overcomes chemoresistance by eliminating cancer stem cells

Oncotarget

Volumn 6, Issue 24, 2015, Pages 20570-20577

  Davies, Alastair H ^a   Reipas, Kristen ^b   Hu, Kaiji ^c   Berns, Rachel ^c   Firmino, Natalie ^c   Stratford, Anna L ^c   Dunn, Sandra E ^d  

^a VANCOUVER PROSTATE CENTRE   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d Phoenix Molecular Diagnostics Ltd   (Canada)

Author keywords

Breast cancer; Cancer stem cells; Drug resistance; Drug target; RSK; YB 1

Indexed keywords

ALPHA6 INTEGRIN; BI D1870; DOXORUBICIN; FLUOROURACIL; GEFITINIB; HERMES ANTIGEN; LJI 308; LUTEOLIN; PACLITAXEL; PROTEIN SERINE THREONINE KINASE INHIBITOR; S6 KINASE; UNCLASSIFIED DRUG; Y BOX BINDING PROTEIN 1; PTERIDINE DERIVATIVE;

ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST EPITHELIUM CELL; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER RESISTANCE; CANCER STEM CELL; CELL TRANSFORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE TECHNIQUE; DRUG POTENCY; DRUG SENSITIVITY; DRUG TARGETING; ENZYME INHIBITION; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; METASTASIS INHIBITION; MULTIDRUG RESISTANCE; PHENOTYPE; THREE DIMENSIONAL CULTURE; TRIPLE NEGATIVE BREAST CANCER; TWO DIMENSIONAL CULTURE; Y BOX BINDING PROTEIN 1 ONCOGENE; CELL PROLIFERATION; DRUG RESISTANCE; FEMALE; GENETICS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; NEOPLASTIC STEM CELLS; PTERIDINES; TRIPLE NEGATIVE BREAST NEOPLASMS;

EID: 84940210760     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4135     Document Type: Article

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