Classical transient receptor potential 1 (TRPC1): Channel or channel regulator?

Cells

Volumn 3, Issue 4, 2014, Pages 939-962

  Dietrich, Alexander ^a   Fahlbusch, Meike ^a   Gudermann, Thomas ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Acinar cells; Bone formation; Cardiopulmonary system; Immune cells; Kidney; Neurons; Platelets; Skeletal muscle; TRPC1 deficient animal model; Tumor

Indexed keywords

CALCIUM CHANNEL; CYTOKINE; POTASSIUM CHANNEL; PROTEIN HOMER; SODIUM CHANNEL; STROMAL INTERACTION MOLECULE 1; STROMAL INTERACTION MOLECULE 2; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 2; TRANSIENT RECEPTOR POTENTIAL CHANNEL 4; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TUMOR MARKER;

BIOCHEMISTRY; BLADDER INNERVATION; BODY HEIGHT; BODY WEIGHT; BONE DEVELOPMENT; CARDIOPULMONARY HEMODYNAMICS; DIABETIC NEPHROPATHY; DUCHENNE MUSCULAR DYSTROPHY; ENDOPLASMIC RETICULUM; GLOMERULUS FILTRATION RATE; HEART VENTRICLE HYPERTROPHY; HUMAN; KIDNEY POLYCYSTIC DISEASE; NONHUMAN; OSSIFICATION; OSTEOCLASTOGENESIS; PANCREAS; PARKINSON DISEASE; PROTEIN EXPRESSION; REVIEW; SALIVARY GLAND; SEIZURE; SKELETAL MUSCLE; THROMBOCYTE;

ANIMALIA;

EID: 85056746661     PISSN: None     EISSN: 20734409     Source Type: Journal    
DOI: 10.3390/cells3040939     Document Type: Review

References (124)

1. Nilius, B.; Szallasi, A. Transient receptor potential channels as drug targets: From the science of basic research to the art of medicine. Pharm. Rev. 2014, 66, 676–814.
2. Wu, L.J.; Sweet, T.B.; Clapham, D.E. International union of basic and clinical pharmacology. Lxxvi. Current progress in the mammalian trp ion channel family. Pharm. Rev. 2010, 62, 381–404.
3. Montell, C.; Rubin, G.M. Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction. Neuron 1989, 2, 1313–1323.
4. Zhu, X.; Chu, P.B.; Peyton, M.; Birnbaumer, L. Molecular cloning of a widely expressed human homologue for the drosophila trp gene. FEBS Lett. 1995, 373, 193–198.
5. Wes, P.D.; Chevesich, J.; Jeromin, A.; Rosenberg, C.; Stetten, G.; Montell, C. TRPC1, a human homolog of a drosophila store-operated channel. Proc. Natl. Acad. Sci. USA 1995, 92, 9652–9656.
6. Zitt, C.; Zobel, A.; Obukhov, A.G.; Harteneck, C.; Kalkbrenner, F.; Luckhoff, A.; Schultz, G. Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion. Neuron 1996, 16, 1189–1196.
7. Clapham, D.E.; Julius, D.; Montell, C.; Schultz, G. International union of pharmacology. Xlix. Nomenclature and structure-function relationships of transient receptor potential channels. Pharm. Rev. 2005, 57, 427–450.
8. Dietrich, A.; Chubanov, V.; Kalwa, H.; Rost, B.R.; Gudermann, T. Cation channels of the transient receptor potential superfamily: Their role in physiological and pathophysiological processes of smooth muscle cells. Pharmacol. Ther. 2006, 112, 744–760.
9. Sakura, H.; Ashcroft, F.M. Identification of four TRP1 gene variants murine pancreatic beta-cells. Diabetologia 1997, 40, 528–532.
10. Ong, E.C.; Nesin, V.; Long, C.L.; Bai, C.X.; Guz, J.L.; Ivanov, I.P.; Abramowitz, J.; Birnbaumer, L.; Humphrey, M.B.; Tsiokas, L. A TRPC1 protein-dependent pathway regulates osteoclast formation and function. J. Biol. Chem. 2013, 288, 22219–22232.
11. Rychkov, G.; Barritt, G.J. TRPC1 Ca2+-permeable channels in animal cells. Handb. Exp. Pharmacol. 2007, 23–52.
12. Nesin, V.; Tsiokas, L. TRPC1. Handb. Exp. Pharmacol. 2014, 222, 15–51.
13. Boulay, G.; Brown, D.M.; Qin, N.; Jiang, M.; Dietrich, A.; Zhu, M.X.; Chen, Z.; Birnbaumer, M.; Mikoshiba, K.; Birnbaumer, L. Modulation of Ca2+ entry by polypeptides of the inositol 1,4,5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): Evidence for roles of TRP and IP3R in store depletion-activated Ca2+ entry. Proc. Natl. Acad. Sci. USA 1999, 96, 14955–14960.
14. Liao, M.; Cao, E.; Julius, D.; Cheng, Y. Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature 2013, 504, 107–112.
15. Maroto, R.; Raso, A.; Wood, T.G.; Kurosky, A.; Martinac, B.; Hamill, O.P. TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nat. Cell Biol. 2005, 7, 179–185.
16. Gottlieb, P.; Folgering, J.; Maroto, R.; Raso, A.; Wood, T.G.; Kurosky, A.; Bowman, C.; Bichet, D.; Patel, A.; Sachs, F.; et al. Revisiting TRPC1 and TRPC6 mechanosensitivity. Pflugers Arch. 2008, 455, 1097–1103.
17. Dietrich, A.; Kalwa, H.; Storch, U.; Mederos y Schnitzler, M.; Salanova, B.; Pinkenburg, O.; Dubrovska, G.; Essin, K.; Gollasch, M.; Birnbaumer, L.; et al. Pressure-induced and store-operated cation influx in vascular smooth muscle cells is independent of TRPC1. Pflugers Arch. 2007, 455, 465–477.
18. Mederos y Schnitzler, M.; Storch, U.; Meibers, S.; Nurwakagari, P.; Breit, A.; Essin, K.; Gollasch, M.; Gudermann, T. Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction. EMBO J. 2008, 27, 3092–3103.
19. Storch, U.; Mederos y Schnitzler, M.; Gudermann, T. G protein-mediated stretch reception. Am. J. Physiol Heart Circ. Physiol 2012, 302, H1241–H1249.
20. Eijkelkamp, N.; Quick, K.; Wood, J.N. Transient receptor potential channels and mechanosensation. Annu Rev. Neurosci 2013, 36, 519–546.
21. Hanlon, M.R.; Wallace, B.A. Structure and function of voltage-dependent ion channel regulatory beta subunits. Biochemistry 2002, 41, 2886–2894.
22. Hofmann, T.; Schaefer, M.; Schultz, G.; Gudermann, T. Subunit composition of mammalian transient receptor potential channels in living cells. Proc. Natl Acad Sci USA 2002, 99, 7461–7466.
23. Alfonso, S.; Benito, O.; Alicia, S.; Angelica, Z.; Patricia, G.; Diana, K.; Vaca, L. Regulation of the cellular localization and function of human transient receptor potential channel 1 by other members of the TRPC family. Cell Calcium 2008, 43, 375–387.
24. Cheng, K.T.; Liu, X.; Ong, H.L.; Swaim, W.; Ambudkar, I.S. Local Ca2+ entry via orai1 regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca2+ signals required for specific cell functions. PLoS Biol. 2011, 9, e1001025.
25. Souza, L.B.; Ambudkar, I.S. Trafficking mechanisms and regulation of TRPC channels. Cell Calcium 2014, 56, 43–50.
26. Barrera, N.P.; Shaifta, Y.; McFadzean, I.; Ward, J.P.T.; Henderson, R.M.; Edwardson, J.M. Afm imaging reveals the tetrameric structure of the TRPC1 channel. Biochem. Biophys. Res. Commun. 2007, 358, 1086–1090.
27. Beech, D.J.; Muraki, K.; Flemming, R. Non-selective cationic channels of smooth muscle and the mammalian homologues of drosophila trp. J. Physiol. 2004, 559, 685–706.
28. Lintschinger, B.; Balzer-Geldsetzer, M.; Baskaran, T.; Graier, W.F.; Romanin, C.; Zhu, M.X.; Groschner, K. Coassembly of TRP1 and TRP3 proteins generates diacylglycerol- and Ca2+- sensitive cation channels. J. Biol. Chem. 2000, 275, 27799–27805.
29. Storch, U.; Forst, A.L.; Philipp, M.; Gudermann, T.; Mederos y Schnitzler, M. Transient receptor potential channel 1 (TRPC1) reduces calcium permeability in heteromeric channel complexes. J. Biol. Chem. 2012, 287, 3530–3540.
30. Strubing, C.; Krapivinsky, G.; Krapivinsky, L.; Clapham, D.E. TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 2001, 29, 645–655.
31. Strubing, C.; Krapivinsky, G.; Krapivinsky, L.; Clapham, D.E. Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J. Biol. Chem. 2003, 278, 39014–39019.
32. Goel, M.; Sinkins, W.G.; Schilling, W.P. Selective association of TRPC channel subunits in rat brain synaptosomes. J. Biol. Chem. 2002, 277, 48303–48310.
33. Zagranichnaya, T.K.; Wu, X.; Villereal, M.L. Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in hek-293 cells. J. Biol. Chem. 2005, 280, 29559–29569.
34. Kim, J.; Kwak, M.; Jeon, J.P.; Myeong, J.; Wie, J.; Hong, C.; Kim, S.Y.; Jeon, J.H.; Kim, H.J.; So, I. Isoform- and receptor-specific channel property of canonical transient receptor potential (TRPC)1/4 channels. Pflugers Arch. 2014, 466, 491–504.
35. Tsiokas, L.; Arnould, T.; Zhu, C.; Kim, E.; Walz, G.; Sukhatme, V.P. Specific association of the gene product of pkd2 with the TRPC1 channel. Proc. Natl. Acad. Sci. USA 1999, 96, 3934–3939.
36. Bai, C.X.; Giamarchi, A.; Rodat-Despoix, L.; Padilla, F.; Downs, T.; Tsiokas, L.; Delmas, P. Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits. EMBO Rep. 2008, 9, 472–479.
37. Kobori, T.; Smith, G.D.; Sandford, R.; Edwardson, J.M. The transient receptor potential channels TRPP2 and TRPC1 form a heterotetramer with a 2:2 stoichiometry and an alternating subunit arrangement. J. Biol. Chem. 2009, 284, 35507–35513.
38. Schindl, R.; Fritsch, R.; Jardin, I.; Frischauf, I.; Kahr, H.; Muik, M.; Riedl, M.C.; Groschner, K.; Romanin, C. Canonical transient receptor potential (TRPC) 1 acts as a negative regulator for vanilloid TRPV6-mediated Ca2+ influx. J. Biol. Chem. 2012, 287, 35612–35620.
39. Courjaret, R.; Hubrack, S.; Daalis, A.; Dib, M.; Machaca, K. The xenopus TRPV6 homolog encodes a Mg2+ -permeant channel that is inhibited by interaction with TRPC1. J. Cell. Physiol 2013, 228, 2386–2398.
40. Ma, X.; Cheng, K.T.; Wong, C.O.; O’Neil, R.G.; Birnbaumer, L.; Ambudkar, I.S.; Yao, X. Heteromeric TRPV4-c1 channels contribute to store-operated Ca2+ entry in vascular endothelial cells. Cell Calcium 2011, 50, 502–509.
41. Du, J.; Ma, X.; Shen, B.; Huang, Y.; Birnbaumer, L.; Yao, X. TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel. FASEB J. 2014.
42. Singh, B.B.; Liu, X.; Tang, J.; Zhu, M.X.; Ambudkar, I.S. Calmodulin regulates Ca2+-dependent feedback inhibition of store-operated Ca2+ influx by interaction with a site in the c terminus of TRPC1. Mol. Cell 2002, 9, 739–750.
43. Yuan, J.P.; Kiselyov, K.; Shin, D.M.; Chen, J.; Shcheynikov, N.; Kang, S.H.; Dehoff, M.H.; Schwarz, M.K.; Seeburg, P.H.; Muallem, S.; et al. Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell 2003, 114, 777–789.
44. Stiber, J.A.; Zhang, Z.S.; Burch, J.; Eu, J.P.; Zhang, S.; Truskey, G.A.; Seth, M.; Yamaguchi, N.; Meissner, G.; Shah, R.; et al. Mice lacking homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity. Mol. Cell Biol. 2008, 28, 2637–2647.
45. Strotmann, R.; Semtner, M.; Kepura, F.; Plant, T.D.; Schoneberg, T. Interdomain interactions control Ca2+-dependent potentiation in the cation channel TRPV4. PLoS One 2010, 5, e10580.
46. TRPC1/interactors. Available online: http://trpchannel.org/summaries/TRPC1 (accessed on 23 September 2014)
47. Hoth, M.; Penner, R. Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature 1992, 355, 353–356.
48. Dietrich, A.; Kalwa, H.; Rost, B.R.; Gudermann, T. The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: Functional characterization and physiological relevance. Pflugers Arch. 2005, 451, 72–80.
49. Feske, S.; Gwack, Y.; Prakriya, M.; Srikanth, S.; Puppel, S.H.; Tanasa, B.; Hogan, P.G.; Lewis, R.S.; Daly, M.; Rao, A. A mutation in orai1 causes immune deficiency by abrogating crac channel function. Nature 2006, 441, 179–185.
50. Vig, M.; Peinelt, C.; Beck, A.; Koomoa, D.L.; Rabah, D.; Koblan-Huberson, M.; Kraft, S.; Turner, H.; Fleig, A.; Penner, R.; et al. Cracm1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science 2006, 312, 1220–1223.
51. Cahalan, M.D. Stimulating store-operated Ca2+ entry. Nat. Cell Biol 2009, 11, 669–677.
52. Liao, Y.; Plummer, N.W.; George, M.D.; Abramowitz, J.; Zhu, M.X.; Birnbaumer, L. A role for orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry. Proc. Natl Acad Sci USA 2009, 106, 3202–3206.
53. Lee, K.P.; Yuan, J.P.; So, I.; Worley, P.F.; Muallem, S. Stim1-dependent and stim1-independent function of Transient Receptor Potential Canonical (TRPC) channels tunes their store-operated mode. J. Biol. Chem. 2010, 285, 38666–38673.
54. Cheng, K.T.; Ong, H.L.; Liu, X.B.; Ambudkar, I.S. Contribution and regulation of TRPC channels in store-operated Ca2+ entry. Curr. Top. Membr 2013, 71, 149–179.
55. DeHaven, W.I.; Jones, B.F.; Petranka, J.G.; Smyth, J.T.; Tomita, T.; Bird, G.S.; Putney, J.W. TRPC channels function independently of stim1 and orai 1. J. Physiol-London 2009, 587, 2275–2298.
56. Ong, H.L.; Chen, J.; Chataway, T.; Brereton, H.; Zhang, L.; Downs, T.; Tsiokas, L.; Barritt, G. Specific detection of the endogenous transient receptor potential (trp)-1 protein in liver and airway smooth muscle cells using immunoprecipitation and western-blot analysis. Biochem. J. 2002, 364, 641–648.
57. Liu, X.; Cheng, K.T.; Bandyopadhyay, B.C.; Pani, B.; Dietrich, A.; Paria, B.C.; Swaim, W.D.; Beech, D.; Yildrim, E.; Singh, B.B.; et al. Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice. Proc. Natl. Acad. Sci. USA 2007, 104, 17542–17547.
58. Seth, M.; Zhang, Z.S.; Mao, L.; Graham, V.; Burch, J.; Stiber, J.; Tsiokas, L.; Winn, M.; Abramowitz, J.; Rockman, H.A.; et al. TRPC1 channels are critical for hypertrophic signaling in the heart. Circ. Res. 2009, 105, 1023–1030.
59. Malczyk, M.; Veith, C.; Fuchs, B.; Hofmann, K.; Storch, U.; Schermuly, R.T.; Witzenrath, M.; Ahlbrecht, K.; Fecher-Trost, C.; Flockerzi, V.; et al. Classical transient receptor potential channel 1 in hypoxia-induced pulmonary hypertension. Am. J. Resp. Crit. Care Med. 2013, 188, 1451–1459.
60. Varga-Szabo, D.; Authi, K.S.; Braun, A.; Bender, M.; Ambily, A.; Hassock, S.R.; Gudermann, T.; Dietrich, A.; Nieswandt, B. Store-operated Ca2+ entry in platelets occurs independently of Transient Receptor Potential (TRP) c1. Pflugers Arch. 2008, 457, 377–387.
61. Berbey, C.; Weiss, N.; Legrand, C.; Allard, B. Transient receptor potential canonical type 1 (TRPC1) operates as a sarcoplasmic reticulum calcium leak channel in skeletal muscle. J. Biol. Chem. 2009, 284, 36387–36394.
62. Tajeddine, N.; Zanou, N.; Van Schoor, M.; Lebacq, J.; Gailly, P. TRPC1: Subcellular localization? J. Biol Chem 2010, 285, le1.
63. DeCaen, P.G.; Delling, M.; Vien, T.N.; Clapham, D.E. Direct recording and molecular identification of the calcium channel of primary cilia. Nature 2013, 504, 315–318.
64. Delling, M.; DeCaen, P.G.; Doerner, J.F.; Febvay, S.; Clapham, D.E. Primary cilia are specialized calcium signalling organelles. Nature 2013, 504, 311–314.
65. Sours, S.; Du, J.; Chu, S.; Ding, M.; Zhou, X.J.; Ma, R. Expression of canonical transient receptor potential (TRPC) proteins in human glomerular mesangial cells. Am. J. Physiol. Renal. Physiol. 2006, 290, F1507–F1515.
66. Du, J.; Sours-Brothers, S.; Coleman, R.; Ding, M.; Graham, S.; Kong, D.H.; Ma, R. Canonical transient receptor potential 1 channel is involved in contractile function of glomerular mesangial cells. J. Am. Soc. Nephrol. 2007, 18, 1437–1445.
67. Brownlee, M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001, 414, 813–820.
68. Chen, K.; Jin, X.; Li, Q.; Wang, W.; Wang, Y.; Zhang, J. Association of TRPC1 gene polymorphisms with type 2 diabetes and diabetic nephropathy in han chinese population. Endocr. Res. 2013, 38, 59–68.
69. Niehof, M.; Borlak, J. Hnf4 alpha and the ca-channel TRPC1 are novel disease candidate genes in diabetic nephropathy. Diabetes 2008, 57, 1069–1077.
70. Zhang, D.; Freedman, B.I.; Flekac, M.; Santos, E.; Hicks, P.J.; Bowden, D.W.; Efendic, S.; Brismar, K.; Gu, H.F. Evaluation of genetic association and expression reduction of TRPC1 in the development of diabetic nephropathy. Am. J. Nephrol. 2009, 29, 244–251.
71. Hong, J.H.; Li, Q.; Kim, M.S.; Shin, D.M.; Feske, S.; Birnbaumer, L.; Cheng, K.T.; Ambudkar, I.S.; Muallem, S. Polarized but differential localization and recruitment of stim1, orai1 and TRPC channels in secretory cells. Traffic 2011, 12, 232–245.
72. Vandebrouck, C.; Martin, D.; Colson-Van Schoor, M.; Debaix, H.; Gailly, P. Involvement of TRPC in the abnormal calcium influx observed in dystrophic (mdx) mouse skeletal muscle fibers. J. Cell Biol. 2002, 158, 1089–1096.
73. Sabourin, J.; Cognard, C.; Constantin, B. Regulation by scaffolding proteins of canonical transient receptor potential channels in striated muscle. J. Muscle Res. Cell Motil. 2009, 30, 289–297.
74. Sabourin, J.; Lamiche, C.; Vandebrouck, A.; Magaud, C.; Rivet, J.; Cognard, C.; Bourmeyster, N.; Constantin, B. Regulation of TRPC1 and TRPC4 cation channels requires an alpha1-syntrophindependent complex in skeletal mouse myotubes. J. Biol. Chem. 2009, 284, 36248–36261.
75. Louis, M.; Zanou, N.; Van Schoor, M.; Gailly, P. TRPC1 regulates skeletal myoblast migration and differentiation. J. Cell Sci. 2008, 121, 3951–3959.
76. Zanou, N.; Shapovalov, G.; Louis, M.; Tajeddine, N.; Gallo, C.; van Schoor, M.; Anguish, I.; Cao, M.L.; Schakman, O.; Dietrich, A.; et al. Role of TRPC1 channel in skeletal muscle function. Am. J. Physiol. Cell Physiol. 2010, 298, C149–C162.
77. Zhang, B.T.; Whitehead, N.P.; Gervasio, O.L.; Reardon, T.F.; Vale, M.; Fatkin, D.; Dietrich, A.; Yeung, E.W.; Allen, D.G. Pathways of Ca2+ entry and cytoskeletal damage following eccentric contractions in mouse skeletal muscle. J. Appl. Physiol. 2012, 112, 2077–2086.
78. Zanou, N.; Schakman, O.; Louis, P.; Ruegg, U.T.; Dietrich, A.; Birnbaumer, L.; Gailly, P. TRPC1 ion channel modulates phosphatidylinositol 3-kinase/akt pathway during myoblast differentiation and muscle regeneration. J. Biol. Chem. 2012, 287, 14524–14534.
79. Vandebrouck, A.; Ducret, T.; Basset, O.; Sebille, S.; Raymond, G.; Ruegg, U.; Gailly, P.; Cognard, C.; Constantin, B. Regulation of store-operated calcium entries and mitochondrial uptake by minidystrophin expression in cultured myotubes. FASEB J. 2006, 20, 136–138.
80. Fahlbusch, M. Analyse der Funktion des TRPC1-Proteins durch Charakterisierung eines TRPC1- defizienten Mausmodells. Doctoral Thesis, Philipps-University Marburg, Marburg, Germany, 15 October 2008.
81. Robinson, L.J.; Mancarella, S.; Songsawad, D.; Tourkova, I.L.; Barnett, J.B.; Gill, D.L.; Soboloff, J.; Blair, H.C. Gene disruption of the calcium channel orai1 results in inhibition of osteoclast and osteoblast differentiation and impairs skeletal development. Lab. Invest. 2012, 92, 1071–1083.
82. Hwang, S.Y.; Putney, J.W. Orai1-mediated calcium entry plays a critical role in osteoclast differentiation and function by regulating activation of the transcription factor nfatc 1. FASEB J. 2012, 26, 1484–1492.
83. Zhou, Y.; Lewis, T.L.; Robinson, L.J.; Brundage, K.M.; Schafer, R.; Martin, K.H.; Blair, H.C.; Soboloff, J.; Barnett, J.B. The role of calcium release activated calcium channels in osteoclast differentiation. J. Cell Physiol. 2011, 226, 1082–1089.
84. Abed, E.; Labelle, D.; Martineau, C.; Loghin, A.; Moreau, R. Expression of transient receptor potential (TRP) channels in human and murine osteoblast-like cells. Mol. Membrane Biol. 2009, 26, 146–158.
85. Den Dekker, E.; Molin, D.G.; Breikers, G.; van Oerle, R.; Akkerman, J.W.; van Eys, G.J.; Heemskerk, J.W. Expression of transient receptor potential mrna isoforms and Ca2+ influx in differentiating human stem cells and platelets. Biochim. Biophys. Acta 2001, 1539, 243–255.
86. Grosse, J.; Braun, A.; Varga-Szabo, D.; Beyersdorf, N.; Schneider, B.; Zeitlmann, L.; Hanke, P.; Schropp, P.; Muhlstedt, S.; Zorn, C.; et al. An ef hand mutation in stim1 causes premature platelet activation and bleeding in mice. J. Clin. Invest. 2007, 117, 3540–3550.
87. Rosado, J.A.; Brownlow, S.L.; Sage, S.O. Endogenously expressed TRP1 is involved in store-mediated Ca2+ entry by conformational coupling in human platelets. J. Biol. Chem. 2002, 277, 42157–42163.
88. Galan, C.; Dionisio, N.; Smani, T.; Salido, G.M.; Rosado, J.A. The cytoskeleton plays a modulatory role in the association between stim1 and the Ca2+ channel subunits orai1 and TRPC1. Biochem. Pharmacol. 2011, 82, 400–410.
89. Varga-Szabo, D.; Braun, A.; Kleinschnitz, C.; Bender, M.; Pleines, I.; Pham, M.; Renne, T.; Stoll, G.; Nieswandt, B. The calcium sensor stim1 is an essential mediator of arterial thrombosis and ischemic brain infarction. J. Exp. Med. 2008, 205, 1583–1591.
90. Braun, A.; Varga-Szabo, D.; Kleinschnitz, C.; Pleines, I.; Bender, M.; Austinat, M.; Bosl, M.; Stoll, G.; Nieswandt, B. Orai1 (cracm1) is the platelet soc channel and essential for pathological thrombus formation. Blood 2009, 113, 2056–2063.
91. Yildirim, E.; Carey, M.A.; Card, J.W.; Dietrich, A.; Flake, G.P.; Zhang, Y.; Bradbury, J.A.; Rebolloso, Y.; Germolec, D.R.; Morgan, D.L.; et al. Severely blunted allergen-induced pulmonary th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 2012, 303, L539–L549.
92. Sel, S.; Rost, B.R.; Yildirim, A.O.; Sel, B.; Kalwa, H.; Fehrenbach, H.; Renz, H.; Gudermann, T.; Dietrich, A. Loss of classical transient receptor potential 6 channel reduces allergic airway response. Clin. Exp. Allergy 2008, 38, 1548–1558.
93. Py, B.F.; Jin, M.; Desai, B.N.; Penumaka, A.; Zhu, H.; Kober, M.; Dietrich, A.; Lipinski, M.M.; Henry, T.; Clapham, D.E.; et al. Caspase-11 controls interleukin-1beta release through degradation of TRPC1. Cell Rep. 2014, 6, 1122–1128.
94. Wang, G.X.; Poo, M.M. Requirement of TRPC channels in netrin-1-induced chemotropic turning of nerve growth cones. Nature 2005, 434, 898–904.
95. Shim, S.; Yuan, J.P.; Kim, J.Y.; Zeng, W.; Huang, G.; Milshteyn, A.; Kern, D.; Muallem, S.; Ming, G.L.; Worley, P.F. Peptidyl-prolyl isomerase fkbp52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening. Neuron 2009, 64, 471–483.
96. Dietrich, A.; Fahlbusch, M.; Gudermann, T. LM-University of Munich, Munich, Germany. Unpublished work, 2014.
97. Ariano, P.; Dalmazzo, S.; Owsianik, G.; Nilius, B.; Lovisolo, D. TRPC channels are involved in calcium-dependent migration and proliferation in immortalized gnrh neurons. Cell Calcium 2011, 49, 387–394.
98. Boudes, M.; Uvin, P.; Pinto, S.; Freichel, M.; Birnbaumer, L.; Voets, T.; de Ridder, D.; Vennekens, R. Crucial role of TRPC1 and TRPC4 in cystitis-induced neuronal sprouting and bladder overactivity. PLoS One 2013, 8, e69550.
99. Kim, S.J.; Kim, Y.S.; Yuan, J.P.; Petralia, R.S.; Worley, P.F.; Linden, D.J. Activation of the TRPC1 cation channel by metabotropic glutamate receptor mglur 1. Nature 2003, 426, 285–291.
100. Hartmann, J.; Dragicevic, E.; Adelsberger, H.; Henning, H.A.; Sumser, M.; Abramowitz, J.; Blum, R.; Dietrich, A.; Freichel, M.; Flockerzi, V.; et al. TRPC3 channels are required for synaptic transmission and motor coordination. Neuron 2008, 59, 392–398.
101. Staaf, S.; Maxvall, I.; Lind, U.; Husmark, J.; Mattsson, J.P.; Ernfors, P.; Pierrou, S. Down regulation of TRPC1 by shrna reduces mechanosensitivity in mouse dorsal root ganglion neurons in vitro. Neurosci. Lett. 2009, 457, 3–7.
102. Alessandri-Haber, N.; Dina, O.A.; Chen, X.; Levine, J.D. TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization. J. Neurosci. 2009, 29, 6217–6228.
103. Garrison, S.R.; Dietrich, A.; Stucky, C.L. TRPC1 contributes to light-touch sensation and mechanical responses in low-threshold cutaneous sensory neurons. J. Neurophysiol. 2012, 107, 913–922.
104. Phelan, K.D.; Mock, M.M.; Kretz, O.; Shwe, U.T.; Kozhemyakin, M.; Greenfield, L.J.; Dietrich, A.; Birnbaumer, L.; Freichel, M.; Flockerzi, V.; et al. Heteromeric canonical transient receptor potential 1 and 4 channels play a critical role in epileptiform burst firing and seizure-induced neurodegeneration. Mol. Pharmacol. 2012, 81, 384–392.
105. Phelan, K.D.; Shwe, U.T.; Abramowitz, J.; Wu, H.; Rhee, S.W.; Howell, M.D.; Gottschall, P.E.; Freichel, M.; Flockerzi, V.; Birnbaumer, L.; et al. Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Mol. Pharmacol. 2013, 83, 429–438.
106. Selvaraj, S.; Sun, Y.; Watt, J.A.; Wang, S.; Lei, S.; Birnbaumer, L.; Singh, B.B. Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of akt/mtor signaling. J. Clin. Invest. 2012, 122, 1354–1367.
107. Dietrich, A.; Kalwa, H.; Fuchs, B.; Grimminger, F.; Weissmann, N.; Gudermann, T. In vivo TRPC functions in the cardiopulmonary vasculature. Cell Calcium 2007, 42, 233–244.
108. Dietrich, A.; Gudermann, T. Trp channels in the cardiopulmonary vasculature. Adv. Exp. Med. Biol. 2011, 704, 781–810.
109. Ohba, T.; Watanabe, H.; Murakami, M.; Takahashi, Y.; Iino, K.; Kuromitsu, S.; Mori, Y.; Ono, K.; Iijima, T.; Ito, H. Upregulation of TRPC1 in the development of cardiac hypertrophy. J. Mol. Cell. Cardiol. 2007, 42, 498–507.
110. Molkentin, J.D.; Dorn, G.W., Jr. Cytoplasmic signaling pathways that regulate cardiac hypertrophy. Annu Rev. Physiol. 2001, 63, 391–426.
111. Wu, X.; Eder, P.; Chang, B.; Molkentin, J.D. TRPC channels are necessary mediators of pathologic cardiac hypertrophy. Proc. Natl. Acad. Sci. USA 2010, 107, 7000–7005.
112. Paria, B.C.; Malik, A.B.; Kwiatek, A.M.; Rahman, A.; May, M.J.; Ghosh, S.; Tiruppathi, C. Tumor necrosis factor-alpha induces nuclear factor-kappab-dependent TRPC1 expression in endothelial cells. J. Biol. Chem. 2003, 278, 37195–37203.
113. Paria, B.C.; Vogel, S.M.; Ahmmed, G.U.; Alamgir, S.; Shroff, J.; Malik, A.B.; Tiruppathi, C. Tumor necrosis factor-alpha-induced TRPC1 expression amplifies store-operated Ca2+ influx and endothelial permeability. Am. J. Physiol. Lung Cell. Mol. Physiol. 2004, 287, L1303–L1313.
114. Paria, B.C.; Bair, A.M.; Xue, J.; Yu, Y.; Malik, A.B.; Tiruppathi, C. Ca2+ influx induced by protease-activated receptor-1 activates a feed-forward mechanism of TRPC1 expression via nuclear factor-kappab activation in endothelial cells. J. Biol. Chem. 2006, 281, 20715–20727.
115. Tiruppathi, C.; Freichel, M.; Vogel, S.M.; Paria, B.C.; Mehta, D.; Flockerzi, V.; Malik, A.B. Impairment of store-operated Ca2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeability. Circ. Res. 2002, 91, 70–76.
116. Singh, I.; Knezevic, N.; Ahmmed, G.U.; Kini, V.; Malik, A.B.; Mehta, D. Galphaq-TRPC6- mediated Ca2+ entry induces rhoa activation and resultant endothelial cell shape change in response to thrombin. J. Biol. Chem. 2007, 282, 7833–7843.
117. Weissmann, N.; Sydykov, A.; Kalwa, H.; Storch, U.; Fuchs, B.; Mederos y Schnitzler, M.; Brandes, R.P.; Grimminger, F.; Meissner, M.; Freichel, M.; et al. Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. Nature commun. 2012, 3, 649.
118. Kunichika, N.; Yu, Y.; Remillard, C.V.; Platoshyn, O.; Zhang, S.; Yuan, J.X. Overexpression of TRPC1 enhances pulmonary vasoconstriction induced by capacitative Ca2+ entry. Am. J. Physiol. Lung Cell. Mol. Physiol. 2004, 287, L962–L969.
119. Kumar, B.; Dreja, K.; Shah, S.S.; Cheong, A.; Xu, S.Z.; Sukumar, P.; Naylor, J.; Forte, A.; Cipollaro, M.; McHugh, D.; et al. Upregulated TRPC1 channel in vascular injury in vivo and its role in human neointimal hyperplasia. Circ. Res. 2006, 98, 557–563.
120. Weissmann, N.; Dietrich, A.; Fuchs, B.; Kalwa, H.; Ay, M.; Dumitrascu, R.; Olschewski, A.; Storch, U.; Mederos y Schnitzler, M.; Ghofrani, H.A.; et al. Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange. Proc. Natl. Acad. Sci. USA 2006, 103, 19093–19098.
121. Xia, Y.; Yang, X.R.; Fu, Z.; Paudel, O.; Abramowitz, J.; Birnbaumer, L.; Sham, J.S. Classical transient receptor potential 1 and 6 contribute to hypoxic pulmonary hypertension through differential regulation of pulmonary vascular functions. Hypertension 2014, 63, 173–180.
122. Dhennin-Duthille, I.; Gautier, M.; Faouzi, M.; Guilbert, A.; Brevet, M.; Vaudry, D.; Ahidouch, A.; Sevestre, H.; Ouadid-Ahidouch, H. High expression of transient receptor potential channels in human breast cancer epithelial cells and tissues: Correlation with pathological parameters. Cell. Physiol. Biochem. 2011, 28, 813–822.
123. Bomben, V.C.; Turner, K.L.; Barclay, T.T.; Sontheimer, H. Transient receptor potential canonical channels are essential for chemotactic migration of human malignant gliomas. J. Cell. Physiol. 2011, 226, 1879–1888.
124. Cuddapah, V.A.; Turner, K.L.; Sontheimer, H. Calcium entry via TRPC1 channels activates chloride currents in human glioma cells. Cell Calcium 2013, 53, 187–194.