Gene disruption of the calcium channel Orai1 results in inhibition of osteoclast and osteoblast differentiation and impairs skeletal development

Laboratory Investigation

Volumn 92, Issue 7, 2012, Pages 1071-1083

  Robinson, Lisa J ^a   Mancarella, Salvatore ^b   Songsawad, Duangrat ^a   Tourkova, Irina L ^a   Barnett, John B ^c   Gill, Donald L ^b   Soboloff, Jonathan ^b   Blair, Harry C ^a,d  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

osteoblast; osteoclast; osteogenesis; osteopetrosis; STIM1

Indexed keywords

CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE DEVELOPMENT; BONE REMODELING; BONE STRUCTURE; CELL DIFFERENTIATION; CELL FUNCTION; CELL GROWTH; CONTROLLED STUDY; GENE; GENE DISRUPTION; GENE FUNCTION; HETEROZYGOTE; HUMAN; HUMAN CELL; MORPHOMETRICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORAI1 GENE; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; OSTEOPOROSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL;

ALKALINE PHOSPHATASE; ANIMALS; BASE SEQUENCE; BONE DENSITY; CALCIUM CHANNELS; CELL DIFFERENTIATION; CELLS, CULTURED; DNA PRIMERS; GENE KNOCKOUT TECHNIQUES; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OSTEOBLASTS; OSTEOCLASTS; OSTEOGENESIS; RNA, MESSENGER; X-RAY MICROTOMOGRAPHY;

EID: 84862986770     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2012.72     Document Type: Article

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