Probiotics, mechanisms of action, and clinical perspectives for diarrhea management in children

Food and Function

Volumn 9, Issue 10, 2018, Pages 5074-5095

  do Carmo, Monique Santos ^a   Santos, Camilla itapary dos ^b   Araújo, Mizael Calácio ^b   Girón, Jorge Alberto ^c,d   Fernandes, Elizabeth Soares ^b   Monteiro Neto, Valério ^a,b  

^a FEDERAL UNIVERSITY OF MARANHÃO   (Brazil)

^b CEUMA UNIVERSITY   (Brazil)

^c BENEMÉRITA UNIVERSIDAD AUTÓNOMA DE PUEBLA   (Mexico)

^d UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICROORGANISMS;

ANTIMICROBIAL MECHANISMS; BACTERIAL INFECTIONS; CLINICAL ROUTINE; CONVENTIONAL TREATMENTS; LACTOBACILLUS REUTERI; LACTOBACILLUS RHAMNOSUS; PROBIOTIC STRAIN; SACCHAROMYCES;

ANTIMICROBIAL AGENTS;

PROBIOTIC AGENT;

DIARRHEA; HUMAN; IMMUNOLOGY; LACTOBACILLUS; PEDIATRICS; PHYSIOLOGY; SACCHAROMYCES;

DIARRHEA; HUMANS; LACTOBACILLUS; PEDIATRICS; PROBIOTICS; SACCHAROMYCES;

EID: 85055073320     PISSN: 20426496     EISSN: 2042650X     Source Type: Journal    
DOI: 10.1039/c8fo00376a     Document Type: Review

References (224)

1. A. Guarino S. Ashkenazi D. Gendrel A. Lo Vecchio R. Shamir H. Szajewska European Society for Pediatric Gastroenterology, Nutrition and D. European Society for Pediatric Infectious, European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014 J. Pediatr. Gastroenterol. Nutr. 2014 59 132-152
2. A. C. Cheng J. R. McDonald N. M. Thielman Infectious diarrhea in developed and developing countries J. Clin. Gastroenterol. 2005 39 757-773
3. J. Bryce C. Boschi-Pinto K. Shibuya R. E. Black W. H. O. C. H. E. R. Group WHO estimates of the causes of death in children Lancet 2005 365 1147-1152
4. C. F. Lanata C. L. Fischer-Walker A. C. Olascoaga C. X. Torres M. J. Aryee R. E. Black Global causes of diarrheal disease mortality in children< 5 years of age: a systematic review PLoS One 2013 8 e72788
5. A. Amouzou, L. C.Velez, H.Tarekegn and M.Young, One is too many: ending child deaths from pneumonia and diarrhoea, UNICEF, New York, 2016
6. UNICEF, Statistics by Topic: Diarrhoeal Disease, https://data.unicef.org/topic/child-health/diarrhoeal-disease/
7. J. E. Mellor and J.Zimmerman, 2014 AGU Fall Meeting, 2014
8. A. C. Moreno A. F. Filho A. Gomes Tdo S. T. Ramos L. P. Montemor V. C. Tavares S. Filho Ldos K. Irino M. B. Martinez Etiology of childhood diarrhea in the northeast of Brazil: significant emergent diarrheal pathogens Diagn. Microbiol. Infect. Dis. 2010 66 50-57
9. A. Saeed H. Abd G. Sandstrom Microbial aetiology of acute diarrhoea in children under five years of age in Khartoum, Sudan J. Med. Microbiol. 2015 64 432-437
10. K. L. Anders C. N. Thompson N. T. Thuy N. M. Nguyet T. P. Tu le T. T. Dung V. V. Phat N. T. Van N. T. Hieu N. T. Tham P. T. Ha B. Lien le N. V. Chau S. Baker C. P. Simmons The epidemiology and aetiology of diarrhoeal disease in infancy in southern Vietnam: a birth cohort study Int. J. Infect. Dis. 2015 35 3-10
11. D. J. Operario J. A. Platts-Mills S. Nadan N. Page M. Seheri J. Mphahlele I. Praharaj G. Kang I. T. Araujo J. P. G. Leite D. Cowley S. Thomas C. D. Kirkwood F. Dennis G. Armah J. M. Mwenda P. R. Wijesinghe G. Rey V. Grabovac C. Berejena C. J. Simwaka J. Uwimana J. B. Sherchand H. M. Thu G. Galagoda I. J. O. Bonkoungou S. Jagne E. Tsolenyanu A. Diop C. Enweronu-Laryea S. A. Borbor J. Liu T. McMurry B. Lopman U. Parashar J. Gentsch A. D. Steele A. Cohen F. Serhan E. R. Houpt Etiology of severe acute watery diarrhea in children in the global rotavirus surveillance network using quantitative polymerase chain reaction J. Infect. Dis. 2017 216 220-227
12. WHO, The treatment of diarrhoea: a manual for physicians and other senior health workers, World Health Organization, Geneva, 2005
13. R. R. Das Zinc in acute childhood diarrhea: Is it universally effective? Indian J. Pharmacol. 2012 44 140
14. R. R. Das J. Sankar S. S. Naik Efficacy and safety of diosmectite in acute childhood diarrhoea: a meta-analysis Arch. Dis. Child. 2015 100 704-712
15. A. Guarino C. Dupont A. V. Gorelov F. Gottrand J. K. Lee Z. Lin A. Lo Vecchio T. D. Nguyen E. Salazar-Lindo The management of acute diarrhea in children in developed and developing areas: from evidence base to clinical practice Expert Opin. Pharmacother. 2012 13 17-26
16. R. L. Guerrant T. Van Gilder T. S. Steiner N. M. Thielman L. Slutsker R. V. Tauxe T. Hennessy P. M. Griffin H. DuPont R. B. Sack P. Tarr M. Neill I. Nachamkin L. B. Reller M. T. Osterholm M. L. Bennish L. K. Pickering A. Infectious Diseases Society of Practice guidelines for the management of infectious diarrhea Clin. Infect. Dis. 2001 32 331-351
17. M. S. Riddle H. L. DuPont B. A. Connor ACG clinical guideline: diagnosis, treatment, and prevention of acute diarrheal infections in adults Am. J. Gastroenterol. 2016 111 602-622
18. J. Hines I. Nachamkin Effective use of the clinical microbiology laboratory for diagnosing diarrheal diseases Clin. Infect. Dis. 1996 1292-1301
19. Y. Hu X. Yang J. Qin N. Lu G. Cheng N. Wu Y. Pan J. Li L. Zhu X. Wang Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota Nat. Commmun. 2013 4 2151
20. FAO/WHO, in FAO Food and Nutrition Paper 85, FAO/WHO, Rome, 2006
21. S. J. Czinn and S. S.Blanchard, in Probiotics in Pediatric Medicine, Springer, 2009, pp. 299-306
22. D. Granato G. F. Branco A. G. Cruz J. d. A. F. Faria N. P. Shah Probiotic dairy products as functional foods Compr. Rev. Food Sci. Food Saf. 2010 9 455-470
23. K. Makinen B. Berger R. Bel-Rhlid E. Ananta Science and technology for the mastership of probiotic applications in food products J. Biotechnol. 2012 162 356-365
24. TMR, Probiotic Market (Application-Food and Beverages, Dietary Supplements, and Animal Feed; By End Users-Human Probiotics and Animal Probiotics)-Global Industry Analysis, Size, Share, Growth, and Forecast 2014-2020, Transparency Market Research, Albany, NY, 2015
25. S. Raghuwanshi S. Misra R. Sharma P. Bisen Probiotics: nutritional therapeutic tool J. Probiotics Health 2018 6 2
26. S. Conway A. Hart A. Clark I. Harvey Does eating yogurt prevent antibiotic-associated diarrhoea? A placebo-controlled randomised controlled trial in general practice Br. J. Gen. Pract. 2007 57 953-959
27. D. J. Merenstein J. Foster F. D'Amico A randomized clinical trial measuring the influence of kefir on antibiotic-associated diarrhea: the measuring the influence of Kefir (MILK) Study Arch. Pediatr. Adolesc. Med. 2009 163 750-754
28. R. S. Beniwal V. C. Arena L. Thomas S. Narla T. F. Imperiale R. A. Chaudhry U. A. Ahmad A randomized trial of yogurt for prevention of antibiotic-associated diarrhea Dig. Dis. Sci. 2003 48 2077-2082
29. J. P. Chouraqui L. D. Van Egroo M. C. Fichot Acidified milk formula supplemented with Bifidobacterium lactis: impact on infant diarrhea in residential care settings J. Pediatr. Gastroenterol. Nutr. 2004 38 288-292
30. S. Sazawal U. Dhingra G. Hiremath A. Sarkar P. Dhingra A. Dutta P. Verma V. P. Menon R. E. Black Prebiotic and probiotic fortified milk in prevention of morbidities among children: community-based, randomized, double-blind, controlled trial PLoS One 2010 5 e12164
31. F. Heydarian H. R. Kianifar H. Ahanchian A. Khakshure J. Seyedi D. Moshirian A comparison between traditional yogurt and probiotic yogurt in non-inflammatory acute gastroenteritis Saudi Med. J. 2010 31 280-283
32. S. J. Allen E. G. Martinez G. V. Gregorio L. F. Dans Probiotics for treating acute infectious diarrhoea Cochrane Database Syst. Rev. 2010 CD003048 10.1002/14651858.CD003048.pub3
33. Y. K. Lee and S.Salminen, Handbook of Probiotics and Prebiotics, John Wiley & Sons, 2009
34. D. Hill, R. P.Ross, E.Arendt and C.Stanton, in Yogurt in Health and Disease Prevention, Elsevier, 2017, pp. 69-85
35. WGO, World Gastroenterology Organisation Global Guidelines: Probiotics and prebiotics, Milwaukee, WI, 2017
36. P. Marteau B. Flourie P. Pochart C. Chastang J. F. Desjeux J. C. Rambaud Effect of the microbial lactase (EC 3.2.1.23) activity in yoghurt on the intestinal absorption of lactose: an in vivo study in lactase-deficient humans Br. J. Nutr. 1990 64 71-79
37. Y. Sutas E. Soppi H. Korhonen E. L. Syvaoja M. Saxelin T. Rokka E. Isolauri Suppression of lymphocyte proliferation in vitro by bovine caseins hydrolyzed with Lactobacillus casei GG-derived enzymes J. Allergy Clin. Immunol. 1996 98 216-224
38. S. Khalesi J. Sun N. Buys R. Jayasinghe Effect of probiotics on blood pressure: a systematic review and meta-analysis of randomized, controlled trials Hypertension 2014 64 897-903
39. G. Kiessling J. Schneider G. Jahreis Long-term consumption of fermented dairy products over 6 months increases HDL cholesterol Eur. J. Clin. Nutr. 2002 56 843-849
40. S. Jayasimhan N. Y. Yap Y. Roest R. Rajandram K. F. Chin Efficacy of microbial cell preparation in improving chronic constipation: a randomized, double-blind, placebo-controlled trial Clin. Nutr. 2013 32 928-934
41. J. T. Lamont Mucus: the front line of intestinal mucosal defense Ann. N. Y. Acad. Sci. 1992 664 190-201
42. J. Wehkamp J. Schauber E. F. Stange Defensins and cathelicidins in gastrointestinal infections Curr. Opin. Gastroenterol. 2007 23 32-38
43. M. Zanetti The role of cathelicidins in the innate host defenses of mammals Curr. Issues Mol. Biol. 2005 7 179-196
44. T. Ganz Defensins: antimicrobial peptides of vertebrates C. R. Biol. 2004 327 539-549
45. D. Kelly T. King R. Aminov Importance of microbial colonization of the gut in early life to the development of immunity Mutat. Res. 2007 622 58-69
46. D. R. Mack S. Ahrne L. Hyde S. Wei M. A. Hollingsworth Extracellular MUC3 mucin secretion follows adherence of Lactobacillus, strains to intestinal epithelial cells in vitro Gut 2003 52 827-833
47. V. Lievin-Le Moal A. L. Servin The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides, and microbiota Clin. Microbiol. Rev. 2006 19 315-337
48. A. F. Mattar D. H. Teitelbaum R. A. Drongowski F. Yongyi C. M. Harmon A. G. Coran Probiotics up-regulate MUC-2 mucin gene expression in a Caco-2 cell-culture model Pediatr. Surg. Int. 2002 18 586-590
49. A. D. Walsham D. A. MacKenzie V. Cook S. Wemyss-Holden C. L. Hews N. Juge S. Schuller Lactobacillus reuteri inhibition of enteropathogenic Escherichia coli adherence to human intestinal epithelium Front. Microbiol. 2016 7 244
50. H. C. Clevers C. L. Bevins Paneth cells: maestros of the small intestinal crypts Annu. Rev. Physiol. 2013 75 289-311
51. M. Schlee J. Harder B. Koten E. F. Stange J. Wehkamp K. Fellermann Probiotic lactobacilli and VSL#3 induce enterocyte beta-defensin 2 Clin. Exp. Immunol. 2008 151 528-535
52. J. A. Guttman B. B. Finlay Tight junctions as targets of infectious agents Biochim. Biophys. Acta 2009 1788 832-841
53. T. K. Lapointe P. M. O'Connor A. G. Buret The role of epithelial malfunction in the pathogenesis of enteropathogenic E. coli-induced diarrhea Lab. Invest. 2009 89 964-970
54. M. M. Muza-Moons E. E. Schneeberger G. A. Hecht Enteropathogenic Escherichia coli, infection leads to appearance of aberrant tight junctions strands in the lateral membrane of intestinal epithelial cells Cell. Microbiol. 2004 6 783-793
55. D. J. Philpott D. M. McKay P. M. Sherman M. H. Perdue Infection of T84 cells with enteropathogenic Escherichia coli alters barrier and transport functions Am. J. Physiol. 1996 270 G634-G645
56. B. P. Blackwood C. Y. Yuan D. R. Wood J. D. Nicolas J. S. Grothaus C. J. Hunter Probiotic Lactobacillus species strengthen intestinal barrier function and tight junction integrity in experimental necrotizing enterocolitis J. Probiotics Health 2017 5 28638850
57. J. B. Ewaschuk H. Diaz L. Meddings B. Diederichs A. Dmytrash J. Backer M. Looijer-van Langen K. L. Madsen Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function Am. J. Physiol.: Gastrointest. Liver Physiol 2008 295 G1025-G1034
58. K. C. Johnson-Henry K. A. Donato G. Shen-Tu M. Gordanpour P. M. Sherman Lactobacillus rhamnosus strain GG prevents enterohemorrhagic Escherichia coli, O157:H7-induced changes in epithelial barrier function Infect. Immun. 2008 76 1340-1348
59. V. Lievin-Le Moal R. Amsellem A. Servin M. Coconnier Lactobacillus acidophilus (strain LB) from the resident adult human gastrointestinal microflora exerts activity against brush border damage promoted by a diarrhoeagenic Escherichia coli in human enterocyte-like cells Gut 2002 50 803-811
60. S. Resta-Lenert K. E. Barrett Probiotics and commensals reverse TNF-α-and IFN-γ-induced dysfunction in human intestinal epithelial cells Gastroenterology 2006 130 731-746
61. J. Karczewski F. J. Troost I. Konings J. Dekker M. Kleerebezem R. J. Brummer J. M. Wells Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier Am. J. Physiol.: Gastrointest. Liver Physiol 2010 298 G851-G859
62. R. Mennigen K. Nolte E. Rijcken M. Utech B. Loeffler N. Senninger M. Bruewer Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis Am. J. Physiol.: Gastrointest. Liver Physiol 2009 296 G1140-G1149
63. F. Yang A. Wang X. Zeng C. Hou H. Liu S. Qiao Lactobacillus reuteri I5007 modulates tight junction protein expression in IPEC-J2 cells with LPS stimulation and in newborn piglets under normal conditions BMC Microbiol. 2015 15 32
64. A. A. Zyrek C. Cichon S. Helms C. Enders U. Sonnenborn M. A. Schmidt Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKCzeta redistribution resulting in tight junction and epithelial barrier repair Cell. Microbiol. 2007 9 804-816
65. C.-Y. Yeung J.-S. Chiang Chiau W.-T. Chan C.-B. Jiang M.-L. Cheng H.-L. Liu H.-C. Lee In vitro prevention of Salmonella lipopolysaccharide-induced damages in epithelial barrier function by various Lactobacillus strains Gastroenterol. Res. Pract. 2013 2013
66. S. Resta-Lenert K. E. Barrett Live probiotics protect intestinal epithelial cells from the effects of infection with enteroinvasive Escherichia coli (EIEC) Gut 2003 52 988-997
67. H. Putaala T. Salusjarvi M. Nordstrom M. Saarinen A. C. Ouwehand E. Bech Hansen N. Rautonen Effect of four probiotic strains and Escherichia coli O157:H7 on tight junction integrity and cyclo-oxygenase expression Res. Microbiol. 2008 159 692-698
68. A. Seth F. Yan D. B. Polk R. K. Rao Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC-and MAP kinase-dependent mechanism Am. J. Physiol.: Gastrointest. Liver Physiol 2008 294 G1060-G1069
69. Y. Fukushima Y. Kawata H. Hara A. Terada T. Mitsuoka Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children Int. J. Food Microbiol. 1998 42 39-44
70. S. Rautava H. Arvilommi E. Isolauri Specific probiotics in enhancing maturation of IgA responses in formula-fed infants Pediatr. Res. 2006 60 221-224
71. M. Radke J. C. Picaud A. Loui G. Cambonie D. Faas H. N. Lafeber N. de Groot S. S. Pecquet P. G. Steenhout J. M. Hascoet Starter formula enriched in prebiotics and probiotics ensures normal growth of infants and promotes gut health: a randomized clinical trial Pediatr. Res. 2017 81 622-631
72. A. J. Macpherson E. Slack The functional interactions of commensal bacteria with intestinal secretory IgA Curr. Opin. Gastroenterol. 2007 23 673-678
73. R. C. Monteiro J. G. Van De Winkel IgA Fc receptors Annu. Rev. Immunol. 2003 21 177-204
74. A. Cerutti M. Rescigno The biology of intestinal immunoglobulin A responses Immunity 2008 28 740-750
75. D. C. Roopenian S. Akilesh FcRn: the neonatal Fc receptor comes of age Nat. Rev. Immunol. 2007 7 715-725
76. P. Forsythe J. Bienenstock Immunomodulation by commensal and probiotic bacteria Immunol. Invest. 2010 39 429-448
77. H. Kimoto-Nira K. Mizumachi M. Nomura M. Kobayashi Y. Fujita T. Okamoto I. Suzuki N. M. Tsuji J.-I. Kurisaki S. Ohmomo Lactococcus sp. as potential probiotic lactic acid bacteria JARQ 2007 41 181-189
78. S. Kandasamy K. S. Chattha A. N. Vlasova G. Rajashekara L. J. Saif Lactobacilli and Bifidobacteria enhance mucosal B cell responses and differentially modulate systemic antibody responses to an oral human rotavirus vaccine in a neonatal gnotobiotic pig disease model Gut Microbes 2014 5 639-651
79. A. N. Vlasova K. S. Chattha S. Kandasamy Z. Liu M. Esseili L. Shao G. Rajashekara L. J. Saif Lactobacilli and bifidobacteria promote immune homeostasis by modulating innate immune responses to human rotavirus in neonatal gnotobiotic pigs PLoS One 2013 8 e76962
80. I. D. Iliev H. Kitazawa T. Shimosato S. Katoh H. Morita F. He M. Hosoda T. Saito Strong immunostimulation in murine immune cells by Lactobacillus rhamnosus, GG DNA containing novel oligodeoxynucleotide pattern Cell. Microbiol. 2005 7 403-414
81. N. Takahashi H. Kitazawa T. Shimosato N. Iwabuchi J. Z. Xiao K. Iwatsuki S. Kokubo T. Saito An immunostimulatory DNA sequence from a probiotic strain of Bifidobacterium longum inhibits IgE production in vitro FEMS Immunol. Med. Microbiol. 2006 46 461-469
82. F. Sakai T. Hosoya A. Ono-Ohmachi K. Ukibe A. Ogawa T. Moriya Y. Kadooka T. Shiozaki H. Nakagawa Y. Nakayama T. Miyazaki Lactobacillus gasseri SBT2055 induces TGF-beta expression in dendritic cells and activates TLR2 signal to produce IgA in the small intestine PLoS One 2014 9 e105370
83. A. S. Naidu W. R. Bidlack R. A. Clemens Probiotic spectra of lactic acid bacteria (LAB) Crit. Rev. Food Sci. Nutr. 1999 39 13-126
84. N. Tharmaraj N. P. Shah Antimicrobial effects of probiotics against selected pathogenic and spoilage bacteria in cheese-based dips Int. Food Res. J. 2009 16 261-276
85. M. Ogawa K. Shimizu K. Nomoto R. Tanaka T. Hamabata S. Yamasaki T. Takeda Y. Takeda Inhibition of in vitro growth of Shiga toxin-producing Escherichia coli, O157: H7 by probiotic Lactobacillus strains due to production of lactic acid Int. Food Res. J. 2001 68 135-140
86. E. Freese C. W. Sheu E. Galliers Function of lipophilic acids as antimicrobial food additives Nature 1973 241 321
87. ICMSF, Microbial Ecology of Foods: Factors Affecting Life and Death of Microorganisms 3, Academic Press, New York, NY, 1980
88. H. L. Alakomi E. Skytta M. Saarela T. Mattila-Sandholm K. Latva-Kala I. M. Helander Lactic acid permeabilizes Gram-negative bacteria by disrupting the outer membrane Appl. Environ. Microbiol. 2000 66 2001-2005
89. M. A. Daeschel and M. H.Penner, in Food preservatives of microbial origin, ed. B. Ray and M. A. Daeschel, CRD Press, Boca Raton, Fla, 1992, pp. 155-175
90. R. James, C.Lazdunski and F.Pattus, Bacteriocins, microcins and lantibiotics, Springer-Verlag, New York, 1992
91. I. Wiedemann T. Bottiger R. R. Bonelli T. Schneider H. G. Sahl B. Martinez Lipid II-based antimicrobial activity of the lantibiotic plantaricin C Appl. Environ. Microbiol. 2006 72 2809-2814
92. O. McAuliffe M. P. Ryan R. P. Ross C. Hill P. Breeuwer T. Abee Lacticin 3147, a broad-spectrum bacteriocin which selectively dissipates the membrane potential Appl. Environ. Microbiol. 1998 64 439-445
93. M. C. Rea E. Clayton P. M. O'Connor F. Shanahan B. Kiely R. P. Ross C. Hill Antimicrobial activity of lacticin 3,147 against clinical Clostridium difficile strains J. Med. Microbiol. 2007 56 940-946
94. E. Riboulet-Bisson M. H. Sturme I. B. Jeffery M. M. O'Donnell B. A. Neville B. M. Forde M. J. Claesson H. Harris G. E. Gardiner P. G. Casey P. G. Lawlor P. W. O'Toole R. P. Ross Effect of Lactobacillus salivarius bacteriocin Abp118 on the mouse and pig intestinal microbiota PLoS One 2012 7 e31113
95. S. Duquesne D. Destoumieux-Garzon J. Peduzzi S. Rebuffat Microcins, gene-encoded antibacterial peptides from enterobacteria Nat. Prod. Rep. 2007 24 708-734
96. S. Sable A. M. Pons S. Gendron-Gaillard G. Cottenceau Antibacterial activity evaluation of microcin J25 against diarrheagenic Escherichia coli Appl. Environ. Microbiol. 2000 66 4595-4597
97. D. Bujnakova V. Kmet Inhibitory potential of lactobacilli against Escherichia coli internalization by HT 29 cells Folia Microbiol. 2012 57 269-272
98. L. Du X. He H. Zhang F. Liu X. Ju J. Yuan First two domains at the lp_1643 protein N terminus inhibit pathogen adhesion to porcine mucus in vitro J. Food Prot. 2015 78 370-375
99. V. Coeuret M. Gueguen J. P. Vernoux In vitro screening of potential probiotic activities of selected lactobacilli isolated from unpasteurized milk products for incorporation into soft cheese J. Dairy Res. 2004 71 451-460
100. C. U. Riedel F. Foata D. R. Goldstein S. Blum B. J. Eikmanns Interaction of bifidobacteria with Caco-2 cells-adhesion and impact on expression profiles Int. J. Food Microbiol. 2006 110 62-68
101. R. Tallon S. Arias P. Bressollier M. Urdaci Strain-and matrix-dependent adhesion of Lactobacillus plantarum is mediated by proteinaceous bacterial compounds J. Appl. Microbiol. 2007 102 442-451
102. E. M. Tuomola S. J. Salminen Adhesion of some probiotic and dairy Lactobacillus strains to Caco-2 cell cultures Int. J. Food Microbiol. 1998 41 45-51
103. M. C. Collado M. Gueimonde M. Hernandez Y. Sanz S. Salminen Adhesion of selected Bifidobacterium strains to human intestinal mucus and the role of adhesion in enteropathogen exclusion J. Food Prot. 2005 68 2672-2678
104. M. Gueimonde L. Noriega A. Margolles C. G. de los Reyes-Gavilan S. Salminen Ability of Bifidobacterium strains with acquired resistance to bile to adhere to human intestinal mucus Int. J. Food Microbiol. 2005 101 341-346
105. A. Ouwehand P. Kirjavainen M.-M. Grönlund E. Isolauri S. Salminen Adhesion of probiotic microorganisms to intestinal mucus Int. Dairy J. 1999 9 623-630
106. A. Matsumura T. Saito M. Arakuni H. Kitazawa Y. Kawai T. Itoh New binding assay and preparative trial of cell-surface lectin from Lactobacillus acidophilus group lactic acid bacteria J. Dairy Sci. 1999 82 2525-2529
107. B. B. Matijašić M. Narat M. Z. Peternel I. Rogelj Ability of Lactobacillus gasseri, K7 to inhibit Escherichia coli adhesion in vitro on Caco-2 cells and ex vivo on pigs' jejunal tissue Int. J. Food Microbiol. 2006 107 92-96
108. A. C. Ouwehand S. Salminen S. Tolkko P. Roberts J. Ovaska E. Salminen Resected human colonic tissue: new model for characterizing adhesion of lactic acid bacteria Clin. Diagn. Lab. Immunol. 2002 9 184-186
109. E. J. Ladas M. Bhatia L. Chen E. Sandler A. Petrovic D. M. Berman F. Hamblin M. Gates R. Hawks L. Sung M. Nieder The safety and feasibility of probiotics in children and adolescents undergoing hematopoietic cell transplantation Bone Marrow Transplant. 2016 51 262-266
110. G. Gonzalez-Ochoa L. K. Flores-Mendoza R. Icedo-Garcia R. Gomez-Flores P. Tamez-Guerra Modulation of rotavirus severe gastroenteritis by the combination of probiotics and prebiotics Arch. Microbiol. 2017 199 953-961
111. J. Y. Kang D. K. Lee N. J. Ha H. S. Shin Antiviral effects of Lactobacillus ruminis SPM0211 and Bifidobacterium longum SPM1205 and SPM1206 on rotavirus-infected Caco-2 cells and a neonatal mouse model J. Microbiol. 2015 53 796-803
112. F. C. Paim S. N. Langel D. D. Fischer S. Kandasamy L. Shao M. A. Alhamo H. C. Huang A. Kumar G. Rajashekara L. J. Saif A. N. Vlasova Effects of Escherichia coli Nissle 1917 and Ciprofloxacin on small intestinal epithelial cell mRNA expression in the neonatal piglet model of human rotavirus infection Gut Pathog. 2016 8 66
113. T. Botic T. D. Klingberg H. Weingartl A. Cencic A novel eukaryotic cell culture model to study antiviral activity of potential probiotic bacteria Int. J. Food Microbiol. 2007 115 227-234
114. M. Kumar V. Kissoon-Singh A. L. Coria F. Moreau K. Chadee Probiotic mixture VSL#3 reduces colonic inflammation and improves intestinal barrier function in Muc2 mucin-deficient mice Am. J. Physiol.: Gastrointest. Liver Physiol 2017 312 G34-G45
115. M. G. Martinez M. Prado Acosta N. A. Candurra S. M. Ruzal S-layer proteins of Lactobacillus acidophilus inhibits JUNV infection Biochem. Biophys. Res. Commun. 2012 422 590-595
116. K. P. Fernandez-Duarte N. N. Olaya-Galán S. P. Salas-Cárdenas J. Lopez-Rozo M. F. Gutierrez-Fernandez Bifidobacterium adolescentis, (DSM 20083) and Lactobacillus casei (Lafti L26-DSL): probiotics able to block the in vitro adherence of rotavirus in MA104 cells Probiotics Antimicrob. Proteins 2017 10 56-63
117. M. Kaila E. Isolauri E. Soppi E. Virtanen S. Laine H. Arvilommi Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain Pediatr. Res. 1992 32 141-144
118. T. Kawahara Y. Makizaki Y. Oikawa Y. Tanaka A. Maeda M. Shimakawa S. Komoto K. Moriguchi H. Ohno K. Taniguchi Oral administration of Bifidobacterium bifidum, G9-1 alleviates rotavirus gastroenteritis through regulation of intestinal homeostasis by inducing mucosal protective factors PLoS One 2017 12 e0173979
119. S. Lei A. Ramesh E. Twitchell K. Wen T. Bui M. Weiss X. Yang J. Kocher G. Li E. Giri-Rachman N. V. Trang X. Jiang E. P. Ryan L. Yuan High protective efficacy of probiotics and rice bran against human norovirus infection and diarrhea in gnotobiotic pigs Front. Microbiol. 2016 7 1699
120. N. Sarjapuram N. Mekala M. Singh U. Tatu The potential of Lactobacillus casei and Entercoccus faecium combination as a preventive probiotic against Entamoeba Probiotics Antimicrob. Proteins 2017 9 142-149
121. M.-A. Travers I. Florent L. Kohl P. Grellier Probiotics for the control of parasites: an overview J. Parasitol. Res. 2011 2011
122. E. C. Dinleyici M. Eren Z. A. Yargic N. Dogan Y. Vandenplas Clinical efficacy of Saccharomyces boulardii and metronidazole compared to metronidazole alone in children with acute bloody diarrhea caused by amebiasis: a prospective, randomized, open label study Am. J. Trop. Med. Hyg. 2009 80 953-955
123. M. Rigothier J. Maccario P. Gayral Inhibitory activity of Saccharomyces yeasts on the adhesion of Entamoeba histolytica trophozoites to human erythrocytes in vitro Parasitol. Res. 1994 80 10-15
124. P. F. Pérez J. Minnaard M. Rouvet C. Knabenhans D. Brassart G. L. De Antoni E. J. Schiffrin Inhibition of Giardia intestinalis, by extracellular factors from lactobacilli: an in vitro study Appl. Environ. Microbiol. 2001 67 5037-5042
125. M. A. Humen G. L. De Antoni J. Benyacoub M. E. Costas M. I. Cardozo L. Kozubsky K.-Y. Saudan A. Boenzli-Bruand S. Blum E. J. Schiffrin Lactobacillus johnsonii La1 antagonizes Giardia intestinalis in vivo Infect. Immun. 2005 73 1265-1269
126. G. Shukla P. Devi R. Sehgal Effect of Lactobacillus casei, as a probiotic on modulation of giardiasis Dig. Dis. Sci. 2008 53 2671-2679
127. N. Pickerd D. Tuthill Resolution of cryptosporidiosis with probiotic treatment Postgrad. Med. J. 2004 80 112-113
128. L. E. Morrow M. H. Kollef Probiotics in the intensive care unit: why controversies and confusion abound Crit. Care 2008 12 160
129. S. Aggarwal A. Upadhyay D. Shah N. Teotia A. Agarwal V. Jaiswal Lactobacillus GG for treatment of acute childhood diarrhoea: an open labelled, randomized controlled trial Indian J. Med. Res. 2014 139 379-385
130. S. Guandalini L. Pensabene M. A. Zikri J. A. Dias L. G. Casali H. Hoekstra S. Kolacek K. Massar D. Micetic-Turk A. Papadopoulou J. S. de Sousa B. Sandhu H. Szajewska Z. Weizman Lactobacillus GG administered in oral rehydration solution to children with acute diarrhea: a multicenter European trial J. Pediatr. Gastroenterol. Nutr. 2000 30 54-60
131. E. Salazar-Lindo P. Miranda-Langschwager M. Campos-Sanchez E. Chea-Woo R. B. Sack Lactobacillus casei strain GG in the treatment of infants with acute watery diarrhea: a randomized, double-blind, placebo controlled clinical trial [ISRCTN67363048] BMC Pediatr. 2004 4 18
132. E. C. Dinleyici N. Dalgic S. Guven O. Metin O. Yasa Z. Kurugol O. Turel G. Tanir A. S. Yazar V. Arica M. Sancar A. Karbuz M. Eren M. Ozen A. Kara Y. Vandenplas Lactobacillus reuteri DSM 17938 shortens acute infectious diarrhea in a pediatric outpatient setting J. Pediatr. 2015 91 392-396
133. E. C. Dinleyici P. S. Group Y. Vandenplas Lactobacillus reuteri DSM 17938 effectively reduces the duration of acute diarrhoea in hospitalised children Acta Paediatr. 2014 103 e300-e305
134. R. Francavilla E. Lionetti S. Castellaneta F. Ciruzzi F. Indrio A. Masciale C. Fontana M. La Rosa L. Cavallo A. Francavilla Randomised clinical trial: Lactobacillus reuteri DSM 17938 vs. placebo in children with acute diarrhoea-a double-blind study Aliment. Pharmacol. Ther. 2012 36 363-369
135. F. Savino S. Fornasero S. Ceratto A. De Marco N. Mandras J. Roana V. Tullio G. Amisano Probiotics and gut health in infants: A preliminary case-control observational study about early treatment with Lactobacillus reuteri, DSM 17938 Clin. Chim. Acta 2015 451 82-87
136. N. Simakachorn V. Pichaipat P. Rithipornpaisarn C. Kongkaew P. Tongpradit W. Varavithya Clinical evaluation of the addition of lyophilized, heat-killed Lactobacillus acidophilus LB to oral rehydration therapy in the treatment of acute diarrhea in children J. Pediatr. Gastroenterol. Nutr. 2000 30 68-72
137. N. H. El-Soud R. N. Said D. S. Mosallam N. A. Barakat M. A. Sabry Bifidobacterium lactis in treatment of children with acute diarrhea. A randomized double blind controlled trial Open Access Maced. J. Med. Sci. 2015 3 403-407
138. S. Das P. K. Gupta R. R. Das Efficacy and safety of Saccharomyces boulardii, in acute rotavirus diarrhea: double blind randomized controlled trial from a developing country J. Trop. Pediatr. 2016 62 464-470
139. G. Villarruel D. M. Rubio F. Lopez J. Cintioni R. Gurevech G. Romero Y. Vandenplas Saccharomyces boulardii in acute childhood diarrhoea: a randomized, placebo-controlled study Acta Paediatr. 2007 96 538-541
140. H. Szajewska A. Skorka M. Ruszczynski D. Gieruszczak-Bialek Meta-analysis: Lactobacillus, GG for treating acute gastroenteritis in children-updated analysis of randomised controlled trials Aliment. Pharmacol. Ther. 2013 38 467-476
141. A. Florowska K. Krygier T. Florowski E. Dłużewska Prebiotics as functional food ingredients preventing diet-related diseases Food Funct. 2016 7 2147-2155
142. R. Ranadheera S. Baines M. Adams Importance of food in probiotic efficacy Food Res. Int. 2010 43 1-7
143. A. E. Özen M. del Mar Bibiloni A. Pons J. A. Tur Consumption of functional foods in Europe; a systematic review Nutr. Hosp. 2014 29 470-478
144. V. Rashid M. F. Engberink M. van Eijsden M. Nicolaou L. H. Dekker A. P. Verhoeff P. J. M. Weijs Ethnicity and socioeconomic status are related to dietary patterns at age 5 in the Amsterdam born children and their development (ABCD) cohort BMC Public Health 2018 18 115
145. T. S. B. Schmidt J. Raes P. Bork The Human Gut Microbiome: From Association to Modulation Cell 2018 172 1198-1215
146. S. A. Sarker S. Sultana G. J. Fuchs N. H. Alam T. Azim H. Brüssow L. Hammarström Lactobacillus paracasei strain ST11 has no effect on rotavirus but ameliorates the outcome of nonrotavirus diarrhea in children from Bangladesh Pediatrics 2005 116 e221-e228
147. A. V. Shornikova I. A. Casas E. Isolauri H. Mykkanen T. Vesikari Lactobacillus reuteri, as a therapeutic agent in acute diarrhea in young children J. Pediatr. Gastroenterol. Nutr. 1997 24 399-404
148. C. M. Collins S. E. D'Orazio Bacterial ureases: structure, regulation of expression and role in pathogenesis Mol. Microbiol. 1993 9 907-913
149. L. Schaefer T. A. Auchtung K. E. Hermans D. Whitehead B. Borhan R. A. Britton The antimicrobial compound reuterin (3-hydroxypropionaldehyde) induces oxidative stress via interaction with thiol groups Microbiology 2010 156 1589-1599
150. L. Noriega I. Cuevas A. Margolles G. Clara Deconjugation and bile salts hydrolase activity by Bifidobacterium strains with acquired resistance to bile Int. Dairy J. 2006 16 850-855
151. R. L. Guerrant R. B. Oriá S. R. Moore M. O. Oriá A. A. Lima Malnutrition as an enteric infectious disease with long-term effects on child development Nutr. Rev. 2008 66 487-505
152. T. S. Steiner A. A. Lima J. P. Nataro R. L. Guerrant Enteroaggregative Escherichia coli produce intestinal inflammation and growth impairment and cause interleukin-8 release from intestinal epithelial cells J. Infect. Dis. 1998 177 88-96
153. H. Sokol B. Pigneur L. Watterlot O. Lakhdari L. G. Bermúdez-Humarán J.-J. Gratadoux S. Blugeon C. Bridonneau J.-P. Furet G. Corthier Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients Proc. Natl. Acad. Sci. U. S. A. 2008 105 16731-16736
154. L. Steidler W. Hans L. Schotte S. Neirynck F. Obermeier W. Falk W. Fiers E. Remaut Treatment of murine colitis by Lactococcus lactis secreting interleukin-10 Science 2000 289 1352-1355
155. M. Urbanska D. Gieruszczak-Bialek H. Szymanski H. Szajewska Effectiveness of Lactobacillus reuteri DSM 17938 for the prevention of nosocomial diarrhea in children: A randomized, double-blind, placebo-controlled Trial Pediatr. Infect. Dis. J. 2016 35 142-145
156. R. A. Oberhelman R. H. Gilman P. Sheen D. N. Taylor R. E. Black L. Cabrera A. G. Lescano R. Meza G. Madico A placebo-controlled trial of Lactobacillus GG to prevent diarrhea in undernourished Peruvian children J. Pediatr. 1999 134 15-20
157. E. Bruzzese M. C. Fedele D. Bruzzese S. Viscovo A. Giannattasio C. Mandato P. Siani A. Guarino Randomised clinical trial: a Lactobacillus GG and micronutrient-containing mixture is effective in reducing nosocomial infections in children, vs. placebo Aliment. Pharmacol. Ther. 2016 44 568-575
158. S. Alam M. Mushtaq Antibiotic associated diarrhea in children Indian Pediatr. 2009 46 491-496
159. L. V. McFarland M. Ozen E. C. Dinleyici S. Goh Comparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infections World J. Gastroenterol. 2016 22 3078-3104
160. H. Szajewska M. Ruszczynski A. Radzikowski Probiotics in the prevention of antibiotic-associated diarrhea in children: a meta-analysis of randomized controlled trials J. Pediatr. 2006 149 367-372
161. S. Sazawal G. Hiremath U. Dhingra P. Malik S. Deb R. E. Black Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomised, placebo-controlled trials Lancet Infect. Dis. 2006 6 374-382
162. K. Korpela A. Salonen L. J. Virta M. Kumpu R. A. Kekkonen W. M. de Vos Lactobacillus rhamnosus GG intake modifies preschool children's intestinal microbiota, alleviates penicillin-associated changes, and reduces antibiotic use PLoS One 2016 11 e0154012
163. S. R. Hayes A. J. Vargas Probiotics for the prevention of pediatric antibiotic-associated diarrhea Explore 2016 12 463-466
164. M. J. Fox K. D. Ahuja I. K. Robertson M. J. Ball R. D. Eri Can probiotic yogurt prevent diarrhoea in children on antibiotics? A double-blind, randomised, placebo-controlled study BMJ Open 2015 5 e006474
165. M. Hickson Probiotics in the prevention of antibiotic-associated diarrhoea and Clostridium difficile infection Ther. Adv. Gastroenterol. 2011 4 185-197
166. D. Cameron Q. S. Hock M. Kadim N. Mohan E. Ryoo B. Sandhu Y. Yamashiro C. Jie H. Hoekstra A. Guarino Probiotics for gastrointestinal disorders: Proposed recommendations for children of the Asia-Pacific region World J. Gastroenterol. 2017 23 7952
167. S. Cruchet R. Furnes A. Maruy E. Hebel J. Palacios F. Medina N. Ramirez M. Orsi L. Rondon V. Sdepanian The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts Paediatr. Drugs 2015 17 199-216
168. J. M. Saavedra N. A. Bauman I. Oung J. A. Perman R. H. Yolken Feeding of Bifidobacterium bifidum and Streptococcus thermophilus, to infants in hospital for prevention of diarrhoea and shedding of rotavirus Lancet 1994 344 1046-1049
169. J. M. Pinto A. Petrova Lactobacillus acidophilus mixture in treatment of children hospitalized with acute diarrhea Clin. Pediatr. 2016 55 1202-1209
170. R. B. Canani P. Cirillo G. Terrin L. Cesarano M. I. Spagnuolo A. De Vincenzo F. Albano A. Passariello G. De Marco F. Manguso A. Guarino Probiotics for treatment of acute diarrhoea in children: randomised clinical trial of five different preparations Br. Med. J. 2007 335 340
171. Y. Rivera-Espinoza Y. Gallardo-Navarro Non-dairy probiotic products Food Microbiol. 2010 27 1-11
172. M. T. Cook G. Tzortzis D. Charalampopoulos V. V. Khutoryanskiy Microencapsulation of probiotics for gastrointestinal delivery J. Controlled Release 2012 162 56-67
173. T. W. Yeung I. J. Arroyo-Maya D. J. McClements D. A. Sela Microencapsulation of probiotics in hydrogel particles: enhancing Lactococcus lactis subsp. cremoris LM0230 viability using calcium alginate beads Food Funct. 2016 7 1797-1804
174. V. Sreeja J. B. Prajapati Probiotic formulations: Application and status as pharmaceuticals—A review Probiotics Antimicrob. Proteins 2013 5 81-91
175. E. Isolauri M. Juntunen T. Rautanen P. Sillanaukee T. Koivula A human Lactobacillus strain (Lactobacillus casei sp strain GG) promotes recovery from acute diarrhea in children Pediatrics 1991 88 90-97
176. C. A. Adams The probiotic paradox: live and dead cells are biological response modifiers Nutr. Res. Rev. 2010 23 37-46
177. J. Cannon T. Lee J. Bolanos L. Danziger Pathogenic relevance of Lactobacillus: a retrospective review of over 200 cases Eur. J. Clin. Microbiol. Infect. Dis. 2005 24 31-40
178. M. A. De Groote D. N. Frank E. Dowell M. P. Glode N. R. Pace Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome Pediatr. Infect. Dis. J. 2005 24 278-280
179. M. Molinaro M. Aiazzi A. T. La E. Cini R. Banfi Lactobacillus rhamnosus sepsis in a preterm infant associated with probiotic integrator use: a case report Recenti Prog. Med. 2016 107 485-486
180. C. Dani C. C. Coviello I. I. Corsini F. Arena A. Antonelli G. M. Rossolini Lactobacillus sepsis and probiotic therapy in newborns: Two new cases and literature review AJP Rep. 2016 6 e25-e29
181. F. Gouriet M. Million M. Henri P. E. Fournier D. Raoult Lactobacillus rhamnosus bacteremia: an emerging clinical entity Eur. J. Clin. Microbiol. Infect. Dis. 2012 31 2469-2480
182. D. Scalabrin C. Harris W. H. Johnston C. L. Berseth Long-term safety assessment in children who received hydrolyzed protein formulas with Lactobacillus rhamnosus GG: a 5-year follow-up Eur. J. Pediatr. 2017 176 217-224
183. I. C. Imperial J. A. Ibana Addressing the Antibiotic Resistance Problem with Probiotics: Reducing the Risk of Its Double-Edged Sword Effect Front. Microbiol. 2016 7 1983
184. D. R. Snydman The safety of probiotics Clin. Infect. Dis. 2008 46 S104-S111
185. H. Konishi M. Fujiya H. Tanaka N. Ueno K. Moriichi J. Sasajima K. Ikuta H. Akutsu H. Tanabe Y. Kohgo Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis Nat. Commun. 2016 7 12365
186. M. Lenoir S. Del Carmen N. G. Cortes-Perez D. Lozano-Ojalvo D. Munoz-Provencio F. Chain P. Langella A. de Moreno de LeBlanc J. G. LeBlanc L. G. Bermudez-Humaran Lactobacillus casei, BL23 regulates Treg and Th17 T-cell populations and reduces DMH-associated colorectal cancer J. Gastroenterol. 2016 51 862-873
187. Y. Vandenplas S. Salvatore M. Vieira T. Devreker B. Hauser Probiotics in infectious diarrhoea in children: are they indicated? Eur. J. Pediatr. 2007 166 1211-1218
188. L. Noriega M. Gueimonde B. Sánchez A. Margolles C. G. de los Reyes-Gavilán Effect of the adaptation to high bile salts concentrations on glycosidic activity, survival at low pH and cross-resistance to bile salts in Bifidobacterium Int. J. Food Microbiol. 2004 94 79-86
189. M. Camilleri L. Colemont S. F. Phillips M. L. Brown G. M. Thomforde N. Chapman A. R. Zinsmeister Human gastric emptying and colonic filling of solids characterized by a new method Am. J. Physiol.: Gastrointest. Liver Physiol 1989 257 G284-G290
190. A. K. Anal H. Singh Recent advances in microencapsulation of probiotics for industrial applications and targeted delivery Trends Food Sci. Technol. 2007 18 240-251
191. A. Barzegari A. A. Saei Designing probiotics with respect to the native microbiome Future Microbiol. 2012 7 571-575
192. E. Elliott K. Teversham An evaluation of nine probiotics available in South Africa, August 2003 S. Afr. Med. J. 2004 94 121-124
193. R. Temmerman B. Pot G. Huys J. Swings Identification and antibiotic susceptibility of bacterial isolates from probiotic products Int. J. Food Microbiol. 2003 81 1-10
194. N. Ibnou-Zekri S. Blum E. J. Schiffrin T. von der Weid Divergent patterns of colonization and immune response elicited from two intestinal Lactobacillus strains that display similar properties in vitro Infect. Immun. 2003 71 428-436
195. S. U. Islam Clinical uses of probiotics Medicine 2016 95 e2658
196. K. Guenther E. Straube W. Pfister A. Guenther A. Huebler Sever sepsis after probiotic treatment with Escherichia coli NISSLE 1917 Pediatr. Infect. Dis. J. 2010 29 188-189
197. R. Herbrecht Y. Nivoix Saccharomyces cerevisiae fungemia: an adverse effect of Saccharomyces boulardii probiotic administration Clin. Infect. Dis. 2005 40 1635-1637
198. H. Kitajima S. Hirano Safety of Bifidobacterium breve (BBG-01) in preterm infants Pediatr. Int. 2017 59 328-333
199. A. N. Kunz J. M. Noel M. P. Fairchok Two cases of Lactobacillus bacteremia during probiotic treatment of short gut syndrome J. Pediatr. Gastroenterol. Nutr. 2004 38 457-458
200. L. E. Morrow V. Gogineni M. A. Malesker Probiotic, prebiotic, and synbiotic use in critically ill patients Curr. Opin. Crit. Care 2012 18 186-191
201. P. Mullany A. M. Field M. M. McConnell S. M. Scotland H. R. Smith B. Rowe Expression of plasmids coding for colonization factor antigen II (CFA/II) and enterotoxin production in Escherichia coli J. Gen. Microbiol. 1983 129 3591-3601
202. A. D. O'Brien R. K. Holmes Shiga and Shiga-like toxins Microbiol. Rev. 1987 51 206-220
203. S. J. Savarino A. Fasano D. C. Robertson M. M. Levine Enteroaggregative Escherichia coli elaborate a heat-stable enterotoxin demonstrable in an in vitro rabbit intestinal model J. Clin. Invest. 1991 87 1450-1455
204. S. B. Formal P. Gemski Jr. R. A. Giannella S. Austin Mechanisms of Shigella pathogenesis Am. J. Clin. Nutr. 1972 25 1427-1432
205. R. A. Giannella S. B. Formal G. J. Dammin H. Collins Pathogenesis of salmonellosis. Studies of fluid secretion, mucosal invasion, and morphologic reaction in the rabbit ileum J. Clin. Invest. 1973 52 441-453
206. G. Grandy M. Medina R. Soria C. G. Teran M. Araya Probiotics in the treatment of acute rotavirus diarrhoea. A randomized, double-blind, controlled trial using two different probiotic preparations in Bolivian children BMC Infect. Dis. 2010 10 253
207. A. Guarino S. Guandalini A. Lo Vecchio Probiotics for prevention and treatment of diarrhea J. Clin. Gastroenterol. 2015 49 Suppl 1 S37-S45
208. Y. Vandenplas Probiotics and prebiotics in infectious gastroenteritis Best Pract. Res., Clin. Gastroenterol. 2016 30 49-53
209. C. L. F. Walker I. Rudan L. Liu H. Nair E. Theodoratou Z. A. Bhutta K. L. O'Brien H. Campbell R. E. Black Global burden of childhood pneumonia and diarrhoea Lancet 2013 381 1405-1416
210. M. Alander R. Satokari R. Korpela M. Saxelin T. Vilpponen-Salmela T. Mattila-Sandholm A. von Wright Persistence of colonization of human colonic mucosa by a probiotic strain, Lactobacillus rhamnosus, GG, after oral consumption Appl. Environ. Microbiol. 1999 65 351-354
211. G. W. Tannock K. Munro H. J. Harmsen G. W. Welling J. Smart P. K. Gopal Analysis of the fecal microflora of human subjects consuming a probiotic product containing Lactobacillus rhamnosus DR20 Appl. Environ. Microbiol. 2000 66 2578-2588
212. J. Henker M. W. Laass B. M. Blokhin V. G. Maydannik Y. K. Bolbot M. Elze C. Wolff A. Schreiner J. Schulze Probiotic Escherichia coli Nissle 1917 versus placebo for treating diarrhea of greater than 4 days duration in infants and toddlers Pediatr. Infect. Dis. J. 2008 27 494-499
213. V. Rosenfeldt K. F. Michaelsen M. Jakobsen C. N. Larsen P. L. Moller M. Tvede H. Weyrehter N. H. Valerius A. Paerregaard Effect of probiotic Lactobacillus, strains on acute diarrhea in a cohort of nonhospitalized children attending day-care centers Pediatr. Infect. Dis. J. 2002 21 417-419
214. S. Basu M. Chatterjee S. Ganguly P. K. Chandra Efficacy of Lactobacillus rhamnosus GG in acute watery diarrhoea of Indian children: a randomised controlled trial J. Paediatr. Child Health 2007 43 837-842
215. P. Dutta U. Mitra S. Dutta K. Rajendran T. K. Saha M. K. Chatterjee Randomised controlled clinical trial of Lactobacillus sporogenes (Bacillus coagulans), used as probiotic in clinical practice, on acute watery diarrhoea in children Trop. Med. Int. Health 2011 16 555-561
216. Z. Kurugol G. Koturoglu Effects of Saccharomyces boulardii in children with acute diarrhoea Acta Paediatr. 2005 94 44-47
217. I. Hojsak V. Tokic Pivac A. Mocic Pavic A. M. Pasini S. Kolacek Bifidobacterium animalis subsp. lactis fails to prevent common infections in hospitalized children: a randomized, double-blind, placebo-controlled study Am. J. Clin. Nutr. 2015 101 680-684
218. H. Szymanski M. Armanska K. Kowalska-Duplaga H. Szajewska Bifidobacterium longum PL03, Lactobacillus rhamnosus KL53A, and Lactobacillus plantarum, PL02 in the prevention of antibiotic-associated diarrhea in children: a randomized controlled pilot trial Digestion 2008 78 13-17
219. M. Ruszczynski A. Radzikowski H. Szajewska Clinical trial: effectiveness of Lactobacillus rhamnosus (strains E/N, Oxy and Pen) in the prevention of antibiotic-associated diarrhoea in children Aliment. Pharmacol. Ther. 2008 28 154-161
220. H. Szajewska M. Kotowska J. Z. Mrukowicz M. Armanska W. Mikolajczyk Efficacy of Lactobacillus, GG in prevention of nosocomial diarrhea in infants J. Pediatr. 2001 138 361-365
221. I. Hojsak N. Snovak S. Abdovic H. Szajewska Z. Misak S. Kolacek Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double-blind, placebo-controlled trial Clin. Nutr. 2010 29 312-316
222. H. Szajewska M. Wanke B. Patro Meta-analysis: the effects of Lactobacillus rhamnosus, GG supplementation for the prevention of healthcare-associated diarrhoea in children Aliment. Pharmacol. Ther. 2011 34 1079-1087
223. M. Wanke H. Szajewska Lack of an effect of Lactobacillus reuteri DSM 17938 in preventing nosocomial diarrhea in children: a randomized, double-blind, placebo-controlled trial J. Pediatr. 2012 161 40-43
224. M. Kotowska P. Albrecht H. Szajewska Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea in children: a randomized double-blind placebo-controlled trial Aliment. Pharmacol. Ther. 2005 21 583-590