Efficacy and safety of saccharomyces boulardii in acute rotavirus diarrhea: Double blind randomized controlled trial from a developing country

Journal of Tropical Pediatrics

Volumn 62, Issue 6, 2016, Pages 464-470

  Das, Susrut ^a   Gupta, Pradeep Kumar ^a   Das, Rashmi Ranjan ^b  

^a Manipal Tata Medical College Jamshedpur   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Acute gastroenteritis; Pediatric; Probiotics; Reoviridae

Indexed keywords

PLACEBO; PROBIOTIC AGENT; VIRUS ANTIGEN;

ABSENCE OF SIDE EFFECTS; ACUTE DIARRHEA; ARTICLE; CHILD; CONTROLLED STUDY; DEHYDRATION; DEVELOPING COUNTRY; DISEASE DURATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; ENZYME IMMUNOASSAY; FECES ANALYSIS; FEMALE; FEVER; HUMAN; INDIA; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; REHYDRATION; ROTAVIRUS INFECTION; SACCHAROMYCES BOULARDII; VOMITING; ACUTE DISEASE; DIARRHEA; DIARRHEA, INFANTILE; DRUG ADMINISTRATION; FECES; FLUID THERAPY; INFANT; ISOLATION AND PURIFICATION; ROTAVIRUS; ROTAVIRUS INFECTIONS; TREATMENT OUTCOME; VIROLOGY;

ACUTE DISEASE; CHILD, PRESCHOOL; DIARRHEA; DIARRHEA, INFANTILE; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FECES; FEMALE; FLUID THERAPY; HUMANS; INDIA; INFANT; LENGTH OF STAY; MALE; PROBIOTICS; ROTAVIRUS; ROTAVIRUS INFECTIONS; SACCHAROMYCES BOULARDII; TREATMENT OUTCOME; VOMITING;

EID: 85016078186     PISSN: 01426338     EISSN: 14653664     Source Type: Journal    
DOI: 10.1093/tropej/fmw032     Document Type: Article

References (25)

1. Walker CL, Rudan I, Liu L, et al. Global burden of childhood pneumonia and diarrhoea. Lancet 2013;381:1405-16.
2. Wilhelmi I, Román E, Sánchez-Fauquier A. Viruses causing gastroenteritis. Clin Microbiol Infect 2003;9:247-62.
3. Tate JE, Chitambar S, Esposito DH, et al. Disease and economic burden of rotavirus diarrhoea in India. Vaccine 2009;27:F18-24.
4. World Health Organization (WHO). The treatment of diarrhoea: A manual for physicians and other senior health workers. 4th rev. Geneva: WHO, 2005; WHO/COD/SER/80.2. http://whqlibdoc.who.int/publications/2005/9241593180.pdf (24 January 2015, date last accessed).
5. Das RR. Zinc in acute childhood diarrhea: Is it universally effective? Indian J Pharmacol 2012;44:140.
6. Guarino A, Dupont C, Gorelov AV, et al. The management of acute diarrhea in children in developed and developing areas: From evidence base to clinical practice. Expert Opin Pharmacother 2012;13:17-26.
7. Das RR, Sankar J, Naik SS. Efficacy and safety of diosmec-tite in acute childhood diarrhoea: A meta-analysis. Arch Dis Child 2015;100:704-12.
8. Joint FAO/WHO Working Group Report on Drafting Guidelines for the Evaluation of Probiotics in Food. London, Ontario, Canada, 2002. http://www.who.int/foodsafety/fs_management/en/probiotic_guidelines.pdf [15 January 2016, date last accessed].
9. Das RR, Naik SS, Singh M. Probiotics as additives on therapy in allergic airway diseases: A systematic review of benefits and risks. Biomed Res Int 2013;2013:231979.
10. Das RR. Probiotics in necrotizing enterocolitis: More questions than answers? Clin Nutr 2012;31:431.
11. Szajewska H, Guarino A, Hojsak I, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Use of probiotics for management of acute gastroenteritis: A position paper by the ESPGHAN Working Group for Probiotics and Prebiotics. J Pediatr Gastroenterol Nutr 2014;58:531-9.
12. Kelesidis T, Pothoulakis C. Efficacy and safety of the pro-biotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders. Therap Adv Gastroenterol 2012;5:111-25.
13. Grandy G, Medina M, Soria R, et al. Probiotics in the treatment of acute rotavirus diarrhoea. A randomized, double-blind, controlled trial using two different probiotic preparations in Bolivian children. BMC Infect Dis 2010;10:253.
14. Correa NB, Penna FJ, Lima FM, et al. Treatment of acute diarrhea with Saccharomyces boulardii in infants. J Pediatr Gastroenterol Nutr 2011;53:497-501.
15. Erdoğan O, Tanyeri B, Torun E, et al. The comparition of the efficacy of two different probiotics in rotavirus gastroenteritis in children. J Trop Med 2012;2012:787240.
16. Guarino A, Berni Canani R, Spagnuolo MI, et al. Oral bacterial therapy reduces the duration of symptoms and of viral excretion in children with mild diarrhea. J Pediatr Gastroenterol Nutr 1997;25:516-19.
17. Bonett DG, Price RM. Statistical inference for a linear function of medians: Confidence intervals, hypothesis testing, and sample size requirements. Psychol Methods 2002;7:370-83.
18. Feizizadeh S, Salehi-Abargouei A, Akbari V. Efficacy and safety of Saccharomyces boulardii for acute diarrhea. Pediatrics 2014;134:e176-91.
19. Htwe K, Yee KS, Tin M, et al. Effect of Saccharomyces bou-lardii in the treatment of acute watery diarrhea in Myanmar children: A randomized controlled study. Am J Trop Med Hyg 2008;78:214-16.
20. Pant AR, Graham SM, Allen SJ, et al. Lactobacillus GG and acute diarrhea in young children in the tropics. J Trop Pediatr 1996;42:162-5.
21. Raza S, Graham SM, Allen SJ, et al. Lactobacillus GG promotes recovery from acute nonbloody diarrhoea in Pakistan. Ped Infect Dis J 1995;14:107-11.
22. Burande MA. Comparison of efficacy of Saccharomyces boulardii strain in the treatment of acute diarrhea in children: A prospective, single-blind, randomized controlled clinical trial. J Pharmacol Pharmacother 2013;4:205-8.
23. Shornikova AV, Casas IA, Isolauri E, et al. Lactobacillus reuteri as a therapeutic agent in acute diarrhea in young children. J Pediatr Gastroenterol Nutr 1997;24:399-404.
24. Teran CG, Teran-Escalera CN, Villarroel P. Nitazoxanide vs. probiotics for the treatment of acute rotavirus diarrhea in children: A randomized, single-blind, controlled trial in Bolivian children. Int J Infect Dis 2009;13:518-23.
25. Colbère-Garapin F, Martin-Latil S, Blondel B, et al. Prevention and treatment of enteric viral infections: Possible benefits of probiotic bacteria. Microbes Infect 2007;9:1623-31.