Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis

Nature Communications

Volumn 7, Issue , 2016, Pages

  Konishi, Hiroaki ^a   Fujiya, Mikihiro ^a   Tanaka, Hiroki ^a   Ueno, Nobuhiro ^a   Moriichi, Kentaro ^a   Sasajima, Junpei ^a   Ikuta, Katsuya ^a   Akutsu, Hiroaki ^a   Tanabe, Hiroki ^b   Kohgo, Yutaka ^b  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

^b International University of Health and Welfare Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; FERRICHROME; FLUOROURACIL; PROBIOTIC AGENT; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTOME; ANTINEOPLASTIC AGENT;

APOPTOSIS; BACTERIUM; CANCER; GENETIC ANALYSIS; GENOME; INHIBITION; PEPTIDE; PROBIOTICS;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BACTERIUM CULTURE; CANCER CELL; CANCER GROWTH; COLON CANCER; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INTESTINE CELL; LACTOBACILLUS CASEI; MASS SPECTROMETRY; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; SUPERNATANT; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CELL SURVIVAL; COLON; COLON TUMOR; CYTOLOGY; DISEASE EXACERBATION; DRUG EFFECT; GENE EXPRESSION PROFILING; GENETICS; MALE; MAPK SIGNALING; METABOLISM; NUDE MOUSE; PATHOLOGY; PROCEDURES; RAT; TREATMENT OUTCOME; TUMOR CELL LINE; UPREGULATION;

LACTOBACILLUS CASEI;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CISPLATIN; COLON; COLONIC NEOPLASMS; DISEASE PROGRESSION; FERRICHROME; FLUOROURACIL; GENE EXPRESSION PROFILING; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LACTOBACILLUS CASEI; MALE; MAP KINASE SIGNALING SYSTEM; MASS SPECTROMETRY; MICE; MICE, INBRED BALB C; MICE, NUDE; PROBIOTICS; RATS; TREATMENT OUTCOME; UP-REGULATION;

EID: 84981510294     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms12365     Document Type: Article

References (20)

1. Isolauri, E. et al. Nutrition, Allergy, Mucosal Immunology, and Intestinal Microbiota (NAMI) Research Group Report. Probiotics: use in allergic disorders: a Nutrition, Allergy, Mucosal Immunology, and Intestinal Microbiota (NAMI) Research Group Report. J. Clin. Gastroenterol. 42, S91-S96 (2008).
2. Kalliomäki, M. et al. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 357, 1076-1079 (2001).
3. Rowland, I. R. et al. Effect of Bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-induced aberrant crypt foci in rats. Carcinogenesis 19, 281-285 (1998).
4. Marchesi, J. R. et al. Towards the human colorectal cancer microbiome. PLoS ONE 6, e20447 (2011).
5. Sobhani, I. et al. Microbial dysbiosis in colorectal cancer (CRC) patients. PLoS ONE 6, e16393 (2011).
6. Jan, G. et al. Propionibacteria induce apoptosis of colorectal carcinoma cells via short-chain fatty acids acting on mitochondria. Cell Death Differ. 9, 179-188 (2002).
7. Cousin, F. J. et al. Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells. PLoS ONE 7, e31892 (2012).
8. Miao, L. et al. Optimization of the culture condition for an antitumor bacterium Serratia proteamacula 657 and identification of the active compounds. World J. Microbiol. Biotechnol. 29, 855-863 (2013).
9. DuPont, A. W. et al. The intestinal microbiota and chronic disorders of the gut. Nat. Rev. Gastroenterol. Hepatol. 8, 523-531 (2011).
10. Femia, A. P. et al. Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats. Carcinogenesis 23, 1953-1960 (2002).
11. Fujiya, M. et al. The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter. Cell Host Microbe 1, 299-308 (2007).
12. Segawa, S. et al. Probiotic-derived polyphosphate enhances the epithelial barrier function and maintains intestinal homeostasis through integrin-p38 MAPK pathway. PLoS ONE 6, e23278 (2011).
13. Yan, F. et al. Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology 132, 562-575 (2007).
14. Schalk, I. J. et al. New roles for bacterial siderophores in metal transport and tolerance. Environ. Microbiol. 13, 2844-2854 (2011).
15. Tabas, I. et al. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat. Cell Biol. 13, 184-190 (2011).
16. Okamoto, K. et al. Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection. Int. J. Colorectal Dis. 27, 1039-1046 (2012).
17. Konishi, H. et al. Traffic control of bacteria-derived molecules: a new system of host-bacterial crosstalk. Int. J. Cell Biol. 2013, 757148 (2013).
18. Konishi, H. et al. Host-microbe interactions via membrane transport systems. Environ. Microbiol. 17, 931-937 (2015).
19. Kashima, S. et al. Polyphosphate, an active molecule derived from probiotic Lactobacillus brevis, improves the fibrosis in murine colitis. Transl. Res. 166, 163-175 (2015).
20. Liu, X. et al. ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells. Am. J. Pathol. 180, 599-607 (2012).