Bifidobacterium animalis subsp. lactis fails to prevent common infections in hospitalized children: A randomized, double-blind, placebo-controlled study

American Journal of Clinical Nutrition

Volumn 101, Issue 3, 2015, Pages 680-684

  Hojsak, Iva ^a   Pivac, Višnja Tokić ^a   Pavić, Ana Močić ^a   Pasini, Agneza Marija ^a   Kolaček, Sanja ^a,b  

^a Children's University Hospital Zagreb   (Croatia)

^b UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

Bifidobacterium animalis subsp. lactis; Children; Nosocomial infection; Prevention; Probiotics

Indexed keywords

BB 12; PROBIOTIC AGENT; UNCLASSIFIED DRUG; IMMUNOLOGIC FACTOR;

ADENOVIRUS INFECTION; ARTICLE; BIFIDOBACTERIUM ANIMALIS; CHILD; COMMON COLD; CONTROLLED STUDY; DIARRHEA; DISEASE DURATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; FEMALE; GASTROINTESTINAL INFECTION; HOSPITAL INFECTION; HUMAN; INCIDENCE; INTENTION TO TREAT ANALYSIS; MAJOR CLINICAL STUDY; MALE; NAUSEA AND VOMITING; OUTCOME ASSESSMENT; PHARYNGITIS; PNEUMONIA; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFECTION; RHINITIS; ROTAVIRUS INFECTION; SCORING SYSTEM; SINUSITIS; VESIKARI SCORE; VISUAL ANALOG SCALE; ADOLESCENT; BIFIDOBACTERIUM; CROATIA; CROSS INFECTION; FOLLOW UP; GASTROENTERITIS; HOSPITAL; IMMUNOLOGY; INFANT; INNATE IMMUNITY; LENGTH OF STAY; PATHOPHYSIOLOGY; PRESCHOOL CHILD; RESPIRATORY TRACT INFECTIONS; SEVERITY OF ILLNESS INDEX;

BIFIDOBACTERIUM ANIMALIS SUBSP. LACTIS;

ADOLESCENT; BIFIDOBACTERIUM; CHILD; CHILD, PRESCHOOL; CROATIA; CROSS INFECTION; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; GASTROENTERITIS; HOSPITALS, PEDIATRIC; HUMANS; IMMUNITY, INNATE; IMMUNOLOGIC FACTORS; INCIDENCE; INFANT; INTENTION TO TREAT ANALYSIS; LENGTH OF STAY; MALE; PROBIOTICS; RESPIRATORY TRACT INFECTIONS; SEVERITY OF ILLNESS INDEX;

EID: 84928428003     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.114.102004     Document Type: Article

References (17)

1. Mühlemann K, Franzini C, Aebi C, Berger C, Nadal D, Stahelin J, Gnehm H, Posfay-Barbe K, Gervaix A, Sax H, et al. Prevalence of nosocomial infections in Swiss children's hospitals. Infect Control Hosp Epidemiol 2004;25:765-71.
2. Rutledge-Taylor K, Matlow A, Gravel D, Embree J, Le Saux N, Johnston L, Suh K, Embil J, Henderson E, John M, et al. A point prevalence survey of health care-associated infections in Canadian pediatric inpatients. Am J Infect Control 2012.
3. Kinnula S, Buettcher M, Tapiainen T, Renko M, Vepsalainen K, Lantto R, Heininger U, Uhari M. Hospital-associated infections in children: a prospective post-discharge follow-up survey in three different paediatric hospitals. J Hosp Infect 2012;80:17-24.
4. World Health Organization; Department of Communicable Disease, Surveillance and Response. Prevention of hospital-acquired infections. Geneva (Switzerland): WHO; 2002. Publication No.: WHO/CDS/CSR/EPH/2002.12.
5. Mlinaric-Galinovic G, Varda-Brkic D. Nosocomial respiratory syncytial virus infections in children's wards. Diagn Microbiol Infect Dis 2000;37:237-46.
6. Hojsak I, Abdovic S, Szajewska H, Milosevic M, Krznaric Z, Kolacek S. Lactobacillus GG in the prevention of nosocomial gastrointestinal and respiratory tract infections. Pediatrics 2010;125:e1171-7.
7. Posfay-Barbe KM, Zerr DM, Pittet D. Infection control in paediatrics. Lancet Infect Dis 2008;8:19-31.
8. Szajewska H, Kotowska M, Mrukowicz JZ, Armanska M, Mikolajczyk W. Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants. J Pediatr 2001;138:361-5.
9. Mastretta E, Longo P, Laccisaglia A, Balbo L, Russo R, Mazzaccara A, Gianino P. Effect of Lactobacillus GG and breast-feeding in the prevention of rotavirus nosocomial infection. J Pediatr Gastroenterol Nutr 2002;35:527-31.
10. Saavedra JM, Bauman NA, Oung I, Perman JA, Yolken RH. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. Lancet 1994;344:1046-9.
11. Chouraqui JP, Van Egroo LD, Fichot MC. Acidified milk formula supplemented with bifidobacterium lactis: impact on infant diarrhea in residential care settings. J Pediatr Gastroenterol Nutr 2004;38:288-92.
12. Wanke M, Szajewska H. Lack of an effect of Lactobacillus reuteri DSM 17938 in preventing nosocomial diarrhea in children: a randomized, double-blind, placebo-controlled trial. J Pediatr 2012;161:40-3, e1.
13. Ruuska T, Vesikari T. Rotavirus disease in Finnish children: use of numerical scores for clinical severity of diarrhoeal episodes. Scand J Infect Dis 1990;22:259-67.
14. Floch MH, Walker WA, Madsen K, Sanders ME, Macfarlane GT, Flint HJ, Dieleman LA, Ringel Y, Guandalini S, Kelly CP, et al. Recommendations for probiotic use-2011 update. J Clin Gastroenterol 2011; 45(Suppl):S168-71.
15. Szajewska H, Wanke M, Patro B. Meta-analysis: the effects of Lactobacillus rhamnosus GG supplementation for the prevention of healthcare-associated diarrhoea in children. Aliment Pharmacol Ther 2011;34:1079-87.
16. Szajewska H, Guarino A, Hojsak I, Indrio F, Kolacek S, Shamir R, Vandenplas Y, Weizman Z. Use of probiotics for management of acute gastroenteritis: a position paper by the ESPGHAN Working Group for Probiotics and Prebiotics. J Pediatr Gastroenterol Nutr 2014;58:531-9.
17. Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, et al. Expert consensus document: the International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 2014;11:506-14.