Evolution on the biophysical fitness landscape of an RNA virus

Molecular Biology and Evolution

Volumn 35, Issue 10, 2018, Pages 2390-2400

  Rotem, Assaf ^a   Serohijos, Adrian W R ^b,c   Chang, Connie B ^a,d   Wolfe, Joshua T ^e   Fischer, Audrey E ^e   Mehoke, Thomas S ^e   Zhang, Huidan ^a,f   Tao, Ye ^a   Lloyd Ung, W ^a   Choi, Jeong Mo ^b   Rodrigues, João V ^b   Kolawole, Abimbola O ^g   Koehler, Stephan A ^a   Wu, Susan ^e   Thielen, Peter M ^e   Cui, Naiwen ^a   Demirev, Plamen A ^e   Giacobbi, Nicholas S ^h   Julian, Timothy R ^i,j   Schwab, Kellogg ⁱ   Lin, Jeffrey S ^e   Smith, Thomas J ^k   Pipas, James M ^h   Wobus, Christiane E ^g   Feldman, Andrew B ^l   Weitz, David A ^a   Shakhnovich, Eugene I ^b   more..

^a HARVARD UNIVERSITY   (United States)

^b HARVARD UNIVERSITY   (United States)

^c Universite de Montreal   (Canada)

^d Montana State University   (United States)

^e JOHNS HOPKINS UNIVERSITY APPLIED PHYSICS LABORATORY   (United States)

^f CHINA MEDICAL UNIVERSITY   (China)

^g UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^h UNIVERSITY OF PITTSBURGH   (United States)

ⁱ JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^j SWISS FEDERAL INSTITUTE OF AQUATIC SCIENCE AND TECHNOLOGY   (Switzerland)

^k University of Texas Medical Branch School of Medicine   (United States)

^l JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

Fitness landscape; Folding stability; Lab evolution; Microfluidics; Neutralizing antibody; Viral evolution

Indexed keywords

CAPSID PROTEIN; NEUTRALIZING ANTIBODY;

ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; DISSOCIATION CONSTANT; EPISTASIS; HAPLOTYPE; MICROFLUIDICS; MOLECULAR EVOLUTION; MURINE NOROVIRUS; NONHUMAN; NOROVIRUS; POPULATION DYNAMICS; POPULATION SIZE; PROTEIN FOLDING; RNA VIRUS; VIROGENESIS; VIRUS CAPSID; VIRUS GENOME; VIRUS INFECTION; ANIMAL; ANTIBODY AFFINITY; BIOLOGICAL MODEL; EVOLUTION; GENETIC SELECTION; GENETICS; MOUSE; PHYSIOLOGY; PROTEIN STABILITY; REPRODUCTIVE FITNESS;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODY AFFINITY; BIOLOGICAL EVOLUTION; CAPSID PROTEINS; EPISTASIS, GENETIC; GENETIC FITNESS; MICE; MODELS, GENETIC; NOROVIRUS; PROTEIN FOLDING; PROTEIN STABILITY; SELECTION, GENETIC;

EID: 85054956180     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msy131     Document Type: Article

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