Determination of steviol glycosides in commercial extracts of Stevia rebaudiana and sweeteners by ultra-high performance liquid chromatography Orbitrap mass spectrometry

Journal of Chromatography A

Volumn 1578, Issue , 2018, Pages 8-14

  Gardana, C ^a   Simonetti, P ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Food; High resolution mass spectrometry; Stevia rebaudiana extract; Steviol glycosides; Sweetener

Indexed keywords

AMIDES; EXTRACTION; FOOD ADDITIVES; FOOD PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZATION; MASS SPECTROMETRY; SUGAR SUBSTITUTES; SUGARS;

EUROPEAN REGULATION; HIGH RESOLUTION MASS SPECTROMETRY; ORBITRAP MASS SPECTROMETRIES; QUANTITATIVE DETERMINATIONS; STEVIA REBAUDIANA; STEVIOL GLYCOSIDES; SWEETENER; ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHIES;

GLYCOSIDES;

AMIDE; FORMIC ACID; GLYCOSIDE; ISOSTEVIOL; PLANT EXTRACT; STEVIA REBAUDIANA EXTRACT; STEVIOL GLYCOSIDE; SWEETENING AGENT; UNCLASSIFIED DRUG; FOOD ADDITIVE; GLUCOSIDE; KAURANE DERIVATIVE; STEVIOSIDE;

ARTICLE; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; CHROMATOGRAPHY; LIMIT OF DETECTION; MEASUREMENT PRECISION; NONHUMAN; PRIORITY JOURNAL; STEVIA REBAUDIANA; SWEETENED BEVERAGE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANALYSIS; BEVERAGE; CHEMISTRY; FOOD ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROCEDURES; STEVIA;

BEVERAGES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DITERPENES, KAURANE; FOOD ADDITIVES; FOOD ANALYSIS; GLUCOSIDES; GLYCOSIDES; MASS SPECTROMETRY; PLANT EXTRACTS; STEVIA; SWEETENING AGENTS;

EID: 85054100836     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2018.09.057     Document Type: Article

References (26)

1. Ferrazzano, G.F., Cantile, T., Alcidi, B., Coda, M., Ingenito, A., Zarrelli, A., Di Fabio, G., Pollio, A., Is Stevia rebaudiana Bertoni a non cariogenic sweetener? A review. Molecules, 21, 2015, E38.
2. Ruiz-Ruiz, J.C., Moguel-Ordoñez, Y.B., Segura-Campos, M.R., Biological activity of Stevia rebaudiana Bertoni and their relationship to health. Crit. Rev. Food Sci. Nutr. 57 (2017), 2680–2690.
3. Momtazi-Borojeni, A.A., Esmaeili, S.A., Abdollahi, E., Sahebkar, A., A review on the pharmacology and toxicology of steviol glycosides extracted from Stevia rebaudiana. Curr. Pharm. Des. 23 (2017), 1616–1622.
4. Ceunen, S., Geuns, J.M.C., Steviol glycosides: chemical diversity, metabolism, and function. J. Nat. Prod. 76 (2013), 1201–1228.
5. Gerwig, G.J., te Poele, E.M., Dijkhuizen, L., Kamerling, J.P., Chapter one - Stevia glycosides: chemical and enzymatic modifications of their carbohydrate moieties to improve the sweet-tasting quality. Adv. Carbohydr. Chem. Biochem. 73 (2016), 1–72.
6. Adari, B.R., Alavala, S., George, S.A., Meshram, H.M., Tiwari, A.K., Sarma, A.V.S., Synthesis of rebaudioside A by enzymatic transglycosylation of stevioside present in the leaves of Stevia rebaudiana Bertoni. Food Chem. 200 (2016), 154–158.
7. Prakash, I., Bunders, C., Devkota, K.P., Charan, R.D., Ramirez, C., Snyder, T.M., Priedemann, C., Markosyan, A., Jarrin, C., Halle, R.T., Bioconversion of rebaudioside I from rebaudioside A. Molecules 19 (2014), 17345–17355.
8. Commission Regulation (EU) 2016/1814. Of 13 October 2016 amending the Annex to Regulation (EU) No 231/2012 laying down specifications for food additives listed in Annexes II and III to Regulation (EC) No 1333/2008 of the European Parliament and of the Council as regards specifications for steviol glycosides (E 960). Off. J. Eur. Union L278/37–L278/41. http://data.europa.eu/eli/reg/2016/1814/oj.
9. Wald, J.P., Morlock, G.E., Quantification of steviol glycosides in food products, Stevia leaves and formulations by planar chromatography, including proof of absence for steviol and isosteviol. J. Chromatogr. A 1506 (2017), 109–119.
10. Udompaisarn, S., Arthan, D., Somana, J., Development and validation of an enzymatic method to determine stevioside content from Stevia rebaudiana. J. Agric. Food Chem. 65 (2017), 3223–3229.
11. Pavlíček, V., Tůma, P., The use of capillary electrophoresis with contactless conductivity detection for sensitive determination of stevioside and rebaudioside A in foods and beverages. Food Chem. 219 (2017), 193–198.
12. Hearn, L.K., Subedi, P.P., Determining levels of steviol glycosides in the leaves of Stevia rebaudiana by near infrared reflectance spectroscopy. J. Food Composit. Anal. 22 (2009), 165–168.
13. Aranda-González, I., Moguel-Ordoñez, Y., Betancur-Ancona, D., Validation of HPLC-UV method for determination of minor glycosides contained in Stevia rebaudiana Bertoni leaves. Biomed. Chromatogr. 29 (2015), 733–738.
14. Woelwer-Rieck, U., Lankes, C., Wawrzun, A., Wüst, M., Improved HPLC method for the evaluation of the major steviol glycosides in leaves of Stevia rebaudiana. Eur. Food Res. Technol. 231 (2010), 581–588.
15. Wang, Y.H., Avula, B., Tang, W., Wang, M., Elsohly, M.A., Khan, I.A., Ultra-HPLC method for quality and adulterant assessment of steviol glycosides sweeteners – stevia rebaudiana and stevia products. Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess. 32 (2015), 674–685.
16. Minne, V.J.Y., Compernolle, F., Toppet, S., Geuns, J.M.C., Steviol quantification at the picomole level by high-performance liquid chromatography. J. Agric. Food Chem. 52 (2004), 2445–2449.
17. Jackson, A.U., Tata, A., Wu, C., Perry, R.H., Haas, G., West, L., Cooks, R.G., Direct analysis of Stevia leaves for diterpene glycosides by desorption electrospray ionization mass spectrometry. Analyst 134 (2009), 867–874.
18. Gardana, C., Scaglianti, M., Simonetti, P., Evaluation of steviol and its glycosides in Stevia rebaudiana leaves and commercial sweetener by ultra-high-performance liquid chromatography-mass spectrometry. J. Chromatogr. A 1217 (2010), 1463–1470.
19. Soufi, S., D'Urso, G., Pizza, C., Rezgui, S., Bettaieb, T., Montoro, P., Steviol glycosides targeted analysis in leaves of Stevia rebaudiana (Bertoni) from plants cultivated under chilling stress conditions. Food Chem. 190 (2016), 572–580.
20. Kubica, P., Namieśnik, J., Wasik, A., Determination of eight artificial sweeteners and common Stevia rebaudiana glycosides in non-alcoholic and alcoholic beverages by reversed-phase liquid chromatography coupled with tandem mass spectrometry. Anal. Bioanal. Chem. 407 (2015), 1505–1512.
21. Di Donna, L., Mazzotti, F., Santoro, I., Sindona, G., Tandem mass spectrometry: a convenient approach in the dosage of steviol glycosides in stevia sweetened commercial food beverages. J. Mass Spectrom. 52 (2017), 290–295.
22. Molina-Calle, M., Priego-Capote, F., Luque de Castro, M.D., Characterization of stevia leaves by LC–QTOF MS/MS analysis of polar and non-polar extracts. Food Chem. 219 (2017), 329–338.
23. Perera, W.H., Ghiviriga, I., Rodenburg, D.L., Carvalho, R., Alves, K., McChesney, J.D., Development of a high-performance liquid chromatography procedure to identify known and detect novel C-13 oligosaccharide moieties in diterpene glycosides from Stevia rebaudiana (Bertoni) Bertoni (Asteraceae): structure elucidation of rebaudiosides V and W. J. Sep. Sci. 40 (2017), 3771–3781.
24. Espinoza, M.I., Vincken, J.P., Sanders, M., Castro, C., Stieger, M., Agosin, E., Identification, quantification, and sensory characterization of steviol glycosides from differently processed Stevia rebaudiana commercial extracts. J. Agric. Food Chem. 62 (2014), 11797–11804.
25. Ohta, M., Sasa, S., Inoue, A., Tamai, T., Fujita, I., Motita, K., Matsuura, F., Characterization of novel Steviol glycosides from leaves of Stevia rebaudiana Morita. J. Appl. Glycosci. 57 (2010), 199–209.
26. Ye, F., Yang, R., Hua, X., Shen, Q., Zhao, W., Zhang, W., Modification of stevioside using transglucosylation activity of Bacillus amyloliquefaciens α-amylase to reduce its bitter aftertaste. LWT - Food Sci. Technol. 51 (2013), 524–530.