Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury

Molecular Medicine Reports

Volumn 18, Issue 5, 2018, Pages 4399-4409

  Li, Dandan ^a   Ren, Weiying ^a   Jiang, Zhilong ^a   Zhu, Lei ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Acute lung injury; Acute respiratory distress syndrome; Alveolar macrophages; Leucine rich containing family; Nucleotide binding domain; P38 mitogen activated protein kinase signaling pathway; Pyrin domain containing 3 inflammasome; Pyroptosis

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BETA ACTIN; CASPASE 3; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MITOGEN ACTIVATED PROTEIN KINASE P38; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; CASPASE; IL1B PROTEIN, MOUSE; IMIDAZOLE DERIVATIVE; NLRP3 PROTEIN, MOUSE; PYRIDINE DERIVATIVE;

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MALE; MAPK SIGNALING; MOUSE; NONHUMAN; PNEUMONIA; PROTEIN EXPRESSION; PYROPTOSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; DRUG EFFECT; GENETICS; HUMAN; INFLAMMATION; LUNG; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

ACUTE LUNG INJURY; ANIMALS; CASPASES; DISEASE MODELS, ANIMAL; HUMANS; IMIDAZOLES; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-18; INTERLEUKIN-1BETA; LUNG; MACROPHAGES; MICE; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; PYROPTOSIS; RESPIRATORY DISTRESS SYNDROME, ADULT; SIGNAL TRANSDUCTION;

EID: 85053834590     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2018.9427     Document Type: Article

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