NLRP3 gene knockout blocks NF-κB and MAPK signaling pathway in CUMS-induced depression mouse model

Behavioural Brain Research

Volumn 322, Issue , 2017, Pages 1-8

  Su, Wen Jun ^a   Zhang, Yi ^a   Chen, Ying ^b   Gong, Hong ^a   Lian, Yong Jie ^a   Peng, Wei ^a   Liu, Yun Zi ^a   Wang, Yun Xia ^a   You, Zi Li ^c   Feng, Shi Jie ^a   Zong, Ying ^a   Lu, Guo Cai ^a   Jiang, Chun Lei ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b The 81st Hospital of PLA   (China)

^c UNIVERSITY OF ELECTRONIC SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

Depression; Inflammation; Interleukin 1 ; Knockout; NLRP3 inflammasome; Stress

Indexed keywords

CRYOPYRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; IL1B PROTEIN, MOUSE; NLRP3 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPRESSION; ENZYME ACTIVATION; GENE INACTIVATION; HIPPOCAMPUS; IMMOBILIZATION; INFLAMMATION; MALE; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STRESS; SUCROSE PREFERENCE TEST; WEIGHT GAIN; ANIMAL; BLOOD; BODY WEIGHT; C57BL MOUSE; CHRONIC DISEASE; DEFICIENCY; DISEASE MODEL; FEEDING BEHAVIOR; GENETICS; IMMUNOLOGY; MAPK SIGNALING; MENTAL STRESS; METABOLISM; MOTOR ACTIVITY; PATHOLOGY; PHYSIOLOGY; SUGAR INTAKE; UNCERTAINTY;

ANIMALS; BODY WEIGHT; CHRONIC DISEASE; DEPRESSIVE DISORDER; DIETARY SUCROSE; DISEASE MODELS, ANIMAL; FEEDING BEHAVIOR; HIPPOCAMPUS; INFLAMMASOMES; INTERLEUKIN-1BETA; MALE; MAP KINASE SIGNALING SYSTEM; MICE, INBRED C57BL; MOTOR ACTIVITY; NF-KAPPA B; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; STRESS, PSYCHOLOGICAL; UNCERTAINTY;

EID: 85009518279     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2017.01.018     Document Type: Article

References (47)

1. [1] Sawamura, J., Morishita, S., Ishigooka, J., Symmetrical treatment of diagnostic and statistical manual of mental disorders, fifth edition, for major depressive disorders. Source Code Biol. Med., 11, 2016, 1.
2. [2] Murray, C.J., Vos, T., Lozano, R., Naghavi, M., Flaxman, A.D., Michaud, C., et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380 (2012), 2197–2223.
3. [3] Organization, W.H., The Global Burden of Disease 2004 Update. 2008, World Health Organization, Geneva.
4. [4] Gu, L., Xie, J., Long, J., Chen, Q., Chen, Q., Pan, R., et al. Epidemiology of major depressive disorder in mainland china: a systematic review. PLoS One, 8, 2013, e65356.
5. [5] Kessler, R.C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K.R., et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 289 (2003), 3095–3105.
6. [6] Maes, M., Evidence for an immune response in major depression: a review and hypothesis. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 19 (1995), 11–38.
7. [7] Blume, J., Douglas, S.D., Evans, D.L., Immune suppression and immune activation in depression. Brain Behav. Immun. 25 (2011), 221–229.
8. [8] Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E.K., et al. A meta-analysis of cytokines in major depression. Biol. Psychiatry 67 (2010), 446–457.
9. [9] Adler, U.C., Marques, A.H., Calil, H.M., Inflammatory aspects of depression. Inflamm. Allergy Drug Targets 7 (2008), 19–23.
10. [10] Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., et al. Cytokine-associated emotional and cognitive disturbances in humans. Arch. Gen. Psychiatry 58 (2001), 445–452.
11. [11] Goshen, I., Kreisel, T., Ben-Menachem-Zidon, O., Licht, T., Weidenfeld, J., Ben-Hur, T., et al. Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol. Psychiatry 13 (2008), 717–728.
12. [12] Schroder, K., Tschopp, J., The inflammasomes. Cell 140 (2010), 821–832.
13. [13] Cassel, S.L., Joly, S., Sutterwala, F.S., The NLRP3 inflammasome: a sensor of immune danger signals. Semin. Immunol. 21 (2009), 194–198.
14. [14] Lamkanfi, M., Kanneganti, T.D., Nlrp3: an immune sensor of cellular stress and infection. Int. J. Biochem. Cell Biol. 42 (2010), 792–795.
15. [15] Iwata, M., Ota, K.T., Duman, R.S., The inflammasome: pathways linking psychological stress, depression, and systemic illnesses. Brain Behav. Immun. 31 (2013), 105–114.
16. [16] Zhang, Y., Liu, L., Liu, Y.Z., Shen, X.L., Wu, T.Y., Zhang, T., et al. NLRP3 inflammasome mediates chronic mild stress-induced depression in mice via neuroinflammation. Int. J. Neuropsychopharmacol., 18, 2015.
17. [17] Zhang, Y., Liu, L., Peng, Y.L., Liu, Y.Z., Wu, T.Y., Shen, X.L., et al. Involvement of inflammasome activation in lipopolysaccharide-induced mice depressive-like behaviors. CNS Neurosci. Ther. 20 (2014), 119–124.
18. [18] Alcocer-Gomez, E., Ulecia-Moron, C., Marin-Aguilar, F., Rybkina, T., Casas-Barquero, N., Ruiz-Cabello, J., et al. Stress-induced depressive behaviors require a functional NLRP3 inflammasome. Mol. Neurobiol. 53 (2016), 4874–4882.
19. [19] Iwata, M., Ota, K.T., Li, X.Y., Sakaue, F., Li, N., Dutheil, S., et al. Psychological stress activates the inflammasome via release of adenosine triphosphate and stimulation of the purinergic type 2 × 7 receptor. Biol. Psychiatry 80 (2016), 12–22.
20. [20] Zhang, Y., Su, W.J., Chen, Y., Wu, T.Y., Gong, H., Shen, X.L., et al. Effects of hydrogen-rich water on depressive-like behavior in mice. Sci. Rep., 6, 2016, 23742.
21. [21] Bakunina, N., Pariante, C.M., Zunszain, P.A., Immune mechanisms linked to depression via oxidative stress and neuroprogression. Immunology, 2015.
22. [22] Ji, H.F., Zhuang, Q.S., Shen, L., Genetic overlap between type 2 diabetes and major depressive disorder identified by bioinformatics analysis. Oncotarget 7 (2016), 17410–17414.
23. [23] Monaco, C., Andreakos, E., Kiriakidis, S., Mauri, C., Bicknell, C., Foxwell, B., et al. Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis. Proc. Natl. Acad. Sci. U. S. A. 101 (2004), 5634–5639.
24. [24] Song, X.Q., Lv, L.X., Li, W.Q., Hao, Y.H., Zhao, J.P., The interaction of nuclear factor-kappa B and cytokines is associated with schizophrenia. Biol. Psychiatry 65 (2009), 481–488.
25. [25] Cai, Z., Zhang, X., Wang, G., Wang, H., Liu, Z., Guo, X., et al. BDNF attenuates IL-1beta-induced F-actin remodeling by inhibiting NF-kappaB signaling in hippocampal neurons. Neuro Endocrinol. Lett. 35 (2014), 13–19.
26. [26] Lukic, I., Mitic, M., Djordjevic, J., Tatalovic, N., Bozovic, N., Soldatovic, I., et al. Lymphocyte levels of redox-sensitive transcription factors and antioxidative enzymes as indicators of pro-oxidative state in depressive patients. Neuropsychobiology 70 (2014), 1–9.
27. [27] Malki, K., Pain, O., Tosto, M.G., Du Rietz, E., Carboni, L., Schalkwyk, L.C., Identification of genes and gene pathways associated with major depressive disorder by integrative brain analysis of rat and human prefrontal cortex transcriptomes. Transl. Psychiatry, 5, 2015, e519.
28. [28] Zhang, Z.T., Du, X.M., Ma, X.J., Zong, Y., Chen, J.K., Yu, C.L., et al. Activation of the NLRP3 inflammasome in lipopolysaccharide-induced mouse fatigue and its relevance to chronic fatigue syndrome. J. Neuroinflamm., 13, 2016, 71.
29. [29] Feng, S.J., Zong, Y., Zhang, Z.T., Du, X.M., Yuan, B.J., Lu, G.C., Breeding and genotype identification of NLRP3 gene knock-out mice. Acad. J. Second Mil. Med. Univ. 35 (2014), 555–559 (in Chinese).
30. [30] Peng, Y.L., Liu, Y.N., Liu, L., Wang, X., Jiang, C.L., Wang, Y.X., Inducible nitric oxide synthase is involved in the modulation of depressive behaviors induced by unpredictable chronic mild stress. J. Neuroinflamm., 9, 2012, 75.
31. [31] Lu, M., Yang, J.Z., Geng, F., Ding, J.H., Hu, G., Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis. Int. J. Neuropsychopharmacol. 17 (2014), 1501–1510.
32. [32] Smith, S.M., Vale, W.W., The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues Clin. Neurosci. 8 (2006), 383–395.
33. [33] Goshen, I., Yirmiya, R., Interleukin-1 (IL-1): a central regulator of stress responses. Front. Neuroendocrinol. 30 (2009), 30–45.
34. [34] Koo, J.W., Duman, R.S., IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc. Natl. Acad. Sci. U. S. A. 105 (2008), 751–756.
35. [35] Kheirbek, M.A., Klemenhagen, K.C., Sahay, A., Hen, R., Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders. Nat. Neurosci. 15 (2012), 1613–1620.
36. [36] Bauernfeind, F.G., Horvath, G., Stutz, A., Alnemri, E.S., MacDonald, K., Speert, D., et al. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 183 (2009), 787–791.
37. [37] Juliana, C., Fernandes-Alnemri, T., Wu, J., Datta, P., Solorzano, L., Yu, J.W., et al. Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J. Biol. Chem. 285 (2010), 9792–9802.
38. [38] Baeuerle, P.A., Henkel, T., Function and activation of NF-kappa B in the immune system. Annu. Rev. Immunol. 12 (1994), 141–179.
39. [39] Baeuerle, P.A., Baltimore, D., NF-kappa B: ten years after. Cell 87 (1996), 13–20.
40. [40] Johnson, G.L., Lapadat, R., Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298 (2002), 1911–19912.
41. [41] Taylor, D.M., Moser, R., Regulier, E., Breuillaud, L., Dixon, M., Beesen, A.A., et al. MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in huntington's disease via additive effects of JNK and p38 inhibition. J. Neurosci. 33 (2013), 2313–2325.
42. [42] Jeffrey, K.L., Camps, M., Rommel, C., Mackay, C.R., Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses. Nat. Rev. Drug Discov. 6 (2007), 391–403.
43. [43] Duric, V., Banasr, M., Licznerski, P., Schmidt, H.D., Stockmeier, C.A., Simen, A.A., et al. A negative regulator of MAP kinase causes depressive behavior. Nat. Med., 16, 2010 1328–U36.
44. [44] Hui, L.Y., Wang, Y.W., Zhou, F.L., Ma, X.C., Yan, R.Z., Zhang, L., et al. Association between MKP-1, BDNF, and gonadal hormones with depression on perimenopausal women. J. Womens Health 25 (2016), 71–77.
45. [45] Gustin, A., Kirchmeyer, M., Koncina, E., Felten, P., Losciuto, S., Heurtaux, T., et al. NLRP3 inflammasome is expressed and functional in mouse brain microglia but not in astrocytes. PLoS One, 10, 2015, e0130624.
46. [46] Kreisel, T., Frank, M.G., Licht, T., Reshef, R., Ben-Menachem-Zidon, O., Baratta, M.V., et al. Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis. Mol. Psychiatry 19 (2014), 699–709.
47. [47] Johann, S., Heitzer, M., Kanagaratnam, M., Goswami, A., Rizo, T., Weis, J., et al. NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients. Glia 63 (2015), 2260–2273.