Administration of SB239063, a potent p38 MAPK inhibitor, alleviates acute lung injury induced by intestinal ischemia reperfusion in rats associated with AQP4 downregulation

International Immunopharmacology

Volumn 38, Issue , 2016, Pages 54-60

  Xiong, Liu Lin ^a,c   Tan, Yan ^a   Ma, Hong Yu ^a   Dai, Ping ^b   Qin, Yan Xia ^d   Yang, Rui Ai ^a   Xu, Yan Yan ^a   Deng, Zheng ^a   Zhao, Wei ^a   Xia, Qin Jie ^c   Wang, Ting Hua ^b,c   Zhang, Yun Hui ^a  

^a First People's Hospital of Yunnan Province   (China)

^b KUNMING MEDICAL UNIVERSITY   (China)

^c SICHUAN UNIVERSITY   (China)

^d SICHUAN UNIVERSITY   (China)

Author keywords

Acute lung injury; AQP4; Intestinal ischemia reperfusion; p38 MAPK; Rat

Indexed keywords

4 [4 (4 FLUOROPHENYL) 5 (2 METHOXY 4 PYRIMIDINYL) 1 IMIDAZOLYL]CYCLOHEXANOL; AQUAPORIN 4; BETA ACTIN; MITOGEN ACTIVATED PROTEIN KINASE P38; AQP4 PROTEIN, RAT; IMIDAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ACUTE LUNG INJURY; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELIAC ARTERY; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; ENZYME INHIBITION; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INJURY SEVERITY; INTESTINE ISCHEMIA; LUNG ALVEOLUS; LUNG EDEMA; LUNG WEIGHT; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REPERFUSION INJURY; SUPERIOR MESENTERIC ARTERY; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; COMPLICATION; DISEASE MODEL; DRUG EFFECT; GENETICS; HUMAN; INTESTINE; LUNG; MESENTERIC ARTERY; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; SPRAGUE DAWLEY RAT; SURGERY;

ACUTE LUNG INJURY; ANIMALS; AQUAPORIN 4; DISEASE MODELS, ANIMAL; HUMANS; IMIDAZOLES; INTESTINES; LUNG; MALE; MESENTERIC ARTERIES; MOLECULAR TARGETED THERAPY; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 85000384399     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2016.03.036     Document Type: Article

References (55)

1. U. Haglund, and D. Bergqvist Intestinal ischemia - the basics Langenbeck's Arch. Surg. 384 3 1999 233 238
2. I.H. Mallick, W. Yang, M.C. Winslet, and A.M. Seifalian Ischemia-reperfusion injury of the intestine and protective strategies against injury Dig. Dis. Sci. 49 9 2004 1359 1377
3. H.T. Hassoun, B.C. Kone, D.W. Mercer, F.G. Moody, N.W. Weisbrodt, and F.A. Moore Post-injury multiple norgan failure: the role of the gut Shock 15 2001 1 10
4. S. Higuchi, R. Wu, M. Zhou, C.P. Marini, T.S. Ravikumar, and P. Wang Gut hyperpermiability after ischemia and reperfusion: attenuation with adrenomedullin and its binding protein treatment Int. J. Clin. Exp. Pathol. 1 2008 409 418
5. L. Zhou, S.L. Wang, B. Wei, R.A. Yang, Y.Y. Yu, and C.Z. Luo Temporal and spatial changes of lung injury induced by intestine ischemia Idiscovery. 1 1 2014 1 8
6. L. Zhou, Z. Deng, J. Tian, W. Zhao, and B. Liu Differential expression of growth factor in injured lung following brain ischemia from neonatal rats Imedicine. 1 1 2014 1 6
7. L. Jiang, Y. Tan, J. Tian, H.Y. Ma, JT, and C.Z. Luo Morphological character of lung injury and its functional implication in adult rats subjected to brain ischemia Ibrain. 1 1 2015 1 8
8. G.J. Bellingan The pulmonary physician in critical care∗6: the pathogenesis of ALI/ARDS Thorax 57 2002 540 546
9. D.G. Souza, A.T. Vieira, A.C. Soares, V. Pinho, J.R. Nicoli, L.Q. Vieira, and M.M. Teixeira The essential role of the intestinal microbiota in facilitating acute inflammatory responses J. Immunol. 173 2004 4137 4146
10. F. Tamion, V. Richard, S. Lyoumi, M. Daveau, G. Bonmarchand, J. Leroy, C. Thuillez, and J.P. Lebreton Gut ischemia and mesenteric synthesis of inflammatory cytokines after hemorrhagic or endotoxic shock Am. J. Phys. 273 1997 G314 G321
11. Rachel L. Zemans, and Michael A. Matthay Bench-to-bedside review: the role of the alveolar epithelium in the resolution of pulmonary edema in acute lung injury Critical Care 8 2004 469 477
12. J. Grommes, and O. Soehnlein Contribution of neutrophils to acute lung injury Mol. Med. 17 2011 293 307
13. T. Zarubin, and J. Han Activation and signaling of the p38 MAP kinase pathway Cell Res. 15 1 2005 11 18
14. Y.H. Pei, X.M. Cai, J. Chen, B.D. Sun, Z.R. Sun, X. Wang, and X.M. Qian The role of p38 MAPK in acute paraquat-induced lung injury in rats Inhal. Toxicol. 26 14 2014 880 884
15. S. Zhang, M. Rahman, S. Zhang, Y. Wang, H. Herwald, B. Jeppsson, and H. Thorlacius p38 mitogen-activated protein kinase signaling regulates streptococcal M1 protein-induced neutrophil activation and lung injury J. Leukoc. Biol. 91 1 2012 137 145
16. Y.M. Fan, X.L. Huang, Z.F. Dong, and Y.L. Ling Hydrogen sulfide reduces lipopolysaccharide-induced acute lung injury and inhibits expression of phosphorylated p38 MAPK in rats Sheng Li Xue Bao 64 6 2012 666 672
17. D. Yu, M. Li, Y. Tian, J. Liu, and J. Shang Luteolin inhibits ROS-activated MAPK pathway in myocardial ischemia/reperfusion injury Life Sci. 122 2015 15 25
18. M. Jiang, J. Li, Q. Peng, Y. Liu, W. Liu, C. Luo, J. Peng, J. Li, K.K. Yung, and Z. Mo Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation J. Neuroinflammation 11 2014 167
19. K.L. Walton, L. Holt, and R.B. Sartor Lipopolysaccharide activates innate immune responses in murine intestinal myofibroblasts through multiple signaling pathways Am. J. Physiol. Gastrointest. Liver Physiol. 296 2009 G601 G611
20. J. Cheriyan, A.J. Webb, L. Sarov-Blat, M. Elkhawad, S.M. Wallace, K.M. Mäki-Petäjä, D.J. Collier, J. Morgan, Z. Fang, R.N. Willette, J.J. Lepore, J.R. Cockcroft, D.L. Sprecher, and I.B. Wilkinson Inhibition of p38 mitogen-activated protein kinase improves nitric oxide-mediated vasodilatation and reduces inflammation in hypercholesterolemia Circulation 123 2011 515 523
21. N. Damjanov, R.S. Kauffman, and G.T. Spencer-Green Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: Results of two randomized, double-blind, placebo-controlled clinical studies Arthritis Rheum. 60 2009 1232 1241
22. S. Medicherla, J.Y. Ma, M. Reddy, I. Esikova, I. Kerr, F. Movius, L.S. Higgins, and A.A. Protter Topical alpha-selective p38 MAP kinase inhibition reduces acute skin inflammation in guinea pig J. Inflamm. Res. 3 2010 9 16
23. D.Y. Zheng, M. Zhou, J. Jin, M. He, Y. Wang, J. Du, X.Y. Xiao, P.Y. Li, A.Z. Ye, J. Liu, and T.H. Wang Inhibition of P38 MAPK Downregulates the Expression of IL-1β to Protect Lung from Acute Injury in Intestinal Ischemia Reperfusion Rats Mediat. Inflamm. 2016 9348037 8 pages. [Epub ahead of print]
24. L.L. Xiong, Y.X. Zuo, C.Z. Luo, J. Yu, Q.J. Xia, F.F. Xu, J. Liu, and T.H. Wang p38 MAPK inhibitor administration provides protection against acute lung injury in rats with intestinal ischemia reperfusion via downregulating interlukin-6 expression Journal of Anesthesia and Perioperative Medicine 3 1 2016 (Epub ahead of print)
25. D. Wei, Z.H. Huang, R.H. Zhang, C.L. Wang, M.J. Xu, B.J. Liu, G.H. Wang, and T. Xu Roles of p38 MAPK in the regulation of the inflammatory response to swine influenza virus-induced acute lung injury in mice Acta Virol. 58 4 2014 374 379
26. D.K. He, Y.R. Shao, L. Zhang, J. Shen, Z.Y. Zhong, J. Wang, and G. Xu Adenovirus-delivered angiopoietin-1 suppresses NF-κB and p38 MAPK and attenuates inflammatory responses in phosgene-induced acute lung injury Inhal. Toxicol. 26 2014 185 192
27. R. Di Paola, C. Crisafulli, E. Mazzon, T. Genovese, I. Paterniti, P. Bramanti, and S. Cuzzocrea Effect of PD98059, a selective MAPK3/MAPK1 inhibitor, on acute lung injury in mice Int. J. Immunopathol. Pharmacol. 22 2009 937 950
28. Alan S. Verkman, Marc O. Anderson, and Marios C. Papadopoulos Aquaporins: important but elusive drug targets Nat. Rev. Drug. Discov. 13 4 2014 259 277 -26
29. C.V. Verschuur, A.J. Kooi, and D. Troost Anti-aquaporin 4 related paraneoplastic neuromyelitis optica in the presence of adenocarcinoma of the lung Clin. Neuropathol. 34 2015 232 236
30. A.S. Verkman Aquaporins in clinical medicine Annu. Rev. Med. 63 2012 303 316
31. L.S. King, S. Nielsen, and P. Agre Aquaporin-1 water channel protein in lung: ontogeny, steroidinduced expression, and distribution in rat J. Clin. Invest. 97 1996 2183 2191
32. J. She, B. J, L. Tong, Y.L. Song, and C.X. Bai New insights of aquaporin 5 in the pathogenesis of high altitude pulmonary edema Diagn. Pathol. 8 2013 193
33. G. Fabregat, J. García-de-la-Asunción, B. Sarriá, J. Cortijo, J. De Andrés, M. Mata, E. Pastor, and F.J. Belda Increased expression of AQP 1 and AQP 5 in rat lungs Ventilated with low tidal volume is time dependent PLoS ONE 9 2014 e114247
34. O. Bloch, and G.T. Manley The role of aquaporin-4 in cerebral water transport and edema," Neurosurgical Focus Neurosurg. Focus. 22 2007 E3
35. L.S. King, and P. Agre Pathophysiology of the aquaporin water channels Annu. Rev. Physiol. 58 1996 619 648
36. Y. Zhou, H.Q. Li, L. Lu, D.L. Fu, A.J. Liu, J.H. Li, and G.Q. Zheng Ginsenoside Rg1 provides neuroprotection against blood brain barrier disruption and neurological injury in a rat model of cerebral ischemia/reperfusion through downregulation of aquaporin 4 expression Phytomedicine 21 7 2014 998 1003
37. P. Bhattacharya, A.K. Pandey, S. Paul, and R. Patnaik Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia Life Sci. 100 2 2014 97 109
38. P. Bhattacharya, A.K. Pandey, S. Paul, R. Patnaik, and D.R. Yavagal Aquaporin-4 inhibition mediates piroxicam-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rodents PLoS ONE 8 9 2013 e73481
39. X.D. Li, Y.J. Yang, Y.T. Cheng, K.F. Dou, Y. Tian, and X.M. Meng Protein kinase A-mediated cardioprotection of Tongxinluo relates to the inhibition of myocardial inflammation, apoptosis, and edema in reperfused swine hearts Chin. Med. J. 126 8 2013 1469 1479
40. J. Vella, C. Zammit, G. Di Giovanni, R. Muscat, and M. Valentino The central role of aquaporins in the pathophysiology of ischemic stroke Front. Cell. Neurosci. 9 2015 108
41. F. Liang, C. Luo, G. Xu, F. Su, X. He, S. Long, H. Ren, Y. Liu, Y. Feng, and Z. Pei Deletion of aquaporin-4 is neuroprotective during the acute stage of micro traumatic brain injury in mice Neurosci. Lett. 598 2015 29 35
42. S. Mondello, M. Galuppo, E. Mazzon, I. Domeico, P. Mondello, A. Carmela, and S. Cuzocea Glutamine treatment attenuates the development of ischaemia/reperfusion injury of the gut Eur. J. Pharmacol. 643 2010 304 315
43. C. Crisafulli, E. Mazzon, M. Galuppo, R. Caminiti, and S. Cuzzocrea Olprinone attenuates the development of ischemia/reperfusion injury of the gut Intensive Care Med. 36 2010 1235 1247
44. K. Kim, Y. Li, G. Jin, W. Chong, B. Liu, J. Lu, K. Lee, M. deMoya, Velmahos G.C., and Alam H.B. Effect of valproic acid on acute lung injury in a rodent model of intestinal ischemia reperfusion Resuscitation 83 2012 243 248
45. W. Chen, V. Jadhav, J. Tang, and J.H. Zhang HIF-1alpha inhibition ameliorates neonatal brain injury in a rat pup hypoxicischemic model Neurobiology 31 2008 433 441
46. H. Sayan, V.H. Ozacmak, F. Sen, M. Cabuk, D.Y. Atik, A.A. Igdem, and I.D. Ozacmak Pharmacological preconditioning with erythropoietin reduces ischemia-reperfusion injury in the small intestine of rats Life Science. 84 2009 364 371
47. I. Sukhotnik, N. Slijper, Y. Pollak, E. Chemodanov, R. Shaoul, A.G. Coran, and d J.G. Mogilner Parenteral omega-3 fatty acids (Omegaven) modulate intestinal recovery after intestinal ischemia- reperfusion in a rat model Journal Of Pediatric Surgery 46 2011 1353 1360
48. J. Grommes, and O. Soehnlein Contribution of neutrophils to acute lung injury Mol. Med. 17 2011 293 307
49. M. Gao, L. Chen, H. Yu, Q. Sun, J. Kou, and B. Yu Diosgenin down-regulates NF-κB p65/p50 and p38MAPK pathways and attenuates acute lung injury induced by lipopolysaccharide in mice Int. Immunopharmacol. 15 2013 240 245
50. C. Liang, X. Liu, L. Liu, and D. He Effect of hydrogen inhalation on p38 MAPK activation in rats with lipopolysaccharide- induced acute lung injury Nan Fang Yi Ke Da Xue Xue Bao. 32 2012 1211 1213
51. Chikako Nito, Hiroshi Kamada, Hidenori Endo, Purnima Narasimhan, Yong-Sun Lee, and Pak H. Chan Involvement of mitogen-activated protein kinase pathways in expression of the water channel protein aquaporin-4 after ischemia in rat cortical astrocytes Journal of Neurotrauma 29 2012 2404 2412
52. L. Yu, J. Yi, G. Ye, Y. Zheng, Z. Song, Y. Yang, Y. Song, Z. Wang, and Q. Bao Effects of curcumin on levels of nitric oxide synthase and AQP-4 in a rat model of hypoxia-ischemic brain damage Brain Res. 1475 2012 88 95
53. H. Wang, X. Wang, and Q. Guo The correlation between DTI parameters and levels of AQP-4 in the early phases of cerebral edema after hypoxic-ischemic/reperfusion injury in piglets Pediatr. Radiol. 42 2012 992 999
54. X. Fu, Q. Li, Z. Feng, and D. Mu The roles of aquaporin-4 in brain edema following neonatal hypoxia ischemia and reoxygenation in a cultured rat astrocyte model Glia 55 2007 935 941
55. O. Brissaud, F. Villega, J. Pieter Konsman, S. Sanchez, G. Raffard, J.M. Franconi, J.F. Chateil, and A.K. Bouzier-Sore Short-term effect of erythropoietin on brain lesions and aquaporin-4 expression in a hypoxic-ischemic neonatal rat model assessed by magnetic resonance diffusion weighted imaging and immunohistochemistry Pediatr. Res. 68 2010 123 127