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Volumn 49, Issue 8, 2018, Pages 522-529

Apolipoprotein E in Cardiovascular Diseases: Novel Aspects of an Old-fashioned Enigma

Author keywords

ApoE polymorphism; Cardiovascular diseases; Cell membrane; Lipids

Indexed keywords

APOLIPOPROTEIN E; CARRIER PROTEIN; ISOPROTEIN; LIPID;

EID: 85053072421     PISSN: 01884409     EISSN: 18735487     Source Type: Journal    
DOI: 10.1016/j.arcmed.2018.08.008     Document Type: Review
Times cited : (19)

References (97)
  • 1
    • 0024299370 scopus 로고
    • Apolipoprotein E: cholesterol transport protein with expanding role in cell biology
    • Mahley, R.W., Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240 (1988), 622–630.
    • (1988) Science , vol.240 , pp. 622-630
    • Mahley, R.W.1
  • 2
    • 0020419894 scopus 로고
    • Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes
    • Zannis, V.I., Breslow, J.L., Utermann, G., et al. Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes. J Lipid Res 23 (1982), 911–914.
    • (1982) J Lipid Res , vol.23 , pp. 911-914
    • Zannis, V.I.1    Breslow, J.L.2    Utermann, G.3
  • 3
    • 0024529337 scopus 로고
    • Changes of genetic apolipoprotein phenotypes caused by liver transplantation. Implications for apolipoprotein synthesis
    • Kraft, H.G., Menzel, H.J., Hoppichler, F., et al. Changes of genetic apolipoprotein phenotypes caused by liver transplantation. Implications for apolipoprotein synthesis. J Clin Invest 83 (1989), 137–142.
    • (1989) J Clin Invest , vol.83 , pp. 137-142
    • Kraft, H.G.1    Menzel, H.J.2    Hoppichler, F.3
  • 4
    • 0021681194 scopus 로고
    • Extrahepatic synthesis of apolipoprotein E
    • Driscoll, D.M., Getz, G.S., Extrahepatic synthesis of apolipoprotein E. J Lipid Res 25 (1984), 1368–1379.
    • (1984) J Lipid Res , vol.25 , pp. 1368-1379
    • Driscoll, D.M.1    Getz, G.S.2
  • 5
    • 0025821171 scopus 로고
    • Apolipoprotein E gene expression in mouse 3T3–L1 adipocytes and human adipose tissue and its regulation by differentiation and lipid content
    • Zechner, R., Moser, R., Newman, T.C., et al. Apolipoprotein E gene expression in mouse 3T3–L1 adipocytes and human adipose tissue and its regulation by differentiation and lipid content. J Biol Chem 266 (1991), 10583–11058.
    • (1991) J Biol Chem , vol.266 , pp. 10583-11058
    • Zechner, R.1    Moser, R.2    Newman, T.C.3
  • 6
    • 0024449363 scopus 로고
    • The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein
    • Beisiegel, U., Weber, W., Ihrke, G., et al. The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein. Nature 341 (1989), 162–164.
    • (1989) Nature , vol.341 , pp. 162-164
    • Beisiegel, U.1    Weber, W.2    Ihrke, G.3
  • 7
    • 0027067987 scopus 로고
    • Hepatic clearance of plasma chylomicron remnants
    • Cooper, A.D., Hepatic clearance of plasma chylomicron remnants. Semin Liver Dis 12 (1992), 386–396.
    • (1992) Semin Liver Dis , vol.12 , pp. 386-396
    • Cooper, A.D.1
  • 8
    • 0032743737 scopus 로고    scopus 로고
    • Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes
    • Mahley, R.W., Huang, Y., Rall, S.C. Jr., Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes. J Lipid Res 40 (1999), 1933–1949.
    • (1999) J Lipid Res , vol.40 , pp. 1933-1949
    • Mahley, R.W.1    Huang, Y.2    Rall, S.C.3
  • 9
    • 0029784503 scopus 로고    scopus 로고
    • Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia
    • Dong, L.M., Parkin, S., Trakhanov, S.D., et al. Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia. Nat Struct Biol 3 (1996), 718–722.
    • (1996) Nat Struct Biol , vol.3 , pp. 718-722
    • Dong, L.M.1    Parkin, S.2    Trakhanov, S.D.3
  • 10
    • 0029766916 scopus 로고    scopus 로고
    • Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins
    • Dong, L.M., Weisgraber, K.H., Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins. J Biol Chem 271 (1996), 19053–19057.
    • (1996) J Biol Chem , vol.271 , pp. 19053-19057
    • Dong, L.M.1    Weisgraber, K.H.2
  • 11
    • 0033613228 scopus 로고    scopus 로고
    • Assessment of cardiovascular risk by use of multiple-risk-factor assessment equations: a statement for healthcare professionals from the American Heart Association and the American College of Cardiology
    • Grundy, S.M., Pasternak, R., Greenland, P., et al. Assessment of cardiovascular risk by use of multiple-risk-factor assessment equations: a statement for healthcare professionals from the American Heart Association and the American College of Cardiology. Circulation 100 (1999), 1481–1492.
    • (1999) Circulation , vol.100 , pp. 1481-1492
    • Grundy, S.M.1    Pasternak, R.2    Greenland, P.3
  • 12
    • 0037968932 scopus 로고    scopus 로고
    • Plasma concentration and lipoprotein distribution of ApoC-I is dependent on ApoE genotype rather than the Hpa I ApoC-I promoter polymorphism
    • Cohn, J.S., Tremblay, M., Boulet, L., et al. Plasma concentration and lipoprotein distribution of ApoC-I is dependent on ApoE genotype rather than the Hpa I ApoC-I promoter polymorphism. Atherosclerosis 169 (2003), 63–70.
    • (2003) Atherosclerosis , vol.169 , pp. 63-70
    • Cohn, J.S.1    Tremblay, M.2    Boulet, L.3
  • 13
    • 0023860891 scopus 로고
    • Apolipoprotein E polymorphism and atherosclerosis
    • Davignon, J., Gregg, R.E., Sing, C.F., Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 8 (1988), 1–21.
    • (1988) Arteriosclerosis , vol.8 , pp. 1-21
    • Davignon, J.1    Gregg, R.E.2    Sing, C.F.3
  • 14
    • 0025968375 scopus 로고
    • Apolipoprotein E polymorphism association with lipoprotein profile in endogenous hypertriglyceridemia and familial hypercholesterolemia
    • Dallongeville, J., Roy, M., Leboeuf, N., et al. Apolipoprotein E polymorphism association with lipoprotein profile in endogenous hypertriglyceridemia and familial hypercholesterolemia. Arterioscler Thromb 11 (1991), 272–278.
    • (1991) Arterioscler Thromb , vol.11 , pp. 272-278
    • Dallongeville, J.1    Roy, M.2    Leboeuf, N.3
  • 15
    • 0029090627 scopus 로고
    • Polymorphisms of the apolipoprotein E gene and severity of coronary artery disease defined by angiography
    • Wang, X.L., McCredie, R.M., Wilcken, D.E., Polymorphisms of the apolipoprotein E gene and severity of coronary artery disease defined by angiography. Arterioscler Thromb Vasc Biol 15 (1995), 1030–1034.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 1030-1034
    • Wang, X.L.1    McCredie, R.M.2    Wilcken, D.E.3
  • 16
    • 0031444185 scopus 로고    scopus 로고
    • The apolipoprotein E and beta-fibrinogen G/A-455 gene polymorphisms are associated with ischemic stroke involving large-vessel disease
    • Kessler, C., Spitzer, C., Stauske, D., et al. The apolipoprotein E and beta-fibrinogen G/A-455 gene polymorphisms are associated with ischemic stroke involving large-vessel disease. Arterioscler Thromb Vasc Biol 17 (1997), 2880–2884.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 2880-2884
    • Kessler, C.1    Spitzer, C.2    Stauske, D.3
  • 17
    • 0028168225 scopus 로고
    • Impact of apolipoprotein E polymorphism on lipoproteins and risk of myocardial infarction. The ECTIM Study
    • Luc, G., Bard, J.M., Arveiler, D., et al. Impact of apolipoprotein E polymorphism on lipoproteins and risk of myocardial infarction. The ECTIM Study. Arterioscler Thromb 14 (1994), 1412–1419.
    • (1994) Arterioscler Thromb , vol.14 , pp. 1412-1419
    • Luc, G.1    Bard, J.M.2    Arveiler, D.3
  • 18
    • 0031666790 scopus 로고    scopus 로고
    • An ecological study of association between coronary heart disease mortality rates in men and the relative frequencies of common allelic variations in the gene coding for apolipoprotein E
    • Stengard, J.H., Weiss, K.M., Sing, C.F., An ecological study of association between coronary heart disease mortality rates in men and the relative frequencies of common allelic variations in the gene coding for apolipoprotein E. Hum Genet 103 (1998), 234–241.
    • (1998) Hum Genet , vol.103 , pp. 234-241
    • Stengard, J.H.1    Weiss, K.M.2    Sing, C.F.3
  • 19
    • 0028946248 scopus 로고
    • Apolipoprotein E polymorphism, serum lipids, myocardial infarction and severity of angiographically verified coronary artery disease in men and women
    • Lehtinen, S., Lehtimaki, T., Sisto, T., et al. Apolipoprotein E polymorphism, serum lipids, myocardial infarction and severity of angiographically verified coronary artery disease in men and women. Atherosclerosis 114 (1995), 83–91.
    • (1995) Atherosclerosis , vol.114 , pp. 83-91
    • Lehtinen, S.1    Lehtimaki, T.2    Sisto, T.3
  • 20
    • 0028832051 scopus 로고
    • Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men
    • Stengard, J.H., Zerba, K.E., Pekkanen, J., et al. Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men. Circulation 91 (1995), 265–269.
    • (1995) Circulation , vol.91 , pp. 265-269
    • Stengard, J.H.1    Zerba, K.E.2    Pekkanen, J.3
  • 21
    • 0028174622 scopus 로고
    • Dietary sitostanol related to absorption, synthesis and serum level of cholesterol in different apolipoprotein E phenotypes
    • Miettinen, T.A., Vanhanen, H., Dietary sitostanol related to absorption, synthesis and serum level of cholesterol in different apolipoprotein E phenotypes. Atherosclerosis 105 (1994), 217–226.
    • (1994) Atherosclerosis , vol.105 , pp. 217-226
    • Miettinen, T.A.1    Vanhanen, H.2
  • 22
    • 0034332915 scopus 로고    scopus 로고
    • Apolipoprotein E genotypes and response of plasma lipids and progression-regression of coronary atherosclerosis to lipid-lowering drug therapy
    • Ballantyne, C.M., Herd, J.A., Stein, E.A., et al. Apolipoprotein E genotypes and response of plasma lipids and progression-regression of coronary atherosclerosis to lipid-lowering drug therapy. J Am Coll Cardiol 36 (2000), 1572–1578.
    • (2000) J Am Coll Cardiol , vol.36 , pp. 1572-1578
    • Ballantyne, C.M.1    Herd, J.A.2    Stein, E.A.3
  • 23
    • 0030024169 scopus 로고    scopus 로고
    • Mouse models of atherosclerosis
    • Breslow, J.L., Mouse models of atherosclerosis. Science 272 (1996), 685–688.
    • (1996) Science , vol.272 , pp. 685-688
    • Breslow, J.L.1
  • 24
    • 0036080373 scopus 로고    scopus 로고
    • Mouse models of atherosclerosis
    • Daugherty, A., Mouse models of atherosclerosis. Am J Med Sci 323 (2002), 3–10.
    • (2002) Am J Med Sci , vol.323 , pp. 3-10
    • Daugherty, A.1
  • 25
    • 84895067360 scopus 로고    scopus 로고
    • Role of extracellular RNA in atherosclerotic plaque formation in mice
    • Simsekyilmaz, S., Cabrera-Fuentes, H.A., Meiler, S., et al. Role of extracellular RNA in atherosclerotic plaque formation in mice. Circulation 129 (2014), 598–606.
    • (2014) Circulation , vol.129 , pp. 598-606
    • Simsekyilmaz, S.1    Cabrera-Fuentes, H.A.2    Meiler, S.3
  • 26
    • 84924089923 scopus 로고    scopus 로고
    • Response to letter regarding article “Role of extracellular RNA in atherosclerotic plaque formation in mice”
    • Simsekyilmaz, S., Cabrera-Fuentes, H.A., Meiler, S., et al. Response to letter regarding article “Role of extracellular RNA in atherosclerotic plaque formation in mice”. Circulation 130 (2014), e144–e145.
    • (2014) Circulation , vol.130 , pp. e144-e145
    • Simsekyilmaz, S.1    Cabrera-Fuentes, H.A.2    Meiler, S.3
  • 27
    • 84950311838 scopus 로고    scopus 로고
    • Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside
    • Cabrera-Fuentes, H.A., Alba-Alba, C., Aragones, J., et al. Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside. Basic Res Cardiol, 111, 2016, 7.
    • (2016) Basic Res Cardiol , vol.111 , pp. 7
    • Cabrera-Fuentes, H.A.1    Alba-Alba, C.2    Aragones, J.3
  • 28
    • 84991383711 scopus 로고    scopus 로고
    • From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on “New frontiers in cardiovascular research
    • Cabrera-Fuentes, H.A., Aragones, J., Bernhagen, J., et al. From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on “New frontiers in cardiovascular research. Basic Res Cardiol, 111, 2016, 69.
    • (2016) Basic Res Cardiol , vol.111 , pp. 69
    • Cabrera-Fuentes, H.A.1    Aragones, J.2    Bernhagen, J.3
  • 29
    • 0032084129 scopus 로고    scopus 로고
    • The question not asked: the challenge of pleiotropic genetic tests
    • Wachbroit, R., The question not asked: the challenge of pleiotropic genetic tests. Kennedy Inst Ethics J 8 (1998), 131–144.
    • (1998) Kennedy Inst Ethics J , vol.8 , pp. 131-144
    • Wachbroit, R.1
  • 30
    • 84907289344 scopus 로고    scopus 로고
    • Genetic variants of ApoE and ApoER2 differentially modulate endothelial function
    • Ulrich, V., Konaniah, E.S., Herz, J., et al. Genetic variants of ApoE and ApoER2 differentially modulate endothelial function. Proc Natl Acad Sci U S A 111 (2014), 13493–13498.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 13493-13498
    • Ulrich, V.1    Konaniah, E.S.2    Herz, J.3
  • 31
    • 84873424343 scopus 로고    scopus 로고
    • Apolipoprotein E-mediated cell cycle arrest linked to p27 and the Cox2-dependent repression of miR221/222
    • Kothapalli, D., Castagnino, P., Rader, D.J., et al. Apolipoprotein E-mediated cell cycle arrest linked to p27 and the Cox2-dependent repression of miR221/222. Atherosclerosis 227 (2013), 65–71.
    • (2013) Atherosclerosis , vol.227 , pp. 65-71
    • Kothapalli, D.1    Castagnino, P.2    Rader, D.J.3
  • 32
    • 0032254189 scopus 로고    scopus 로고
    • Influence of alleles of apolipoprotein E on restenosis after coronary angioplasty in women
    • Flork, L., Jouanel, P., Lusson, J.R., et al. Influence of alleles of apolipoprotein E on restenosis after coronary angioplasty in women. Arch Mal Coeur Vaiss 91 (1998), 1475–1479.
    • (1998) Arch Mal Coeur Vaiss , vol.91 , pp. 1475-1479
    • Flork, L.1    Jouanel, P.2    Lusson, J.R.3
  • 33
    • 33845900465 scopus 로고    scopus 로고
    • Chemokines: inflammatory mediators of atherosclerosis
    • Liehn, E.A., Zernecke, A., Postea, O., et al. Chemokines: inflammatory mediators of atherosclerosis. Arch Physiol Biochem 112 (2006), 229–238.
    • (2006) Arch Physiol Biochem , vol.112 , pp. 229-238
    • Liehn, E.A.1    Zernecke, A.2    Postea, O.3
  • 34
    • 81855184881 scopus 로고    scopus 로고
    • Repair after myocardial infarction, between fantasy and reality: the role of chemokines
    • Liehn, E.A., Postea, O., Curaj, A., et al. Repair after myocardial infarction, between fantasy and reality: the role of chemokines. J Am Coll Cardiol 58 (2011), 2357–2362.
    • (2011) J Am Coll Cardiol , vol.58 , pp. 2357-2362
    • Liehn, E.A.1    Postea, O.2    Curaj, A.3
  • 35
    • 85041589954 scopus 로고    scopus 로고
    • Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities
    • Ong, S.B., Hernandez-Resendiz, S., Crespo-Avilan, G.E., et al. Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities. Pharmacol Ther 186 (2018), 73–87.
    • (2018) Pharmacol Ther , vol.186 , pp. 73-87
    • Ong, S.B.1    Hernandez-Resendiz, S.2    Crespo-Avilan, G.E.3
  • 36
    • 70350494273 scopus 로고    scopus 로고
    • Apolipoprotein-mediated lipid antigen presentation in B cells provides a pathway for innate help by NKT cells
    • Allan, L.L., Hoefl, K., Zheng, D.J., et al. Apolipoprotein-mediated lipid antigen presentation in B cells provides a pathway for innate help by NKT cells. Blood 114 (2009), 2411–2416.
    • (2009) Blood , vol.114 , pp. 2411-2416
    • Allan, L.L.1    Hoefl, K.2    Zheng, D.J.3
  • 37
    • 84893925215 scopus 로고    scopus 로고
    • ApoE production in human monocytes and its regulation by inflammatory cytokines
    • Braesch-Andersen, S., Paulie, S., Smedman, C., et al. ApoE production in human monocytes and its regulation by inflammatory cytokines. PLoS One, 8, 2013, e79908.
    • (2013) PLoS One , vol.8 , pp. e79908
    • Braesch-Andersen, S.1    Paulie, S.2    Smedman, C.3
  • 38
    • 27144481169 scopus 로고    scopus 로고
    • Apolipoprotein-mediated pathways of lipid antigen presentation
    • van den Elzen, P., Garg, S., Leon, L., et al. Apolipoprotein-mediated pathways of lipid antigen presentation. Nature 437 (2005), 906–910.
    • (2005) Nature , vol.437 , pp. 906-910
    • van den Elzen, P.1    Garg, S.2    Leon, L.3
  • 39
    • 77953172656 scopus 로고    scopus 로고
    • The role of apolipoprotein E in Guillain-Barre syndrome and experimental autoimmune neuritis
    • Zhang, H.L., Wu, J., Zhu, J., The role of apolipoprotein E in Guillain-Barre syndrome and experimental autoimmune neuritis. J Biomed Biotechnol, 2010, 2010, 357412.
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 357412
    • Zhang, H.L.1    Wu, J.2    Zhu, J.3
  • 40
    • 0029765553 scopus 로고    scopus 로고
    • Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides
    • Miyata, M., Smith, J.D., Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides. Nature Genet 14 (1996), 55–61.
    • (1996) Nature Genet , vol.14 , pp. 55-61
    • Miyata, M.1    Smith, J.D.2
  • 41
    • 84866319499 scopus 로고    scopus 로고
    • Apolipoprotein E regulation of myeloid cell plasticity in atherosclerosis
    • Raffai, R.L., Apolipoprotein E regulation of myeloid cell plasticity in atherosclerosis. Curr Opin Lipidol 23 (2012), 471–478.
    • (2012) Curr Opin Lipidol , vol.23 , pp. 471-478
    • Raffai, R.L.1
  • 42
    • 80053421469 scopus 로고    scopus 로고
    • ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice
    • Murphy, A.J., Akhtari, M., Tolani, S., et al. ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice. J Clin Invest 121 (2011), 4138–4149.
    • (2011) J Clin Invest , vol.121 , pp. 4138-4149
    • Murphy, A.J.1    Akhtari, M.2    Tolani, S.3
  • 43
    • 0022970945 scopus 로고
    • Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium
    • Murry, C.E., Jennings, R.B., Reimer, K.A., Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74 (1986), 1124–1136.
    • (1986) Circulation , vol.74 , pp. 1124-1136
    • Murry, C.E.1    Jennings, R.B.2    Reimer, K.A.3
  • 44
    • 0026039107 scopus 로고
    • New insights into potential mechanisms of ischemic preconditioning
    • Murry, C.E., Jennings, R.B., Reimer, K.A., New insights into potential mechanisms of ischemic preconditioning. Circulation 84 (1991), 442–445.
    • (1991) Circulation , vol.84 , pp. 442-445
    • Murry, C.E.1    Jennings, R.B.2    Reimer, K.A.3
  • 45
    • 0037272231 scopus 로고    scopus 로고
    • Myocardial ischaemia/reperfusion injury and preconditioning: effects of hypercholesterolaemia/hyperlipidaemia
    • Ferdinandy, P., Myocardial ischaemia/reperfusion injury and preconditioning: effects of hypercholesterolaemia/hyperlipidaemia. Br J Pharmacol 138 (2003), 283–285.
    • (2003) Br J Pharmacol , vol.138 , pp. 283-285
    • Ferdinandy, P.1
  • 46
    • 84991769840 scopus 로고    scopus 로고
    • Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery
    • Hausenloy, D.J., Barrabes, J.A., Botker, H.E., et al. Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery. Basic Res Cardiol, 111, 2016, 70.
    • (2016) Basic Res Cardiol , vol.111 , pp. 70
    • Hausenloy, D.J.1    Barrabes, J.A.2    Botker, H.E.3
  • 47
    • 0035052551 scopus 로고    scopus 로고
    • Preconditioning protects the severely atherosclerotic mouse heart
    • discussion 303–304
    • Li, G., Tokuno, S., Tahep ld, P., et al. Preconditioning protects the severely atherosclerotic mouse heart. Ann Thorac Surg 71 (2001), 1296–1303 discussion 303–304.
    • (2001) Ann Thorac Surg , vol.71 , pp. 1296-1303
    • Li, G.1    Tokuno, S.2    Tahep ld, P.3
  • 48
    • 33744465518 scopus 로고    scopus 로고
    • Is the ApoE polymorphism associated with dilated cardiomyopathy?
    • Jurkovicova, D., Goncalvesova, E., Sedlakova, B., et al. Is the ApoE polymorphism associated with dilated cardiomyopathy?. Gen Physiol Biophys 25 (2006), 3–10.
    • (2006) Gen Physiol Biophys , vol.25 , pp. 3-10
    • Jurkovicova, D.1    Goncalvesova, E.2    Sedlakova, B.3
  • 49
    • 37549023499 scopus 로고    scopus 로고
    • EMMPRIN mediates beta-adrenergic receptor-stimulated matrix metalloproteinase activity in cardiac myocytes
    • Siwik, D.A., Kuster, G.M., Brahmbhatt, J.V., et al. EMMPRIN mediates beta-adrenergic receptor-stimulated matrix metalloproteinase activity in cardiac myocytes. J Mol Cell Cardiol 44 (2008), 210–217.
    • (2008) J Mol Cell Cardiol , vol.44 , pp. 210-217
    • Siwik, D.A.1    Kuster, G.M.2    Brahmbhatt, J.V.3
  • 50
    • 84861418194 scopus 로고    scopus 로고
    • Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
    • Bell, R.D., Winkler, E.A., Singh, I., et al. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature 485 (2012), 512–516.
    • (2012) Nature , vol.485 , pp. 512-516
    • Bell, R.D.1    Winkler, E.A.2    Singh, I.3
  • 51
    • 77049117972 scopus 로고    scopus 로고
    • EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation
    • Seizer, P., Schonberger, T., Schott, M., et al. EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation. Atherosclerosis 209 (2010), 51–57.
    • (2010) Atherosclerosis , vol.209 , pp. 51-57
    • Seizer, P.1    Schonberger, T.2    Schott, M.3
  • 52
    • 3042730974 scopus 로고    scopus 로고
    • Cyclophilin A is a proinflammatory cytokine that activates endothelial cells
    • Jin, Z.G., Lungu, A.O., Xie, L., et al. Cyclophilin A is a proinflammatory cytokine that activates endothelial cells. Arterioscler Thromb Vasc Biol 24 (2004), 1186–1191.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1186-1191
    • Jin, Z.G.1    Lungu, A.O.2    Xie, L.3
  • 53
    • 67349235964 scopus 로고    scopus 로고
    • Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms
    • Satoh, K., Nigro, P., Matoba, T., et al. Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. Nat Med 15 (2009), 649–656.
    • (2009) Nat Med , vol.15 , pp. 649-656
    • Satoh, K.1    Nigro, P.2    Matoba, T.3
  • 54
    • 84920400886 scopus 로고    scopus 로고
    • Extracellular cyclophilin A activates platelets via EMMPRIN (CD147) and PI3K/Akt signaling, which promotes platelet adhesion and thrombus formation in vitro and in vivo
    • Seizer, P., Ungern-Sternberg, S.N., Schonberger, T., et al. Extracellular cyclophilin A activates platelets via EMMPRIN (CD147) and PI3K/Akt signaling, which promotes platelet adhesion and thrombus formation in vitro and in vivo. Arterioscler Thromb Vasc Biol 35 (2015), 655–663.
    • (2015) Arterioscler Thromb Vasc Biol , vol.35 , pp. 655-663
    • Seizer, P.1    Ungern-Sternberg, S.N.2    Schonberger, T.3
  • 55
    • 0028273371 scopus 로고
    • Insulin as a predictor of coronary heart disease: interaction with apolipoprotein E phenotype. A report from the Multiple Risk Factor Intervention Trial
    • Orchard, T.J., Eichner, J., Kuller, L.H., et al. Insulin as a predictor of coronary heart disease: interaction with apolipoprotein E phenotype. A report from the Multiple Risk Factor Intervention Trial. Ann Epidemiol 4 (1994), 40–45.
    • (1994) Ann Epidemiol , vol.4 , pp. 40-45
    • Orchard, T.J.1    Eichner, J.2    Kuller, L.H.3
  • 56
    • 0032585934 scopus 로고    scopus 로고
    • Apovarepsilon(4) allele increases the risk for exercise-induced silent myocardial ischemia in non-insulin-dependent diabetes mellitus
    • Guangda, X., Bangshun, X., Xiujian, L., et al. Apovarepsilon(4) allele increases the risk for exercise-induced silent myocardial ischemia in non-insulin-dependent diabetes mellitus. Atherosclerosis 147 (1999), 293–296.
    • (1999) Atherosclerosis , vol.147 , pp. 293-296
    • Guangda, X.1    Bangshun, X.2    Xiujian, L.3
  • 58
    • 80052146064 scopus 로고    scopus 로고
    • Heparin protects against septic mortality via apoE-antagonism
    • Chuang, K.I., Leung, B., Hsu, N., et al. Heparin protects against septic mortality via apoE-antagonism. Am J Surg 202 (2011), 325–335.
    • (2011) Am J Surg , vol.202 , pp. 325-335
    • Chuang, K.I.1    Leung, B.2    Hsu, N.3
  • 59
    • 84922825103 scopus 로고    scopus 로고
    • Apolipoprotein E (APOE) genotype regulates body weight and fatty acid utilization-Studies in gene-targeted replacement mice
    • Huebbe, P., Dose, J., Schloesser, A., et al. Apolipoprotein E (APOE) genotype regulates body weight and fatty acid utilization-Studies in gene-targeted replacement mice. Mol Nutr Food Res 59 (2015), 334–343.
    • (2015) Mol Nutr Food Res , vol.59 , pp. 334-343
    • Huebbe, P.1    Dose, J.2    Schloesser, A.3
  • 60
    • 84904741764 scopus 로고    scopus 로고
    • Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
    • Deelen, J., Beekman, M., Uh, H.W., et al. Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. Hum Mol Genet 23 (2014), 4420–4432.
    • (2014) Hum Mol Genet , vol.23 , pp. 4420-4432
    • Deelen, J.1    Beekman, M.2    Uh, H.W.3
  • 61
    • 79961208019 scopus 로고    scopus 로고
    • A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals
    • Nebel, A., Kleindorp, R., Caliebe, A., et al. A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals. Mech Ageing Dev 132 (2011), 324–330.
    • (2011) Mech Ageing Dev , vol.132 , pp. 324-330
    • Nebel, A.1    Kleindorp, R.2    Caliebe, A.3
  • 62
    • 79953216712 scopus 로고    scopus 로고
    • Endogenous adipocyte apolipoprotein E is colocalized with caveolin at the adipocyte plasma membrane
    • Yue, L., Mazzone, T., Endogenous adipocyte apolipoprotein E is colocalized with caveolin at the adipocyte plasma membrane. J Lipid Res 52 (2011), 489–498.
    • (2011) J Lipid Res , vol.52 , pp. 489-498
    • Yue, L.1    Mazzone, T.2
  • 63
    • 38949088891 scopus 로고    scopus 로고
    • Analysis of apolipoprotein E nuclear localization using green fluorescent protein and biotinylation approaches
    • Kim, W.S., Elliott, D.A., Kockx, M., et al. Analysis of apolipoprotein E nuclear localization using green fluorescent protein and biotinylation approaches. Biochem J 409 (2008), 701–709.
    • (2008) Biochem J , vol.409 , pp. 701-709
    • Kim, W.S.1    Elliott, D.A.2    Kockx, M.3
  • 64
    • 85064471967 scopus 로고    scopus 로고
    • The still valid fluid mosaic model for molecular organization of biomembranes: accumulating data confirm it
    • Leabu, M., The still valid fluid mosaic model for molecular organization of biomembranes: accumulating data confirm it. Discoveries, 1, 2013, e7.
    • (2013) Discoveries , vol.1 , pp. e7
    • Leabu, M.1
  • 65
    • 84929144905 scopus 로고    scopus 로고
    • Update of the 1972 Singer-Nicolson Fluid-Mosaic Model of Membrane Structure
    • Nicolson, G.L., Update of the 1972 Singer-Nicolson Fluid-Mosaic Model of Membrane Structure. Discoveries, 1, 2013, e3.
    • (2013) Discoveries , vol.1 , pp. e3
    • Nicolson, G.L.1
  • 66
    • 0015514472 scopus 로고
    • The fluid mosaic model of the structure of cell membranes
    • Singer, S.J., Nicolson, G.L., The fluid mosaic model of the structure of cell membranes. Science 175 (1972), 720–731.
    • (1972) Science , vol.175 , pp. 720-731
    • Singer, S.J.1    Nicolson, G.L.2
  • 67
    • 0036317070 scopus 로고    scopus 로고
    • A new role for apolipoprotein E: modulating transport of polyunsaturated phospholipid molecular species in synaptic plasma membranes
    • Igbavboa, U., Hamilton, J., Kim, H.Y., et al. A new role for apolipoprotein E: modulating transport of polyunsaturated phospholipid molecular species in synaptic plasma membranes. J Neurochem 80 (2002), 255–261.
    • (2002) J Neurochem , vol.80 , pp. 255-261
    • Igbavboa, U.1    Hamilton, J.2    Kim, H.Y.3
  • 68
    • 0027179487 scopus 로고
    • Phospholipids in animal eukaryotic membranes: transverse asymmetry and movement
    • Zachowski, A., Phospholipids in animal eukaryotic membranes: transverse asymmetry and movement. Biochem J 294 (1993), 1–14.
    • (1993) Biochem J , vol.294 , pp. 1-14
    • Zachowski, A.1
  • 69
    • 79851488392 scopus 로고    scopus 로고
    • Cholesterol asymmetry in synaptic plasma membranes
    • Wood, W.G., Igbavboa, U., Muller, W.E., et al. Cholesterol asymmetry in synaptic plasma membranes. J Neurochem 116 (2011), 684–689.
    • (2011) J Neurochem , vol.116 , pp. 684-689
    • Wood, W.G.1    Igbavboa, U.2    Muller, W.E.3
  • 70
    • 0029060391 scopus 로고
    • Protein kinase C and lipid signaling for sustained cellular responses
    • Nishizuka, Y., Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 9 (1995), 484–496.
    • (1995) FASEB J , vol.9 , pp. 484-496
    • Nishizuka, Y.1
  • 71
    • 0037171006 scopus 로고    scopus 로고
    • Cholesterol is increased in the exofacial leaflet of synaptic plasma membranes of human apolipoprotein E4 knock-in mice
    • Hayashi, H., Igbavboa, U., Hamanaka, H., et al. Cholesterol is increased in the exofacial leaflet of synaptic plasma membranes of human apolipoprotein E4 knock-in mice. Neuroreport 13 (2002), 383–386.
    • (2002) Neuroreport , vol.13 , pp. 383-386
    • Hayashi, H.1    Igbavboa, U.2    Hamanaka, H.3
  • 72
    • 68449090009 scopus 로고    scopus 로고
    • Lipid raft in cardiac health and disease
    • Das, M., Das, D.K., Lipid raft in cardiac health and disease. Curr Cardiol Rev 5 (2009), 105–111.
    • (2009) Curr Cardiol Rev , vol.5 , pp. 105-111
    • Das, M.1    Das, D.K.2
  • 73
    • 84919800659 scopus 로고    scopus 로고
    • Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload
    • Elezaby, A., Sverdlov, A.L., Tu, V.H., et al. Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload. J Mol Cell Cardiol 79 (2015), 275–283.
    • (2015) J Mol Cell Cardiol , vol.79 , pp. 275-283
    • Elezaby, A.1    Sverdlov, A.L.2    Tu, V.H.3
  • 74
    • 84910067714 scopus 로고    scopus 로고
    • Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo
    • Abdurrachim, D., Ciapaite, J., Wessels, B., et al. Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo. Biochim Biophys Acta 1842 (2014), 1525–1537.
    • (2014) Biochim Biophys Acta , vol.1842 , pp. 1525-1537
    • Abdurrachim, D.1    Ciapaite, J.2    Wessels, B.3
  • 75
    • 0042315364 scopus 로고    scopus 로고
    • Cardiac lipid accumulation associated with diastolic dysfunction in obese mice
    • Christoffersen, C., Bollano, E., Lindegaard, M.L., et al. Cardiac lipid accumulation associated with diastolic dysfunction in obese mice. Endocrinology 144 (2003), 3483–3490.
    • (2003) Endocrinology , vol.144 , pp. 3483-3490
    • Christoffersen, C.1    Bollano, E.2    Lindegaard, M.L.3
  • 76
    • 79551498811 scopus 로고    scopus 로고
    • A murine model of isolated cardiac steatosis leads to cardiomyopathy
    • Glenn, D.J., Wang, F., Nishimoto, M., et al. A murine model of isolated cardiac steatosis leads to cardiomyopathy. Hypertension 57 (2011), 216–222.
    • (2011) Hypertension , vol.57 , pp. 216-222
    • Glenn, D.J.1    Wang, F.2    Nishimoto, M.3
  • 77
    • 7644222841 scopus 로고    scopus 로고
    • Order from disorder, corralling cholesterol with chaotic lipids. The role of polyunsaturated lipids in membrane raft formation
    • Wassall, S.R., Brzustowicz, M.R., Shaikh, S.R., et al. Order from disorder, corralling cholesterol with chaotic lipids. The role of polyunsaturated lipids in membrane raft formation. Chem Phys Lipids 132 (2004), 79–88.
    • (2004) Chem Phys Lipids , vol.132 , pp. 79-88
    • Wassall, S.R.1    Brzustowicz, M.R.2    Shaikh, S.R.3
  • 78
    • 32444447144 scopus 로고    scopus 로고
    • Involvement of lipid rafts and caveolae in cardiac ion channel function
    • Maguy, A., Hebert, T.E., Nattel, S., Involvement of lipid rafts and caveolae in cardiac ion channel function. Cardiovasc Res 69 (2006), 798–807.
    • (2006) Cardiovasc Res , vol.69 , pp. 798-807
    • Maguy, A.1    Hebert, T.E.2    Nattel, S.3
  • 79
    • 77954746046 scopus 로고    scopus 로고
    • Neuroscience and heart-brain medicine: the year in review
    • Goldstein, D.S., Neuroscience and heart-brain medicine: the year in review. Cleve Clin J Med 77:Suppl 3 (2010), S34–S39.
    • (2010) Cleve Clin J Med , vol.77 , pp. S34-S39
    • Goldstein, D.S.1
  • 80
    • 4644350976 scopus 로고    scopus 로고
    • Lewy bodies in the sinoatrial nodal ganglion: clinicopathological studies
    • Okada, Y., Ito, Y., Aida, J., et al. Lewy bodies in the sinoatrial nodal ganglion: clinicopathological studies. Pathol Int 54 (2004), 682–687.
    • (2004) Pathol Int , vol.54 , pp. 682-687
    • Okada, Y.1    Ito, Y.2    Aida, J.3
  • 81
    • 85064473612 scopus 로고    scopus 로고
    • Strains of Pathological Protein Aggregates in Neurodegenerative Diseases
    • Wang, X., Noroozian, Z., Lynch, M., et al. Strains of Pathological Protein Aggregates in Neurodegenerative Diseases. Discoveries, 5, 2017, e78.
    • (2017) Discoveries , vol.5 , pp. e78
    • Wang, X.1    Noroozian, Z.2    Lynch, M.3
  • 82
    • 84960383157 scopus 로고    scopus 로고
    • Effects of different isoforms of apoE on aggregation of the alpha-synuclein protein implicated in Parkinson's disease
    • Emamzadeh, F.N., Aojula, H., McHugh, P.C., et al. Effects of different isoforms of apoE on aggregation of the alpha-synuclein protein implicated in Parkinson's disease. Neurosci Lett 618 (2016), 146–151.
    • (2016) Neurosci Lett , vol.618 , pp. 146-151
    • Emamzadeh, F.N.1    Aojula, H.2    McHugh, P.C.3
  • 83
    • 27644578107 scopus 로고    scopus 로고
    • Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein
    • Ellis, C.E., Murphy, E.J., Mitchell, D.C., et al. Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein. Mol Cell Biol 25 (2005), 10190–10201.
    • (2005) Mol Cell Biol , vol.25 , pp. 10190-10201
    • Ellis, C.E.1    Murphy, E.J.2    Mitchell, D.C.3
  • 84
    • 84889088204 scopus 로고    scopus 로고
    • Confluence of alpha-synuclein, tau, and beta-amyloid pathologies in dementia with Lewy bodies
    • Colom-Cadena, M., Gelpi, E., Charif, S., et al. Confluence of alpha-synuclein, tau, and beta-amyloid pathologies in dementia with Lewy bodies. J Neuropathol Exp Neurol 72 (2013), 1203–1212.
    • (2013) J Neuropathol Exp Neurol , vol.72 , pp. 1203-1212
    • Colom-Cadena, M.1    Gelpi, E.2    Charif, S.3
  • 85
    • 39749185957 scopus 로고    scopus 로고
    • A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides
    • Gallardo, G., Schluter, O.M., Sudhof, T.C., A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides. Nature Neurosci 11 (2008), 301–308.
    • (2008) Nature Neurosci , vol.11 , pp. 301-308
    • Gallardo, G.1    Schluter, O.M.2    Sudhof, T.C.3
  • 86
    • 85064473099 scopus 로고    scopus 로고
    • Amyloids and their Possible Influence on Alzheimer Disease
    • Lau, A., Bourkas, M., Lu, Y.Q.Q., et al. Amyloids and their Possible Influence on Alzheimer Disease. Discoveries, 5, 2017, e79.
    • (2017) Discoveries , vol.5 , pp. e79
    • Lau, A.1    Bourkas, M.2    Lu, Y.Q.Q.3
  • 87
    • 0344667494 scopus 로고    scopus 로고
    • Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease
    • Chauhan, N.B., Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease. J Lipid Res 44 (2003), 2019–2029.
    • (2003) J Lipid Res , vol.44 , pp. 2019-2029
    • Chauhan, N.B.1
  • 88
    • 2942552153 scopus 로고    scopus 로고
    • Alpha-synuclein is expressed in different tissues during human fetal development
    • Ltic, S., Perovic, M., Mladenovic, A., et al. Alpha-synuclein is expressed in different tissues during human fetal development. J Mol Neurosci 22 (2004), 199–204.
    • (2004) J Mol Neurosci , vol.22 , pp. 199-204
    • Ltic, S.1    Perovic, M.2    Mladenovic, A.3
  • 89
    • 0030464403 scopus 로고    scopus 로고
    • Alterations in apolipoprotein E expression during aging and neurodegeneration
    • Masliah, E., Mallory, M., Veinbergs, I., et al. Alterations in apolipoprotein E expression during aging and neurodegeneration. Prog Neurobiol 50 (1996), 493–503.
    • (1996) Prog Neurobiol , vol.50 , pp. 493-503
    • Masliah, E.1    Mallory, M.2    Veinbergs, I.3
  • 90
    • 84955489626 scopus 로고    scopus 로고
    • Comparative proteomics reveals abnormal binding of ATGL and dysferlin on lipid droplets from pressure overload-induced dysfunctional rat hearts
    • Li, L., Zhang, H., Wang, W., et al. Comparative proteomics reveals abnormal binding of ATGL and dysferlin on lipid droplets from pressure overload-induced dysfunctional rat hearts. Sci Rep, 6, 2016, 19782.
    • (2016) Sci Rep , vol.6 , pp. 19782
    • Li, L.1    Zhang, H.2    Wang, W.3
  • 91
    • 11244275436 scopus 로고    scopus 로고
    • Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation
    • Heeren, J., Grewal, T., Laatsch, A., et al. Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation. J Biol Chem 279 (2004), 55483–55492.
    • (2004) J Biol Chem , vol.279 , pp. 55483-55492
    • Heeren, J.1    Grewal, T.2    Laatsch, A.3
  • 92
    • 0642318009 scopus 로고    scopus 로고
    • Apolipoprotein E expression in localized prostate cancers
    • Venanzoni, M.C., Giunta, S., Muraro, G.B., et al. Apolipoprotein E expression in localized prostate cancers. Int J Oncol 22 (2003), 779–786.
    • (2003) Int J Oncol , vol.22 , pp. 779-786
    • Venanzoni, M.C.1    Giunta, S.2    Muraro, G.B.3
  • 93
    • 0034573833 scopus 로고    scopus 로고
    • Detection of apolipoprotein A-I, B, and E immunoreactivity in the nuclei of various rat tissue cells
    • Panin, L.E., Russkikh, G.S., Polyakov, L.M., Detection of apolipoprotein A-I, B, and E immunoreactivity in the nuclei of various rat tissue cells. Biochemistry (Mosc) 65 (2000), 1419–1423.
    • (2000) Biochemistry (Mosc) , vol.65 , pp. 1419-1423
    • Panin, L.E.1    Russkikh, G.S.2    Polyakov, L.M.3
  • 94
    • 84955121156 scopus 로고    scopus 로고
    • Direct Transcriptional Effects of Apolipoprotein E
    • Theendakara, V., Peters-Libeu, C.A., Spilman, P., et al. Direct Transcriptional Effects of Apolipoprotein E. J Neurosci 36 (2016), 685–700.
    • (2016) J Neurosci , vol.36 , pp. 685-700
    • Theendakara, V.1    Peters-Libeu, C.A.2    Spilman, P.3
  • 95
    • 84862809492 scopus 로고    scopus 로고
    • Interaction between NFκB and NFAT coordinates cardiac hypertrophy and pathological remodeling
    • Liu, Q., Chen, Y., Auger-Messier, M., et al. Interaction between NFκB and NFAT coordinates cardiac hypertrophy and pathological remodeling. Circ Res 110 (2012), 1077–1086.
    • (2012) Circ Res , vol.110 , pp. 1077-1086
    • Liu, Q.1    Chen, Y.2    Auger-Messier, M.3
  • 96
    • 84955513081 scopus 로고    scopus 로고
    • SIRT1 activation attenuates diastolic dysfunction by reducing cardiac fibrosis in a model of anthracycline cardiomyopathy
    • Cappetta, D., Esposito, G., Piegari, E., et al. SIRT1 activation attenuates diastolic dysfunction by reducing cardiac fibrosis in a model of anthracycline cardiomyopathy. Int J Cardiol 205 (2016), 99–110.
    • (2016) Int J Cardiol , vol.205 , pp. 99-110
    • Cappetta, D.1    Esposito, G.2    Piegari, E.3
  • 97
    • 33947258832 scopus 로고    scopus 로고
    • Apoptosis induces neuronal apolipoprotein-E synthesis and localization in apoptotic bodies
    • Elliott, D.A., Kim, W.S., Jans, D.A., et al. Apoptosis induces neuronal apolipoprotein-E synthesis and localization in apoptotic bodies. Neurosci Lett 416 (2007), 206–210.
    • (2007) Neurosci Lett , vol.416 , pp. 206-210
    • Elliott, D.A.1    Kim, W.S.2    Jans, D.A.3


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