메뉴 건너뛰기




Volumn 36, Issue 3, 2016, Pages 685-700

Direct transcriptional effects of apolipoprotein E

Author keywords

Activity dependent neuroprotective protein; Alzheimer s disease; Amyloid precursor protein; Apolipoprotein E; MAP kinaseactivating death domain; Sirtuin

Indexed keywords

ADAM10 ENDOPEPTIDASE; APOLIPOPROTEIN E4; DOUBLE STRANDED DNA; INTERLEUKIN 6; INTERLEUKIN 8; SIRTUIN 1; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR RECEPTOR 1; UPSTREAM STIMULATORY FACTOR 1; PROTEIN BINDING;

EID: 84955121156     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3562-15.2016     Document Type: Article
Times cited : (114)

References (54)
  • 2
    • 0036592518 scopus 로고    scopus 로고
    • Non-familial Alzheimer’s disease is mainly due to genetic factors
    • Medline
    • Ashford JW, Mortimer JA (2002) Non-familial Alzheimer’s disease is mainly due to genetic factors. J Alzheimers Dis 4:169-177. Medline
    • (2002) J Alzheimers Dis , vol.4 , pp. 169-177
    • Ashford, J.W.1    Mortimer, J.A.2
  • 3
    • 67749139805 scopus 로고    scopus 로고
    • Neurodegeneration in Alzheimer’s disease: Caspases and synaptic element interdependence
    • CrossRef Medline
    • Bredesen DE (2009) Neurodegeneration in Alzheimer’s disease: caspases and synaptic element interdependence. Mol Neurodegener 4:27. CrossRef Medline
    • (2009) Mol Neurodegener , vol.4 , pp. 27
    • Bredesen, D.E.1
  • 4
    • 84878699428 scopus 로고    scopus 로고
    • Next generation therapeutics for Alzheimer’s disease
    • CrossRef Medline
    • Bredesen DE, John V (2013) Next generation therapeutics for Alzheimer’s disease. EMBO Mol Med 5:795-798. CrossRef Medline
    • (2013) EMBO Mol Med , vol.5 , pp. 795-798
    • Bredesen, D.E.1    John, V.2
  • 6
    • 84865011518 scopus 로고    scopus 로고
    • Apolipoprotein E4 impairs macrophage efferocytosis and potentiates apoptosis by accelerating endoplasmic reticulum stress
    • CrossRef Medline
    • Cash JG, Kuhel DG, Basford JE, Jaeschke A, Chatterjee TK, Weintraub NL, Hui DY (2012) Apolipoprotein E4 impairs macrophage efferocytosis and potentiates apoptosis by accelerating endoplasmic reticulum stress. J Biol Chem 287:27876-27884. CrossRef Medline
    • (2012) J Biol Chem , vol.287 , pp. 27876-27884
    • Cash, J.G.1    Kuhel, D.G.2    Basford, J.E.3    Jaeschke, A.4    Chatterjee, T.K.5    Weintraub, N.L.6    Hui, D.Y.7
  • 7
    • 28844474597 scopus 로고    scopus 로고
    • SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling
    • CrossRef Medline
    • Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L (2005a) SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J Biol Chem 280:40364-40374. CrossRef Medline
    • (2005) J Biol Chem , vol.280 , pp. 40364-40374
    • Chen, J.1    Zhou, Y.2    Mueller-Steiner, S.3    Chen, L.F.4    Kwon, H.5    Yi, S.6    Mucke, L.7    Gan, L.8
  • 9
    • 0017891056 scopus 로고
    • Isolation of a high density lipoprotein with high contents of arginine-rich apoprotein (ApoE) from rat plasma
    • CrossRef Medline
    • Danielsson B, Ekman R, Johansson BG, Nilsson-Ehle P, Petersson BG (1978) Isolation of a high density lipoprotein with high contents of arginine-rich apoprotein (apoE) from rat plasma. FEBS Lett 86:299-302. CrossRef Medline
    • (1978) FEBS Lett , vol.86 , pp. 299-302
    • Danielsson, B.1    Ekman, R.2    Johansson, B.G.3    Nilsson-Ehle, P.4    Petersson, B.G.5
  • 11
    • 1642570212 scopus 로고    scopus 로고
    • Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer’s disease brain and hippocampal neurons
    • CrossRef Medline
    • Del Villar K, Miller CA (2004) Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer’s disease brain and hippocampal neurons. Proc Natl Acad Sci U S A 101:4210-4215. CrossRef Medline
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 4210-4215
    • Del Villar, K.1    Miller, C.A.2
  • 12
    • 0037085434 scopus 로고    scopus 로고
    • Modulation of apolipoprotein D and apolipoprotein E mRNA expression by growth arrest and identification of key elements in the promoter
    • CrossRef Medline
    • Do Carmo S, Séguin D, Milne R, Rassart E (2002) Modulation of apolipoprotein D and apolipoprotein E mRNA expression by growth arrest and identification of key elements in the promoter. J Biol Chem 277:5514-5523. CrossRef Medline
    • (2002) J Biol Chem , vol.277 , pp. 5514-5523
    • Do Carmo, S.1    Séguin, D.2    Milne, R.3    Rassart, E.4
  • 13
    • 84878617717 scopus 로고    scopus 로고
    • Sirtuins as possible targets in neurodegenerative diseases
    • CrossRef Medline
    • Donmez G (2013) Sirtuins as possible targets in neurodegenerative diseases. Curr Drug Targets 14:644-647. CrossRef Medline
    • (2013) Curr Drug Targets , vol.14 , pp. 644-647
    • Donmez, G.1
  • 14
    • 77952319277 scopus 로고    scopus 로고
    • Prolonged endoplasmic reticulum stress promotes mislocalization of immunoglobulins to the cytoplasm
    • CrossRef Medline
    • Drori A, Misaghi S, Haimovich J, Messerle M, Tirosh B (2010) Prolonged endoplasmic reticulum stress promotes mislocalization of immunoglobulins to the cytoplasm. Mol Immunol 47:1719-1727. CrossRef Medline
    • (2010) Mol Immunol , vol.47 , pp. 1719-1727
    • Drori, A.1    Misaghi, S.2    Haimovich, J.3    Messerle, M.4    Tirosh, B.5
  • 15
    • 0031594756 scopus 로고    scopus 로고
    • Alpha2-macroglobulin attenuates beta-amyloid peptide 1-40 fibril formation and associated neurotoxicity of cultured fetal rat cortical neurons
    • Medline
    • Du Y, Bales KR, Dodel RC, Liu X, Glinn MA, Horn JW, Little SP, Paul SM (1998) Alpha2-macroglobulin attenuates beta-amyloid peptide 1-40 fibril formation and associated neurotoxicity of cultured fetal rat cortical neurons. J Neurochem 70:1182-1188. Medline
    • (1998) J Neurochem , vol.70 , pp. 1182-1188
    • Du, Y.1    Bales, K.R.2    Dodel, R.C.3    Liu, X.4    Glinn, M.A.5    Horn, J.W.6    Little, S.P.7    Paul, S.M.8
  • 16
    • 77950187707 scopus 로고    scopus 로고
    • Activity-dependent neuroprotective protein (ADNP) expression in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer’s disease
    • CrossRef Medline
    • Fernandez-Montesinos R, Torres M, Baglietto-Vargas D, Gutierrez A, Gozes I, Vitorica J, Pozo D (2010) Activity-dependent neuroprotective protein (ADNP) expression in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer’s disease. J Mol Neurosci 41:114-120. CrossRef Medline
    • (2010) J Mol Neurosci , vol.41 , pp. 114-120
    • Fernandez-Montesinos, R.1    Torres, M.2    Baglietto-Vargas, D.3    Gutierrez, A.4    Gozes, I.5    Vitorica, J.6    Pozo, D.7
  • 17
    • 76549115951 scopus 로고    scopus 로고
    • Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: Roles of infection, inflammation, and nutrition
    • CrossRef
    • Finch CE (2010) Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition. Proc Natl Acad Sci U S A 107 [Suppl 1]: 1718-1724. CrossRef
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 1718-1724
    • Finch, C.E.1
  • 18
    • 34147096369 scopus 로고    scopus 로고
    • Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: A position paper
    • CrossRef Medline
    • Finch CE, Morgan TE (2007) Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper. Curr Alzheimer Res 4:185-189. CrossRef Medline
    • (2007) Curr Alzheimer Res , vol.4 , pp. 185-189
    • Finch, C.E.1    Morgan, T.E.2
  • 19
  • 20
    • 84893459319 scopus 로고    scopus 로고
    • SIRT1 in neurodevelopment and brain senescence
    • CrossRef Medline
    • Herskovits AZ, Guarente L (2014) SIRT1 in neurodevelopment and brain senescence. Neuron 81:471-483. CrossRef Medline
    • (2014) Neuron , vol.81 , pp. 471-483
    • Herskovits, A.Z.1    Guarente, L.2
  • 21
    • 0033559412 scopus 로고    scopus 로고
    • Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer’s disease
    • CrossRef Medline
    • Holtzman DM, Bales KR, Wu S, Bhat P, Parsadanian M, Fagan AM, Chang LK, Sun Y, Paul SM (1999) Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer’s disease. J Clin Invest 103:R15-R21. CrossRef Medline
    • (1999) J Clin Invest , vol.103 , pp. R15-R21
    • Holtzman, D.M.1    Bales, K.R.2    Wu, S.3    Bhat, P.4    Parsadanian, M.5    Fagan, A.M.6    Chang, L.K.7    Sun, Y.8    Paul, S.M.9
  • 22
    • 84877064267 scopus 로고    scopus 로고
    • Redox regulation of SIRT1 in inflammation and cellular senescence
    • CrossRef Medline
    • Hwang JW, Yao H, Caito S, Sundar IK, Rahman I (2013) Redox regulation of SIRT1 in inflammation and cellular senescence. Free Radic Biol Med 61:95-110. CrossRef Medline
    • (2013) Free Radic Biol Med , vol.61 , pp. 95-110
    • Hwang, J.W.1    Yao, H.2    Caito, S.3    Sundar, I.K.4    Rahman, I.5
  • 23
    • 84867581847 scopus 로고    scopus 로고
    • Upstream transcription factor 1 (USF1) polymorphisms associate with Alzheimer’s disease-related neuropathological lesions: Tampere Autopsy Study
    • CrossRef Medline
    • Isotalo K, Kok EH, Luoto TM, Haikonen S, Haapasalo H, Lehtimäki T, Karhunen PJ (2012) Upstream transcription factor 1 (USF1) polymorphisms associate with Alzheimer’s disease-related neuropathological lesions: Tampere Autopsy Study. Brain Pathol 22:765-775. CrossRef Medline
    • (2012) Brain Pathol , vol.22 , pp. 765-775
    • Isotalo, K.1    Kok, E.H.2    Luoto, T.M.3    Haikonen, S.4    Haapasalo, H.5    Lehtimäki, T.6    Karhunen, P.J.7
  • 24
    • 77749309273 scopus 로고    scopus 로고
    • Probing the DNA-binding affinity and specificity of designed zinc finger proteins
    • CrossRef Medline
    • Jantz D, Berg JM (2010) Probing the DNA-binding affinity and specificity of designed zinc finger proteins. Biophys J 98:852-860. CrossRef Medline
    • (2010) Biophys J , vol.98 , pp. 852-860
    • Jantz, D.1    Berg, J.M.2
  • 25
    • 84880160092 scopus 로고    scopus 로고
    • Antagonistic crosstalk between NF-kappaB and SIRT1 in the regulation of inflammation and metabolic disorders
    • CrossRef Medline
    • Kauppinen A, Suuronen T, Ojala J, Kaarniranta K, Salminen A (2013) Antagonistic crosstalk between NF-kappaB and SIRT1 in the regulation of inflammation and metabolic disorders. Cell Signal 25:1939-1948. CrossRef Medline
    • (2013) Cell Signal , vol.25 , pp. 1939-1948
    • Kauppinen, A.1    Suuronen, T.2    Ojala, J.3    Kaarniranta, K.4    Salminen, A.5
  • 26
    • 84916878837 scopus 로고    scopus 로고
    • Cooperative therapeutic action of retinoic acid receptor and retinoid x receptor agonists in a mouse model of Alzheimer’s disease
    • CrossRef Medline
    • Kawahara K, Suenobu M, Ohtsuka H, Kuniyasu A, Sugimoto Y, Nakagomi M, Fukasawa H, Shudo K, Nakayama H (2014) Cooperative therapeutic action of retinoic acid receptor and retinoid x receptor agonists in a mouse model of Alzheimer’s disease. J Alzheimers Dis 42:587-605. CrossRef Medline
    • (2014) J Alzheimers Dis , vol.42 , pp. 587-605
    • Kawahara, K.1    Suenobu, M.2    Ohtsuka, H.3    Kuniyasu, A.4    Sugimoto, Y.5    Nakagomi, M.6    Fukasawa, H.7    Shudo, K.8    Nakayama, H.9
  • 27
    • 84863248755 scopus 로고    scopus 로고
    • New molecular bridge between RelA/p65 and NF-kappaB target genes via histone acetyltransferase TIP60 cofactor
    • CrossRef Medline
    • Kim JW, Jang SM, Kim CH, An JH, Kang EJ, Choi KH (2012) New molecular bridge between RelA/p65 and NF-kappaB target genes via histone acetyltransferase TIP60 cofactor. J Biol Chem 287:7780-7791. CrossRef Medline
    • (2012) J Biol Chem , vol.287 , pp. 7780-7791
    • Kim, J.W.1    Jang, S.M.2    Kim, C.H.3    An, J.H.4    Kang, E.J.5    Choi, K.H.6
  • 28
    • 38949088891 scopus 로고    scopus 로고
    • Analysis of apolipoprotein E nuclear localization using green fluorescent protein and biotinylation approaches
    • CrossRef Medline
    • Kim WS, Elliott DA, Kockx M, Kritharides L, Rye KA, Jans DA, Garner B (2008) Analysis of apolipoprotein E nuclear localization using green fluorescent protein and biotinylation approaches. Biochem J 409:701-709. CrossRef Medline
    • (2008) Biochem J , vol.409 , pp. 701-709
    • Kim, W.S.1    Elliott, D.A.2    Kockx, M.3    Kritharides, L.4    Rye, K.A.5    Jans, D.A.6    Garner, B.7
  • 29
    • 66249144685 scopus 로고    scopus 로고
    • Identification and characterization of proteins interacting with SIRT1 and SIRT3: Implications in the anti-aging and metabolic effects of sirtuins
    • CrossRef Medline
    • Law IK, Liu L, Xu A, Lam KS, Vanhoutte PM, Che CM, Leung PT, Wang Y (2009) Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins. Proteomics 9:2444-2456. CrossRef Medline
    • (2009) Proteomics , vol.9 , pp. 2444-2456
    • Law, I.K.1    Liu, L.2    Xu, A.3    Lam, K.S.4    Vanhoutte, P.M.5    Che, C.M.6    Leung, P.T.7    Wang, Y.8
  • 30
    • 84906319574 scopus 로고    scopus 로고
    • Cilostazol suppresses _-amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1-coupled retinoic acid receptor
    • CrossRef Medline
    • Lee HR, Shin HK, Park SY, Kim HY, Lee WS, Rhim BY, Hong KW, Kim CD (2014) Cilostazol suppresses _-amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1-coupled retinoic acid receptor. J Neurosci Res 92:1581-1590. CrossRef Medline
    • (2014) J Neurosci Res , vol.92 , pp. 1581-1590
    • Lee, H.R.1    Shin, H.K.2    Park, S.Y.3    Kim, H.Y.4    Lee, W.S.5    Rhim, B.Y.6    Hong, K.W.7    Kim, C.D.8
  • 31
    • 84888009512 scopus 로고    scopus 로고
    • Binding and repressive activities of apolipoprotein E3 and E4 isoforms on the human ApoD promoter
    • CrossRef Medline
    • Levros LC Jr, Labrie M, Charfi C, Rassart E (2013) Binding and repressive activities of apolipoprotein E3 and E4 isoforms on the human ApoD promoter. Mol Neurobiol 48:669-680. CrossRef Medline
    • (2013) Mol Neurobiol , vol.48 , pp. 669-680
    • Levros, L.C.1    Labrie, M.2    Charfi, C.3    Rassart, E.4
  • 32
    • 33645808672 scopus 로고    scopus 로고
    • Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease
    • CrossRef Medline
    • Mahley RW, Weisgraber KH, Huang Y (2006) Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer’s disease. Proc Natl Acad Sci U S A 103:5644-5651. CrossRef Medline
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 5644-5651
    • Mahley, R.W.1    Weisgraber, K.H.2    Huang, Y.3
  • 33
    • 34047179944 scopus 로고    scopus 로고
    • Analysis of protein-DNA interactions using surface plasmon resonance
    • Medline
    • Majka J, Speck C (2007) Analysis of protein-DNA interactions using surface plasmon resonance. Adv Biochem Eng Biotechnol 104:13-36. Medline
    • (2007) Adv Biochem Eng Biotechnol , vol.104 , pp. 13-36
    • Majka, J.1    Speck, C.2
  • 34
    • 0027453552 scopus 로고
    • Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8
    • CrossRef Medline
    • Matsusaka T, Fujikawa K, Nishio Y, Mukaida N, Matsushima K, Kishimoto T, Akira S (1993) Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci U S A 90:10193-10197. CrossRef Medline
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 10193-10197
    • Matsusaka, T.1    Fujikawa, K.2    Nishio, Y.3    Mukaida, N.4    Matsushima, K.5    Kishimoto, T.6    Akira, S.7
  • 35
    • 74749094150 scopus 로고    scopus 로고
    • Targeting of the prion protein to the cytosol: Mechanisms and consequences
    • Medline
    • Miesbauer M, Rambold AS, Winklhofer KF, Tatzelt J (2010) Targeting of the prion protein to the cytosol: mechanisms and consequences. Curr Issues Mol Biol 12:109-118. Medline
    • (2010) Curr Issues Mol Biol , vol.12 , pp. 109-118
    • Miesbauer, M.1    Rambold, A.S.2    Winklhofer, K.F.3    Tatzelt, J.4
  • 36
    • 0034573833 scopus 로고    scopus 로고
    • Detection of apolipoprotein A-I, B, and E immunoreactivity in the nuclei of various rat tissue cells
    • CrossRef Medline
    • Panin LE, Russkikh GS, Polyakov LM (2000) Detection of apolipoprotein A-I, B, and E immunoreactivity in the nuclei of various rat tissue cells. Biochemistry 65:1419-1423. CrossRef Medline
    • (2000) Biochemistry , vol.65 , pp. 1419-1423
    • Panin, L.E.1    Russkikh, G.S.2    Polyakov, L.M.3
  • 37
    • 0034711265 scopus 로고    scopus 로고
    • Self-association of human apolipoprotein E3 and E4 in the presence and absence of phospholipid
    • CrossRef Medline
    • Perugini MA, Schuck P, Howlett GJ (2000) Self-association of human apolipoprotein E3 and E4 in the presence and absence of phospholipid. J Biol Chem 275:36758-36765. CrossRef Medline
    • (2000) J Biol Chem , vol.275 , pp. 36758-36765
    • Perugini, M.A.1    Schuck, P.2    Howlett, G.J.3
  • 38
    • 33644861785 scopus 로고    scopus 로고
    • Model of biologically active apolipoprotein E bound to dipalmitoylphosphatidylcholine
    • CrossRef Medline
    • Peters-Libeu CA, Newhouse Y, Hatters DM, Weisgraber KH (2006) Model of biologically active apolipoprotein E bound to dipalmitoylphosphatidylcholine. J Biol Chem 281:1073-1079. CrossRef Medline
    • (2006) J Biol Chem , vol.281 , pp. 1073-1079
    • Peters-Libeu, C.A.1    Newhouse, Y.2    Hatters, D.M.3    Weisgraber, K.H.4
  • 42
    • 7744232493 scopus 로고    scopus 로고
    • Misfolded proteins, endoplasmic reticulum stress and neurodegeneration
    • CrossRef Medline
    • Rao RV, Bredesen DE (2004) Misfolded proteins, endoplasmic reticulum stress and neurodegeneration. Curr Opin Cell Biol 16:653-662. CrossRef Medline
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 653-662
    • Rao, R.V.1    Bredesen, D.E.2
  • 44
    • 4143055668 scopus 로고    scopus 로고
    • Apolipoprotein E4 as a target for developing new therapeutics for Alzheimer’s disease
    • CrossRef Medline
    • Refolo LM, Fillit HM (2004) Apolipoprotein E4 as a target for developing new therapeutics for Alzheimer’s disease. J Mol Neurosci 23:151-155. CrossRef Medline
    • (2004) J Mol Neurosci , vol.23 , pp. 151-155
    • Refolo, L.M.1    Fillit, H.M.2
  • 46
    • 0030481305 scopus 로고    scopus 로고
    • Apolipoprotein E and Alzheimer’s disease. A rapidly expanding field with medical and epidemiological consequences
    • CrossRef Medline
    • Roses AD (1996) Apolipoprotein E and Alzheimer’s disease. A rapidly expanding field with medical and epidemiological consequences. Ann N Y Acad Sci 802:50-57. CrossRef Medline
    • (1996) Ann N Y Acad Sci , vol.802 , pp. 50-57
    • Roses, A.D.1
  • 48
    • 0030741533 scopus 로고    scopus 로고
    • Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis
    • CrossRef Medline
    • Sullivan PM, Mezdour H, Aratani Y, Knouff C, Najib J, Reddick RL, Quarfordt SH, Maeda N (1997) Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis. J Biol Chem 272: 17972-17980. CrossRef Medline
    • (1997) J Biol Chem , vol.272 , pp. 17972-17980
    • Sullivan, P.M.1    Mezdour, H.2    Aratani, Y.3    Knouff, C.4    Najib, J.5    Reddick, R.L.6    Quarfordt, S.H.7    Maeda, N.8
  • 49
    • 0036570338 scopus 로고    scopus 로고
    • Defective neuronal sprouting by human apolipoprotein E4 is a gain-of-negative function
    • CrossRef Medline
    • Teter B, Xu PT, Gilbert JR, Roses AD, Galasko D, Cole GM (2002) Defective neuronal sprouting by human apolipoprotein E4 is a gain-of-negative function. J Neurosci Res 68:331-336. CrossRef Medline
    • (2002) J Neurosci Res , vol.68 , pp. 331-336
    • Teter, B.1    Xu, P.T.2    Gilbert, J.R.3    Roses, A.D.4    Galasko, D.5    Cole, G.M.6
  • 52
    • 84906712846 scopus 로고    scopus 로고
    • The impact of the endoplasmic reticulum protein-folding environment on cancer development
    • CrossRef Medline
    • Wang M, Kaufman RJ (2014) The impact of the endoplasmic reticulum protein-folding environment on cancer development. Nat Rev Cancer 14:581-597. CrossRef Medline
    • (2014) Nat Rev Cancer , vol.14 , pp. 581-597
    • Wang, M.1    Kaufman, R.J.2
  • 53
    • 0030175279 scopus 로고    scopus 로고
    • Human Apolipoprotein E2, E3, And E4 Isoform-Specific Transgenic Mice: Human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice
    • CrossRef Medline
    • Xu PT, Schmechel D, Rothrock-Christian T, Burkhart DS, Qiu HL, Popko B, Sullivan P, Maeda N, Saunders AM, Roses AD, Gilbert JR (1996) Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice. Neurobiol Dis 3:229-245. CrossRef Medline
    • (1996) Neurobiol Dis , vol.3 , pp. 229-245
    • Xu, P.T.1    Schmechel, D.2    Rothrock-Christian, T.3    Burkhart, D.S.4    Qiu, H.L.5    Popko, B.6    Sullivan, P.7    Maeda, N.8    Saunders, A.M.9    Roses, A.D.10    Gilbert, J.R.11
  • 54
    • 70350448412 scopus 로고    scopus 로고
    • Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function
    • CrossRef Medline
    • Zhong N, Ramaswamy G, Weisgraber KH (2009) Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function. J Biol Chem 284:27273-27280. CrossRef Medline
    • (2009) J Biol Chem , vol.284 , pp. 27273-27280
    • Zhong, N.1    Ramaswamy, G.2    Weisgraber, K.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.