Extracellular Cyclophilin A Activates Platelets Via EMMPRIN (CD147) and PI3K/Akt Signaling, Which Promotes Platelet Adhesion and Thrombus Formation in Vitro and in Vivo

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 35, Issue 3, 2015, Pages 655-663

  Seizer, Peter ^a   Ungern Sternberg, Saskia N I V ^a   Schönberger, Tanja ^a   Borst, Oliver ^a   Münzer, Patrick ^b   Schmidt, Eva Maria ^b   Mack, Andreas F ^c   Heinzmann, David ^a   Chatterjee, Madhumita ^a   Langer, Harald ^a   Malešević, Miroslav ^d   Lang, Florian ^b   Gawaz, Meinrad ^a   Fischer, Gunter ^e   May, Andreas E ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b Institute of Physiology   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^e MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

antigens, CD147; blood platelets; cyclophilin A

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CALCIUM ION; CD147 ANTIGEN; COLLAGEN; CYCLOPHILIN A; CYCLOSPORIN A [4 N METHYLISOLEUCINE]; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PADGEM PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STROMAL CELL DERIVED FACTOR 1; THROMBIN; WORTMANNIN; AKT1 PROTEIN, MOUSE; ANTITHROMBOCYTIC AGENT; BSG PROTEIN, HUMAN; BSG PROTEIN, MOUSE; CHLORIDE; FERRIC CHLORIDE; FERRIC ION; FIBRINOLYTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INJURY; ARTICLE; BLOOD CLOTTING; CALCIUM SIGNALING; CAROTID ARTERY; CAROTID ARTERY LIGATION; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEGRANULATION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MICROSCOPY; MOUSE; NONHUMAN; PLATELET DEGRANULATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; THROMBOCYTE MEMBRANE; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; C57BL MOUSE; CAROTID ARTERY INJURY; CHEMICALLY INDUCED; DEFICIENCY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; GENETICS; KNOCKOUT MOUSE; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOSIS; TIME FACTOR;

ANIMALS; ANTIGENS, CD147; BLOOD PLATELETS; CAROTID ARTERY INJURIES; CELL DEGRANULATION; CHLORIDES; CYCLOPHILIN A; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FERRIC COMPOUNDS; FIBRINOLYTIC AGENTS; HUMANS; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHATIDYLINOSITOL 3-KINASES; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; THROMBOSIS; TIME FACTORS;

EID: 84920400886     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.305112     Document Type: Article

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