Cigarette whole smoke solutions disturb mucin homeostasis in a human in vitro airway tissue model

Toxicology

Volumn 409, Issue , 2018, Pages 119-128

  Cao, Xuefei ^a   Wang, Yiying ^a   Xiong, Rui ^a   Muskhelishvili, Levan ^b   Davis, Kelly ^b   Richter, Patricia A ^c,d   Heflich, Robert H ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b Toxicologic Pathology Associates   (United States)

^c CENTER FOR TOBACCO PRODUCTS   (United States)

^d CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

Apoptosis; Cigarette whole smoke solutions (WSSs); Cilia beating frequency (CBF); Goblet cell hyperplasia; Human air liquid interface (ALI) airway tissue model; Mucus secretion

Indexed keywords

CIGARETTE SMOKE; MUCIN; MUCIN 5AC; MUCIN 5B; TOBACCO SMOKE; MUC1 PROTEIN, HUMAN; MUCIN 1;

ARTICLE; CELL DENSITY; CELL SIZE; CILIATED EPITHELIUM CELL; CONTROLLED STUDY; GOBLET CELL; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LUNG PARENCHYMA; MUCOCILIARY CLEARANCE; PRIORITY JOURNAL; UPREGULATION; BRONCHUS; CELL CULTURE; CELL CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECT; METABOLISM; SMOKE; SOLUTION AND SOLUBILITY; TOBACCO;

BRONCHI; CELL CULTURE TECHNIQUES; CELLS, CULTURED; GOBLET CELLS; HOMEOSTASIS; HUMANS; MUCIN 5AC; MUCIN-1; SMOKE; SOLUTIONS; TOBACCO PRODUCTS;

EID: 85051279112     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2018.07.015     Document Type: Article

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