Cigarette smoke extract-induced BEAS-2B cell apoptosis and anti-oxidative Nrf-2 up-regulation are mediated by ROS-stimulated p38 activation

Toxicology Mechanisms and Methods

Volumn 24, Issue 8, 2014, Pages 575-583

  Lin, Xi Xi ^a   Yang, Xin Fu ^a   Jiang, Jun Xia ^a   Zhang, Shui Juan ^a   Guan, Yan ^a   Liu, Ya Nan ^a   Sun, Yan Hong ^a   Xie, Qiang Min ^a,b  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Apoptosis; Bronchial epithelial cell; Cigarette smoke extract; Nrf 2; Oxidative stress; P38 MAPK

Indexed keywords

ACETYLCYSTEINE; APOPTOSIS SIGNAL REGULATING KINASE 1; CIGARETTE SMOKE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT; DRUG MIXTURE; MAP3K5 PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN; SMOKE;

APOPTOSIS; ARTICLE; BEAS 2B CELL; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; ADVERSE EFFECTS; AGONISTS; ANTAGONISTS AND INHIBITORS; ANTIOXIDANT RESPONSIVE ELEMENT; BRONCHUS; CELL LINE; CHEMISTRY; DRUG EFFECTS; DRUG MIXTURE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; RESPIRATORY TRACT MUCOSA; SMOKE; SMOKING; TOBACCO; TOXICITY;

ACETYLCYSTEINE; ANTIOXIDANT RESPONSE ELEMENTS; ANTIOXIDANTS; APOPTOSIS; BRONCHI; CELL LINE; COMPLEX MIXTURES; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENE SILENCING; HUMANS; MAP KINASE KINASE KINASE 5; MAP KINASE SIGNALING SYSTEM; NF-E2-RELATED FACTOR 2; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES; RESPIRATORY MUCOSA; SMOKE; SMOKING; TOBACCO PRODUCTS; UP-REGULATION;

EID: 84910079090     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376516.2014.956909     Document Type: Article

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