Evaluating the toxicity of cigarette whole smoke solutions in an air-liquid-interface human in Vitro airway tissue model

Toxicological Sciences

Volumn 156, Issue 1, 2017, Pages 14-24

  Cao, Xuefei ^a   Muskhelishvili, Levan ^b   Latendresse, John ^b   Richter, Patricia ^c,d   Heflich, Robert H ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b Toxicologic Pathology Associates   (United States)

^c CENTER FOR TOBACCO PRODUCTS   (United States)

^d CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

Cigarette whole smoke solution (WSS); Human air liquid interface (ALI) airway tissue model; Matrix metalloproteinase (MMP); Mucin; Oxidative stress

Indexed keywords

CIGARETTE SMOKE; MATRIX METALLOPROTEINASE; MUCIN; ACETYLCYSTEINE; BIOLOGICAL MARKER; MUC5AC PROTEIN, HUMAN; MUCIN 5AC; OXIDIZING AGENT; SCAVENGER;

AIRWAY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME RELEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; OXIDATIVE STRESS; SMOKING; AGONISTS; ANTAGONISTS AND INHIBITORS; BRONCHUS; CELL CULTURE; COMPARATIVE STUDY; DRUG EFFECTS; DRUG MIXTURE; FLUORESCENCE MICROSCOPY; IMPEDANCE; KINETICS; LUNG BURN; METABOLISM; PATHOLOGY; PROCEDURES; RESPIRATORY MUCOSA; SECRETION (PROCESS); SMOKE; SOLUBILITY; TOBACCO; TOXICITY; TOXICITY TESTING;

ACETYLCYSTEINE; BIOMARKERS; BRONCHI; CELLS, CULTURED; COMPLEX MIXTURES; ELECTRIC IMPEDANCE; FREE RADICAL SCAVENGERS; HUMANS; KINETICS; MATRIX METALLOPROTEINASES; MICROSCOPY, FLUORESCENCE; MUCIN 5AC; OXIDANTS; OXIDATIVE STRESS; RESPIRATORY MUCOSA; SMOKE; SMOKE INHALATION INJURY; SOLUBILITY; TOBACCO PRODUCTS; TOXICITY TESTS, ACUTE;

EID: 85019944603     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfw239     Document Type: Article

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