Cigarette smoke suppresses Bik to cause epithelial cell hyperplasia and mucous cell metaplasia

American Journal of Respiratory and Critical Care Medicine

Volumn 183, Issue 11, 2011, Pages 1531-1538

  Mebratu, Yohannes A ^a   Schwalm, Kurt ^a   Smith, Kevin R ^a   Schuyler, Mark ^b   Tesfaigzi, Yohannes A ^a  

^a LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

Bcl 2 family of proteins; Chronic bronchitis; Differentiated human airway cultures; Former smokers; MUC5AC

Indexed keywords

CIGARETTE SMOKE; LEUCINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MUCIN 5AC; PROTEIN BCL 2; PROTEIN BIK; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL HYPERPLASIA; CHRONIC BRONCHITIS; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; METAPLASIA; MOUSE; MUCOUS CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM;

ANIMALS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPITHELIAL CELLS; FEMALE; GENES, BCL-2; HUMANS; HYPERPLASIA; LUNG; MALE; METAPLASIA; MICE; MICE, INBRED C57BL; MIDDLE AGED; MUCOUS MEMBRANE; MUCUS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SMOKING;

EID: 79957941753     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201011-1930OC     Document Type: Article

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