Cigarette smoke alters primary human bronchial epithelial cell differentiation at the air-liquid interface

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Schamberger, Andrea C ^a   Staab Weijnitz, Claudia A ^a   Mise Racek, Nikica ^a   Eickelberg, Oliver ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN 14; FORKHEAD TRANSCRIPTION FACTOR; FOXJ1 PROTEIN, HUMAN; KRT14 PROTEIN, HUMAN; MUC5AC PROTEIN, HUMAN; MUCIN 5AC; SCGB1A1 PROTEIN, HUMAN; SMOKE; TUBULIN; UTEROGLOBIN;

ACETYLATION; BRONCHUS; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; GENETICS; HUMAN; METABOLISM; SMOKE; TOBACCO; TOXICITY;

ACETYLATION; BRONCHI; CELL DIFFERENTIATION; EPITHELIAL CELLS; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; KERATIN-14; MUCIN 5AC; SMOKE; TOBACCO PRODUCTS; TUBULIN; UTEROGLOBIN;

EID: 84940655268     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep08163     Document Type: Article

References (43)

1. Staudt, M. R. et al. Smoking Is Associated With A Loss Of Ciliated Cells Throughout The Airways. Am J Resp Crit Care Med-Meeting Abstracts 2014 189, A4097-A4097, doi:10.1164/ajrccm-conference.2014.189.1-MeetingAbstracts. A4097 (2014).
2. Boers, J. E., Ambergen, A. W., Thunnissen, F. B. Number and proliferation of clara cells in normal human airway epithelium. Am J Resp Crit Care Med 159, 1585-1591, doi:10.1164/ajrccm.159.5.9806044 (1999).
3. Rogers, D. F. The airway goblet cell. Int J Biochem Cell 35, 1-6, doi:10.1016/S1357-2725(02)00083-3 (2003).
4. Boers, J. E., Ambergen, A. W., Thunnissen, F. B. Number and proliferation of basal and parabasal cells in normal human airway epithelium. AmJ Resp Crit Care Med 157, 2000-2006, doi:10.1164/ajrccm.157.6.9707011 (1998).
5. Tam, A., Wadsworth, S., Dorscheid, D., Man, S. F., Sin, D. D. The airway epithelium: more than just a structural barrier. Ther Adv Respir Dis 5, 255-273, doi:10.1177/1753465810396539 (2011).
6. Rock, J. R., Randell, S. H., Hogan, B. L. Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling. DisModel Mech 3, 545-556, doi:10.1242/dmm.006031 (2010).
7. Hong, K. U., Reynolds, S. D., Watkins, S., Fuchs, E., Stripp, B. R. In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations. Am J Physiol Lung Cell Mol Physiol 286, L643-649, doi:10.1152/ajplung.00155.2003 (2004).
8. Rock, J. R. et al. Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci USA 106, 12771-12775, doi:10.1073/pnas.0906850106 (2009).
9. Rock, J., Konigshoff, M. Endogenous lung regeneration: potential and limitations. Am J Resp Crit Care Med 186, 1213-1219, doi:10.1164/rccm.201207-1151PP (2012).
10. Hong, K. U., Reynolds, S. D., Watkins, S., Fuchs, E., Stripp, B. R. Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium.AmJ Pathol 164, 577-588, doi:10.1016/S0002-9440(10)63147-1 (2004).
11. Mandal, A. K. et al. Uteroglobin represses allergen-induced inflammatory response by blocking PGD2 receptor-mediated functions. J Exp Med 199, 1317-1330, doi:10.1084/jem.20031666 (2004).
12. Chen, L. C., Zhang, Z., Myers, A. C., Huang, S. K. Cutting edge: altered pulmonary eosinophilic inflammation in mice deficient for Clara cell secretory 10-kDa protein. J Immunol 167, 3025-3028 (2001).
13. Auerbach, O., Stout, A. P., Hammond, E. C., Garfinkel, L. Changes in bronchial epithelium in relation to cigarette smoking and in relation to lung cancer. N Engl J Med 265, 253-267, doi:10.1056/NEJM196108102650601 (1961).
14. Randell, S. H. Airway epithelial stem cells and the pathophysiology of chronic obstructive pulmonary disease. Proc Am Thorac Soc 3, 718-725, doi:10.1513/pats.200605-117SF (2006).
15. Peters, E. J. et al. Squamous metaplasia of the bronchial mucosa and its relationship to smoking. Chest 103, 1429-1432 (1993).
16. Decramer, M., Janssens, W., Miravitlles, M. Chronic obstructive pulmonary disease. Lancet 379, 1341-1351, doi:10.1016/S0140-6736(11)60968-9 (2012).
17. Innes, A. L. et al. Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction. Chest 130, 1102-1108, doi:10.1378/chest.130.4.1102 (2006).
18. O9Donnell, R. A. et al. Expression of ErbB receptors and mucins in the airways of long term current smokers. Thorax 59, 1032-1040, doi:10.1136/thx.2004.028043 (2004).
19. Burgel, P. R. et al. Update on the roles of distal airways in COPD. Eur Respir Rev 20, 7-22, doi:10.1183/09059180.10010610 (2011).
20. Cosio, M. G., Hale, K. A., Niewoehner, D. E. Morphologic and morphometric effects of prolonged cigarette smoking on the small airways. Am Rev Respir Dis 122, 265-221 (1980).
21. Cosio, M. et al. The relations between structural changes in small airways and pulmonary-function tests. N Engl J Med 298, 1277-1281, doi:10.1056/NEJM197806082982303 (1978).
22. Leopold, P. L. et al. Smoking is associated with shortened airway cilia. PloS one 4, e8157, doi:10.1371/journal.pone.0008157 (2009).
23. Lam, H. C. et al. Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. J Clinical Invest 123, 5212-5230, doi:10.1172/JCI69636 (2013).
24. Schamberger, A. C. et al. Cigarette smoke-induced disruption of bronchial epithelial tight junctions is prevented by transforming growth factor-beta. Am J Respir Cell Mol Biol 50, 1040-1052, doi:10.1165/rcmb.2013-0090OC (2014).
25. Heijink, I. H., Brandenburg, S. M., Postma, D. S., van Oosterhout, A. J. Cigarette smoke impairs airway epithelial barrier function and cell-cell contact recovery. Eur Respir J 39, 419-428, doi:10.1183/09031936.00193810 (2012).
26. Iba, M. M., Scholl, H., Fung, J., Thomas, P. E., Alam, J. Induction of pulmonary CYP1A1 by nicotine. Xenobiotica 28, 827-843, doi:10.1080/004982598239083 (1998).
27. Didon, L. et al. RFX3 modulation of FOXJ1 regulation of cilia genes in the human airway epithelium. Respir Res 14, 70, doi:10.1186/1465-9921-14-70 (2013).
28. Wanner, A., Salathe, M., O9Riordan, T. G. Mucociliary clearance in the airways. Am J Resp Crit Care Med 154, 1868-1902, doi:10.1164/ajrccm.154.6.8970383 (1996).
29. Bartalesi, B. et al.Different lung responses to cigarette smoke in two strains of mice sensitive to oxidants. Eur Respir J 25, 15-22, doi:10.1183/09031936.04.00067204 (2005).
30. Brekman, A., Walters, M. S., Tilley, A. E., Crystal, R. G. FOXJ1 Prevents Cilia Growth Inhibition by Cigarette Smoke in Human Airway Epithelium in Vitro. Am J Respir Cell Mol Biol, doi:10.1165/rcmb.2013-0363OC (2014).
31. You, Y. et al. Role of f-box factor foxj1 in differentiation of ciliated airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 286, L650-657, doi:10.1152/ajplung.00170.2003 (2004).
32. Rock, J. R., Hogan, B. L. Epithelial progenitor cells in lung development, maintenance, repair, and disease. Annu Rev Cell Dev Biol 27, 493-512, doi:10.1146/annurev-cellbio-100109-104040 (2011).
33. Rock, J. R. et al. Notch-dependent differentiation of adult airway basal stem cells. Cell stem cell 8, 639-648, doi:10.1016/j.stem.2011.04.003 (2011).
34. Lourenco, R. V., Klimek, M. F., Borowski, C. J. Deposition and clearance of 2 micron particles in the tracheobronchial tree of normal subjects-smokers and nonsmokers. J Clin Invest 50, 1411-1420, doi:10.1172/JCI106624 (1971).
35. Lumsden, A. B., McLean, A., Lamb, D. Goblet and Clara cells of human distal airways: evidence for smoking induced changes in their numbers. Thorax 39, 844-849 (1984).
36. Liao, J. P., Chi, C. H., Li, H. C., Tang, X. Y. Effects of N-acetylcysteine on Clara cells in rats with cigarette smoke exposure. Chin Med J 123, 412-417 (2010).
37. Adair-Kirk, T. L. et al. Distal airways in mice exposed to cigarette smoke: Nrf2-regulated genes are increased in Clara cells. Am J Respir Cell Mol Biol 39, 400-411, doi:10.1165/rcmb.2007-0295OC (2008).
38. Park, H. Y. et al. Club cell protein 16 and disease progression in chronic obstructive pulmonary disease. Am J Resp Crit Care Med 188, 1413-1419, doi:10.1164/rccm.201305-0892OC (2013).
39. Maestrelli, P., Saetta, M., Mapp, C. E., Fabbri, L. M. Remodeling in response to infection and injury. Airway inflammation and hypersecretion of mucus in smoking subjects with chronic obstructive pulmonary disease. Am J Resp Crit Care Med 164, S76-80, doi:10.1164/ajrccm.164.supplement-2.2106067 (2001).
40. Lamb, D., Reid, L. Goblet cell increase in rat bronchial epithelium after exposure to cigarette and cigar tobacco smoke. Br Med J 1, 33-35 (1969).
41. Coles, S. J., Levine, L. R., Reid, L. Hypersecretion of mucus glycoproteins in rat airways induced by tobacco smoke. Am J Pathol 94, 459-472 (1979).
42. Wills-Karp, M. et al. Interleukin-13: central mediator of allergic asthma. Science 282, 2258-2261 (1998).
43. Turner, J. et al. Goblet cells are derived from a FOXJ1-expressing progenitor in a human airway epithelium. Am J Respir Cell Mol Biol 44, 276-284, doi:10.1165/rcmb.2009-0304OC (2011).