메뉴 건너뛰기




Volumn 54, Issue , 2018, Pages 128-137

Towards better understanding of industrial cell factories: novel approaches for 13C metabolic flux analysis in complex nutrient environments

Author keywords

[No Author keywords available]

Indexed keywords

METABOLISM;

EID: 85050875691     PISSN: 09581669     EISSN: 18790429     Source Type: Journal    
DOI: 10.1016/j.copbio.2018.07.001     Document Type: Review
Times cited : (28)

References (64)
  • 1
    • 84958119733 scopus 로고    scopus 로고
    • Biotechnology for chemical production: challenges and opportunities
    • Burk, M.J., Van Dien, S., Biotechnology for chemical production: challenges and opportunities. Trends Biotechnol 34 (2016), 187–190.
    • (2016) Trends Biotechnol , vol.34 , pp. 187-190
    • Burk, M.J.1    Van Dien, S.2
  • 2
    • 84994762931 scopus 로고    scopus 로고
    • Biomanufacturing: history and perspective
    • Zhang, Y.-P., Sun, J., Ma, Y., Biomanufacturing: history and perspective. J Ind Microbiol Biotechnol 44 (2017), 773–784.
    • (2017) J Ind Microbiol Biotechnol , vol.44 , pp. 773-784
    • Zhang, Y.-P.1    Sun, J.2    Ma, Y.3
  • 3
    • 85041927498 scopus 로고    scopus 로고
    • Impacts of bioprocess engineering on product formation by Acetobacter pasteurianus
    • Zheng, Y., Chang, Y., Xie, S., Song, J., Wang, M., Impacts of bioprocess engineering on product formation by Acetobacter pasteurianus. Appl Microbiol Biotechnol 102 (2018), 2535–2541.
    • (2018) Appl Microbiol Biotechnol , vol.102 , pp. 2535-2541
    • Zheng, Y.1    Chang, Y.2    Xie, S.3    Song, J.4    Wang, M.5
  • 5
    • 84867209510 scopus 로고    scopus 로고
    • Systems and synthetic metabolic engineering for amino acid production – the heartbeat of industrial strain development
    • Becker, J., Wittmann, C., Systems and synthetic metabolic engineering for amino acid production – the heartbeat of industrial strain development. Curr Opin Biotechnol 23 (2012), 718–726.
    • (2012) Curr Opin Biotechnol , vol.23 , pp. 718-726
    • Becker, J.1    Wittmann, C.2
  • 6
    • 84864801619 scopus 로고    scopus 로고
    • Bio-based production of chemicals, materials and fuels – Corynebacterium glutamicum as versatile cell factory
    • Becker, J., Wittmann, C., Bio-based production of chemicals, materials and fuels – Corynebacterium glutamicum as versatile cell factory. Curr Opin Biotechnol 23 (2012), 631–640.
    • (2012) Curr Opin Biotechnol , vol.23 , pp. 631-640
    • Becker, J.1    Wittmann, C.2
  • 7
    • 84941217806 scopus 로고    scopus 로고
    • Top value platform chemicals: bio-based production of organic acids
    • Becker, J., Lange, A., Fabarius, J., Wittmann, C., Top value platform chemicals: bio-based production of organic acids. Curr Opin Biotechnol 36 (2015), 168–175.
    • (2015) Curr Opin Biotechnol , vol.36 , pp. 168-175
    • Becker, J.1    Lange, A.2    Fabarius, J.3    Wittmann, C.4
  • 8
    • 84982836684 scopus 로고    scopus 로고
    • Systems metabolic engineering of Escherichia coli for the heterologous production of high value molecules – a veteran at new shores
    • Becker, J., Wittmann, C., Systems metabolic engineering of Escherichia coli for the heterologous production of high value molecules – a veteran at new shores. Curr Opin Biotechnol 42 (2016), 178–188.
    • (2016) Curr Opin Biotechnol , vol.42 , pp. 178-188
    • Becker, J.1    Wittmann, C.2
  • 10
    • 79952106791 scopus 로고    scopus 로고
    • From zero to hero – design-based systems metabolic engineering of Corynebacterium glutamicum for L-lysine production
    • Becker, J., Zelder, O., Häfner, S., Schröder, H., Wittmann, C., From zero to hero – design-based systems metabolic engineering of Corynebacterium glutamicum for L-lysine production. Metab Eng 13 (2011), 159–168.
    • (2011) Metab Eng , vol.13 , pp. 159-168
    • Becker, J.1    Zelder, O.2    Häfner, S.3    Schröder, H.4    Wittmann, C.5
  • 11
    • 85050857299 scopus 로고    scopus 로고
    • 13C metabolic flux analysis for the cancer biologist
    • 13C metabolic flux analysis for the cancer biologist. Exp Mol Med, 50, 2018, 19.
    • (2018) Exp Mol Med , vol.50 , pp. 19
    • Antoniewicz, M.R.1
  • 12
    • 79551508527 scopus 로고    scopus 로고
    • 13C metabolic flux analysis in complex systems
    • 13C metabolic flux analysis in complex systems. Curr Opin Biotechnol 22 (2011), 103–108.
    • (2011) Curr Opin Biotechnol , vol.22 , pp. 103-108
    • Zamboni, N.1
  • 13
    • 33847691476 scopus 로고    scopus 로고
    • Fluxome analysis using GC–MS
    • Wittmann, C., Fluxome analysis using GC–MS. Microb Cell Fact, 6, 2007, 17.
    • (2007) Microb Cell Fact , vol.6 , pp. 17
    • Wittmann, C.1
  • 14
    • 78149407462 scopus 로고    scopus 로고
    • Metabolic fluxes and beyond-systems biology understanding and engineering of microbial metabolism
    • Kohlstedt, M., Becker, J., Wittmann, C., Metabolic fluxes and beyond-systems biology understanding and engineering of microbial metabolism. Appl Microbiol Biotechnol 88 (2010), 1065–1075.
    • (2010) Appl Microbiol Biotechnol , vol.88 , pp. 1065-1075
    • Kohlstedt, M.1    Becker, J.2    Wittmann, C.3
  • 17
    • 84877881315 scopus 로고    scopus 로고
    • Towards better understanding of an industrial cell factory: investigating the feasibility of real-time metabolic flux analysis in Pichia pastoris
    • Fazenda, M.L., Dias, J.M., Harvey, L.M., Nordon, A., Edrada-Ebel, R., LittleJohn, D., McNeil, B., Towards better understanding of an industrial cell factory: investigating the feasibility of real-time metabolic flux analysis in Pichia pastoris. Microb Cell Fact, 12, 2013, 51.
    • (2013) Microb Cell Fact , vol.12 , pp. 51
    • Fazenda, M.L.1    Dias, J.M.2    Harvey, L.M.3    Nordon, A.4    Edrada-Ebel, R.5    LittleJohn, D.6    McNeil, B.7
  • 18
    • 84952663246 scopus 로고    scopus 로고
    • Biobased organic acids production by metabolically engineered microorganisms
    • Chen, Y., Nielsen, J., Biobased organic acids production by metabolically engineered microorganisms. Curr Opin Biotechnol 37 (2016), 165–172.
    • (2016) Curr Opin Biotechnol , vol.37 , pp. 165-172
    • Chen, Y.1    Nielsen, J.2
  • 19
    • 0038293260 scopus 로고    scopus 로고
    • Toward consistent and productive complex media for industrial fermentations: studies on yeast extract for a recombinant yeast fermentation process
    • Zhang, J.Y., Reddy, J., Buckland, B., Greasham, R., Toward consistent and productive complex media for industrial fermentations: studies on yeast extract for a recombinant yeast fermentation process. Biotechnol Bioeng 82 (2003), 640–652.
    • (2003) Biotechnol Bioeng , vol.82 , pp. 640-652
    • Zhang, J.Y.1    Reddy, J.2    Buckland, B.3    Greasham, R.4
  • 20
    • 84884271403 scopus 로고    scopus 로고
    • Core fluxome and metafluxome of lactic acid bacteria under simulated cocoa pulp fermentation conditions
    • 13C tracer strategy provided impressive details on the interplay of different bacterial strains to the process.
    • 13C tracer strategy provided impressive details on the interplay of different bacterial strains to the process.
    • (2013) Appl Environ Microbiol , vol.79 , pp. 5670-5681
    • Adler, P.1    Bolten, C.J.2    Dohnt, K.3    Hansen, C.E.4    Wittmann, C.5
  • 21
    • 84904910796 scopus 로고    scopus 로고
    • The key to acetate: metabolic fluxes of acetic acid bacteria under cocoa pulp fermentation-simulating conditions
    • Here, the role of acetic acid bacteria in the cocoa pulp fermentation was investigated. A functionally separated metabolism relies on the fine-tuned ratio of different microbes contributing to the process.
    • Adler, P., Frey, L.J., Berger, A., Bolten, C.J., Hansen, C.E., Wittmann, C., The key to acetate: metabolic fluxes of acetic acid bacteria under cocoa pulp fermentation-simulating conditions. Appl Environ Microbiol 80 (2014), 4702–4716 Here, the role of acetic acid bacteria in the cocoa pulp fermentation was investigated. A functionally separated metabolism relies on the fine-tuned ratio of different microbes contributing to the process.
    • (2014) Appl Environ Microbiol , vol.80 , pp. 4702-4716
    • Adler, P.1    Frey, L.J.2    Berger, A.3    Bolten, C.J.4    Hansen, C.E.5    Wittmann, C.6
  • 22
    • 85011290939 scopus 로고    scopus 로고
    • 13C flux analysis to identify high-productivity CHO metabolic phenotypes
    • For the first time, the fluxome of several IgG-producing CHO cell lines was analyzed and compared. Upregulated mitochondrial metabolism and lactate consumption instead of secretion are associated with the producing phenotype.
    • 13C flux analysis to identify high-productivity CHO metabolic phenotypes. Metab Eng 43 (2017), 218–225 For the first time, the fluxome of several IgG-producing CHO cell lines was analyzed and compared. Upregulated mitochondrial metabolism and lactate consumption instead of secretion are associated with the producing phenotype.
    • (2017) Metab Eng , vol.43 , pp. 218-225
    • Templeton, N.1    Smith, K.D.2    McAtee-Pereira, A.G.3    Dorai, H.4    Betenbaugh, M.J.5    Lang, S.E.6    Young, J.D.7
  • 23
    • 85046410120 scopus 로고    scopus 로고
    • 13C metabolic network analysis with combined labeling analysis by GC/MS, LC/MS, 1D, and 2D NMR
    • 13C tracer experiments and a combination of GC–MS, LC–MS, and NMR provide impressive details into riboflavin production with Ashbya gossypii under industrial conditions. Based on the obtained data, tailor-made process optimization resulted in a 45 % increased riboflavin titer.
    • 13C tracer experiments and a combination of GC–MS, LC–MS, and NMR provide impressive details into riboflavin production with Ashbya gossypii under industrial conditions. Based on the obtained data, tailor-made process optimization resulted in a 45 % increased riboflavin titer.
    • (2018) Metab Eng , vol.47 , pp. 357-373
    • Schwechheimer, S.K.1    Becker, J.2    Peyriga, L.3    Portais, J.-C.4    Sauer, D.5    Müller, R.6    Hoff, B.7    Haefner, S.8    Schröder, H.9    Zelder, O.10    Wittmann, C.11
  • 25
    • 51049091904 scopus 로고    scopus 로고
    • Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line
    • Yoo, H., Antoniewicz, M.R., Stephanopoulos, G., Kelleher, J.K., Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line. J Biol Chem 283 (2008), 20621–20627.
    • (2008) J Biol Chem , vol.283 , pp. 20621-20627
    • Yoo, H.1    Antoniewicz, M.R.2    Stephanopoulos, G.3    Kelleher, J.K.4
  • 26
    • 85008620712 scopus 로고    scopus 로고
    • Understanding metabolism with flux analysis: from theory to application
    • Dai, Z., Locasale, J.W., Understanding metabolism with flux analysis: from theory to application. Metab Eng 43 (2017), 94–102.
    • (2017) Metab Eng , vol.43 , pp. 94-102
    • Dai, Z.1    Locasale, J.W.2
  • 31
    • 85052059877 scopus 로고    scopus 로고
    • From systems biology to metabolically engineered cells – an omics perspective on the development of industrial microbes
    • (in press)
    • Becker, J., Wittmann, C., From systems biology to metabolically engineered cells – an omics perspective on the development of industrial microbes. Curr Opin Biotechnol, 2018 (in press).
    • (2018) Curr Opin Biotechnol
    • Becker, J.1    Wittmann, C.2
  • 34
    • 33846442438 scopus 로고    scopus 로고
    • Transcriptional and metabolic responses of Bacillus subtilis to the availability of organic acids: transcription regulation is important but not sufficient to account for metabolic adaptation
    • Schilling, O., Frick, O., Herzberg, C., Ehrenreich, A., Heinzle, E., Wittmann, C., Stülke, J., Transcriptional and metabolic responses of Bacillus subtilis to the availability of organic acids: transcription regulation is important but not sufficient to account for metabolic adaptation. Appl Environ Microbiol 73 (2007), 499–507.
    • (2007) Appl Environ Microbiol , vol.73 , pp. 499-507
    • Schilling, O.1    Frick, O.2    Herzberg, C.3    Ehrenreich, A.4    Heinzle, E.5    Wittmann, C.6    Stülke, J.7
  • 35
    • 84887628469 scopus 로고    scopus 로고
    • 13C metabolic flux analysis: optimal design of isotopic labeling experiments
    • 13C metabolic flux analysis: optimal design of isotopic labeling experiments. Curr Opin Biotechnol 24 (2013), 1116–1121.
    • (2013) Curr Opin Biotechnol , vol.24 , pp. 1116-1121
    • Antoniewicz, M.R.1
  • 36
    • 0036956758 scopus 로고    scopus 로고
    • Genealogy profiling through strain improvement by using metabolic network analysis: metabolic flux genealogy of several generations of lysine-producing Corynebacteria
    • Wittmann, C., Heinzle, E., Genealogy profiling through strain improvement by using metabolic network analysis: metabolic flux genealogy of several generations of lysine-producing Corynebacteria. Appl Environ Microbiol 68 (2002), 5843–5859.
    • (2002) Appl Environ Microbiol , vol.68 , pp. 5843-5859
    • Wittmann, C.1    Heinzle, E.2
  • 37
    • 85050871321 scopus 로고    scopus 로고
    • 13C tracer experiments and mass spectrometry in Corynebacterium glutamicum
    • J.-L. Barredo Humana Press
    • 13C tracer experiments and mass spectrometry in Corynebacterium glutamicum. Barredo, J.-L., (eds.) Microbial Processes and Products, 2005, Humana Press, 191–204.
    • (2005) Microbial Processes and Products , pp. 191-204
    • Wittmann, C.1    Heinzle, E.2
  • 38
    • 84992401825 scopus 로고    scopus 로고
    • Tracing metabolism from lignocellulosic biomass and gaseous substrates to products with stable-isotopes
    • Gonzalez, J.E., Antoniewicz, M.R., Tracing metabolism from lignocellulosic biomass and gaseous substrates to products with stable-isotopes. Curr Opin Biotechnol 43 (2017), 86–95.
    • (2017) Curr Opin Biotechnol , vol.43 , pp. 86-95
    • Gonzalez, J.E.1    Antoniewicz, M.R.2
  • 39
    • 16344378267 scopus 로고    scopus 로고
    • 13C metabolic flux analysis with sole quantification of carbon dioxide labeling
    • 13C metabolic flux analysis with sole quantification of carbon dioxide labeling. Comput Biol Chem 29 (2005), 121–133.
    • (2005) Comput Biol Chem , vol.29 , pp. 121-133
    • Yang, T.H.1    Heinzle, E.2    Wittmann, C.3
  • 40
    • 0034811345 scopus 로고    scopus 로고
    • Modeling and experimental design for metabolic flux analysis of lysine-producing corynebacteria by mass spectrometry
    • Wittmann, C., Heinzle, E., Modeling and experimental design for metabolic flux analysis of lysine-producing corynebacteria by mass spectrometry. Metab Eng 3 (2001), 173–191.
    • (2001) Metab Eng , vol.3 , pp. 173-191
    • Wittmann, C.1    Heinzle, E.2
  • 42
    • 84973441412 scopus 로고    scopus 로고
    • 13C metabolic flux analysis: a new precision and synergy scoring system
    • 13C tracer selection, both for single and also for parallel labeling experiments.
    • 13C tracer selection, both for single and also for parallel labeling experiments.
    • (2016) Metab Eng , vol.38 , pp. 10-18
    • Crown, S.B.1    Long, C.P.2    Antoniewicz, M.R.3
  • 43
    • 84951185679 scopus 로고    scopus 로고
    • Green pathways: metabolic network analysis of plant systems
    • Dersch, L.M., Beckers, V., Wittmann, C., Green pathways: metabolic network analysis of plant systems. Metab Eng 34 (2016), 1–24.
    • (2016) Metab Eng , vol.34 , pp. 1-24
    • Dersch, L.M.1    Beckers, V.2    Wittmann, C.3
  • 45
    • 33750918907 scopus 로고    scopus 로고
    • Residue analysis of 500 high priority pesticides: better by GC–MS or LC–MS/MS?
    • Alder, L., Greulich, K., Kempe, G., Vieth, B., Residue analysis of 500 high priority pesticides: better by GC–MS or LC–MS/MS?. Mass Spectrom Rev 25 (2006), 838–865.
    • (2006) Mass Spectrom Rev , vol.25 , pp. 838-865
    • Alder, L.1    Greulich, K.2    Kempe, G.3    Vieth, B.4
  • 46
    • 84958981814 scopus 로고    scopus 로고
    • Applications of NMR spectroscopy to systems biochemistry
    • Fan, T.W.M., Lane, A.N., Applications of NMR spectroscopy to systems biochemistry. Prog Nucl Magn Reson Spectrosc 92-93 (2016), 18–53.
    • (2016) Prog Nucl Magn Reson Spectrosc , vol.92-93 , pp. 18-53
    • Fan, T.W.M.1    Lane, A.N.2
  • 48
    • 84873356152 scopus 로고    scopus 로고
    • Comparison of GC–MS and NMR for metabolite profiling of rice subjected to submergence stress
    • Barding, G.A. Jr., Beni, S., Fukao, T., Bailey-Serres, J., Larive, C.K., Comparison of GC–MS and NMR for metabolite profiling of rice subjected to submergence stress. J Proteome Res 12 (2013), 898–909.
    • (2013) J Proteome Res , vol.12 , pp. 898-909
    • Barding, G.A.1    Beni, S.2    Fukao, T.3    Bailey-Serres, J.4    Larive, C.K.5
  • 49
    • 84962375964 scopus 로고    scopus 로고
    • The cocoa bean fermentation process: from ecosystem analysis to starter culture development
    • De Vuyst, L., Weckx, S., The cocoa bean fermentation process: from ecosystem analysis to starter culture development. J Appl Microbiol 121 (2016), 5–17.
    • (2016) J Appl Microbiol , vol.121 , pp. 5-17
    • De Vuyst, L.1    Weckx, S.2
  • 53
    • 84971673738 scopus 로고    scopus 로고
    • 13C-metabolic flux analysis
    • 13C metabolic flux analysis, the authors demonstrated for the first time that carbon is lost in the pentose phosphate pathway of mammalian cells, not only in the oxidative branch, but also due to the action of the transketolase-like protein 1.
    • 13C metabolic flux analysis, the authors demonstrated for the first time that carbon is lost in the pentose phosphate pathway of mammalian cells, not only in the oxidative branch, but also due to the action of the transketolase-like protein 1.
    • (2016) Metab Eng , vol.37 , pp. 72-78
    • Ahn, W.S.1    Crown, S.B.2    Antoniewicz, M.R.3
  • 55
    • 85037088224 scopus 로고    scopus 로고
    • Meta-analysis of gut microbiome studies identifies disease-specific and shared responses
    • Duvallet, C., Gibbons, S.M., Gurry, T., Irizarry, R.A., Alm, E.J., Meta-analysis of gut microbiome studies identifies disease-specific and shared responses. Nat Commun 8 (2017), 017–01973.
    • (2017) Nat Commun , vol.8 , pp. 017-01973
    • Duvallet, C.1    Gibbons, S.M.2    Gurry, T.3    Irizarry, R.A.4    Alm, E.J.5
  • 57
    • 84871639510 scopus 로고    scopus 로고
    • Opportunities and challenges for biosimilars: what's on the horizon in the global insulin market?
    • Rotenstein, L.S., Ran, N., Shivers, J.P., Yarchoan, M., Close, K.L., Opportunities and challenges for biosimilars: what's on the horizon in the global insulin market?. Clin Diabetes 30 (2012), 138–150.
    • (2012) Clin Diabetes , vol.30 , pp. 138-150
    • Rotenstein, L.S.1    Ran, N.2    Shivers, J.P.3    Yarchoan, M.4    Close, K.L.5
  • 59
    • 0345526382 scopus 로고    scopus 로고
    • Fungal morphology and metabolite production in submerged mycelial processes
    • Papagianni, M., Fungal morphology and metabolite production in submerged mycelial processes. Biotechnol Adv 22 (2004), 189–259.
    • (2004) Biotechnol Adv , vol.22 , pp. 189-259
    • Papagianni, M.1
  • 60
    • 0038236925 scopus 로고    scopus 로고
    • Industrial production of β-lactam antibiotics
    • Elander, R.P., Industrial production of β-lactam antibiotics. Appl Microbiol Biotechnol 61 (2003), 385–392.
    • (2003) Appl Microbiol Biotechnol , vol.61 , pp. 385-392
    • Elander, R.P.1
  • 62
    • 85050863264 scopus 로고    scopus 로고
    • Method of producing l-lysine by fermentation. US 6,040,160
    • Kojima H, Ogawa Y, Kawamura KS: Method of producing l-lysine by fermentation. US 6,040,160. 2000.
    • (2000)
    • Kojima, H.1    Ogawa, Y.2    Kawamura, K.S.3
  • 63
    • 85050891089 scopus 로고    scopus 로고
    • Methods and materials for the production of organic products in cells of Candida species. US 7,141,410 B2
    • Rajgarhia V, Penttilä M, Ruohonen L, Ilmén M, Koivuranta K, Suominen P: Methods and materials for the production of organic products in cells of Candida species. US 7,141,410 B2. 2006.
    • (2006)
    • Rajgarhia, V.1    Penttilä, M.2    Ruohonen, L.3    Ilmén, M.4    Koivuranta, K.5    Suominen, P.6
  • 64
    • 69949136867 scopus 로고    scopus 로고
    • Biotechnological production of itaconic acid and its biosynthesis in Aspergillus terreus
    • Okabe, M., Lies, D., Kanamasa, S., Park, E.Y., Biotechnological production of itaconic acid and its biosynthesis in Aspergillus terreus. Appl Microbiol Biotechnol 84 (2009), 597–606.
    • (2009) Appl Microbiol Biotechnol , vol.84 , pp. 597-606
    • Okabe, M.1    Lies, D.2    Kanamasa, S.3    Park, E.Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.