Bio-based succinate from sucrose: High-resolution 13C metabolic flux analysis and metabolic engineering of the rumen bacterium Basfia succiniciproducens

Metabolic Engineering

Volumn 44, Issue , 2017, Pages 198-212

  Lange, Anna ^a   Becker, Judith ^a   Schulze, Dennis ^a   Cahoreau, Edern ^b,c,d   Portais, Jean Charles ^b,c,d   Haefner, Stefan ^e   Schröder, Hartwig ^e   Krawczyk, Joanna ^e   Zelder, Oskar ^e   Wittmann, Christoph ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b INSA   (France)

^c UMR792 INGÉNIERIE DES SYSTÈMES BIOLOGIQUES ET DES PROCÉDÉS   (France)

^d CNRS   (France)

^e BASF SE   (Germany)

Author keywords

13C metabolic flux analysis; Fructokinase; Fructose; Fructose phosphotransferase system; Isotopomer; Mass spectrometry; Metabolic engineering; OpenFLUX; Succinate, succinic acid; Sucrose

Indexed keywords

BACTERIA; BATCH CELL CULTURE; BATCH DATA PROCESSING; BYPRODUCTS; FRUCTOSE; MASS SPECTROMETRY; METABOLISM; SUBSTRATES; SUGAR (SUCROSE);

FRUCTOKINASE; ISOTOPOMER; METABOLIC FLUX ANALYSIS; OPENFLUX; PHOSPHOTRANSFERASE SYSTEM; SUCCINIC ACIDS;

METABOLIC ENGINEERING;

CARBON 13; FRUCTOKINASE; FRUCTOSE; PYRUVIC ACID; SUCCINIC ACID; SUCROSE; CARBON;

ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM CULTURE; BASFIA SUCCINICIPRODUCENS; BIOTECHNOLOGY; CITRIC ACID CYCLE; FED BATCH CULTURE; METABOLIC ENGINEERING; METABOLIC FLUX ANALYSIS; MUTANT; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RUMEN MICROORGANISM; ANIMAL; BIOLOGICAL MODEL; GENETICS; METABOLISM; MICROBIOLOGY; PASTEURELLACEAE; RUMEN;

ANIMALS; CARBON ISOTOPES; METABOLIC ENGINEERING; MODELS, BIOLOGICAL; PASTEURELLACEAE; RUMEN; SUCCINIC ACID; SUCROSE;

EID: 85031825399     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2017.10.003     Document Type: Article

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