Elucidating the role of copper in CHO cell energy metabolism using 13C metabolic flux analysis

Biotechnology Progress

Volumn 31, Issue 5, 2015, Pages 1179-1186

  Nargund, Shilpa ^a   Qiu, Jinshu ^a   Goudar, Chetan T ^a  

^a AMGEN INC   (United States)

Author keywords

13C metabolic flux analysis; Aerobic glycolysis; Chinese hamster ovary; Copper deficiency; Lactate production; Oxidative phosphorylation

Indexed keywords

CARBON; CELLS; CYTOLOGY; ELECTRON TRANSPORT PROPERTIES; GLUCOSE; METABOLISM; METABOLITES; MONTE CARLO METHODS; PATHOLOGY; PHOSPHORYLATION; RECOMBINANT PROTEINS; SUPERCONDUCTING MATERIALS;

AEROBIC GLYCOLYSIS; CENTRAL CARBON METABOLISMS; CHINESE HAMSTER OVARY; ELECTRON TRANSPORT CHAIN; FED-BATCH BIOREACTORS; METABOLIC FLUX ANALYSIS; OXIDATIVE PHOSPHORYLATION; PENTOSE PHOSPHATE PATHWAY;

COPPER;

CARBON; COPPER; LACTIC ACID; MALIC ACID; MALIC ACID DERIVATIVE; PYRUVIC ACID;

ANIMAL; BIOREACTOR; CELL CULTURE TECHNIQUE; CHO CELL LINE; CRICETULUS; ENERGY METABOLISM; GLYCOLYSIS; HAMSTER; MASS FRAGMENTOGRAPHY; METABOLIC FLUX ANALYSIS; METABOLISM; PENTOSE PHOSPHATE CYCLE; PHOSPHORYLATION; PROCEDURES;

ANIMALS; BIOREACTORS; CARBON ISOTOPES; CELL CULTURE TECHNIQUES; CHO CELLS; COPPER; CRICETINAE; CRICETULUS; ENERGY METABOLISM; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLYCOLYSIS; LACTIC ACID; MALATES; METABOLIC FLUX ANALYSIS; PENTOSE PHOSPHATE PATHWAY; PHOSPHORYLATION; PYRUVIC ACID;

EID: 84945470795     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.2131     Document Type: Article

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